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Pathway and Network Analysis in Glioma with the Partial Least Squares Method
Gu, Wen-Tao,Gu, Shi-Xin,Shou, Jia-Jun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Gene expression profiling facilitates the understanding of biological characteristics of gliomas. Previous studies mainly used regression/variance analysis without considering various background biological and environmental factors. The aim of this study was to investigate gene expression differences between grade III and IV gliomas through partial least squares (PLS) based analysis. The expression data set was from the Gene Expression Omnibus database. PLS based analysis was performed with the R statistical software. A total of 1,378 differentially expressed genes were identified. Survival analysis identified four pathways, including Prion diseases, colorectal cancer, CAMs, and PI3K-Akt signaling, which may be related with the prognosis of the patients. Network analysis identified two hub genes, ELAVL1 and FN1, which have been reported to be related with glioma previously. Our results provide new understanding of glioma pathogenesis and prognosis with the hope to offer theoretical support for future therapeutic studies.
Gu, Wei-Guang,Huang, Yan,Yuan, Zhong-Yu,Peng, Rou-Jun,Luo, Hai-Tao,He, Zhi-Ren,Wang, Shu-Sen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
This study evaluated the effects of ZD1839, an orally active, selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, on nasopharyngeal carcinoma (NPC) both in vitro and in vivo. Influence of ZD1839 alone or combined with cisplatin on the NPC cell line CNE2 was detected by MTT assay with flow cytometry assessment of cell cycle distribution and apoptosis rates. Nude mice NPC xenografts were also used to evaluate the effects of ZD1839 alone or combined with cisplatin. The Student's t test evaluated statistical significance. ZD1839 alone or combined with cisplatin inhibited CNE2 cell line proliferation. ZD1839 induced CNE2 cell cycle arrest in the G1 phase, and higher concentrations induced apoptosis. Xenograft tumors were significantly smaller when treated with 200 mg/kg ZD1839, cisplatin, or cisplatin combined with 100 mg/kg ZD1839 than untreated controls. ZD1839 (200 mg/kg) alone showed good tumor inhibition effects, reduction of tumor weights, and smaller tumor volume without loss of body weight. ZD1839 (200 mg/kg) might provide a good and effective therapeutic reagent for NPC.
Terahertz Computed Tomorgraphy with a Quantum Cascade Laser and a Quantum-well Photodetector
Tao Zhou,Li Gu,Zhi-Yong Tan,Jun Cheng Cao 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.2
In this letter, a terahertz (THz) tomography system based on a quantum cascade laser (QCL)and a quantum-well photodetector (QWP) is demonstrated. The QCL provides a relatively high power (a few microwatts) in a continuous-wave mode at 3.9 THz as a light source, and the QWP provides a narrow response range from 3 to 7 THz with a calibrated peak response of 0.5 A/W under background-limited performance. We employ the widely-used filtered back projection (FBP)and algebraic reconstruction algorithms for terahertz tomography technology. The reconstructed cross-sectional image of a sample has successfully revealed the internal and the external structures with a resolution of around 1.5 mm. This experiment demonstrates that the terahertz QCL and the photodetector are potentially useful for terahertz tomography applications.
Tao Wang,Jin-Jun Yue,Xue-Ji Wang,Lu Xu,Lu-Bin Li,Xiao-Ping Gu 한국유전학회 2016 Genes & Genomics Vol.38 No.8
The Dof (DNA binding with One Finger) family of single zinc finger proteins is a family of plant-specific transcription factors. These transcription factors have a variety of important functions in different biological processes in plants. In the current study, we identified 26 Dof family genes in moso bamboo (Phyllostachys heterocycla var. pubescens). A complete overview of PhDof genes in moso bamboo is presented, including the gene structures, phylogeny, protein motifs and expression patterns. Phylogenetic analysis of the 26 PhDof proteins identified four classes constituting seven clusters (A, B1, C1, C2, D1, D2 and D3). In addition, a comparative analysis between the Dof genes in moso bamboo, Arabidopsis (Arabidopsis thaliana L.) and rice (Oryza sativa L.) was also performed, and several putative paralogous and orthologous genes were identified. The exon numbers in Dof genes ranged from one to three in many plants; however, the exon number in PhDofs ranged from one to four. The PhDof genes displayed differential expression in different parts of the shoot and at different flower development stages. This study represents the first step towards a genome-wide analysis of the Dof genes in moso bamboo. Our study provides a useful reference for cloning and functional analysis of members of the Dof gene family in moso bamboo and other species.
