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Historical Long-term Exposure to Pentachlorophenol Causing Risk of Cancer - A Community Study
Zheng, Rui-Zhi,Zhang, Qing-He,He, Yi-Xin,Zhang, Qian,Yang, Lin-Shen,Zhang, Zhi-Hua,Zhang, Xiu-Jun,Hu, Jing-Ting,Huang, Fen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Background: Pervious studies suggested occupational workers exposure to pentachlorophenol (PCP) might contribute to increased risk of cancer. However, few studies have focused on associations between PCP and cancer risk at the community level. Objective: The present study was to explore the cancer risk for the community population living long-term in a PCP contaminated area. Methods: All the cancer cases diagnosed in 2009-2011 in Tongling City were collected. The cancer patients' residencies were geo-referenced in each district. The historical PCP usage for each district of Tongling was calculated as the PCP pollution index, which was further used to divide into PCP exposure categories. Standardized rate ratios (SRRs) of cancer incidence were applied to detect the cancer risk as exposure grade elevated. Correlation analysis was performed to analyze the relationship between PCP pollution and cancer incidence. Results: A total of 5,288 cancer cases (3,451 male and 1,837 female) were identified. PCP usage was correlated with the incidence of leukemia (r=0.88, P=0.002) for males, and with cancer of the esophagus for males (r=0.83, P=0.008) and females (r=0.71, P=0.020). Compared with the low exposure category, significant SRRs for total cancer sites was obtained for high PCP exposure category (SRR=1.61, 95%CI=1.59-1.62). Most SRR values of the cancer sites were significantly increased as exposure grade elevated and exposure time extended. Conclusion: The present study found that community residents living in the PCP contaminated area had increased risk of cancers. Leukemias, lymphomas and nasopharyngeal and esophageal cancers are most possibly associated with PCP exposure.
Study on Evenness Control for Tensionof Rapier Loom by Neural Network
Zheng Laijiu,Du Bing Jin,Wei Li Fen 한국멀티미디어학회 2006 한국멀티미디어학회 국제학술대회 Vol.2006 No.-
This paper presents the use of neural network model (NNM) for air-jet loom's let-off process, which is used to model the uncertain parameters of this process. The adaptive model was used to estimate let-off tension recursively and is incorporated in predictive control strategies. Control tests showed excellent behavior following different set point and variations, such as diameter of weaver's beam, air stream, density of warp and weft, type of textile, etc. An optimum steady state scheme in keeping evenness of let-off tension of loom has been realized. After adopting the method, it improves production efficiency and product quality obviously, its flaw amount also falls 80%.
Fen-Qiang Li,Juehao Ding,Miao Zheng,Jianlin Xu,Xiaohong Ge,Hui Li,Jun Zhao 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.7
A combination of multi-physics numerical simulation and experiment was conducted to study the magnetic pulse compaction technology driven by two aluminum tubes of tungsten copper powder. Then, the effects of different process parameters on the density and uniformity of the compact were studied by tuning the thickness of the pack and driver tubes and the gap between them. Results show that the density of compact is the highest when the thickness of the driver tube is 1.0 mm. More energy is consumed for force conduction as the thickness of the pack tube increases. Thus, the density of the compact is the highest when the thickness of the packer tube is 0.8 mm. The speed of the driver tube impacting the pack tube also increases with the rise in the gap. Accordingly, the compaction density with the gap of 1.5 mm is the highest under the same other parameters.
Xue-fen Wan(만설분),Yi Yang(양의),Jian Cui(최검),Tao Zheng(정도),Li Ma(마려) 대한전자공학회 2012 전자공학회논문지 Vol.49 No.12
본 논문에서는 중국 현지 염색 기업의 열 센서망에 적용 가능한 원격 가상 현실 제어 플랫폼에서 실행할 수 있는 데이터베이스 액세스를 가상 현실 모델링 언어 (VRML)를 소개하였다. 또한, 3차원 실시간 자료 시각화를 위한 가상 현실 모델링 언어-액티브엑스 서버 페이지(VRML-ASP)를 소개하였다. 나아가 이와 관련된 스크립트도 다루었을 뿐만 아니라, 열 센서 노드와 센서 영역에서의 움직임을 분석하였다. 이 데이터베이스 프레임워크는 마이크로칩에서 발표한 마이와이<SUP>TM</SUP>(MiWi<SUP>TM</SUP>)의 표준에 최적화되었다. 이러한 분석 결과를 근거로, 시스템 구성에 따라 가상 현실 모델링 언어-액티브엑스 서버 페이지(VRML-ASP) 데이터 액세스 프레임워크가 가상 현실 원격 산업 공정 제어 시스템을 위한 하나의 경쟁력 있는 데이터 관리 해결책이 될 수 있음을 확인할 수 있었다. A Virtual Reality Modeling Language (VRML) database access in remote virtual reality control platform for dyeing enterprise MiWi<SUP>TM</SUP> thermal sensor network is presented in this paper. The VRML-ASP framework is introduced for 3D real-time data plotting in this application. The activities of thermal sensor nodes and sensor area are analyzed. The database access framework is optimized for MiWi<SUP>TM</SUP> wireless sensor networks. The experimental results show that VRML-ASP database access framework could be a reliable and competitive data-manage candidate for targeted virtual reality remote industrial visualization application.
