위매독 (胃梅毒) 3예의 내시경적 (內視鏡的) 관찰

현진해(Jin Hae Hyun),최재현(Jae Hyeun Choi),유호상(Ho Sang Ryu),설익주(Ig Ju Seol) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.2

Today, the gastric syphilis is very rare disease. Final diagnosis of gastric syphilis is very difficult due to inconsistent symptoms and nonspecific gastric lesions. We found 3 cases of gastric syphilis by gastroscopy Gastroscopic findings were multiple, irregular and superficial ulcers which did not manifest the mucosal convergence, rugae obliteration and epithelialization,

화농성 육아종

현진해(Jin Hae Hyun),류호상(Ho Sang Ryu),김창덕(Chang Duck Kim),노경아(Kyung Ah Noh),문정섭(Jeong Seop Moon),김경수(Kyung Soo Kim) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.3

The Pyogenic granuloma is one of numerous forms of hemangioma that primarily involves skin and mucosa. It is a benign, polypoid tumor and easily bleeds. The cause of the pyogenic granuloma is the secondary infection with Botryomyces orgainism or Staphylococci. On histopathologic examination, the pyogenic granuloma shows exophytic growth associated with inflammatory characters. Most common sites of involvement are gingiva, finger, lip, face and tongue in the order of rarity. Several reported cases proved that the back, neck, and eyeballs were involved, also. However there was no reported cases about the involvement with gastrointestinal mucosa. We are to report a case of the pyogenic granulorna that involved upper esophagus.

다발성 조기식도암

현진해(Jin Hae Hyun),류호상(Ho Sang Ryu),김창덕(Chang Duck Kim),김혜랑(Hye Rang Kim),박종재(Jong Jae Park),김광희(Kwang Hee Kim) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.4

With progress in diagnostic procedures such as endoscopy and dye method, early diagnosis of esophageal cancer has become possible. Esophageal cancer shows poor prognosis generally, but shows variable outcome according to tumor invasion to underlying tissue. Esophageal cancer not infiltrated beyond submucosal layer without lymphatic invasion shows excellent postoperative outcome because of high curability of early esophageal cancer. We experienced a case of multiple, early esophageal cancer in a asymptomatic patient who visited for general check up, and was diagnosed by endoscopy and surgical specimen. The lesions were a polypoid lesion with irregular erosive surface and slightly elevated lesion on middle and lower esophagus respectively. The histopathologic finding revealed the moderately differentiated squamous carcinoma infiltrated to the level of submucosa. The patient was treated with surgical operation and discharged with cured condition.

위정맥류 (胃靜脈瘤) 경화요법 (硬化療法)에 관한 연구

현진해(Jin Hae Hyun),김종웅(Jong Woong Kim) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.4

N/A Gastric varices are being seen increasingly often in the patient presenting acute gastrointestinal hemorrhage. Unlike esophageal varices, the prevalence of gastric varices is unknown but it seems they are uncommon and there is no detailed report about the endoscopic injection sclerotherapy (EIS). Therefore, to evaluate the efficacy of EIS on gastric varix and influencing factors of EIS, we conducted a retrospective study of 41 patients with gastric varices from June, 1986 to March, 1989 at Haewha Hospital, Medical Center, Korea University. Gastric varices were incompletely eradicated in 9 cases 21.9%, completely eradicated in 28 cases 68.3%. Gastric varices bleeding were not controlled in 4 cases 9.8%. Influencing factors on EIS include injection approach, varix size, patient's condition (p<0.05), mucosal change (p<0.001). Complications were in order, fever 24 cases 49.1%, chest pain 7 cases 14.3%, ulcer on injection site 6 cases 12.2%, epigastric pain 6 cases 12.2%.

