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The mineralization inducing peptide derived from dentin sialophosphoprotein for bone regeneration
Choi, Young Suk,Lee, Jue Yeon,Suh, Jin Sook,Lee, Gene,Chung, Chong Pyoung,Park, Yoon Jeong Wiley Subscription Services, Inc., A Wiley Company 2013 Journal of biomedical materials research. Part A Vol.101 No.2
<P><B>Abstract</B></P><P>Dentin sialophosphoprotein (DSPP) has been shown to play a primary role in the formation and growth of hydroxyapatite crystals in an extracellular matrix of hard tissue such as bone and teeth. We hypothesized that the mineralization ability of DSPP might depend on a specific domain within it. Three peptides, which have hydroxyapatite (HA) binding affinity, denoted as mineralization inducing peptide (MIP1, MIP2, and MIP3) were identified from DSPP. The both of MIP2 and MIP3 had HA nucleation activity demonstrated by XRD. Among three MIPs, MIP3 significantly supported the human bone marrow stromal cell differentiation into osteoblastic cells. An immunoblot with antibodies specific for the phosphorylated forms of ERK was conducted with cells treated by MIP3. MIP3 transduced intracellular signals via the ERK pathways and was able to induce osteoblastic differentiation, as seen by high expression of ALP, type 1 collagen, OC, OPN, and Runx2 in accordance with applied MIP3 concentration. The Asp, Glu, and Ser residues in MIP3 play important roles for the affinity of calcium in HA bone mineral. Further animal experiment with MIP3 in combination with hydroxyapatite mineral induced marked new bone formation for 4 weeks at rabbit calvarial defect model. The new bone area was much higher in test group, implying that the peptide modified group had excellent biocompatibility when compared with the unmodified group. Taken together, the MIP from DSPP has potential to enhance mineralization followed by to enhance osteoblastic differentiation and bone regeneration. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.</P>
( Su Mi Lee ),( Hwa Seong Nam ),( Eu Gene Jeong ),( Young Ki Son ),( Seong Eun Kim ),( Won Suk An ) 대한신장학회 2014 Kidney Research and Clinical Practice Vol.33 No.3
Background: Catheter-related exit site infection is a major risk factor for thedevelopment of peritonitis and can contribute to failure of treatment maintenancein peritoneal dialysis (PD) patients. Although povidone-iodine can be used forexit site care, the irritation induced by the local application of povidone-iodinecould lead to secondary infection. Therefore, we evaluated the clinical effectivenessof normal saline compared with povidone-iodine as a method of exit site care inchronic PD patients. Methods: In all, 126 patients undergoing PD treatment for46 months betweenJanuary 2006 and December 2009 were enrolled. Data were retrospectivelyanalyzed for the incidence of exit site infection and peritonitis for 2 years prior toand after December 2007. In addition, we identified the incidences of catheterrelatedinfections during follow-ups from January 2010 to December 2013. Results: The participants`` mean age was 58.8712.9 years. The incidences of exitsite infection and peritonitis were one episode per 64.6 patients-months andone episode per 40.4 patients-months in the povidone-iodine group, respectively,whereas these were one episode per 57.5 patients-months and one episode per 45.6patients-months in the normal saline group, respectively. Whereas Gram-positivebacteria most frequently caused catheter-related infections in both groups, culturenegativeinfections were dominant in the normal saline group. Conclusion: Exit site care using normal saline did not increase the incidence ofexit site infection and peritonitis. Therefore, normal saline may be an alternativetreatment for exit site care in patients receiving PD.
문흥규,석진영,김선창 ( Heung Kyu Moon,Gene Young Suk,Sun Chang Kim ) 한국산림과학회 1997 한국산림과학회지 Vol.86 No.4
Axillary bud explants from 3-year-old seedlings of Forsythia saxatilis N., rare and endangered species in Korea, were cultured on Murashige and Skoog`s medium. The effect of various cytokinins (BAP, kinetin, and zeatin) at the different concentration(0.2, 0.5 and 1.0㎎/ℓ) was tested. Although an apparent shoot proliferation was not observed, zeatin showed slight promotional effect on normal shoot and leaf development. Both shoots and adventive roots could be induced simultaneously when the explants were cultured on the medium with kinetin, but adventive rooting was gradually reduced according as BAP and zeatin concentrations increased. Axillary shoot growth was promoted by the etiolation treatment. Shoot proliferation has been maintained more than three years with consecutive subculture. Rooted plantlets were successfully acclimatized in the artificial soil mixture and showed normal growth after transplantation into field.
