N_3O_2형의 Dibenzoic Polyether Nitrogen과 Fe족 금속이온의 錯物에 關한 硏究(Ⅰ)

丁學鎭,丁梧鎭,曺正煥 조선대학교 기초과학연구소 1984 自然科學硏究 Vol.7 No.1

새로운 N_2O_3형 Dibenzonic Polyether Nitrogen을 합성하여 여러 비양자성 용매하에서〔Acetonitrile (AN), N, N-Dimethylformamide(DMF), Dimethylsulfoxide(DMSO) 및 Tetrahydrofuran(THF)와 Fe족 금속이온염과 합성한 Ligandrks의 착물생성에 따른 안정도 상수를 전기전도도법으로 구하고 착물생성으로 유발되는 음이온효과 용매효과 등을 UV-Spectrum으로부터 알아보았다. 그리고 비양자성 용매하에서의 전기전도도 자료로부터 착물이온들의 행동을 검토하였다. Dibenzonic Polyether Nitrogen (DBPN)의 구조는 원소분석과 IR-Spectrum 자료로부터 확인하였다. DBPN-CoCl_2DBPN-NiCl_2DBPN-Co(NO_3)_2 및 DBPN-Ni(NO_3)_2 착이온들의 비전도도를 Tokyo Electric Conductivitymeter에 의하여 25℃에서 측정하였다. 용매의 첨가량에 따라 Complex ion들의 당량전도도는 용매효과 금속양이온 및 음이온 등에 의하여 영향을 받는다. 특히 DBPN-metal(Co^2+, Ni^2+) Complex의 안정도상수 값은 AN>DMSO>THF 순이다. 일정 용매하에서 DBPN-metal(Co^2+, Ni^2+) 착물들의 안정도정수들은 Co^2+>Ni^2+와 Cl^->NO_3^-의 순으로 증가하였다. 이런 결과들로부터 DBPN-Ni과 Co의 착물들의 안정도정수는 DBPN의 동공 크기와 양이온크기의 상대적인 비에 의하여 크게 의존하였다. 그리고 비양자성 용매하에서 Complex ion들의 최대흡광 Peak는 핵전이 장파장이동 Peak를 보여준다. The ligand of the new Dibenzoic Polyether Nitrogen(DBPN) or the N_3O_2 type has been synthezised. The stability constants for the 1‥1 complexes of DBPN with cobalt and nickel in Acetonitrile, Dimethylsulfoxide, Tetrahydrofrane and and N, N-Dimethylforamide have been determined by electrical conductivitimeter and the effect of solvents, cations and anions indused from formation of complexes with DBPN ligand, have been discussed by the data of the UV-spectrum, and then the behaviors of these complexes ions have been discussed from the data of analysis of elements and IR-spectrum. The structures of DBPN are indentified from the data of analysis of elements and IR-spectrum. The specific conductances of the complexes with DBPN, chloride and nitrate salt of cobalt and nickel are measured Conductances at 25℃. The equivalent conductances are affected by the volume of organosolvents added, kinds of organosolvents, solvation, cations and anions, and the stability constants of complexes with Co^2+ and Ni^2+ are in the order of AN>DMSO>TMF>DMF, and the stability constants of these complexes are in the order of Co^2+>Ni^2+ and Cl^->NO_3^-, respectively. The stability constants of these complexes depends highly on relative ratio of cavity size of DBPN and cation size. The λ_max. of these complexes are shifted by solvents used and these complexes are also shifted in the direction of the long wavelength under the aprotic solvents.

위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

溶媒添加에 따른 Ethylene Disulfide Dibenzoic Acid와 희토류 금속 ion과의 錯物에 對한 分光學的 硏究(Ⅰ).

