The Frequency of and Risk Factors for the Use of Bisphosphonates in the Adjuvant Setting of Primary Breast Cancer in Germany

Eva-Maria Fick,Alexander Katalinic,Annika Waldmann 대한암학회 2015 Cancer Research and Treatment Vol.47 No.4

Purpose The aim of this cross-sectional health care study (use of bisphosphonates in primary tumorsof the mammae, EBisMa) is to determine how often bisphosphonate medication is used inpatients with non-metastatic primary breast cancer treatment, but who do not suffer fromosteoporosis. Furthermore, we describe patients’ characteristics and the most frequentlyused type of bisphosphonate in adjuvant therapy. Materials and MethodsThe study population included primary breast cancer patients of four breast centers in northernGermany. Data on bisphosphonate therapy were collected by use of patient questionnaires;clinical data were extracted from the registers. Patients with and without prescribedbisphosphonate adjuvant treatment were tested for statistically significant differencesregarding their characteristics. ResultsFour hundred seventy-four of 663 contacted patients participated in the study. Thirty-nineout of 474 patients (9.6%) were on adjuvant bisphosphonate therapy. Zoledronic acid wasthe most frequently reported bisphosphonate used for prevention of bone metastases. Comparedto patients who did not report bisphosphonate medication, women who did reportbisphosphonate therapy had a significantly higher advanced tumor stage (p < 0.001). Boththe T2-T4 stage and N+ stage remained significant predictors in multivariate-adjustedregression models. ConclusionBisphosphonates are rarely used in the adjuvant treatment of primary breast cancer. Patients with advanced tumor stage were more likely to use bisphosphonates in the adjuvanttreatment of primary breast cancer. Further research is needed to identify patientswho may benefit most from adjuvant bisphosphonate treatment.

(UN)SAVING FACE, OR THE DESIGNER FACE AS A NEW CONSUMER COMMODITY

Maria Kniazeva,Eva Babicheva 글로벌지식마케팅경영학회 2016 Global Marketing Conference Vol.2016 No.7

We develop a concept of the face in the consumer behavior discipline and contribute to the theory of lookism defined as bias toward people because of their perceived physical appearance (Tietje & Cresap,, 2005). “What is the face?” –is our fundamental research question. What makes the face become the site of voluntary alteration? How do marketing forces drive the mainstream embrace of surgical correction of facial features as a commercial commodity, similar to shoes? While the latest medical advances have handed some control over appearance to consumers and provided them with a product (plastic surgery) designed to correct one’s genetic make-up, the designer face as a new consumer commodity hasn’t been addressed academically yet. Presumably, the face is the most distinctive human body element that sets a person apart from others, but academic studies that incorporate the phenomenon of treating people in a way biased by their perceived physical attractiveness have largely focused on the entire physique. To fill the academic gap, we specifically study the normative function of advertising as it presents itself in the format of street billboards. Examining this advertising language in the context of an emerging pattern of consumer behavior—designing one’s face through surgery—we theorize how the marketing channel normalizes this novel pattern, fitting it into historical, philosophical, social, and cultural contexts; how it legitimizes plastic surgery as a mainstream consumer commodity; and how it makes the face an object of alteration. Moreover, we perform the study in the specific cultural domain of Asia that places a strong metaphorical value on the face and has historically developed the honor-centered concept of “saving face” as a guiding principle of life (Lee, 1999). Driven by the fundamental question “What is the face?” and its examination in the context of the face-saving culture of South Korea, we developed a working research question to guide our inquiry: what makes a culture rooted in conservative beliefs and respect for the elderly so openly question and surgically correct the “quality” of the body received from one’s parents?

Mitral-Aortic Intervalvular Fibrosa Pseudoaneurysm

Maria Bonou,Eva D Papadimitraki,Sophia Vaina,Glafkos Kelepeshis,Kostas Tsakalis,Nikolaos Alexopoulos,John Barbetseas 한국심초음파학회 2015 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.23 No.4

Pseudoaneurysm of the mitral aortic intervalvular fibrosa (MAIVF-P) usually ensues as a complication of endocarditis or aortic valve surgery. When large, symptomatic or related to complications (rupture, compression of adjacent structures, embolic events, mitral regurgitation or heart failure) it warrants surgical excision. The natural course of uncomplicated/asymptomatic MAIVF-Ps is largely unknown since most patients are offered surgery. Increased surgical risk imposed by repeat operations in the majority of these patients is an important consideration and conservative treatment should not be excluded in selected cases. Herein we present two illustrative cases of MAIVF-P manifesting with significant arrhythmogenesis and complex endocarditis respectively. Both patients were managed conservatively. By briefly reviewing the existing literature, we discuss important diagnostic and therapeutic issues for MAIVF-Ps. To our knowledge complex ventricular arrhythmia has not been previously described as a prominent manifestation of MAIVF-P.

