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이구,박의동,안인옥,Lee, Goo,Park, Eaui-Dong,Ahn, In-Oak 대한영상의학회 1993 대한영상의학회지 Vol.29 No.4
For the purpose of the precise diagnosis and proper treatment planning of obstructive jaundice, various techniques to obtain tissues from biliary strictrue sites have been proposed. We performed perutaneous transcatheter biopsies of biliary strictrues with a biotome in six patients with obstructive jaundice. The sites of biliary stricture were distal common bile ducts (n=3), common hepatic duct (n=1), and confluence of both intrahepatic ducts (n=2). Their histologic diagnoses were adenocarcinoma (n=2), chronic choledochitis (n=3), and atypical cell suspicious of malignancy (n=1). False positive or false negative results were not documented by other means (including laparotomy), when regarding atypical cell suspicious of malignancy as true positive for malignancy. Percutaneous transcatheter biliary biopsy with a biotome is easy to perform in conjunction with percutaneous transhepatic biliary drainage procedure, and can be able to obtain specific tissues for correct diagnosis.
이구,한호성,유진종,정성훈,Lee, Goo,Han, Ho-Seong,You, Jin-Jong,Chung, Sung-Hoon 대한영상의학회 1993 대한영상의학회지 Vol.29 No.3
Since Kappis described percutaneous celiac plexus block in 1914, variations and refinements of his technic have been proposed. Recently. computed tomography (CT) guided nerve block has improved results of the block and made it safer, particularly when neurolytic druge are injected for the relief of intractable abdominal pain caused by malignancy or chronic pancreatitis. We report a case of CT-guided alcohol block of the celiac plexus with the anterior approach in a patient with a common bile duct carcinoma
골 육종 환자에서 항암제 동맥 주입 효과에 대한 방사선학적 분석: 자기공명영상과 동맥내 디지털감산혈관조영 소견을 중심으로
이구,김인원,연경모,윤현기,안효섭,Lee, Goo,Kim, In-One,Yeon, Kyung-Mo,Yoon, Hyun-Ki,Ahn, Hyo-Seop 대한영상의학회 1991 대한영상의학회지 Vol.27 No.5
For the evaluation of the effect of intraarterial chemotherapy with CDDP(cis-diaminedichloroplatinum) in the treatment of osteogenic sarcoma, we compared radiographic findings of magnetic resonance imaging(MRI) and intraarterial digital subtraction angiography(IA DSA) with the degree of tumor necrosis in pathologic speciments. The decrease in neovascularity and tumor stain in IA DSA showed good correlation with tumor response(necrosis) to IA chemotherapy. MRI was useful in the localization of intra-and extramedullary tumor. and detection of skip metastases, but signal intensity changes showed poor correlation with tumor response to chemotherapy. In gadolinium diethyltriamine pentaacetic acid enhanced MRI(Gd-DTPA MRI), the enhancing areas closely correlated with the areas of tumor stain IA DSA. In conclusion, IA DSA is a good imaging tool and Gd-DTPA MRI is expected to become a more useful modality in the evaluation of tumor response to chemotherapy in osteogenic sarcoma.
강직성 척추염에서의 천장골염: 방사선학적 등급과 골 스캔에서의 천잔관절 대 천골 섭취비의 비교
이구,강흥식,안중모,차상훈,정준기,송영욱,Lee, Goo,Kang, Heung-Sik,Ahn, Joong-Mo,Cha, Sang-Hoon,Chung, June-Key,Song, Yeong-Wook 대한영상의학회 1991 대한영상의학회지 Vol.27 No.3
To evaluate the correlation between plain radiography and bone scintigraphy in the diagnosis of sacroiliitis, we analyzed 50 sacroiliac joints of 25 patients diagnosed as ankylosing spondylitis, The sacroiliac-sacral(SIS) ration significantly increases in patients with sacroiliitis of Grade l, ll, lll and was normal in completely ankylosed sacroiliac joints(Grade IV). However, there was no correlation between the degree of increase of SIS ratio and that of the radiographic changes in Grade l. ll. lll groups. Bone scintigraphy might be useful in the early detection of sacroiliitis. but plain radiography is more valuable in evaluating progression.
Helicobacter pylori 제균이 위장 전정부 점막의 세포증식능과 apoptosis 에 미치는 영향
이구(Goo Lee),최석진(Suk Jin Choi),최영환(Young Hwan Choi),박동건(Dong Gun Park),서완다(Wan Da Seo),서정일(Jeong Il Suh),양창헌(Chang Heon Yang),이창우(Chang Woo Lee),장태정(Tae Jung Jang),김정란(Jung Ran Kim) 대한내과학회 1999 대한내과학회지 Vol.57 No.3
N/A Helicobacter pylori (H. pylori) is the principle cause of type B gastritis and peptic ulcer disease and has been classified as group I carcinogen for gastric cancer. H. pylori may affect the normal balance between gastric cell proliferation and epithelial cell death, thus interfering with the maintenance of gastric mucosal integrity. The aim of this study was to investigate the effect of H. pylori on cell proliferation and apoptosis according to the effect of eradication of H. pylori. Methods : The subjects were 45 patients who had undergone diagnostic gastroduodenoscopy; 11 with gastritis, seven with gastric ulcer and 27 duodenal ulcer. H. pylori infection was assessed by H&E and immunohistochemical stain with anti-H. pylori polyclonal antibody and rapid urease test. Acute and chronic inflammation, apoptosis and intestinal metaplasia were scored according to the updated Sydney system. Gastric epithelial cell proliferation was assessed by immunohostochemical method using Ki-67 monoclonal antibody. In situ apoptosis was detected with in situ terminal deoxyribonucleotide transferase (TdT)-mediated dUTP nick end labeling. Results : Acute and chronic inflammation, intestinal metaplasia, Ki-67 labeling index, and apoptosis were significantly higher in H. pylori infected persons (n=45) than in uninfected persons (n=5)(p<0.05). Acute and chronic inflammation, intestinal metaplasia, Ki-67 labeling index and apoptosis in H. pylori eradicated group (n=25) significantly decreased after eradication therapy (p<0.05), but no significant differences of them was observed in H. pylori non-eradicated goup (n=20) after eradication therapy. Ki-67 labeling index was significantly correlated with acute inflammation, chronic inflammation and apoptosis (p<0.05). Apoptosis was significantly correlated with acute and chronic inflammation (p<0.05). Conclusion : In eradicated group, epithelial apoptosis and proliferation closely associated with gastric carcinogenesis are stabilized after treatment, which suggests H. pylori eradication therapymay preven the early step of gastric carcinogenesis. (Korean J Med 57:288-297, 1999)
이구(Goo Lee),조은래(Eun Rae Jo),구양서(Yang Suh Koo),이홍식(Hong Sik Lee),이상우(Sang Woo Lee),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu),현진해(Jin Hae Hyun) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.5
Carcinoma of the extrahepatic bile duct,s may be classified as papillary, nodular, scirrhous constricting and diffusely infiltrating types according to their rnacroscopic characteristics. Among these, the papillary carcinomas are polypoid lesions that grow exophytically into the duct lumen and often produce duct obstruction before they invade the wall of the duct. For this reason, they are more favorable than the other forms and offer the greatest chance of cu- rative resection. Hence we report two cases of papillary adenocarcinoma of extrahepatic bile ducts for which curative surgery was performed successfully. (Korean J Gastroenterol 1994; 879 884)