복강경검사중 (腹腔鏡檢査) 병발된 (倂發) 대장천공 (大腸穿孔) 1예

현진해(Jin Hae Hyun),최종수(Jong Soo Choi) 대한소화기학회 1983 대한소화기학회지 Vol.15 No.2

N/A Peritoneoscopic examination has been accepted throughout the world as a safe diagnonostic procedure in selected case. Peritoneoscopy for diagnostic and therapeutic purpose can be applied. Indication and contraindication for the procedure are set forth in detail. The authors have experienced a colon perforation during peritoneoscopic examination for diagnostic purpose in suspected intra-abdominal malignancy, who has not intraabdominaladhesion sign. Puncture of a viscus is a complication that may confront anyone attempting peritoneoscopic examination. Ordinarily the intestine will recede or slip aside before the trocar, and a viscus is punctured only when it is firmly fixed by adhesion or is tensly dilated. Such an occurrence can be avoided by 1) Careful examination of the patient before attempting the procedure. 2) Selection of a point of puncture to avoid all operative abdominal scar. 3) Using bistoury plungers with dull tip. 4) Perfection of technique. 5) Making sure the stomach and the bladder are empty and collapsed at the time of examination.

건강 ( 健康 ) 한 한국인 ( 韓國人 ) 의 간장기능검사 ( 肝臟機能檢査 ) 에 관 ( 關 ) 한 연구 ( 硏究 )

현진해(Jin Hae Hyun),고광도(Kwang Do Koh) 대한소화기학회 1970 대한소화기학회지 Vol.2 No.1

N/A A statistical study of various liver function tests was performed on the healthy Korean adults who- were visited to the department of gastroenterology for the purpose of physical checking for their healthy evaluation and some cases of admitted orthopedics and neurosurgevy department in the Woo Fok Universi.s- Medical College Hospital becuse of minor traffic injury who were going to leave from the hospital following complete recovery. Autlior selected 345 cases(male : 211, female : 134) who has No medical abnormalities such as histor ical, physical, pathological and labolatory findings. In this study, serum bililubin, serum protein, thymol tuvbidity, cephalin-cholesterol flocculation, serum lipid (total lipid, phospholipid, cholesterol), serum enzyme (SGOT, SGPT, alkaline phosphatase) and serum Fe. Were estimated in healthy Korean adults and observed its inter-relationship between age and sex, The results of this study were as follows: 1) The value of serum total bilirubin is 0. 637+-0. 358 (0.1~ 2.0) mg %, 0.685+-0.551 (0.1~2.0) mg.% in male and 0.561+-0.324 (0.1~1.57) mg.% in female. The value of serum direct bilirubin is 0. 1360. 090 (0.0~ 0.57) mg.%, 0.140+-0.118 (0.0~0.57)mg.% in male and 0.131~0.105 (0.0~0.55)mg.% in female. 2) The value of B.S.P. retention, 5 mg./kg./45 min., is 4. 442+2. 773 (0. 0 7. 0) Fo, 4. 3412. 673 (0. 0 7. 0) Fo in male and 4. 6722. 985 (0. 06. 5) py in female. There is no difference on basis of sex and the mean values of over 60 years old are low. 3) In serum protein .' Total protein value is 7. 054+-0. 734 (5. 6 B. 9) G Fo', 7. 2160. 682 (5. 8 8. 9) Gm.% in male and 6. 800+0. 741 (5. 6 8. 6) Gm Fo in female. The mean value of toDl protein is low in female and over 60 years old. Serum albumin value is 4. 914+ 0. 733 (3. 05 6. 7) Gm Fo, 5. 002+ 0. 735 (3. 05 6. 66) Gm. Yy in male and 4. 774+0. 707 (3. 1 6. 7) Gm.Zo in female. The mean value of serum albumin is low in female and over 50 years old. Serum globulin value is 2. 2760. 549 (l. 01 3. 75) Gm Yo, 2. 2330. 549 (l. 05 3. 5) Gm. Io in male and 2 3430. 530 (1. 01 3. 75) Gm Fo' in female. A/G valuc is 2. 047+ 0. 236, 2. 1040. 295 in male and l. 967+ 0. 162 in female. The value of albumin percent to total serum protein is 68. 71-7. 016 (43. 3 80. 3)Yo, 69. 65+6. 88e (43. 3 80. 0)M in male and 67. 28 6. 976 (47. 8 80. 3) po in female. Ay-globulin value is 2. 98+ l. 074 (l. 0 5, 4)%, 2, 930. 871 (1. 3 5. 4)Fo in male and 3. 07+l. 206 (l. 0 5, 4)gy in female. A,-gtobulin value is 5. 72+ l. 792 (2, 3 10. 4)Zg, 5.74 l. 757 (2. 3 10. 4), in male and 5. 68+ l. 835 (2. 5 10. 4) py in female. J'3-globulin value is 8. 5o2. 2o0 (3. 7 14. 9)M, 8. 14+ 2. 2o2 (3. 7 14. 9) Fo in male and 8, 802. 245 (4. 0 14. 6)Fo in female. P-globulin value is 13. 86+-3. 899 (6. 6 23. 6) Yo, 13. 24+-3 9iil (6. 7 23. 6) % in male and 14. 82 3. O87 (6. 6 21. 0) gy in female. The 7-globulin value is slightly increased according to aging and there is no difference in y-globulin value on basis of sex. 4) The value of thymol turbidity is 3. 11 +2. 057 (0. 2 6. 9) Shank-Hoagland unit, 2. 83+l. 875 (0. 2 5, 7) unit in male and 3. 56+-2. 238 (0. 3 6. 9) unit in female. 5) When the results of cephalin-cholesterol flocculation are indicated by 0, 1, 2, 3 and 4, the value 24h.. Is 0. 84+ 0. 785 (0 2), 0. 76+ 0. 761 (0 2) in male and 9, 97(3. 805 (0 2) in female, and the value of 48hr. Is 1. 27+ 0. 663 (0 3), l. 26+ 0. 700 (0 3) in male and 1. 30+ 0. 600 (0 3) in fem.ale. G The value of total serum lipid is 46o. 9+-72. 139 (210 737')mg.%, 461. 6 66. 200 (275 737) mg. , in msle and 473. 4+78. 375 (210 669) mR Yo in female. The serum phospholipid value is 217. 4743. 831 (100 365) mg.gg, 214. 7048. 388 (120 356) mg ;> in mle and 220. 93-t34. 354 (100 3o5) mg.z in female. Total and phospholipid appeared to be different on basis of sex and age. The value of serum total cholesterol is 193. 40+39. 589 (10o 295) mg.%, 191. 47+38. 224 (106 ')0) mg.p in male and 196, 44+41. 483 (115 295) mg.

