괴사후성과 비괴사후성 간경변증에서 원인별 주석교질 (^99mTc-tin colloid) 간스캔의 차이

이헌영,허승식,이강욱,정현용,김삼용,신영태,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

The differences of the liver scintigraphic features between postnecrotic and nonpostnecrotic liver cirrhosis were studied for 69 patients. Degrees of mottling and splenomegaly were no different between two groups but shrinked form was more frequent finding in postnecrotic type(23:10), and normal shape & enlarged left lobe with shrinked right lobe were relatively dominant in non-postnecrotic group(15:6, 10:2). Grade of extrahepatic uptake of ^99mTc-tin colloid was significantly higher in Child-Pugh B & C group than A group(p<0.05), but there was no difference between postnecrotic and non-postnecrotic groups. These will be important results on the dicision for the presence of cirrhosis according to the variable causes.

Risperidone이 백서의 억제된 자발적 교대행동에 미치는 영향

이기철,이정호,김진규,정홍경,천강훈,류정환,최영민,전성일 대한생물치료정신의학회 1998 생물치료정신의학 Vol.4 No.2

Objectives : Recently, some case reports have shown that risperidone is effective to refractory obsessive-compulsive disorder. Possible explanations for efficacy of risperidone in refractory obsessive-compulsive disorder maybe due to that it is both serolonin and dopamine receptor antagonist. On the basis of serotonin-dopamine interaction hypothesis, a biological etiology of obsessive-compulsive disorder, the effect of risperidone was evaluated to the suppressed spontaneous alternation behaviour of animal model of obsessive-compulsive disorder in rats. Methods : The apparatus for spontaneous alternation behaviour was a black plexiglas T-maze with distinctive black and white goal boxes. Black gullotine doors separated the start box and the goal boxes from the main body of the T-maze Small cups were placed in the corners of both goal boxes(all arms measured 50×10cm) 24 hours prior to experiment, rats(Spraque-Dawley) were food-deprived. The food-deprived rats were put into T-maze, in which both goal boxes were baited with small amounts of chocolate milk. Each rat was given 2 set of 7 trials during which it was placed in the start box and allowed to choose the one of the goal boxes for checked. After baseline of the number of choices of spontaneous alternation behaviour was stabilized, the pontaneous alternation disrupted by nonselective 5-HT agonist, 5-MeODMT (1.25mg/kg/IP). The experimental animals were stratified into 5 groups, fluoxetine(10mg/kg/IP), risperidone(0.1mg/Kg/IP), haloperidol(0.1㎎/Kg/IP), fluoxetine(10mg/Kg) with haloperidol(0.1 mg/Kg), and saline(0.5cc/IP) control group. Each drugs were injected for 21 days as a chronic treatment. The protective effects were evaluated on the nest day of discontinuation of the each drugs among 5 groups. Results : 1) After 21 days of the drug treatment, the risperidone group and the fluoxetine group showed significant difference from the haloperidol group and the saline control group on the protection of the 5-MeODMT induced suppression of spontaneous alternation behaviour. 2) The fluoxetine group and fluoxetine with haloperidol group showed significant difference between before and after treatment in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour. The risperidone group also showed significant difference between before and after treatment in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour, but the protective effect of risperidone was superior to fluoxetine. Conclusion : These findings suggest that both risperidone and fluoxetine have a favorable effect in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour. We think that risperidone can be possible alternatives to SSRIs in the treatment of refractory obsessive-compulsive disorder in clinical situation.

폐모세포종 : 1례보고 A Case Report

최영호,서홍주,임영혁,김정중,박성강,이석기,임진수,김은규 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Pulmonary blastoma is a very rare primary neoplasm of the lung. We experienced a case of pulmonary blastoma in a 40 years old man. The mediobasal segmentectomy of the right lower lobe was performed. The patient was discharge on the postoperative days 6. There is no evidence of recurrence or metastasis on followup study during 7 months period after operation.

