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Jin, Hai-Rong,Kim, Woo Jean,Song, Jae Sook,Piao, Shuguang,Choi, Min Ji,Tumurbaatar, Munkhbayar,Shin, Sun Hwa,Yin, Guo Nan,Koh, Gou Young,Ryu, Ji-Kan,Suh, Jun-Kyu American Diabetes Association 2011 Diabetes Vol.60 No.3
<P><B>OBJECTIVE</B></P><P>Patients with diabetic erectile dysfunction often have severe endothelial dysfunction and respond poorly to oral phosphodiesterase-5 inhibitors. We examined the effectiveness of the potent angiopoietin-1 (Ang1) variant, cartilage oligomeric matrix protein (COMP)-Ang1, in promoting cavernous endothelial regeneration and restoring erectile function in diabetic animals.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>Four groups of mice were used: controls; streptozotocin (STZ)-induced diabetic mice; STZ-induced diabetic mice treated with repeated intracavernous injections of PBS; and STZ-induced diabetic mice treated with COMP-Ang1 protein (days −3 and 0). Two and 4 weeks after treatment, we measured erectile function by electrical stimulation of the cavernous nerve. The penis was harvested for histologic examinations, Western blot analysis, and cGMP quantification. We also performed a vascular permeability test.</P><P><B>RESULTS</B></P><P>Local delivery of the COMP-Ang1 protein significantly increased cavernous endothelial proliferation, endothelial nitric oxide (NO) synthase (NOS) phosphorylation, and cGMP expression compared with that in the untreated or PBS-treated STZ-induced diabetic group. The changes in the group that received COMP-Ang1 restored erectile function up to 4 weeks after treatment. Endothelial protective effects, such as marked decreases in the expression of p47<SUP>phox</SUP> and inducible NOS, in the generation of superoxide anion and nitrotyrosine, and in the number of apoptotic cells in the corpus cavernosum tissue, were noted in COMP-Ang1–treated STZ-induced diabetic mice. An intracavernous injection of COMP-Ang1 completely restored endothelial cell-cell junction proteins and decreased cavernous endothelial permeability. COMP-Ang1–induced promotion of cavernous angiogenesis and erectile function was abolished by the NOS inhibitor, <I>N</I>-nitro-L-arginine methyl ester, but not by the NADPH oxidase inhibitor, apocynin.</P><P><B>CONCLUSIONS</B></P><P>These findings support the concept of cavernous endothelial regeneration by use of the recombinant Ang1 protein as a curative therapy for diabetic erectile dysfunction.</P>
Yin, Guo Nan,Kim, Woo Jean,Jin, Hai-Rong,Kwon, Mi-Hye,Song, Kang-Moon,Choi, Min Ji,Park, Jin-Mi,Das, Nando Dulal,Kwon, Ki-Dong,Batbold, Dulguun,Kim, Kyu-Won,Ryu, Ji-Kan,Suh, Jun-Kyu Blackwell Pub 2013 The journal of sexual medicine Vol.10 No.6
<P>Radical prostatectomy for prostate cancer can not only induce cavernous nerve injury (CNI) but also result in structural changes in the cavernous tissues. Nerve injury-induced protein 1, Ninjurin-1 (Ninj1), is known to be involved in neuroinflammatory processes and to be related to vascular regression during the embryonic period.</P>
Yin, Guo Nan,Jin, Hai-Rong,Choi, Min-Ji,Limanjaya, Anita,Ghatak, Kalyan,Minh, Nguyen Nhat,Ock, Jiyeon,Kwon, Mi-Hye,Song, Kang-Moon,Park, Heon Joo,Kim, Ho Min,Kwon, Young-Guen,Ryu, Ji-Kan,Suh, Jun-Kyu American Diabetes Association 2018 Diabetes Vol.67 No.6
<P>Penile erection requires well-coordinated interactions between vascular and nervous systems. Penile neurovascular dysfunction is amajor cause of erectile dysfunction (ED) in patients with diabetes, which causes poor response to oral phosphodiesterase-5 inhibitors. Dickkopf2 (DKK2), a Wnt antagonist, is known to promote angiogenesis. Here, using DKK2-Tg mice or DKK2 protein administration, we demonstrate that the overexpression of DKK2 in diabetic mice enhances penile angiogenesis and neural regeneration and restores erectile function. Transcriptome analysis revealed that angiopoietin-1 and angiopoietin-2 are target genes for DKK2. Using an endothelial cell-pericyte co-culture system and ex vivo neurite sprouting assay, we found that DKK2-mediated juxtacrine signaling in pericyte-endothelial cell interactions promotes angiogenesis and neural regeneration through an angiopoietin-1-Tie2 pathway, rescuing erectile function in diabetic mice. The dual angiogenic and neurotrophic effects of DKK2, especially as a therapeutic protein, will open new avenues to treating diabetic ED.</P>
