Efficacy and Safety of Sorafenib for Advanced Non-Small Cell Lung Cancer: a Meta-analysis of Randomized Controlled Trials

Wang, Wei-Lan,Tang, Zhi-Hui,Xie, Ting-Ting,Xiao, Bing-Kun,Zhang, Xin-Yu,Guo, Dai-Hong,Wang, Dong-Xiao,Pei, Fei,Si, Hai-Yan,Zhu, Man Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14

Background: Many clinical trials have been conducted to evaluate sorafenib for the treatment of advanced NSCLC, but the results for efficacy have been inconsistent. The aim of this study was to evaluate the efficacy and safety of sorafenib in patients with advanced NSCLC in more detail by meta-analysis. Methods: This meta-analysis of randomized controlled trials (RCTs) was performed after searching PubMed, EMBASE, ASCO Abstracts, ESMO Abstracts, and the proceedings of major conferences for relevant clinical trials. Two reviewers independently assessed the quality of the trials. Outcomes analysis were disease control rate (DCR), progression- free survival (PFS), overall survival (OS) with 95% confidence intervals (CI) and major toxicity. Subgroup analysis was conducted according to sorafenib monotherapy, in combination with chemotherapy or EGFR-TKI to investigate the preferred therapy strategy. Results: Results reported from 6 RCTs involving 2, 748 patients were included in the analysis. Compared to sorafenib-free group, SBT was not associated with higher DCR (RR 1.31 (0.96- 1.79), p=0.09), PFS (HR 0.82 (0.66-1.02), p=0.07) and OS (HR 1.01 (0.92-1.12), p=0.77). In terms of subgroup results, sorafenib monotherapy was associated with significant superior DCR and longer PFS, but failed to show advantage with regard to OS. Grade 3 or greater sorafenib-related adverse events included fatigue, hypertension, diarrhea, oral mucositis, rash and HFSR. Conclusions: SBT was revealed to yield no improvement in DCR, PFS and OS. However, sorafenib as monotherapy showed some activity in NSCLC. Further evaluation may be considered in subsets of patients who may benefit from this treatment. Sorafenib combined inhibition therapy should be limited unless the choice of platinum-doublet regimen, administration sequence or identification of predictive biomarkers are considered to receive better anti-tumor activity and prevention of resistance mechanisms.

Improved Global Maximum Power Point Tracking Method Based on Voltage Interval for PV Array under Partially Shaded Conditions

Kun Ding,Xiang Wang,Quan-Xin Zhai,Jun-Wei Xu,Jing-Wei Zhang,Hai-Hao Liu 전력전자학회 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.4

The power?voltage (P?V) curve of photovoltaic (PV) arrays connected in parallel to bypass diodes would have several local maximum power points (LMPP) under partial shading conditions (PSC). Conventional maximum power point tracking (MPPT) methods fail to search for the global maximum power point (MPP) because the searched peak point may remain at the LMPP on the P?V curve under PSC. This study proposes an improved MPPT algorithm to ensure that PV arrays operate at global maximum power point (GMPP) under PSC. The proposed algorithm is based on a critical study and a series of observations of PV characteristics under PSC. Results show the regularity of voltage interval between LMPPs. The algorithm has the advantages of rapidly reaching GMPP, maintaining stability, and recovering GMPP quickly when the operating condition changes. Simulation and experimental results demonstrate the feasibility of the proposed algorithm.

Improved Global Maximum Power Point Tracking Method Based on Voltage Interval for PV Array under Partially Shaded Conditions

Ding, Kun,Wang, Xiang,Zhai, Quan-Xin,Xu, Jun-Wei,Zhang, Jing-Wei,Liu, Hai-Hao The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.4

The power-voltage (P-V) curve of photovoltaic (PV) arrays connected in parallel to bypass diodes would have several local maximum power points (LMPP) under partial shading conditions (PSC). Conventional maximum power point tracking (MPPT) methods fail to search for the global maximum power point (MPP) because the searched peak point may remain at the LMPP on the P-V curve under PSC. This study proposes an improved MPPT algorithm to ensure that PV arrays operate at global maximum power point (GMPP) under PSC. The proposed algorithm is based on a critical study and a series of observations of PV characteristics under PSC. Results show the regularity of voltage interval between LMPPs. The algorithm has the advantages of rapidly reaching GMPP, maintaining stability, and recovering GMPP quickly when the operating condition changes. Simulation and experimental results demonstrate the feasibility of the proposed algorithm.