A Study on the Triphone Replacement in a Speech Recognition System with DMS Phoneme Models

Lee, Gang-Seong The Acoustical Society of Korea 1999 韓國音響學會誌 Vol.18 No.e3

This paper proposes methods that replace a missing triphone with a new one selected or created by existing triphones, and compares the results. The recognition system uses DMS (Dynamic Multisection) model for acoustic modeling. DMS is one of the statistical recognition techniques proper to a small - or mid - size vocabulary system, while HMM (Hidden Markov Model) is a probabilistic technique suitable for a middle or large system. Accordingly, it is reasonable to use an effective algorithm that is proper to DMS, rather than using a complicated method like a polyphone clustering technique employed in HMM-based systems. In this paper, four methods of filling missing triphones are presented. The result shows that a proposed replacing algorithm works almost as well as if all the necessary triphones existed. The experiments are performed on the 500+ word DMS speech recognizer.

Korean LVCSR for Broadcast News Speech

Lee, Gang-Seong The Acoustical Society of Korea 2001 韓國音響學會誌 Vol.20 No.e2

In this paper, we will examine a Korean large vocabulary continuous speech recognition (LVCSR) system for broadcast news speech. The combined vowel and implosive unit is included in a phone set together with other short phone units in order to obtain a longer unit acoustic model. The effect of this unit is compared with conventional phone units. The dictionary units for language processing are automatically extracted from eojeols appearing in transcriptions. Triphone models are used for acoustic modeling and a trigram model is used for language modeling. Among three major speaker groups in news broadcasts-anchors, journalists and people (those other than anchors or journalists, who are being interviewed), the speech of anchors and journalists, which has a lot of noise, was used for testing and recognition.

당뇨병 환자에서 발생한 Cerivastatin에 의한 횡문근 융해증 3예

이성수 ( Lee Seong Su ),조유경 ( Jo Yu Gyeong ),김해림 ( Kim Hae Lim ),박훈준 ( Park Hun Jun ),박만원 ( Park Man Won ),최민석 ( Choe Min Seog ),이강우 ( Lee Gang U ),장윤식 ( Jang Yun Sig ),방병기 ( Bang Byeong Gi ) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.6

Cerivastatin is novel HMG-CoA reductase inhibitors. Clinical trials showed no significant differences of serum creatine kiase between cerivastatin and placebo, and cerivastatin-induced myopathy was rarely reported. This beneficial effect of cerivastatin is thought to be related to the the dual pathway metabolism by hapatic CYP3A4 and 2C8. We here report three cases of rhabdomyolysis which is associated with cerivastatin therapy. Two patients had diabetes mellitus, and received cerivastatin( 0.8 mg/day) for treating hyperlipidemia and the other patient had chronic renal failure due to diabetic nephropathy and has maintained peritoneal dialysis and received cerivastatin(0.4 mg/day). Within one month of cerivastatin treatment, those patients experienced myalgia or muscle weakness. At that time, laboratory findings including muscle enzyme level, and bone scan finding were compatible with rhadomyolysis. Under the impression of cerivastatininduced rhabodmyolysis, cerivastatin was withdrwan, and conventional treatment for rhabdomyolysis was started. Clinical course was uneventful, and these patients were discharged with good general condition. In conclusion, cerivastatin is regarded as a safe drug as compared with other statins, but it also causes rhabdomyolysis. Careful history taking and regular follow-up of muscle enzyme levels would be necessary to detect cerivastatin-induced rhabdomyolysis.

