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상황버섯(Phellinus linteus)으로부터 Ergosterol의 분리
류하나,유종수,송명종,이대영,김동현,노영덕,김인호,백남인 경희대학교식량자원개발연구소 2007 硏究論文集 Vol.26 No.1
상황버섯을 80% MeOH 용액으로 추출하고, 추출물을 EtOAc, n-BuOH 및 물로 분배, 추출하였다. 이 중 EtOAc 분획을 silica gel 및 octadecylsilica gel(ODS) column chromatography로 정제하여 1종의 sterol 화합물을 분리하였다. 화합물의 화학구조는 NMR, MS 및 IR 등의 스펙트럼 데이터를 해석하여, ergosta-7,22E-diene-3β,5α,6β-triol(cerevisterol, 1)로 동정하였다. 이 화합물은 상황버섯에서 처음 분리 보고 되었다. Phellinus linteus was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H_(2)O. The repeated silica gel and ODS column chromatographies of the EtOAc fraction led to the isolation of one sterol. From the result of spectral data including NMR, MS and IR, the chemical structure of the sterol was determined as ergosta-7,22E-diene-3β,5α,6β-triol (cerevisterol, 1). Compound 1 was isolated from the Phellinus linteus for the first time in this study.
이나경,전송애,하정욱,백현동 경남대학교 환경문제연구소 1998 환경연구 Vol.21 No.-
Bacteriocins are proteins produced by heterogeneous group of bacteria that have a bactericidal effect on closely related organisms. Recently, bacteriocins from lactic acid bacteria(LAB) and other food-related organisms have been the subject of much research of their potential as food biopreservatives. The goal of this study were to isolate LAB from commercial fermented fish products and identify their bacteriocin activity. All bacteriocin-producing isolates were identified as LAB. The NK24, NK34, and SA72 isolates were as identified as Lactococus lactis subsp. Lactis where as SA131 isolate was Lactobacillus brevis according to database of API50 CHL kit. All antimicrobial substance(s) produced from 4 LAB isolates were lost their antibacterial activity completely by treatment of some proteases, which indicate its proteinaceous nature. The bacteriocins produced from NK24, NK34, and SA72 isolate showed broad spectrum of activity when compared to SA131 bacteriocin.
최현정,방나영,송보완,김남재,류봉하 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-
In order to investigate to develop the new dosage form of the traditional herbal medicine which have been used for the treatment of disease in oriental medicine, we conducted a survey on 217 patients who visited oriental hospital in Kyung Hee University Medical Centre during one month since October 2003. They were given questionnaires to answer and results of this study were as the following: 1. About 45% patients visited in oriental hospital believed that oriental medicine was better remedy than modern medicine. 2. Most of patients felt that the oriental medical expenses were expensive. 3. About 60% patients preferred the modernized dosage form such as extract powder and granule, etc. rather than medicinal herbs in package. 4. Most of patients hope that decoction of medicinal herbs in package would change the advanced dosage forms such as tablet, capsule and extract powder, Because patients suffered from inconvenience of making a decoction, unhandy, unwieldy and keeping. 5. About 60% patients pointed out that merits of advanced dosage forms of medicinal herbs were convience to take and handy, etc.. However, they had an Intension that there were some difference of efficacy between decoction and modernized dosage forms of oriental medicine. Because of several defects such as unusual flavor and smell, incompatible food, large volume with amount, inconvenience of carrying and decocting oriental herbal medicines, most of patients would expect the development of the advanced dosage forms of them. In summary, this study show that it was needed to develop the new dosage forms of oriental herbal medicine on the basis of scientific research and economical cost of medical expenses.
Ha-Na Song,Ji-Hyeon Park,Ja-Won Cho 대한예방치과학회 2017 International Journal of Clinical Preventive Denti Vol.13 No.4
Objective: The aim of this clinical study was to determine the desensitization effect of the calcium glycerophosphate-containing dentifrice at bed time. Methods: Patients with symptoms of mild to severe dentin hypersensitivity between 20 and 40 years of age were allocated into two groups; the experimental group and the control group. Each group had used the dentifrice containing or excluding calcium glycerophosphate for 3 weeks. Symptoms of all participants were measured at baseline, after 3 days, 5 days, 1 week, 2 weeks and 3 weeks by the air blow method and the electric pulp tester (EPT). Results: Symptoms of dentin hypersensitivity measured by the air blow method decreased in the experimental group (from 6.03 at baseline to 5.85 at 3 days, 5.36 at 5 days, 5.09 at 1 week, and 4.75 at 2 weeks) and there was a significant difference in the reduction effect after 5 days (p<0.05). With the EPT method, there was a statistically significant difference in the hypersensitivity reduction effect in the experimental group after 1 week (from 18.80 at baseline to 18.80 at 3 days, 19.17 at 5 days, 21.33 at 1 week, and 22.30 at 2 weeks, p<0.05). Conclusion: The use of a dentifrice containing calcium glycerophosphate at bedtime produced significant reductions in hypersensitivity and rapid effects in relieving hyperesthesia, compared with the control group.