Ethanolamine 과 Thrombin 와 지혈효과에 관한 실험적 연구

송태진(Tae Jin Song),현진해(Jin Hae Hyun) 대한내과학회 1991 대한내과학회지 Vol.41 No.4

N/A Esophageal variceal hemorrhage is the most lifethreatening complication of portal hypertension secondary to chronic liver disease. Recently, endoscopic injection sclerotherapy has been regarded as a safe and effective method for hemostasis among the various treatments. During urgent sclerotherapy, however, the intravariceal injection method of sclerosant causes unexpected bleeding and results in poor visualization of the lesion. New techniques to compensate these problems have been suggested. This experimental study using rabbits was conducted to evaluate the efficacy of intravariceal iniection of ethanolamine oleate followed by thrombin injection. The results were as follows: 1) Significantly shortened bleeding times after sclerotherapy were 222±61 seconds in the ethanolamine oleate group (p<0.05) and 153±28 seconds in the thanolamine oleate-with-thrombin group (p<0.001), compared to 268±40 seconds and 281±45 seconds in the control grups, respectively. 2) No relation (correlation value<0.5) was observed between the duration of bleeding and the amount of sclerosants which could affect the color change and dilataion of the veins. 3) None of the animals died because of sclerosants during the procedure. The Platelet count and fibrinogen level were 420,.20 cell/mm³ and 263 mg/dl respectively, and no statistically significant changes were observed after sclerotherapy. 4) Loss of endothelial cells and formation of thrombi and fibrin in the mesenteric veins developed earlier and were more widespread in the ethanolamine oleate with thrombin group than in the ethanolamine oleate group.