丁學鎭,송성식,曺正煥 조선대학교 기초과학연구소 1984 自然科學硏究 Vol.7 No.1

Thiosalicylic acid를 출발물질로 하여 EDDA(Ethylene disulfide dibenzoic zcid) ligand를 합성하였다. 이 ligand는 IR Spectrum과 원소 분석에 의하여 확인하였고 몇가지 희토류 금속이온과 ligand사이에 생성된 착이온의 pH 및 시간에 대한 안정성과 용매첨가에 따른 Complex ion들의 분광학적 현상을 UV분광법으로 확인하였다. 전위차분석법에 의하여 합성된 ligand의 pKa값을 정하고 complex ion들의 금속-리간드간에 존재하는 공유결합성을 ligand의 pKa값과 착이온들의 oscillator strenght 사이에서 얻어진 관계식으로부터 검토하였으며 다음과 같은 결과를 얻었다. 1. 합성된 EDDA ligand의 원소분석결과 이론치에 일치하였으며 IR Spectrum data로부터 aromatic-S-aliphatic 특성 peak와 aromatic-COOH dimer peak를 얻었다. 2. 합성된 EDDA ligand는 4자리 schiff base ligand로 행동한다. 3. 생성된 착이온의 입체적 구조변화는 hypsochromic effect를 갖는 n-π charge transfer complex이다. 4. Lanthanides(Ⅲ)와 EDDA ligand사이에 생성된 complex ion들은 1:1 complex였다. 5. 착이온들의 최대흡광파장은 결합하고 있는 중심금속의 종류에 따라 달라진다. 6. 착이온들에게 몇가지 유기용매를 첨가한 결과 complex ion들의 최대 흡광파장은 bathochromic effect를 갖는다. 7. 착이온들의 P^H 안정성은 pH 6.0∼9.0이며 lanthanides(Ⅲ)와 합성된 ligand를 몇가지 유기용매와 반응시킨때의 시간의 안정성은 30분후이다. 8. Complex ion의 안정도 상수들은 pKa값과 첨가된 용매의 종류의 변화에 따라 달랐다. 9. 착화합물들의 osillator strenght(P_ML) values와 transitonal absorption band들은 P_obs/f_m×10^5 vs。f_M/f_M의 linear dinear diagram과 거의 일치하고 이는 금속-ligand 결합이 -COOH의 산소원자와 황원자들에 의하여 형성되었음을 보여주는 것이다. Ethylene disulfide dibenzoic acid (EDDA) ligand is synthesized with starting matterial of thiosalicylic acid, this ligand is identified with IR spectrum and analytical data of carbon and hydrogen. The stability of time and pH on the complex ions formed between some rare earth metallic ions and ligand synthesized, and spectrophotometrc phenomena of complex ions formed according to the addition of solvent have been investigated by UV.-Vis. spectrophotometry. The pKa values of ligand synthesized have been obtained by the method of potentiotitrator, the covalent bonding property that is existed between metals and ligand of the complex ions has been discussed from the equations given between pKa values of ligand and oscillator strength of complex ions. The results are as follows: 1) The analytical data of hydrogen and carbon of EDDA ligand synthesized correspond with experimental values, the characteristic peaks of aromatic-aliphatic groups and peaks of aromatic-COOH dimer are shown in I R. spectrophotometric data. 2) EDDA behaves as ligand of four site-schiff base. 3) Stereostructure of complex ions formed are n-π charge transfer complexes with hypsochromic effect. 4) Complex ions formed between lanthanides(Ⅲ) and EDDA ligand are 1 : 1 complexes. 5) The λ max. of complex ions are varied depending on the centered metals bonded. 6) The λ max. of complex ions added with various kinds of solvents have bathochromic effect. 7) The pH range of stability is 6.0∼9.0, and stability of time reacted with lanthanides(Ⅲ) and ligand synthesized under various kinds of solvents is 30 minutes. 8) The stability consants of complex ions are varied with the changes of pKa and kinds of solvents added. 9) The oscillator strength(P_ML) of transitional absorption bands of complexes almost corresponds with linnear diagram of P_0bs/f_M×10^6 vs. f_ML/f_M. and these results show that metal-ligand bonding are formed by oxygen atom in rhe carboxyl groups and sulfur atoms.

요오드 이온을 포함한 단결정 고체 전해질의 전기 화학적 특성

정학진,김형윤,문원 조선대학교 기초과학연구소 1986 自然科學硏究 Vol.9 No.1

The electrochemical characteistics of all of tje single crystalline solids that would be used as the solid electrolytes were discussed with the apparatus made to measure the electric spfcific conductivity at various temperatures and with cyclovoltammograph, and measured data were treated by using computer program. It was calculated that the analytical experiment done by the application of A/D converter to the personal computer reduced the analytical error and enhanced the reproductivity by means of the developmental project of computer program. The electrical specific conductivities of Ag solid electrolytes Ag cell were 0.107~0.283 Ohm^-1 cm^-1 at 25℃, and these va1ues were higher than those of the Polycrystalline solids in the same diameter and weight of electrolytes and these values were proportional to temperature and the weight of solid electrolytes. Having measured the cyclovoltammogram of the solid electrolytes, the iodide ions contained in the single crystalline solids were transformed into the iodine and then oxidizing current was increased all at once at tile cathode. The free iodines which had been oxided in range of Ag electrode as cathode were again transformed into iodide ions at the anode and these anodic current appear as the state of reduction.

