급성 심근 경색증과 혈장 Paraoxonase activity와의 관계

김건영,윤상준,박근호,조영신,장성종,장경식,홍순표 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

연구배경: 혈장 파라옥소나제의 감소는 HDL-cholesterol의 항 산화작용의 중요한 요소로 알려져 있어 이의 감소는 항산화작용의 저하로 인해 동맥경화의 진행을 촉진시킬 수 있어 허혈성심장병의 주요 위험인자로 추정하고 있다. 본 연구에서는 급성 심근 경색증 환자를 대상으로 혈장 파라옥소나제의 활성도를 측정하여 정상군과 비교하여 혈장 파라옥소나제 활성도의 감소가 급성 심근 경색증의 위험인자인지 알아보고자 하였다. 대상 및 방법: 급성 심근 경색증으로 입원한 39 명의 환자(남자 : 여자 = 19 : 20, 평균나이: 61±4.3세)와 정상 대조군 36명(남자 : 여자 = 17 : 19, 평균나이: 55±10세)을 대상으로 정맥혈을 채혈 후 파라옥소나제 활성도와 LDL-cholesterol, total cholesterol, HDL-cholesterol를 측정하였다. 두 군간의 비교는 Student T-test를 이용하였다. 결과: 건강 대조군과 급성 심근 경색 환자군 간에 측정치를 비교해본 결과 혈장 콜레스테롤 수치는 182.10± 12mg/dl, 194.87± 40mg/dl이고 HDL 콜레스테롤은 54±5.4mg/dl, 37.52± 13mg/dl 였다. LDL 콜레스테롤은 94.45±13mg/d1, 122±34mg/d1로 급성 심근 경색증 환자의 경우 통계학적으로 의미있는 차이를 보였다. (P<0.05). 그러나 혈장 파라옥소나제 활성도는 건강 대조군 112.35±15U/ml, 급성심근 경색증 환자군 96.10±43.50U/ml로 급성 심근 경색증 환자군이 건강 대조군에 비해 낮은 수치를 보이는 경향이 있었으나 통계학적으로 유의한 차이(P=0.071)는 보이지 않았다(Table 2참조). Background : Human plasma paraoxonase is a HDL-associated ester hydrolase that catalyzes the hydrolysis of organophosphates, aromatic carboxylic acid esters and carbamates. HDL has been implicated in the prevention of LDL lipid peroxidation. Low paraoxonase activity in the Plasma may have responsibility to the development of coronary artery disease partially because oxidized LDL has intimate relationship with atherosclerosis. We studied plasma paraoxonase activities in the plasma of acute myocardial infarction patients in order to evaluate the relationship between these enzyme activities and the acute myocardial infarction. Materials and Methods : plasma samples were obtained from 39 individuals with acute myocardial infarction(M: 19 cases, F: 20cases, mean age: 61(4.3 years) and 36 individuals of healthy control(M: 17 cases, F: 19cases, mean age: 55(10 years). We determined paraoxonase activities, total cholesterol, LDL-cholesterol &DL-cholesterol levels in the plasma samples. Paraoxonase activities were measured spectrophoto metrically in 0.1M Tris-HCl buffer (pH=7.4) at 25℃ with paraoxon as substrate(5.5mM) at 405 nm. We used student T-test to compare the results of both groups. Results : Comparison of the results between myocardial infarction patients and normal control groups revealed that plasma total cholesterol, HDL-cholesterol and LDL-cholesterol levels showed statistically significant differences between groups but plasma paraoxonase activity does not. Conclusion : Our study showed that there was no significant difference of plasma paraoxonase activity between acute myocardial infarction and normal population. So low plasma paraoxonase activity may not be a risk factor of acute myocardial infarction. but further prospective large scale study will be needed to conclude.

정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성

안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.

