다중매체와 여가생활의 변동

김해식,이종구 경상대학교 사회과학연구소 2000 사회과학연구 Vol.18 No.1

韓國人에서 HumFIBRA/FGA와 D21S11 遺傳座의 對立遺傳子 頻度와 遺傳的 變異의 分析

김윤신,황적준,이혜린,구태완,한길로,김성민,이혜승 大韓法醫學會 1998 대한법의학회지 Vol.22 No.1

Allele-and genotype frequencies of the two short tandem repeat (STR) loci, HumFGA and D21S11, were determined in Korean population(n=196). DNA typing was accomplished by applying fluorescence-labeled PCR products and a differently labeled sequenced allelic ladders, followed by automated analysis using ABI 377 automatic sequencer and GeneScan 2.02 software. Prior to typing, allelic ladder of each locus was constructed with a combination of all alleles occuring from the population sample. A total of 15 alleles and 48 genotypes with the heterozygosity of 0.854 for HumFGA, and 12 alleles and 33 genotypes with the heterozygosity of 0.787 for D21S11 are observed in a population of 196 genetically unrelated individuals. No deviations from Hardy-Weinberg equilibrium were observed(p=0.753 for HumFGA, p=0.262 for D21S11). The data presented here (power of discrimination and average power of exclusion) show that both STR Loci, HumFGA and D21S11, are very informative for individualization from criminal evidences, and are also useful for parentage testing.

대구지역의 국지적 대기순환풍의 환기경로에 관한 수치모의 실험

구현숙,김해동,강성대 한국환경과학회 2004 한국환경과학회지 Vol.13 No.4

In urban area, thermal pollution associated with heat island phenomena is generally regarded to make urban life uncomfortable. To overcome this urban thermal pollution problem, urban planning with consideration of urban climate, represented by the concept of urban ventilation lane, is widely practiced in many countries. In this study, the prevailing wind ventilation lane of a local winds in Daegu during the warm climate season was investigated by using surface wind data and RAMS(Reasonal Atmospheric Model System) simulation. The domain of interest is the vicinity of Daegu metropolitan city(about 900 km²) and its horizontal scale is about 30km. The simulations were conducted under the synoptic condition of late spring with the weak gradient wind and mostly clear sky. From the numerical simulations, the following two major conclusions were obtained: (1)The major wind passages of the local circulation wind generated by radiative cooling over the mountains(Mt. Palgong and Mt. Ap) are found. The winds blow down along the valley axis over the eastern part of the Daegu area as a gravity flow during nighttime. (2)After that time, the winds blow toward the western part of Daegu through the city center. As the result, the higher temperature region appears over the western part of Daegu metropolitan area.

석회침착을 동반한 위암 1례

김경숙,하해구 한양대학교 의과대학 1983 한양의대 학술지 Vol.3 No.1

The occurrence of calcification in gastric cancer is extremely rare. Since the first case report by Gruber in 1913, there are about 50 cases in the published literature. (The American Journal of Gastroenterology, 69:481, 1978) The purpose of this paper is to report an additional case of these rare entity with endoscopic observation. This 63 year old, male patient had nausea, vomiting and epigastric hard mass, that is a large apple size, for about 2 months duration. The simple abdomen of this patient showed mottled, stippled, granular, punctuate, sand like and miliary calcifying mass in the upper abdomen. And this was confirmed to mucinous adenocarcinoma of the stomach with upper G-I study, computed tomography, ultrasonography and endoscopic biopsy. The surgery was denied. The fine, sand-like calcifications found in gastric carcinomas appear to be characteristic of a mucus-secreting tumor. It is of interest that the findings permitting correct diagnosis were clearly indicated on a simple film of the abdomen. A few examples which were discorved on pathological examination, but without roentgenographic study, are not considered here.

C-NMR 스펙트럼상에 나타난 벤젠의 치환기효과에 관한 양자화학적 해석

具廣謨,金海原,金明哲 慶一大學校 1993 論文集 Vol.9 No.1

Effect of Substituents on ??C-NMR Spectrum was investigated by quantumchemical calculation. The CNDO/2 calcutions have been applied on molecular models for the monosubstituted benzens. The chemical shifts on NMR spectrum was found to be related primarily to the formal charge density of carbon in benzene. Total energy and dipolemoment were secondary factors affect chemical shift. The calculated formal charge densites have been changed remarkable according to the kind of substituent.