김준호(Joune Ho Kim),송근웅(Keun Woong Song),주진(Gene Joo),석진영(Jin Young Suk) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.5
본 논문은 실물크기 헬리콥터의 무힌지(힌지없는) 로터를 축소화하는 방법과 시험에 관한 것이다 축소형 로터 시험은 실물크기 헬리콥터 로터 개발의 기술적 위험과 비용 절감을 위한 중요한 역할을 한다. 실물크기 무힌지 로터에 축소화 규칙을 적용함으로써 축소화된 기준형(사각형) 및 패들형 블레이드, 금속재 및 복합재 허브시스템과 같은 물리적 형상의 변화에 따른 시험을 통해 실물크기 무힌지 로터의 하중특성을 이해할 수 있다. 또한, 축소화 기법은 헬리콥터 개발의 초기단계인 설계, 모델링 및 시뮬레이션에서 서로 다른 크기의 헬리콥터에 대한 비행성능, 동역학적 특성의 비교에도 활용할 수 있다. 본 논문에서는 상사성을 유지하기 위한 축소화 조건, 축소형 무힌지 로터시험을 위한 시험장치 및 시험방법, 시험결과를 고찰한다. This paper is the study on the scaling method and test of the small-scale hingless rotor for helicopter. The test of small-scale rotor is very important to be able to reduce the technical risk and cost for the development of full-scale helicopter rotor. By applying scaling rules to the full-scale helicopter hingeless rotor, it is possible to understand the characteristics of full-scale rotor loads with the changing of physical configurations such as small-scale rectangular and paddle type of blades, metal and composite type of hub systems. Also, it is used to perform the meaningful comparison of performance between helicopters of different sizes at the initial phase of design, modeling and simulation for the development of helicopter. This study presented herein, scaling requirements for similarity, test rig and testing method, and test results for the small-scale hingeless rotor.
김준호(Joune Ho Kim),송근웅(Keun Woong Song),주진(Gene Joo),석진영(Jin Young Suk) 대한기계학회 2011 大韓機械學會論文集A Vol.35 No.12
축소화된 사각형 및 패들형 블레이드, 금속재 및 복합재 허브와 같은 물리적인 축소형 형상의 변화에 따른 실물크기 무힌지 로터의 하중특성에 대하여 연구하였다. 이를 위하여 축소형 로터 모델을 활용한 정적시험, 지상 및 풍동시험을 수행하였다. 정적시험은 구조강성 및 관성특성, 고유진동수 및 감쇄율을 확인하기 위해 수행하였으며, 지상 및 풍동시험은 정지 및 전진 비행조건에서 안정성 및 공력특성을 확인하기 위해 수행하였다. 시험결과에 따르면, 동일한 조건에서 축소형 복합재 허브와 패들형 블레이드를 결합한 경우가 수직하중이 더 높았다. 축소형 복합재 허브와 패들형 블레이드가 결합된 형태가 금속재 허브의 결합된 형태보다 패들형 블레이드의 운동을 더 유연하게 구속하고 있음을 확인할 수 있었다. It is possible to study the load characteristics of full-scale hingeless rotor with the changing of physical smallscaled configurations such as rectangular and paddle blades, and metal and composite hubs. In this study, a static test, and a ground and wind-tunnel test were carried out using small-scale rotor models. The static test was carried out to confirm structural stiffness, characteristics of inertia, natural frequency, and damping ratio of rotors, and the ground and wind-tunnel test was carried out to confirm the stability and aerodynamic characteristics under hovering and forward flight conditions. According to the test results, the vertical load in the case of a combination of a small composite hub with paddle blades was higher than that in the case of a metal hub with paddle blades at same condition. Further, it was confirmed that the restraint of the combination of composite hub can be more flexible than the metal hub for the motion of paddle blades.