Mao-pu Xia,Hai-bo Li,Nan Jiang,Jun-lin Chen,Jia-wen Zhou 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.1
Rockfall is a major geological disaster that frequently occurs on rock slopes in alpine and gorge regions and poses a significant threat to life and property in areas exposed to rockfall hazards. In this study, a methodology is presented for comprehensive rockfall hazard analysis, including data acquisition, source identification, numerical simulation, quantitative assessment and mitigation evaluation. A high-precision and high-resolution digital terrain model (DTM) is generated based on the point cloud data obtained by terrestrial laser scanning (TLS) and is utilized for rockfall simulation and automatic identification of structural planes. The model parameters are calibrated by three-dimensional (3D) back analysis, and the rockfall motion is simulated based on a probabilistic model and an energy dissipation model. Rockfall mitigation under passive protection is evaluated according to the rockfall interception ratio (RIR), hazard reduction rate (HRR) and statistics of the rockfall characteristics and hazards within the rockfall threat area. Under the influence of construction excavation, the diversion tunnel inlet slope of Jinchuan Hydropower Station has suffered from a series of rockfall events and potential overall instability, which has become a great threat to the construction personnel, equipment and vehicles below the slope. Thus, the presented methodology is applied to thoroughly study the example case of the rockfall events at the inlet slope of the diversion tunnel of Jinchuan Hydropower Station. The advantages, limitations and notes of each link of the presented methodology are discussed, and the suggestion of strengthening the cracked area with integral active support is proposed.
Ryu, Ji-Kan,Tumurbaatar, Munkhbayar,Jin, Hai-Rong,Kim, Woo Jean,Kwon, Mi-Hye,Piao, Shuguang,Choi, Min Ji,Yin, Guo Nan,Song, Kang-Moon,Kang, Yong-Jin,Koh, Young Jun,Koh, Gou Young,Suh, Jun-Kyu Blackwell Pub 2012 JOURNAL OF SEXUAL MEDICINE Vol.9 No.12
<P>Men with diabetic erectile dysfunction (ED) often have severe endothelial dysfunction and respond poorly to oral phosphodiesterase-5 inhibitors.</P>
Nicotine exacerbates tacrolimus-induced renal injury by programmed cell death
( Yu Ji Jiang ),( Sheng Cui ),( Kang Luo ),( Jun Ding ),( Qi Yan Nan ),( Shang Guo Piao ),( Mei Ying Xuan ),( Hai Lan Zheng ),( Yong Jie Jin ),( Ji Zhe Jin ),( Jung Pyo Lee ),( Byung Ha Chung ),( Bum 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.6
Background/Aims: Cigarette smoking is an important modifiable risk factor in kidney disease progression. However, the underlying mechanisms for this are lacking. This study aimed to assess whether nicotine (NIC), a major toxic component of cigarette smoking, would exacerbates tacrolimus (TAC)-induced renal in-jury. Methods: Sprague-Dawley rats were treated daily with NIC, TAC, or both drugs for 4 weeks. The influence of NIC on TAC-caused renal injury was examined via renal function, histopathology, oxidative stress, mitochondria, endoplasmic reticulum (ER) stress, and programmed cell death (apoptosis and autophagy). Results: Both NIC and TAC significantly impaired renal function and histopathology, while combined NIC and TAC treatment aggravated these parameters beyond the effects of either alone. Increased oxidative stress, ER stress, mitochondrial dysfunction, proinflammatory and profibrotic cytokine expressions, and programmed cell death from either NIC or TAC were also aggravated by the two combined. Conclusions: Our observations suggest that NIC exacerbates chronic TAC nephrotoxicity, implying that smoking cessation may be beneficial for transplant smokers taking TAC.