腹部腫瘍(72例)에 있어서의 血管撮影 및 手術所見

河海求,崔斗石,金基延 최신의학사 1973 最新醫學 Vol.16 No.7

Aortography with selective visceral injections has been recognized as highly diagnostic and easy technique for the evaluation of various abdominal mass lesions. At department of Radiology, National Medical Center, Seoul, Korea seventy-two (72) patients whose chief complaints were slowly growing abdominal mass were studied with angiography after conventional examinations (barium study, I. V. P. etc) for last several years(1965-1972). The angiographic patterns were comprehensively analized. Almost cases (about 64 cases) were retroperitoneal expanding lesions which were not well detected with conventional radiological study (barium study, I. V. P. etc). The all expanding lesions were composed of renal expanding lesions(42 cases), other retroperitoneal expanding lesions (17cases), and liver, spleen, pancreatic lesions (13 cases). The angiography with selective visceral injections was the most diagnostic and easy technique without any permament complication than any other conventional studies.

右側 胸廓을 侵犯한 Leiomyosarcoma의 1例

하해구,김기정 최신의학사 1972 最新醫學 Vol.15 No.9

A 33-year-old Korean male patient with leiomyosarcoma involving the right lateral thoracic wall was reported. Leiomyosarcoma in thoracic wall is extremely rare. This patient's chief complaints were dull pain with slowly growing bulging mass in right lateral thoracic wall for about 2 months duration. Physical examination on admission showed moderately developed and nourished man with a large hard bulging mass (about 1OX15cm in diameter) with severe tenderness around the right subaxillary region. Coughing and deep respiration made severe chest pain. Chest X-ray (P-A and lateral view) showed large diffuse soft tissue mass densities were occupying the entire right lateral thoracic wall and also involving the pleura with destructive bony missing of lateral parts of right 4th, 5th and 6th ribs. All biochemical findings were nonspecific except elevated erythrocyte sedimentation rate (127 nimHr) Biopsy with histopathology revealed malignant mesenchymal tumor of smooth muscle cell origin (Leiomyosarcoma). Surgical treatment was not indicated, and palliative radiotherapy was recommended.

소아 장중첩중에 대한 임상적 고찰

박혜덕,김인구 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.2

This paper is a retrospective study of 48 cases of intussusception in infants and childern admitted to the pediatric surgical division of Chungam National University Hospital from Jan 1982 to Sep. 1986. and the results were as follows; 1. The intussusception was commonly occurred under 6th to 12th month of age(66.6%) and the patient age ranged from 3 month old to 5 years. 2. The ratio of male to female was 2:1. 3. The clinical symptoms and signs were as follows; currant jelly stool(100%), abdominal pain (93.8%), vomiting (91.7%), abdominal mass (79.2%) and abdominal distention(20.8%) in order of frequency. 4. The percentile of body weight of patients was as follows: 97%(8.3%), 90%(29.2%) 75%(18.7%), 50%(18.7%), 25%(16.7%), 10%(6.3%) and 3%(2%). The patient within above 50% was 75%, so relatively, the children in good nutritional state and well growing were more affected. 5. The 17 cases(35.4%) of intussusception visited our hospital within 12-24hours after onset of symptoms. In the treatment of 48 cases of intussusception, barium enema reduction was performed in 33 cases (68.8%), manual reduction, 14 cases(31.2%) and ileal segmental resection, 1 case(2.1%) 6. The reduction rate of barium enema according to Oct. 1984 was as follows: barium reduction rate(42.8%), manual reduction rate(57.2%) in 82, 83 and 84 year. Barium reduction rate(89%), manual reduction rate(11.1%) in 85 and 86 year. 7. The reduction rate of barium enema was decreased in the younger patients, and the results were as follows; 2-3 year old(100%), 1-2year old (66.7%), over 3 year old (66.7%) and under 6 month old (55.6%). 8. The anatomical types of intussusception were ileocolic (52.1%), ileocecal (39.6%), ileoileal (6.2%) and colocolic (2.1%). The reduction rate of barium enema according to the type of intussuscdtion were ileocolic (80%), ileocecal (63.2%), colocolic (100%) and ileoileal type, 3 cases (100%) were all failed.

영덕 달산 지역 화산층서와 용암의 공급지

황상구,함희수,김지영,정해오 안동대학교 기초과학연구소 1999 基礎科學 硏究論文集 Vol.10 No.1

We traced the flow direction of Ipbong Andesite and dacite in Dalsan area, Yeongdeok. Elongate vesicles and lathlike plagioclase phenocysts are aligned in the outcrops or under microscope. The lineations from their alignment are excellently indicating the flow direction of lavas. The flow directions, which were measured from the lineations in the Ipbong Andesite, are NNW-SSE in the eastern part and NNE-SSW in the southwestern part. The flow lineations show a fanlike movement pattern from the mid-northern part that the diorite is distributed. The diorite area is prabably a potential source area of the andesite

자궁경부종양에서 HPVDNAChip^(�) 및 Hybrid Capture Ⅱ^(TM)검사를 이용한 인유두종 바이러스의 검출

여소진,김달수,남계현,심일구,김태희,이해혁,이권해 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.2