WHEN A POINTY NOSE IS IN VOGUE: OR (UN) SAVING FACE IN KOREA

Maria Kniazeva,Eva Babicheva 글로벌지식마케팅경영학회 2015 Global Fashion Management Conference Vol.2015 No.06

While borrowing from the theory of lookism, defined as “prejudice toward people because of their appearance” (Tietje and Cresap 2005, p, 31), this paper ventures into an emerging pattern of consumer behavior—designing one’s own body with the help of a surgical blade. The “designer body” idea has gradually moved from futuristic fiction to the exclusive domain of celebrity personalities and has lately arrived in the more mainstream marketplace (Kim, 2015). Available statistics indicate a growing number of plastic surgeries and clinic locations, the booming popularity of the aesthetics surgery specialty in medical schools, and burgeoning medical tourism with the goal of aesthetically reinventing one’s body (Akam 2014). Consumer vocabulary has embraced “rhinoplasty” and “liposuction” and lovingly transformed the dry medical jargon into the softer slang terms “rhino” and ‘lipo.” While breast augmentation is the most popular surgical procedure, in this work we purposely focus on the face. Unless veiled, the face is the body part that is always on display. In addition, we intentionally perform this study in the specific cultural domain that places strong metaphorical value on the face and has historically developed the dignity-centered concept of “saving face” as a major guiding principle of life. The choice of South Korea within this vast cultural realm seems the most logical given the fact that twenty percent of women in the country have something surgically done on their faces, which is arguably the highest known proportion in the world (Willett 2013). Finally, South Korea’s emphasis on Confucian values is part of our approach. Our research objective is to understand the interplay of major cultural forces that define the embrace of a novel mass marketed product (plastic surgery) designed to correct one’s genetic make-up. Considering marketing to be one such cultural force (Fedorenko 2014), we specifically aim to conceptualize its role in an ongoing interaction with Confucian values. What makes a culture rooted in conservative beliefs and respect for the elderly so openly question and surgically correct the “quality” of the body received from one’s parents? Does it happen because of or in opposition to Confucianism? Does fashion simply extend its province by converting desirable pointy noses and v-shaped chins into “in” items similar to pointy shoes? These research questions have shaped our qualitative methodological approach (Strauss and Corbin 1998) that relies on the juxtaposition of norms and values dictated by Confucian beliefs and those manifested through marketing channels. To uncover the normative messages and consumer directions coming from marketers, we turn to the so-called language of the street and perform close analysis of fifty advertising billboards and street signs promoting plastic procedures and located in Seoul, the capital of South Korea. We read both visual and textual data against the traditional Confucian literature. This methodological direction for our study was developed with the purpose to fill in the gap in the existing research, as detailed in the literature review, followed by the analysis of data, discussion of our findings, and the final section outlining a potential course for future research.

Experimental Study of the Dry Facing of Magnesium Pieces Based on the Surface Roughness

Eva Maria Rubio,Jose Luis Valencia,Adolfo Jose Saa,Diego Carou 한국정밀공학회 2013 International Journal of Precision Engineering and Vol. No.

This paper shows an experimental study of dry face turning carried out on UNS M11917 magnesium pieces. The work is focused on repair and maintenance operations which are generally carried out under cutting conditions of low performance. The main goal is to determine if such type of operations can be reached successfully by dry machining, the most drastic and sustainable cooling technique that exists, and, if so, what factor or factors among the involved ones in the machining (spindle speed, feed rate and tool coating) and their possible interactions are more influential in the quality of surface finish. To achieve this objective, a sustainable methodology that combines Taguchi design of experiment (DOE) and the analysis of variance (ANOVA) method are considered. The main result is the establishment of a model for estimating the expected surface roughness,in terms of average roughness, Ra, that allows selecting the best combination of cutting conditions and type of tool to obtain pieces within a certain range of surface roughness. The principal conclusion is that the dry machining technique can be used in the face turning repair and maintenance operations of pieces of magnesium producing a very good quality of the surface roughness and reducing costs and environmental impact.