H2S adsorption performance of alkali lignocarbon/PVA composite membrane
Youjing Li,Fen Li,Menglong Zheng,Hong Yan,Qianliang Liu 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.9
In this work, lignin carbon-based membranes were prepared for H2S adsorption. Alkali lignin was carbonizedto obtain alkali lignocarbon (CLA). Using the CLA and polyvinyl alcohol (PVA) as raw materials, glycerol andwater as plasticizers, and nano-CuO and Cu2+ as dopants, CLA/PVA, CuO-CLA/PVA-1, and Cu-CLA/PVA-2 compositemembranes were prepared by solution casting method. The structures of these membranes and their H2S adsorptionproperties were then analyzed. The results show that with a membrane solution water-alcohol ratio of 3 : 1 and2 wt% CLA content, the prepared CLA/PVA membrane can adsorb H2S for 30 min. The CuO-CLA/PVA-1 and Cu-CLA/PVA-2 membranes, which were obtained after doping with nano-CuO and Cu2+, demonstrate significantlyimproved deodorization performance compared with that of CLA/PVA. The Cu-CLA/PVA-2 membrane can adsorbH2S for up to 75min and also demonstrates better mechanical properties. The H2S adsorption capacity of this membraneis up to 0.27 mol/kg. Structural analysis shows that the veneers of the three composite membranes are smoothand that doped copper is evenly distributed in the membranes as nano-CuO. The surface functional groups of theCLA/PVA, CuO-CLA/PVA-1, and Cu-CLA/PVA-2 membranes are similar and play a positive role in H2S adsorption. Nano-CuO is the main active site for H2S adsorption in the Cu-containing composite membranes.
Jun-Hui Zheng,Jian-Fen Liu 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.3
In this paper, a robust kalman filter is designed for the uncertainty time-varying discrete systems with state delay in process and output matrices combined with the possibility of missing measurements. The uncertainties are expected in the process, output and white noise covariance matrices. A formula for a candidate upper bound on the actual state estimation error variances for all admissible parameter uncertainties and possible missing measurements is obtained. The filter parameters are optimized to give a minimal upper bound on the state estimation error covariance for all admissible uncertainties and missing measurements.
Chen, Jia,Zheng, Xin,Liu, Dong-Yang,Zhao, Qian,Wu, Yi-Wen,Tan, Fen-Lai,Wang, Yin-Xiang,Jiang, Ji,Hu, Pei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
Background: The aim of this study was to evaluate how CYP2C19 affects icotinib and metabolite' exposure, and to determine whether the exposure and EGFR genotype influences survival time, tumor metastasis and adverse drug reactions. Materials and Methods: 274 NSCLC patients who accepted 125mg icotinib/t.i.d. were chosen from a phase III study. Blood samples were obtained in $672^{nd}$ ($4^{th}$ week) and $1,680^{th}$ hours ($10^{th}$ week), and plasma was used to quantify the concentration of icotinib and blood cells were sampled to check the genotypes. Clinical data were also collected at the same time, including EGFR genotypes. Plasma concentrations were assessed by HPLC-MS/MS and genotype by sequencing. All data were analyzed through SPSS 17.0 and SAS 9.2. Results: CYP 2C19 genotypes affected bio-transformation from icotinib to M24 and M26, especially in poor-metabolisers. Higher icotinib concentrations (>1000 ng/mL) not only increased patient PFS and OS but also reduced tumor metastasis. Patients with mutant EGFR experienced a higher median PFS and OS (234 and 627 days), especially those with the 19del genotype demonstrating higher PR ratio. Patients who suffered grade II skin toxicity had a higher icotinib exposure than those with grade I skin toxicity or no adverse effects. Liver toxic reactions might occur in patients with greater M20 and M23 plasma concentrations. Conclusions: CYP2C19 polymorphisms significantly affect icotinib, M24 and M26 exposure. Patients with mutant EGFR genotype and higher icotinib concentration might have increased PFS and OS and lower tumor metastasis. Liver ADR events and serious skin effects might be respectively induced by greater M20, M23 and icotinib concentrations.