고속철도 설계기준 제정 배경 해설

이강재(Lee Gang Jae),이현정(Lee Hyeon Jeong),김성용(Kim Seong Yong),박병은(Park Byeong Eun),김동기(Kim Dong Gi) 한국철도학회 2005 한국철도학회 학술발표대회논문집 Vol.- No.-

Design standard specifications for structures applied to Seoul-Pusan High Speed Rail construction were established in 1991. Those specifications have been changed and supplemented in the process of above construction, and need to improve in accordance with the new criteria for construction works of Korean government. Also, a settlement of the criteria for prevention against disasters of Seoul-Pusan High Speed Rail is needed, and related specifications have been revised. The design criteria for Seoul-Pusan High Speed Rail are enacted with knowhow which resulted from High Speed Rail construction, and those are enacted for the purpose of establishing criteria for High Speed Rail construction in the inside and outside of Korea.

고립성 폐결절에 관한 임상적 고찰

이종인 ( Lee Jong In ),이상수 ( Lee Sang Su ),원구태 ( Won Gu Tae ),안강현 ( An Gang Hyeon ),이성우 ( Lee Seong U ),백순구 ( Baeg Sun Gu ),김승률 ( Kim Seung Lyul ),용석중 ( Yong Seog Jung ),신계철 ( Sin Gye Cheol ),정순희 ( Jeong 대한내과학회 1993 대한내과학회지 Vol.44 No.2

N/A Background : Because there aremany different reporting results about the etologies of solitary pulmonary nodules (SPNs), we cannot know the exact incidence of each causative disease. SPNs have a good prognosis relatively even if it is a malignant lesion. In Korea, where there is a high incidence of pulmonary tuberculosis, the differential diagnosis of SPNs should be performed. Methods : Among 351 patients who visited Wonju Chistian Hospital for SPNs in chest x-ray between 1982 and 1989, we evaluated 74 patients in whom the causes of SPNs could be elucidated by sputum AFB study, cytology, histolgic study, chest of solitary pulmonary nodule (SPN) seen at the Wonju Christian Hospital from 1982 to 1989. The followings were obtained. 1) The malignancies of SPN 74cases were 25 cases (33.7%). The primary lung carcinomas were 24 cases : The epidermoid carcinomas of these were 11 cases (45.8%), metastasis I case, tuberculoma 42 cases, and the other 7 cases. 2) The age distribution of benign lesions was from 19 to 73 years old with the mean age of 46 years old, and the age distribution of malignancies was from 17 to 77 years old with the mean age of 57 years old. The 23 cases (92.0%) of malignant nodules were more than 40 years old. The malignant frequency of SPN in a group of age more than 40 years old was 40.3% and in a group of age less than 40 years old, it was 11.7%. The malignant frequency was directly proportional to the increase of age(p<0.05). 3) The 3 cases of SPN were detected accidentally during physical up, all were benign. The 14 cases were detected during the evaluation of other diseases, 12 cases were benign. The 23 cases (40%) of 57 cases were symptomatic. Chest pain, dyspnea, and weight loss frequency in a group of less than 3cm in size was 11.9% and in a group of less than 3cm in size, it was 62.5% (p<0.05). 6) Calcifications were noted in 15 cases of 74 cases on the plain films, all were 7 central types, 7 diffuse types and 1 popcorn type. One of malignant cases had calcification on the chest CT scar. Among the 59 cases with non-calcified nodules, 25 cases were malignant (42.3%). The mean Hounsfield Unit of benign lesions was 182.5U and that of malignancies was 94U, there was a statistical difference between both groups(p<0.01). 7) The 21 cases (50%) of tuberculomas were located at the apicoposterior segment of upper lobe or the superior segment of lower lobe, but the 7 cases (28%) of malignancies were located at above sites. 8) The diagnostic accuracy of sputum study was 9.4% and that of fiberoptic bronchoscopy (FOB) was 33.3%. The diagnostic accuracy of transbronchial lung biopsy (TBLB) and transthoracic needle aspiration biopsy (TTNAB) was 57.4%. The percentage of primary lung cancer among SPNs which are larger than 3cm in size, occurring in the age of older than 40 years old and with no calcifications on radiologic examintion should be suspected as malignancies and diagnosed with sputum study, fiberoptic bronchoscopy, TBLB, and TTNAB.