Ambulatory blood pressure trajectories and blood pressure variability in kidney transplant recipients: a comparative study against chronic kidney disease patients

Maria Korogiannou,Marieta Theodorakopoulou,Pantelis Sarafidis,Maria Eleni Alexandrou,Eva Pella,Efstathios Xagas,Antonis Argyris,Athanase Protogerou,Aikaterini Papagianni,Ioannis N. Boletis,Smaragdi Ma 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.4

Background: Hypertension is a major cardiovascular risk factor in both kidney transplant recipients (KTRs) and patients with chronickidney disease (CKD). Ambulatory blood pressure monitoring (ABPM) is considered the gold-standard method for hypertension management in these subjects. This is the first study evaluating the full ambulatory blood pressure (BP) profile and short-term BP variability(BPV) in KTRs versus CKD patients without kidney replacement therapy. Methods: Ninety-three KTRs were matched with 93 CKD patients for age, sex, and estimated glomerular filtration rate. All participantsunderwent 24-hour ABPM. Mean ambulatory BP levels, BP trajectories, and BPV indices (standard deviation [SD], weighted SD, and average real variability) were compared between the two groups. Results: There were no significant between-group differences in 24-hour systolic BP (SBP)/diastolic BP (DBP) (KTRs: 126.9 ±13.1/79.1 ± 7.9 mmHg vs. CKD: 128.1 ± 11.2/77.9 ± 8.1 mmHg, p = 0.52/0.29), daytime SBP/DBP and nighttime SBP; nighttimeDBP was slightly higher in KTRs (KTRs: 76.5 ± 8.8 mmHg vs. CKD: 73.8 ± 8.8 mmHg, p = 0.04). Repeated measurements analysis ofvariance showed a significant effect of time on both ambulatory SBP and DBP (SBP: F = [19, 3002] = 11.735, p < 0.001, partial η2=0.069) but not of KTR/CKD status (SBP: F = [1, 158] = 0.668, p = 0.42, partial η2= 0.004). Ambulatory systolic/diastolic BPV indiceswere not different between KTRs and CKD patients, except for 24-hour DBP SD that was slightly higher in the latter group (KTRs: 10.2 ±2.2 mmHg vs. CKD: 10.9 ± 2.6 mmHg, p = 0.04). No differences were noted in dipping pattern between the two groups. Conclusion: Mean ambulatory BP levels, BP trajectories, and short-term BPV indices are not significantly different between KTRs and CKDpatients, suggesting that KTRs have a similar ambulatory BP profile compared to CKD patients without kidney replacement therapy.

Poster Session : PS 0411 ; Infectious Disease ; High Prevalence of Hepatitis B Virus Infection Among Indonesian Migrant Workers from Lombok Island, Indonesia and Their Complete Genome Analysis

( Maria Inge Lusida ),( Takako Utsumi ),( Mochamad Amin ),( Juniastuti ),( Eva Triani ),( Soetjipto ),( Nasronudin ),( Yoshihiko Yano ),( Hak Hotta ),( Yoshitake Hayashi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Due to the high endemicity of hepatitis B in Lombok population, it is important to determine its prevalence among migrant workers (MWs), since Lombok contributes the most from Indonesia abroad. Hepatitis B virus (HBV) (sub)genotypes have geographic specifi c distribution. We have reported HBV strains from Indonesian MWs based on part of envelope region and several strains could not clearly be determined their subgenotypes. In this study we analyse the whole genome sequences of those strains. Methods: Sera were collected from Indonesian MWs, to be screened for HBsAg by Enzyme Immunoassay. Those with HBsAg positive were continued with HBV DNA detection and (sub)genotype/subtype determination based on envelope region and, for several strains, on whole genome sequences. Results: Seventeen point two percent (15/87) sera from the MWs who will go to their destination countries and 12.2% (15/124) of those come back to Indonesia were HBsAg positive. All of 30 HBsAg positive samples showed hepatitis B viremia by part of envelope gene amplifi cation. Six of HBV-B genotype and one HBV-C strains were whole genome sequenced. All together showed that the most isolates (96.2%, 25/26) belonged to HBV B3/adw2 and 3.8% was HBV C8/adrq+. The whole genome phylogenetic analysis of our strains supports a recent argument that subgenotypes B5, B7, B8, B9 could be considered as a quasi-subgenotype of B3, which is most commonly found in West Indonesia, including in Lombok. Conclusions: High prevalent of HBsAg carriers in the Indonesian MWs from Lombok were found, with the predominant of HBV B3/adw2. A tight screening of HBV to the MWs should be applied, in order to limit its transmission abroad. This study also confi rmed a recent fi nding that HBV-B subgenotypes need to be reclassifi ed.