복강종류를 (腹腔腫瘤) 동반한 원발성 (原發性) 출혈성 (出血性) 혈소판증다증 (血小板增多症)

심경보,김장덕,현진해,고광도 ( Kyung Bo Shim,Chang Duck Kim,Jin Hae Hyun,Kwang Do Koh ) 대한소화기학회 1980 대한소화기학회지 Vol.12 No.1

A pg year-old housewife v:as admitted to the hospital because of sustained fever with chilling, nausea, VG'llittine, and LLQ c!ull pain. About 40 days previousl;, a'odominal surgery had been performed due to both ovarian follicular rupture. Thereafter abdominal m-ss had been formed on the left side, progressively enlarged and cea.ed spontaneously in bleeling. On physical examination, she had one finger breadth hepatomeg-ly witl.out splenomegaly and slightly firm and large mass at left sided abdomen with tenderness. The laboratory !'indings:eveled folloveings. The platelet counts varied from 157X10/mm with many giant bizzare forms. She had a leukocytosis (10050 24400/mm') and mild to moderate anemia. In the bone n.arrov, there were numerous megakaryocytes, often shreds of their cytoplasni or naked nuclei, hypersegmented nuclei, and immature megakaryocytes without leukemic or neoplasic cell ir,filtration. Cell blocks showed markedly increased mega- karyocytes in number, hypercellularity, and increased eosinopbils in number. Thromplastin generation time was slightlv to moderately retarded. In platelet aggregation, there v, as tLe absence of a response to epinep!I;ine with a reduced response to ADP. Duririg 5 month., t!iere were no evidence of polycythemia vera, chronic rnyelogneous leukcmia, and myeloi m r,aplasia or myelofibrosis and alsc, she denied rest and famil y history, 3Ye report and po:,tulate with the pri:;.ry hemorrhagic thrombccythemia cn the respect of rarity and the difficulty in classificatien.

한국인 위암의 Ras 암유전자군 점돌연변이 빈도와 의의

국상표(Sang Pyo Kook),현진해(Jin Hae Hyun) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.2

N/A Background/Aims: In the carcinogenic process, several markers have been defined as an evidence of genetic damage. The ras gene fami]y is one of these markers. Point mutation of a certain area of ras gene may represent the specific target of certain carcinogen. To elucidate the mechanism of ras gene activation in gastric carcinogenesis, we conducted this study. The goal of this study was to detect the frequency of K-ras, and H-ras point mutation in Korean gastric carcinoma patients. Methods: Experimental specimens were taken by gastrofiberscopic biopsy from 29 gastric cancer patients and DNA was extracted from the specimen. Intact genomic DNA was extracted from 17 cases and PCR was done with each pair of primers for K-ras 12th and 13th codon, 61st codon, H-ras 12th and 13th codon, 61st codon. These PCR products were selectively hybridized with detecting probes of various mutation. Results: One point mutation was found at K-ras 12th, 13th codon where glycine was substituted by aspartic acid. No other mutation was found at K-ras 6ist, H-ras 12th, 13th and H-ras 61st codon. The patient who showed mutation at K-ras codon 12 was confirmed as moderately differentiated adenocarcinoma. Conclusions: Point mutation of ras gene might be related in gastric carcinoma of the Koreans. In near future, studies for detection of ras gene mutation need to be done in a larger scale in precancerous lesions, and early, advanced and metastatic gastric cancers according to cell differentiation. (Korean J Gastroenterol 1996; 28:151 - 163)

십이지장염의 내시경소견과 병리조직소견의 비교

문정섭(Jeong Seop Moon),현진해(Jin Hae Hyun) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.1

N/A By the development of gastrofiberscopy and biopsy procedure, the diagnosis of duodenitis became easier. In general, the endoscopic findings such as hyperemia, erosion or granularity of duodenal mucosa are suggestive of duodenitis. In this study, we compared the endoscopic findings with microscopic changes using duodenal biopsy specimens of 106 patients with duodenitis and 25 healthy people at Korea University Medical Center. In duodenum of healthy people, the ratio of villi length and crypt length was 2.19: 1 and the percentage of lymphocytes and plasma cells among inflammatory cells was 88.6% and neutro- phil only 1%. In duodenitis, the hyperemic type revealed flattening of villi and neutrophil in- filtration and the erosive type revealed rnarkedly decreased length of mucosal villi and promi- nent neutrophil infiltration as main histological alterations. In the mixed type (hyperemia with hypertrophy) of duodenitis, flattening of mucosal villi and increase of crypt depth were the main histological characteristics and in the mixed type (hyperernia with erosion) of duodenitis, there was only decrease of mucosal villi length, but no significant changes in cellularities. The histological changes in the mucosa near the lesion site of duodenitis were similar to the changes in the lesion site. (Korean J Gastroentero11994; 26: 25 38)