목적 : 인유두종 바이러스는 자궁경부암의 의의있는 원인 인자이다. 이 연구의 목적은 HPVDNAChip??검사를 이용하여 정상, 전암병변, 침윤성 경부암의 인유두종 바이러스의 분포를 알아보고 그 결과를 Hybrid CaptureⅡ^(^(TM)) 검사와 비교하였다. 연구 방법 : 149명의 대상환자 중 57명은 병변이 없었고, 59명은 전암 병변이었으며, 33명은 침윤성 경부암이었다. HPVDNAChip??검사와 이 검사처럼 아형 66, 69를 제외한 고위험군(HPV-16/18/31/33/35/45/51/52/56/58/59/68) 인유두종 바이러스를 검사할 수 있는 Hybrid CaptureⅡ^(^(TM))검사를 이용하여 연구하였다. 결과 : 두 검사 모두 인유두종 바이러스를 검사하는 데 유용하였고, 결과가 의의있게 일치하였다(kappa value 0.721, p<0.01). Hybrid CaptureⅡ^(^(TM))검사에서 양성이나 HPVDNAChip??검사에서 음성인 경우는 18명(12.1%)으로 평균 Hybrid CaptureⅡ^(^(TM))값이 120.7±233.0 (mean±SD)이였고, 두 검사 모두 양성인 경우의 Hybrid CaptureⅡ^(^(TM))값은 448.1±732.8 (mean±SD)이였다. Hybrid CaptureⅡ^(^(TM))검사의 민감도는 94.6%이고, 특이도는 78.9%였고 HPVDNAChip??검사의 민감도는 83.7%이고, 특이도는 89.5%였다. HPVDNAChip??검사는 모두 15가지의 고위험군의 인유두종 바이러스 아형을 알아낼 수 있으며 아형 16이 전암병변(28.8%, 15/59)과 침윤성 경부암(48.5%, 19/33)에서 가장 흔한 아형이었으며 그 다음으로 흔한 아형은 58이었다. 결론 : HPVDNAChip??검사는 Hybrid CaptureⅡ^(^(TM))검사처럼 인유두종 바이러스 검사에 매우 민감하고 유용한 검사이다. HPVDNAChip??검사는 Hybrid CaptureⅡ^(^(TM))검사와 비교할 때, 인유두종 바이러스의 아형과 중복감염에 대한 정보를 준다. 앞으로 HPVDNAChip??검사의 자궁경부암의 선별검사로서의 가치에 대한 연구가 더 필요하다. Objective : Human Papillomavirus (HPV) is well known as one of the major risk HPVDNAChip?? factors for cervical cancer. The purpose of this study is to know HPV genotype distribution in women with normal cervix, precancerous lesion, and invasive cervical cancer by HPVDNAChip?? test. In addition, the result of HPVDNAChip?? test was compared with Hybrid CaptureⅡ^(TM) system for HPV detection. Methods : One hundred forty nine patients were included in this study. 57 women had normal cervix, 59 women had precancerous lesion, and 33 women had invasive cervical cancer. We tested them with two method for detection of Human Papillomavirus (HPV) by HPVDNAChip?? test and Hybrid CaptureⅡ^(TM) system. Hybrid CaptureⅡ^(TM) test can detect same high-risk HPVs (16/18/31/33/35/39/45/51/52/56/58/59/68) with HPVDNAChip?? test which can detect additional 66 & 69 high risk types of HPV. Results : Both methods for the detection of HPV were useful tests. The correlation between the results of two methods was very significant (kappa value 0.721 [p<0.01]). Positive Hybrid CaptureⅡ^(TM) test and negative HPVDNAChip?? test group were 18 women (12.1%) and average Hybrid CaptureⅡ^(TM) titer value of this group was 120.7±233.0 (mean±SD), positive Hybrid CaptureⅡ^(TM) test and positive HPVDNAChip?? test group were 84 women (54.4%) and average titer was 448.1±732.8. The Hybrid CaptureⅡ^(TM) test showed a sensitivity of 94.6% and a specificity of 78.9% and the HPVDNAChip?? test showed a sensitivity of 83.7% and a specificity of 89.5%. HPVDNAChip?? test detected total 14 genotype of HPV. HPV-16 was 28.8% (15/59) in precancerous lesion and 48.5% (19/33) in invasive cancer, most common in both groups. Next common type HPV-58 was 25.4% (12/59) in precancerous lesion and 9.1% (3/33) in invasive cancer. Conclusion : HPVDNAChip?? test is very sensitive and effective method for detection of Human Papillomavirus (HPV) infection as Hybrid CaptureⅡTMtest. In comparison with Hybrid CaptureⅡ^(TM) test, HPV genotype and multiple HPV infection information can be given by HPVDNAChip?? test. Further study will be needed to know the value of screening of cervical cancer by HPVDNAChip?? test in future.