한국의 1차 의료기관에서 발견된 대장용종: 발견율 및 가이드라인 적용 시 문제점
박상현 ( Sang Hyun Park ),홍광일 ( Kwang Il Hong ),박현철 ( Hyun Chul Park ),김영선 ( Young Sun Kim ),복진현 ( Gene Hyun Bok ),김경호 ( Kyung Ho Kim ),신동석 ( Dong Suk Shin ),한재용 ( Jae Yong Han ),김영관 ( Young Kwan Kim ),최 대한소화기학회 2021 대한소화기학회지 Vol.78 No.6
Background/Aims: There have been few multicenter studies on colonic polyps conducted by primary medical institutions. This study examined the detection rate of colonic polyps in primary health care institutions and the related factors while following the guidelines. Methods: The medical records of 14,029 patients who underwent colonoscopy between January-June 2020 at 40 primary medical institutions in Korea were analyzed. High-risk adenoma was defined as advanced adenoma, carcinoma, or ≥3 adenomas. Results: Most patients (71.2%) aged ≥50 years underwent re-colonoscopy within 5 years (51.3%) for diagnostic purposes (61.3%) in Korean primary medical institutions. The detection rates of colon polyps, adenoma, advanced adenoma, high-risk adenoma, and carcinoma was 59.9%, 38.9%, 5.9%, 11.4%, and 0.3% in all subjects and 59.8%, 37.5%, 8.5%, 12.9%, and 0.3% in average-risk patients, respectively. The incidences of adenoma in average-risk patients increased significantly with age (30s/40s/50s: 20.1%/29.4%/43% for adenoma, 4.4%/6.7%/10.3% for advanced adenoma, and 5.6%/9.5%/14.6% for high-risk adenoma; p<0.05). Before 50 years of age, high-risk adenoma was detected in 9.1% of patients in the first-time screening group, and the significant risk factors were being male and ≥40 years of age. The detection rate of high-risk adenoma in the normal index colonoscopy group within 5 years was 9.0%. The significant risk factors included older age, male sex, positive fecal occult blood test, stool form changes, and nonspecific symptoms (gas and indigestion). Conclusions: More colonic adenoma studies targeting real-world clinical practice will be needed to revise the Korean guidelines for colorectal cancer screening and surveillance. (Korean J Gastroenterol 2021;78:328-336)
소아의 하기도 감염에서 아토피 상태에 따른 혈청 Interleukin-8 및 RANTES 농도의 비교
김수정 ( Su Jung Kim ),최승준 ( Seung Jun Choi ),이재금 ( Jae Geum Lee ),김현숙 ( Hyeon Suk Kim ),이희수 ( Hui Su Lee ),오은영 ( Eun Young Oh ),전윤홍 ( Yoon Hong Jeon ),김유진 ( Eu Gene Kim ),윤종서 ( Jong Seo Yoon ),김현희 ( Hyu 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2011 소아알레르기 및 호흡기학회지 Vol.21 No.2
Purpose: Several studies have shown that viral respiratory infections induce more severe respiratory symptoms in atopic patients than in normal subjects. We attempted to investigate if there is any difference in the viral etiology, clinical manifestations, production of interleukin (IL)-8, and regulated on activation in normal T-cell expressed and secreted (RANTES) between atopic and non-atopic subjects with lower respiratory infections. Methods: Sera and nasopharyngeal aspirates (NPA) were collected from 97 children with lower respiratory infections who were admitted to the pediatric ward. Seventy-one children were classified as atopic subjects. We detected respiratory viruses with multiplex reverse transcriptase-polymerase chain reaction in NPA and measured total immunoglobulin E (IgE) and specific IgE in sera. IL-8 and RANTES levels measured in sera by enzyme-linked immunosorbent assay, etiology, and clinical manifestations were compared between atopic and non-atopic subjects. Atopic patients were defined as having elevated specific IgE to more than one allergen or age-matched, high serum total IgE levels. Results: Both serum IL-8 and RANTES levels were significantly higher in atopic than in non-atopic patients. There was no significant difference in viral etiology and clinical diagnosis between the two groups. The frequency of wheezing was higher in atopic than in non-atopic patients. Conclusion: Our study showed that both serum IL-8 and RANTES levels and the frequency of wheezing were significantly higher in atopic than in non-atopic patients. That suggests that chemokine responses to viral respiratory infection may be different between atopic and non-atopic patients and may be associated with a difference in clinical manifestation, such as wheezing, between the two groups. However, further prospective large-scaled studies are required to clarify our conclusion. [Pediatr Allergy Respir Dis(Korea) 2011;21:78-85]