Rare Earth Oxalate Hydrate의 構造變化에 關한 硏究(Ⅱ)

丁學鎭,丁梧鎭,宋基東 조선대학교 기초과학연구소 1984 自然科學硏究 Vol.7 No.1

희토류 옥살산 수화물 및 각 전이점 이후까지 가열하여 얻은 옥살산 시료들의 구조를 원소분석치, 시차열분석법, 열중량분석법, X선회절법 및 전자현미경법으로 연구하였다. 각 희토류는 옥살산 수화물 시료들은 공기중에서 293∼427℃ 사이에서 완전탈수 되어 단사정계 결정에서 무정형의 무수염으로 변한다. 이들 무수물은 346∼698℃ 사이에서 R_2O_2CO_3로 상변화가 생기며 720∼885℃에서 희토류 산화물로 분해된다. 각 희토류 옥살산 수화물의 전이온도와 희토류원소의 원자번호와는 아무런 관계가 없었다. The rare earth oxalate hydrates were synthesized by precipitation method at room temperature. These have the general formula, R_2(C_2O_4)_3. XH_2O. The structures of the hydrates and compounds ignited at each transition temperature have been investigated by analytical data of carbon and hydrogen, differential thermal analysis(DTA), thermogravimetric analysis (TGA) and X-ray diffraction method. The TGA results were similar to all the lanthanides and the DTA results were almost entirely different according to the heating conditions. The lanthanide hydrates lost water in air at the range of 200∼347℃ and monoclinic crystal became the stable anhydrous salt. These anhydrous salts were decomposed into R_2O_2CO_3 at the range of 380∼600℃. The rare earth oxycarbonates have begun to decompose into the rare earth oxide at 600∼885℃. We found that atomic numbers of rare earth elements were not related with each transitional temperatures.

Computer Program에 의한 란탄계 선택성 막전극의 감응전위 측정

정학진,정오진,서혁춘,장동주 조선대학교 기초과학연구소 1985 自然科學硏究 Vol.8 No.1

Having made the selective membrane electrodes with lanthanide fluoride and lanthanide oxalate, the response potentials of 〔F^-〕 and 〔C_2O^2-_4〕 were measured with the selective membrane electrodes and the measured data were treated by using computer program. It was concluded that the analytical experiment done by the application of A/D converter to the personal computer reduced the analytical error and enhanced the reproductivity by means of the development project of computer program. The results were as follows: 1. When the additional ratio of matrixes is 0.1%, the response potentials of 0.1% matrixes were better than 0.3% in the response potentials. 2. The response values of the membrane electride mixed with silicon rubber as matrix is higher than those of the electrode mixed with PVC. 3. The response values of the membrane electrode with reference electrodes were better than that of membrane electrode with calomel electrodes and membrane electrodes. 4. Contrary to the calomel and membrane electrodes the denser concentration of the reference electrode, the less-the electric potential. 5. The response potentials of the insoluble membrane electrodes were inveresely proportional to the size of metallic ions. 6. The stability was the highest, as membrane eletrodes were in to the solution over 24 hours. 7. The response potential of La_2(C_2O_4)_3 and LaF_3 were stable between the range of pH 4.5∼8.0 and pH 3.5∼7.5 respectively.

세자리 Schiff base ligand 금속착물에 관한 연구(Ⅰ)