韩国本土国际汉语教师培训教材的编写原则与思考

王霞(Wang Ha),Jin Zhen-wu,Zhang Ying,Yu Peng,Huang Xiu-kun,Jiang Hai-yan,Xuan Zhen-ji 한국중어중문학회 2019 한국중어중문학회 학술대회 자료집 Vol.2019 No.11

As leaming chinese becomes increasingly popular around the world,it is imperative to cultivate qualified local Chinese language teachers. South Korea not only has the largest number of Chinese learns, and it is also the country with the largest number of Chinese exams, such as HSK , YCT etc. At the same time, it also has the largest number of overseas candidates for the International Chinese Language Teacher Certificate. Compared with this, the research on teachers is obviously insufficient. We hope to use the "Test Syllabus Interpretation for International Chinese Language Teacher Certificate" (2017) as the benchmark, through discussion and research, we can propose the principles and characteristics of the training materials for the International Chinese Teacher Certificate Examination in Korea. In the future, on the basis of this, we hope to write a scientific, targeted and operational training textbook for the Korean native Chinese teachers. Contribute to the development and improvement of the overall level of Chinese language teaching in Korea. And hope that our exploration and enlightenment can provide some reference and help for the localization of the entire international Chinese teacher system.

Prognostic Significance of CYFRA21-1, CEA and Hemoglobin in Patients with Esophageal Squamous Cancer Undergoing Concurrent Chemoradiotherapy

Zhang, Hai-Qin,Wang, Ren-Ben,Yan, Hong-Jiang,Zhao, Wei,Zhu, Kun-Li,Jiang, Shu-Mei,Hu, Xi-Gang,Yu, Jin-Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1

Purpose: To evaluate the prognostic value of serum CYFRA21-1, CEA and hemoglobin levels regarding long-term survival of patients with esophageal squamous cell carcinoma (ESCC) treated with concurrent chemoradiotherapy (CRT). Methods: Age, gender, Karnofsky Performance Status (KPS), tumor location, tumor length, T stage, N stage and serum hemoglobin, and CYFRA21-1 and CEA levels before concurrent CRT were retrospectively investigated and related to outcome in 113 patients receiving 5-fluorouracil and cisplatin combined with radiotherapy for ESCC. The Kaplan-Meier method was used to analyze prognosis, the log-rank to compare groups, the Cox proportional hazards model for multivariate analysis, and ROC curve analysis for assessment of predictive performance of biologic markers. Results: The median survival time was 20.1 months and the 1-, 2-, 3-, 5- year overall survival rates were 66.4%, 43.4%, 31.9% and 15.0%, respectively. Univariate analysis showed that factors associated with prognosis were KPS, tumor length, T-stage, N-stage, hemoglobin, CYFRA21-1 and CEA level. Multivariate analysis showed T-stage, N-stage, hemoglobin, CYFRA21-1 and CEA level were independent predictors of prognosis. By ROC curve, CYFRA21-1 and hemoglobin showed better predictive performance for OS than CEA (AUC= 0.791, 0.704, 0.545; P=0.000, 0.000, 0.409). Conclusions: Of all clinicopathological and molecular factors, T stage, N stage, hemoglobin, CYFRA21-1 and CEA level were independent predictors of prognosis for patients with ESCC treated with concurrent CRT. Among biomarkers, CYFRA21-1 and hemoglobin may have a better predictive potential than CEA for long-term outcomes.

Adaptive Backstepping Control for Spacecraft Rendezvous on Elliptical Orbits Based on Transformed Variables Model

Yu Wang,Kun Li,Kaihong Yang,Hai-bo Ji 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.1

This paper investigates the problem of relative motion control for spacecraft rendezvous on an arbitrary elliptical orbit. The simplified dynamic model describing the relative motion between the chaser spacecraft and the target spacecraft is established via using transformed variables. Due to the presence of time variant parameters in this novel model, robust control scheme and adaptive control scheme are designed to solve the rendezvous problem. Theoretical analyses and simulation results demonstrate the effectiveness of the proposed methods.

Meta-analysis of Seven Randomized Control Trials to Assess the Efficacy and Toxicity of Combining EGFR-TKI with Chemotherapy for Patients with Advanced NSCLC who Failed First-Line Treatment

Xiao, Bing-Kun,Yang, Jian-Yun,Dong, Jun-Xing,Ji, Zhao-Shuai,Si, Hai-Yan,Wang, Wei-Lan,Huang, Rong-Qing Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.7