Comparison of Efficiency between Pre-storage and Post-storage filtration by Leukoreduction Blood Filter

Geon Sik Shin,Bohee Kim,Sung Hoon Kim,Ki-Jong Rhee,Yoon Suk Kim 대한의생명과학회 2017 Biomedical Science Letters Vol.23 No.2

Leukocytes in blood components are involved in diverse adverse transfusion reactions such as febrile non-hemolytic transfusion reactions. Therefore, leukocyte reduction is required to reduce these adverse reactions. The objective of this study was to compare the efficiency of pre-storage filtration and post-storage filtration. Filtration time, residual leukocyte count, RBC recovery, and hemolysis were assessed after pre-storage or post-storage filtration. Compared to pre-storage filtration, filtration time was prolonged and hemolysis was dramatically increased when post-storage filtration was performed. Residual leukocytes count and RBC recovery after post-storage filtration were similar with those obtained after pre-storage filtration. These results suggest that pre-storage filtration has better efficiency than post-storage filtration. These are thought to contribute to the production of better quality of leukoreduction blood components.

항공 통신 기술 : 하이브리드 알고리즘을 이용한 Wi-Fi 기반의 실내 측위 시스템

신건식 ( Geon-sik Shin ),신용현 ( Yong-hyeon Shin ) 한국항행학회 2015 韓國航行學會論文誌 Vol.19 No.6

위치 정보를 제공하는 대표적인 측위 기술은 GPS다. 이 기술은 밀도가 높은 도심이나 숲, 그리고 실내와 같은 음영지역에서는 동작하지 않는 단점이 있다. 본 논문은 실내의 AP로 부터의 Wi-Fi 신호의 세기를 이용하여 보다 정확한 단말의 위치를 추정하게해주는 실내 측위 하이브리드 알고리즘을 제안한다. 사용자의 위치를 결정하기 위해 건물 구조, 사람, 거리 등 다양한 환경에서 측정한 RSSI (received signal strength indicator) 값을 이용하여 측정 환경에 맞는 가장 적절한 경로손실모델을 수립한다. 이러한 경로손실 모델에서 구해진 경로손실지수를 환경에 따라 변화시켜, AP로 부터 얻은 측정값을 이용하여 REKF (robust extended kalmanfilter)와 PF (particle filter) 알고리즘을 사용하여 단말기의 위치를 추정하게 된다 . 보다 더 정확한 위치 추정을 위해 하나의 측위방식만을 사용하지 않고, 실험을 통하여 구해진 임계값에 따라 어떠한 측위방식을 사용할 것인지를 결정한다. 제안한 하이브리드알고리즘을 이용하여 실험한 결과 기존의 단일 측위 방식 보다 평균 17% 성능이 향상 되는 것을 볼 수 있었다. GPS is the representative positioning technology for providing the location information. This technique has the disadvantage that does not operate in the shadow areas, such as urban or dense forest and the interior. This paper proposes a hybrid indoor positioning algorithm, which estimates a more accurate location of the terminal using strength of the Wi-Fi signal from the indoor AP. To determine the location of the user, we establish the most appropriate path loss model for the measurement environment. by using the RSSI value measured in a variety of environment such as building structure, person, distance, etc. The path loss exponent obtained by the path loss model is changed according to the environment. REKF, PF estimate the position of the terminal by using measured value from the AP with path loss exponent. For more accurate position estimation, we select positioning system by the value of threshold measured by experiments rather than a single positioning system. Experimental results using the proposed hybrid algorithm show that the performance is improved by about 17% than the conventional single positioning method.

Effectiveness of hydrogen dilution for designing amorphous to crystalline Si thin film in inductively coupled plasma assisted magnetron sputtering

Shin, Kyung Sik,Sahu, Bibhuti Bhusan,Han, Jeon Geon,Hori, Masaru Institute of Pure and Applied Physics 2015 Japanese Journal of Applied Physics Vol.54 No.6

Time–Frequency-Based Insulation Diagnostic Technique of High-Temperature Superconducting Cable Systems

Geon Seok Lee,Gu-Young Kwon,Su Sik Bang,Yeong Ho Lee,Seung Jin Chang,Song-Ho Sohn,Kijun Park,Yong-June Shin Institute of Electrical and Electronics Engineers 2016 IEEE transactions on applied superconductivity Vol.26 No.4