건축재료 흡음률의 현장측정시스템 개발

이강성(Lee, Gang-Seong),주문기(Chu, Mun-Ki),고효인(Ko, Hyo-In),홍지영(Hong, Ji-Young),오양기(Oh, Yang-Ki) 한국건축친환경설비학회 2014 한국건축친환경설비학회 논문집 Vol.8 No.6

There are a couple of measurement standards in measuring the absorption coefficient of building materials. Impedance tube method and reverberation room method are those standardized absorption coefficient measurement methods. While applicable to the development stage of certain absorptive materials and the measurement of random incident absorption coefficient of multi layered absorption complex, they are unable to be applied to in-situ measurement. There are needs for the in-situ measurement for the assessment of the efficient of absorption materials and for the remodelling design of existing rooms. This research deals with an in-situ absorption coefficient measurement system which is based on the calculation of energy from impulse response of incident and reflected signal on the same axis

갑상선 중독성 저칼륨혈증성 주기성 마비의 임상상

이순구 ( Lee Sun Gu ),김성숙 ( Kim Seong Sug ),정민수 ( Jeong Min Su ),송치운 ( Song Chi Un ),윤상임 ( Yun Sang Im ),성기양 ( Seong Gi Yang ),이강욱 ( Lee Gang Ug ),신영태 ( Sin Yeong Tae ),노흥규 ( No Heung Gyu ) 대한내과학회 1993 대한내과학회지 Vol.44 No.1

연구배경 : 갑상선중독성 저칼륨혈증성 주기성 마비는 갑상선항진중에서 양측성으로 주로 하지에 국한되는 이완성 마비로 현저한 저칼륨혈증을 동반하는 질환으로 젊은 동양인 남자에서 호발한다고 알려져 있다. 방법 : 저자들은 본 질환의 임상적 특징을 알아보고자 충남대학교 병원에 내원하였던 9명의 갑상선중독성 저칼륨혈증성 주기성 마비환자들을 대상으로 각종 임상적 소견들을 분석하였다. 결과 : 1) 대상환자는 9명 모두 남자였으며, 평균연령은 31.3±5.9(23~42)에 였다. 주기성 마비의 가족력은 없었다. 2) 마비 발작시 혈청 칼륨치는 평균 1.82±0.25(1.49~2.33)mmol/L로 현저히 감소되어 있었다. 3) 마비는 주로 늦은밤과 이른 새벽에 발생하였고, 계절적 차이는 없었다. 4) 유발 요인으로는 심한 운동, 과식, 과음, 감염 등 이었다. 5) 갑상선 중독성 저칼륨혈증성 주기성 마비는 칼륨이온 투여와 항갑상선선제 투여로 재발없이 치료되었다. 결론 : 주기성 마비가 동반된 갑상선중독증의 젊은 남자 환자에서 심한 저칼륨혈증 및 각종 유발인자들에 대한 주의가 필요한 것으로 생각되었다. Background : Thyrotoxic hypokalemic periodic paralysis is a well recognized complication of hyperthyroidism in mainly Oriental men, and in association with hypokalemia and flaccid type paralysis of legs. Method : Nine patients with thyrotoxic hypokalemic periodic paralysis hve been studied retrospectively by the authors at the Chungnam National University Hospital from Jan 1989 to Mar 1992 for the evaluation of clinical characteristics. Results : 1) All patients were males aged 31.3±5.9 (range 23~42) years old. 2) The average serum potassium level during paralysis was 1.82±0.25 (range 1.49~2.33) mmol/L. 3) Attacks of paralysis occurred at night and early morning. 4) The precipitating factors were severe exercise, overeating, alcohol drinking, and infection. 5) The attacks of paralysis usually disappeared after effective treatment with potassium salt and antithyroid drug. Conclusion : We thought that meticulous attention should be paid for hypokalemia and thyrotoxicosis in young patients with history of periodic paralysis.