Background: Some recent clinical trials have been conducted to evaluate a combination of EGFR- TKI with chemotherapy for advanced NSCLC patients as second-line therapy, but the results on the efficacy of such trials are inconsistent. The aim of this meta-analysis was to evaluate the efficacy and safety of combination of EGFR-TKI and chemotherapy for patients with advanced NSCLC who failed first-line treatment. Materials and Methods: We searched relative trials from PubMed, EMBASE, ASCO Abstracts, ESMO Abstracts, Cochrane Library and Clinical Trials.gov. Outcomes analyzed were overall response rate (ORR), progression- free survival (PFS), overall survival (OS) and major toxicity. Results: Seven trails eventually were included in this meta-analysis, covering 1,168 patients. The results showed that the combined regimen arm had a significant higher ORR (RR 1.76 [1.16, 2.66], p=0.007) and longer PFS (HR 0.75 [0.66-0.85], p<0.00001), but failed to show effects on OS (HR 0.88 [0.68-1.15], p=0.36). In terms of subgroup results, continuation of EGFR-TKI in addition to chemotherapy after first-line EGFR-TKI resistance confered no improvement in ORR (RR 0.95 [0.68, 1.33], p=0.75) and PFS (HR 0.89[0.69, 1.15], p=0.38), and OS was even shorter (HR1.52 [1.05-2.21], p=0.03). However, combination therapy with EGFR-TKI and chemotherapy after failure of first-line chemotherapy significantly improved the ORR (RR 2.06 [1.42, 2.99], p=0.0002), PFS (HR 0.71 [0.61, 0.82], p<0.00001) and OS (HR 0.74 [0.62-0.88], p=0.0008), clinical benefit being restricted to combining EGFR-TKI with pemetrexed, but not docetaxel. Grade 3-4 toxicity was found at significantly higher incidence in the combined regimen arm. Conclusions: Continuation of EGFR-TKI in addition to chemotherapy after first-line EGFR-TKI resistance should be avoided. Combination therapy of EGFR-TKI and pemetrexed for advanced NSCLC should be further investigated for prognostic and predictive factors to find the group with the highest benefit of the combination strategy.

Support vector machine based estimation of remaining useful life: current research status and future trends

Hong-Zhong Huang,Hai-Kun Wang,Yanfeng Li,Longlong Zhang,Zhiliang Liu 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.1

Estimation of remaining useful life (RUL) is helpful to manage life cycles of machines and to reduce maintenance cost. Support vectormachine (SVM) is a promising algorithm for estimation of RUL because it can easily process small training sets and multi-dimensionaldata. Many SVM based methods have been proposed to predict RUL of some key components. We did a literature review related toSVM based RUL estimation within a decade. The references reviewed are classified into two categories: improved SVM algorithms andtheir applications to RUL estimation. The latter category can be further divided into two types: one, to predict the condition state in thefuture and then build a relationship between state and RUL; two, to establish a direct relationship between current state and RUL. However,SVM is seldom used to track the degradation process and build an accurate relationship between the current health condition stateand RUL. Based on the above review and summary, this paper points out that the ability to continually improve SVM, and obtain a novelidea for RUL prediction using SVM will be future works.

Determining the Walker exponent and developing a modified Smith-Watson-Topper parameter model

Zhiqiang Lv,Hong-Zhong Huang,Hai-Kun Wang,Huiying Gao,Fang-Jun Zuo 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.3

Mean stress effects significantly influence the fatigue life of components. In general, tensile mean stresses are known to reduce the fatigue life of components, whereas compressive mean stresses are known to increase it. To date, various methods that account for mean stress effects have been studied. In this research, considering the high accuracy of mean stress correction and the difficulty in obtaining the material parameter of the Walker method, a practical method is proposed to describe the material parameter of this method. The test data of various materials are then used to verify the proposed practical method. Furthermore, by applying the Walker material parameter and the Smith-Watson-Topper (SWT) parameter, a modified strain-life model is developed to consider sensitivity to mean stress of materials. In addition, three sets of experimental fatigue data from super alloy GH4133, aluminum alloy 7075-T651, and carbon steel are used to estimate the accuracy of the proposed model. A comparison is also made between the SWT parameter method and the proposed strainlife model. The proposed strain-life model provides more accurate life prediction results than the SWT parameter method.

Investigation of Microstructural Evolution and Electrical Properties for Ni-Sn Transient Liquid-Phase Sintering Bonding

Hong-Liang Feng,Ji-Hua Huang,Jian Yang,Shao-Kun Zhou,Rong Zhang,Yue Wang,Shu-Hai Chen 대한금속·재료학회 2017 ELECTRONIC MATERIALS LETTERS Vol.13 No.6

Ni/Ni-Sn/Ni sandwiched simulated package structures weresuccessfully bonded under low temperature and low pressure byNi-Sn transient liquid-phase sintering bonding. The results showthat, after isothermally holding for 240 min at 300 °C and 180 minat 340 °C, Sn was completely transformed into Ni3Sn4 intermetalliccompounds. When the Ni3Sn4 phases around Ni particles werepressed together, the porosity of the bonding layer increased, whichobviously differed from the normal sintering densification process. With further analysis of this phenomenon, it was found that largevolume shrinkage (14.94% at 340 °C) occurred when Ni reactedwith Sn to form Ni3Sn4, which caused void formation. Amechanistic model of the microstructural evolution in the bondinglayer was proposed. Meanwhile, the resistivity of the bonding layerwas measured and analyzed by using the four-probe method; themicrostructural evolution was well reflected by the resistivity ofthe bonding layer. The relationship between the resistivity andmicrostructure was also discussed in detail.