비성형 고형연료의 고정층 가스화 반응에서 합성가스 발생 특성
최하나 ( Ha-na Choi ),송동현 ( Dong-hyun Song ),하동주 ( Dong-ju Ha ),오종혁 ( Jong-hyuk Oh ),이장근 ( Jang-kun Lee ),구재회 ( Jae-hoi Gu ) 한국폐기물자원순환학회(구 한국폐기물학회) 2016 한국폐기물자원순환학회 추계학술발표논문집 Vol.2016 No.-
기후변화가 가속되는 현 상황에서 신재생에너지의 적극적 활용은 전세계적인 추세이며, 국내에서도 가연성 폐자원의 효율적인 친환경적 처리, 에너지 회수를 위한 다양한 연구가 진행되고 있으며, 관련정책과 법규가 만들어져 있다. 가연성 폐기물로부터 에너지를 회수할 수 있는 가스화 기술은 생산된 합성가스를 다양한 방법으로 활용할 수 있다. 합성가스가 가지고 있는 화학적 에너지를 활용하여 직접 엔진을 가동할 수 있으며, 가스화 방식에 따라 합성가스 내에 포함된 수소, 일산화탄소 등의 성분을 화학반응의 원료로 사용할 수도 있다. 따라서, 국내에서도 폐기물로부터 얻어진 합성가스를 다양한 방법으로 활용하기 위한 많은 연구들이 진행중에 있다. 본 연구에서는 폐기물 고형연료 가스화 플랜트 기술의 개발을 위해 생활폐기물을 대상으로 비성형 고형연료를 제조하고, 제조된 고형연료를 파일럿 규모의 고정층 가스화를 통해 합성가스를 생산하여 이를 직접 가스엔진 발전기에 도입함에 있어서, 고정층 반응기에서 발생되는 합성가스의 생산특성에 대해 알아보고자 한다.
유아의 스트레스 반응에 대한 연구: 시간의 경과에 따른 변화를 중심으로
송하나 ( Ha Na Song ) 한국유아교육학회 2013 유아교육연구 Vol.33 No.6
본 연구에서는 유아가 스트레스 상황에서 나타내는 반응의 유형을 살펴보고 이러한 반응들이 시간의 변화에 따라 어떻게 달라지는지 알아보았다. 연구 대상은 만 5세 유아 40명(남아22명, 여아18명)이었으며 이 유아들은 유치원에 구성된 관찰실을 어머니와 방문하였다. 유아들은 어머니가 구석에서 지켜보는 가운데 자유 놀이를 수행하다가 낯선 실험자가 예고 없이 들어와서 가지고 놀던 장난감을 모두 치워버리는 스트레스 상황이 제시되었다. 스트레스 상황은 3-5분간 지속되었으며 유아가 보인 스트레스 반응은 두 명의 코더가 분류하였고 시간의 흐름에 따라 초반, 중반, 후반으로 나누어 평균과 표준편차를 구하였다. 연구 결과, 유아들은 스트레스 상황에서 적응적 반응과 짜증, 저항, 위축 반응을 나타냈으며, 짜증을 포함한 부적 반응에서 유의한 성차가 보고되었다. 또한, 적응적 반응에서는 시간의 경과에 따른 차이가 나타나지 않았으나 짜증은 초반부에서 중반부까지 증가하다 후반부에서 감소하였으며, 저항 반응은 초반에 가장 높았으나 후반으로 갈수록 감소하였다. 반면, 위축 반응은 초반보다는 후반부에 높은 것으로 나타났다. 이러한 결과들은 유아의 스트레스 반응의 변화를 상세히 설명함으로써 적절한 자기 조절 책략을 적용하는데 시사점을 제시할 것으로 생각된다. This study examined adaptive and maladaptive types of reactions to stress stimuli in preschool children, and time-series changes in their reactions. In addition, gender differences in reaction to stress were also examined. Forty children all 5 years of age participated in an experiment in which the experimenter disrupted the children`s playing with toys. Results show that resistant reactions were salient early in the experiment session, and withdrawals were frequently observed in the later period of the experiment, and more so in girls than in boys. There was no significant gender difference in adaptive reactions. These findings are discussed in terms of the fight-flight processes of stress, and suggestions are given for early childhood intervention.