<P>For the electrical insulation of a high-temperature superconducting (HTS) cable, wrapped polypropylene laminated paper (PPLP) tape is typically used. Unfortunately, it is possible that unexpected faults at insulation layers will be present in the cables as a result of either a problematic manufacturing process or an incomplete installation procedure. In order to protect against operational failures of grid-connected HTS cable systems, this paper proposes a nondestructive diagnostic technique, i.e., time-frequency domain reflectometry (TFDR), and focuses on the characteristic of HTS cable that caused the local insulation defects. To verify the performance of the proposed method, detection and localization of local insulation failure via TFDR are compared with traditional time-domain reflectometry. The experiments are conducted at room temperature and under liquid nitrogen in order to check the efficacy of the proposed method in varieties of HTS cable's conditions. In addition, to improve the accuracy of detection and localization, a methodology to analyze incident signals, which are composed of upchirp and downchirp signals, is presented.</P>

Buprofezin이 느타리버섯속의 원형질체 나출 및 재생에 미치는 영향

신관철,황의일,서건식 충남대학교 농업과학연구소 1990 농업과학연구 Vol.17 No.2

Effects of buprofezin, an inhibitor of chitin synthesis, on mycelial growth, protoplast formation and reversion of Pleurotus ostreatus and P. sajor-caju were investigated. The mycelial growth of Pleurotus ostreatus and P. sajor-caju was the inhibited by buprofezin treatment, and the inhibition rate was severer as the concentration of the buprofezin increased. Aerial mycelium formation was increased by buprofezin treatment, but mycelial morphology was not changed. Protoplast formation of Pleurotus ostreatus and P sajor-caju. was significantly increased when buprofezin was added to the culture medium at the concentration of 200-500 ppm and the protoplast reversion of the mushrooms was also increased by the treatment of the buprofezin.

고로슬래그 기반 알칼리 활성 콘크리트의 공극분포에 따른 염화물 확산계수 특성

신경식(Shin Gyeong-Sik),염태진(Yeom Tae-jin),김도형(Kim, Do-Hyoung),김병조(Kim Byeong-Jo),김건우(Kim Geon-Woo),송진규(Song Jin-Gyu) 대한건축학회 2011 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.31 No.2(구조계)

The purpose of this study is to grasp durability properties for developing GGBS-based alkali activated concrete as structural materials and secondary products. MIP and NT Build 492 were used to understand the characteristics of chloride diffusivity according to pore distribution by the water-binder ratio(W/B) and content of Air-entrained(AE) admixtures. This study is expected to be basic data concerning durability assessment of GGBS-based alkali activated concrete.

온도 변화에 따른 초전도케이블 전파특성 분석

이건석(Geon Seok Lee),지경환(Gyeong Hwan Ji),권구영(Gu-Young Kwon),방수식(Su Sik Bang),이영호(Yeong Ho Lee),박기준(Kijun Park),손송호(Song Ho Sohn),신용준(Yong-June Shin) 대한전기학회 2017 대한전기학회 학술대회 논문집 Vol.2017 No.7

Ganoderma lucidum(Fr.) Karst의 培養的 特性에 關한 硏究

徐健植,申寬澈,朴鍾聲 충남대학교 농업과학연구소 1988 農業技術硏究報告 Vol.15 No.1

In order to elucidate the systematic taxonomy and genetic characters of Canoderma lucidum, cultural characteristics of the fungus were investigated. Mycelial growth of Ganoderma lucidum were favorable on oat meal agar medium, and optimum temperature and pH of the medium for mycelial growth were 30℃ and 5.5-6.0 respectively. Irradiation of white fluorescent lamp inhibited mycelial growth and critical time for inhibition of mycelial growth was 4-8 hours. Concentric zones and mycelial strands of Ganoderma lucidum was induced by irradiation of white fluorescent lamp and formation of mycelial sectors was influenced by nutrient source of media and irradiation of white fluorescent lamp. These characters were different among the isolates, but no relationship was observed between these characters and the fruiting body type of the fungus. Basidiospores were formed directly from the mycelium cultured on artificial media without producing fruit body.