The Gender-Sensitive Social Risk Factors for Internet Addiction in College Undergraduate Students
Xia Lin,Jing-yan Gu,Wan-jun Guo,Ya-jing Meng,Hui-yao Wang,Xiao-jing Li,Wei Deng,Lian-sheng Zhao,Xiao-hong Ma,Ming-li Li,Ting Chen,S,K,Cheng,Tao Li 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.7
Objective The current study aims to explore precipitating and social risk factors for internet addiction (IA) in university undergraduate students, and to provide evidence for interventions and the early prevention of IA in different genders. Methods Four thousand eight hundred and fifty-eight college sophomores completed an online survey on their internet use-related behaviours and social risk factors. Results We found that more male (8.3%) than female students (5.4%) had moderate and severe IA. The main online activity in the moderate and severe IA groups was online gaming in males and online streaming in females. Roommates engaging in similar internetbased entertainment was a risk factor of IA only for males, while not being in a romantic relationship was a risk factor of IA for females only. Infatuation with the internet before college and adjustment problems for college life were shared risk factors for both genders in the mild and moderate IA groups. Conclusion IA was a common phenomenon in college students with shared and unique precipitating and social risk factors in males and females. The gender-sensitive risk factors for IA warranted earlier and individualized intervention and prevention strategies for IA in this population.
MiR-421 Regulates Apoptosis of BGC-823 Gastric Cancer Cells by Targeting Caspase-3
Wu, Jian-Hong,Yao, Yong-Liang,Gu, Tao,Wang, Ze-You,Pu, Xiong-Yong,Sun, Wang-Wei,Zhang, Xian,Jiang, Yi-Biao,Wang, Jian-Jun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13
MicroRNAs might act as oncogenes or tumor suppressors in cancer. Recent studies have shown that miR-421 is up-regulated in human gastric cancer. Here, we found that miR-421 was over-expressed in gastric cancer tissues and cell lines. Bioinformatics analysis predicted that the caspase-3 gene was a target of miR-421. Caspase-3 was negatively regulated by miR-421 at the post-transcriptional level. Bax and Bcl-2 were also regulated by miR-421. Moreover, tumor necrosis factor receptor-I and -II, death receptors in the apoptosis pathway, were up-regulated by miR-421. The over-expression of miR-421 promoted gastric cancer cell growth and inhibited apoptosis of the BGC-823 gastric cancer cell line. These observations indicate that miR-421 acts as a tumor promoter by targeting the caspase-3 gene and preventing apoptosis of gastric cancer cells through inhibition of caspase-3 expression. These findings contribute to our understanding of the functions of miR-421 in gastric cancer.
A Study on Cutting and Tribology Performances of TiN and TiAlN Coated Tools
Li, Hua-Ying,He, Hui-Bo,Han, Wen-Qiang,Yang, Jun,Gu, Tao,Li, Yuan-ming,Lyu, Sung-Ki Korean Society for Precision Engineering 2015 International Journal of Precision Engineering and Vol.16 No.4
TiN and TiAlN coatings were deposited on the surface of AISI 5140 steel and cemented carbide YT15 by magnetron sputtering technique (MSP). The reciprocating sliding tests of TiN and TiAIN coatings on the surface of AISI 5140 steel were performed to investigate the friction coefficients of coatings affected by various normal loads with friction pair of 304 stainless steel balls. Dry machining tests on AISI 5140 hardened steel were carried out with the TiN and TiAlN coated tools on a CA6140A lathe. The effects of cutting speed on cutting forces and surface roughness of TiN and TiAlN coated tools were obtained and analyzed to assess the cutting performance of coated tools. The microcosmic micrographs of wear areas of coated tools were observed and investigated by scanning electron microscope and energy dispersive spectrum. The results show that the friction coefficients of TiN coatings are lower than that of TiAlN coatings. The cutting force of TiAlN coated tool decreases and flank wear resistance enhances in comparison with TiN coated tool. The wear form and mechanisms of TiN coated tool are mainly crater wear on the rake face and adhesive wear and abrasive wear on the flank face. The wear form and mechanisms of TiAlN coated tool are mainly adhesive wear, the breakage of cutting edge and the damage of tip, accompanied with diffusion and oxidation wear.
Hui-Bo He,Wen-Qiang Han,Hua-Ying Li,Dong-Yang Li,Jun Yang,Tao Gu,Tao Deng 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.
TiAlN coatings were deposited on the YT15 tungsten carbide inserts by magnetron sputtering technique. The TiAlN coated tools weredeep cryogenic treatment (DCT) at -196oC for 30 h. The dry turning tests of 40Cr steel were carried out to evaluate performancesof uncoated, no cryogenically treated (NCT) and DCT coated tools on the CA6140A lathe. The effect of the three kinds of tools oncutting forces, cutting temperature, surface qualities and tool wear had been investigated to assess the performance of DCT coatedtools. Results of the investigation showed that the cutting forces and cutting temperature obtained by DCT coated tools weresignificantly decreased in comparison with the uncoated and NCT coated tools, especially at higher cutting speeds. Flank wear ofthe DCT coated inserts was less than that of the NCT coated inserts under the same cutting conditions. The DCT coated insertsproduced a good surface finish and yield a tool life of about 65 min. The wear mechanisms of the DCT coated carbide tools are mainlyabrasive and adhesive wear, accompanied with diffusion and oxidation wear.