정학진,정오진,서혁춘 조선대학교 기초과학연구소 1986 自然科學硏究 Vol.9 No.1

The tridenate schiff base legand, 2-(salicyliden imino) -p- cresol, has been synthesized from salicylialdehyde and 2-amino- p- cresol by Duff method. This schiff base ligand has been reacted with Pd(Ⅱ), Rh(Ⅲ) and Nb(Ⅴ) metallic ions to form new complexes: Pd(Ⅱ)C_14H_12NO_2·H_2O, Rh(Ⅲ)C_14H_12NO_2·2H_2O and Nb(Ⅳ)(C_14H_12NO_2)_2·2H_2O Cl. The compositions and structures of the ligand and complexes have been discussed by element analysis, Kahl Fischer's moisture titration method, thermal analysis, ultraviolet spectroscopy, infrared spectroscopy, ^1H-nmr spectroscopy, X-ray diffraction patterns and electric conductance, respectively. It seems the Pd(Ⅲ) and Nb(Ⅴ) complexes have the structure of tetra- , hexa-and oct-acoording system, respectively and the mole ratio of metallic ion to ligand for the Pd(Ⅱ) and Rh(Ⅲ) complex are 1:1, but Nb(Ⅴ) complexis 1:2. Pd(Ⅱ), Rh(Ⅲ) and Nb(Ⅴ) complex with tridenate schiff base ligand have been coordinated with one and two molecules of water in accordance with the kinds of complexes, and the Rh(Ⅲ) complex has the structure of dimer bridge bonded with oxygen atom. The Pd(Ⅱ) and Rh(Ⅲ) complexes are nonpolar molecules but Nb(Ⅴ) complex is a polar molecule which will be dissociated in Nb(Ⅴ)(C_14H_12NO_2)_22H_2O.Cl^- and has structure of 1:1 electrolyte. All of the complexes have phenomena of π- π^* in ligand and d-d and d-π^* charge transfer between ligand and metal.

Crown Ethers Thorium(Ⅳ) Nitrate Hydrate 착물에 관한 연구

정학진,서혁춘 조선대학교 기초과학연구소 1986 自然科學硏究 Vol.9 No.1

The hydrated thorium(Ⅳ) nitrate have been reacted with the crown ethers of the different cavity size in methanol and aceton solvent, respectively. The properties and structures of these complexes are discussed by the element analysis, Kahl-Fisher moisture titration, thermal analysis, X-ay diffraction, ultraviolet and infrared spectroscopy, and electric conductivity. All of the complexes and the nonaccordinated systems with the three, four and five molecules of the hydrates, and the mole ratio of metallic ion to crown ether ligands are 1:1. The structures of the all complexes are different in accordance with the kinds of solvents, but coordinating number and mole ratio are constant in all complexes. The molar absorptivity of the complex obtained in aceton solvent is increased by coordinated bonding of the thorium(Ⅳ) ion to the ligands because the coordinating power of molecule of aceton is larger than that of water. The hydrated thorium(Ⅳ) nitrate complexes with crown ethers have the structure of 1:4 electrolytes deduced from 466-479 ohm^-lcm M^-1. These complexes have been formed by the electrostatic attraction and it is found the hydrated thorium(Ⅳ) nitrate complex with 15-crown-5 ligand is the most stable because thorium(Ⅳ) ion is bonded inside of the ligands. Whereas the other complexes are bonded outside of the cavity of the crown ether because the size of thorium(Ⅳ) ion is smaller or larger than that of the other crown ethers.

적층형태 및 보강방향에 따른 복합적층판의 종방향 모멘트 무시효과

이봉학,홍창우,이정호,김경진 江原大學校 産業技術硏究所 1998 産業技術硏究 Vol.18 No.-

The most of the design engineers for construction has academic background of bachelors degree. Theories for advanced composite sturcutures are too difficult for such engineers and soe simple but accurate enough methods are necessary. The senior athor has reported that soke laminate orientations have decreasing values of D?, B?, D? and B? stiffnesses as the ply number increases. Such plates behave as special orthotropic plates and simple formulas developed by the author can be used. Most of the bridge and building slabs on girders have large aspect ratios. For such cases further simplification is possibe by neglecting the effect of the longitudinal moment terms(M?) on the relvant partial differential equations of equilibrium. In this paper, the result of the study on the subject problem is presented.

방향성 응고된 이상형 스테인레스강에서 질소첨가가 미세조직에 미치는 영향

최병학,정병길,김진우,고석민,이재현,김상식,김성준 국립7개대학공동논문집간행위원회 2001 공업기술연구 Vol.1 No.-

Microstructures in the directionally solidified duplex stainless steels were investigated in order to understand the effect of nitrogen addition. It was found that the addition of nitrogen causes formation of fine precipitates in a matrix and segregation phases of nitrogen in the α/γ interface. Both the fine precipitates and the segregation phases were identified CrN(fcc, a=4.16A˚), which has the coherent phase relationship with bcc α matrix of (200) CrN // (0 1￣ 1) α and (1￣1￣ 1) CrN // ( 3￣ 2￣ 1) α.