직지의 의미

Eva-Maria Hanevutt-Benz 한국서지학회 2004 서지학연구 Vol.28 No.-

유럽 옛 속담에 “책들도 나름대로 개성이 있다”는 말이 있는데, 여기에는 책을 존중하라는 메세지가 담겨있다고 하겠다. 흥덕사의 직지는 다행히 多衆에게 알려져 있으니 그 운명이 고무적이라고 하겠다. 직지의 과거를 살펴보면 19세기 후반기에 서울 주재불란서 대사관 직원, Collin de Plancy(1853-1922)가 한국에서 상기 서적을 습득했고 후에 이 책은 Henri Vever(1854-1943) 개인장서로 귀속된다. Vever 사망 후에 그의 소망에 따라 파리 국립도서관에 기증되었다. 한국인 사서 박병선이 국립도서관에서 직지를 발견하고, 한국문화에서 중요한 의미를 가지는 서적임을 간파한다. 이것을 계기로 직지에 대한 관심이 증폭되고, 드디어 2000년에 유네스코 세계문화유산 목록에 수록됨으로써 한국문화재적 작품임을 인증 받게 되었다. 직지는 분명서적인쇄사 및 문화사에서 역사적 걸작품이다. 나는 유감스럽게도 한국어, 한국사, 또한 한국인쇄사 등에 관해 아는 바 없으므로, 이 테마에 관해서는 일반론을 피력하고자 한다. 인쇄의 역사를 살펴보건데, 지금까지 전폭적으로 유럽 중심이었으니, 15세기 이후 중부 유럽에서 인쇄술이 어떻게 발달해왔는 가에 관한 연구는 활발했으나, 동방의 현대 및 고대인쇄사에 대한 지식은 점진적으로 그 폭을 넓혀가는 중이다. 반면 인쇄의 본질적인 토대인 종이의 역사는 일찌기 극동 지역의 성과로 인정 받았고 인쇄 기술 면에서 가동적인 활자체, 또는 조립가능한 개별타인구(打印具)를 써서 인쇄했던 기술은 더욱 더 경탄을 자아낸다. 여러면에서 직지와 “구텐베르크 성서본”은 상호 비교가 가능하며 두 서적은 출판된 날짜도 추측이 가능하다. 인쇄술은 목판인쇄와 금속활자인쇄가 있는데, 유럽에서도 인쇄는 처음에 목각으로 시작되었음을 상기할 필요가 있다. 한국에서는 이미 풍부한 문헌들이 목판으로 인쇄되었으나, 유럽에서는 목판인쇄가 그다지 성공하지 못했다. 그 이유를 살펴보면 마찰방식의 인쇄시 종이의 질이 중요한 역할을 하는데, 아마에서 생산된 두툼한 종이는 여러가지 부작용을 초래하였으니, 뒷면까지 양각의 표시가 뚜렷해서 뒷면 인쇄가 불가능했고, 작업 과정에서 찢어지고, 잉크가 번지고 압력을 상당히 가해야만 했다. 이러한 제작상의 어려움으로 인하여 금속활자라는 다른 수단을 강구할 수밖에 없었을 것이다. 발표논고를 3가지로 압축해 보면, (1) 아시아에서는 마찰 방식에 잘 견디는 질기고 얇은종이를 생산했고, 인쇄 시간도 짧았다 그러나 아마에서 만들어진 유럽 종이는 두꺼워서 선명한 인쇄를 하려면 오래동안 힘을 주어서 뒷면을 문질러야 했다. 따라서 종이에 뚜렷한 양각이 나타나서 뒷면은 여백으로 놓아두어야 했다. 1450- 1475년에 출판된 목판인쇄물은 양면이 인쇄되었는데, 이것은 각인기(刻印機)가 그 사이 개발되었기 때문이다. (2) 제본 방식의 근본적 차이점이 아시아와 유럽에는 엄연히 존재한다. 아시아에서는 마찰인쇄시 뒷면이 인쇄되지 못해도 한면을 둘로 접어서 제본함으로 아무런 문제가 되지 않는다. 반면 초기 중세이후 관습적인 유럽의 제본방식은 그점을 허용할 수 없었다. (3) 구텐베르크가 자신의 출판물을 위해 고안해 낸 글자체는 소위 Textra체이며, 표기방식은 수평적 배열성과 직선태이다. 이러한 표기 방식과 글자체의 특이성이 목판인쇄에서 벗어나서 금속활자로의 진입을 가속화시킨 것으로 보여진다.

Österreichische Plosive im Wandel des 20. Jahrhunderts - Eine akustische Untersuchung an Sprechern geboren zwischen 1910 und 1960 mit Fokus auf Voice-Onset Time und Pitch Skip

( Eva Maria Luef ) 서울대학교 독일어문화권연구소 2018 독일어문화권연구 Vol.27 No.-

Plosiv-Konsonanten (auch Verschluss- oder Okkulsivlaute genannt) sind Konglomerate aus diversen phonetischen Merkmalen (zum Beispiel Stimmhaftigkeit, Aspiration, gespreitzte Stimmritzen) und sind durch ein komplexes Zusammenspiel dieser besonders anfällig fur phonetische und phonemische Variabilität. Lautwandel in der Form von Plosiv-Mergern findet man öfters in der phonetischen Literatur und zwei im Moment prominente Beispiele betreffen den koreanischen Seoul Dialekt und Afrikaans, wo Plosiv-Kontraste am Auflösen sind. Die vorliegende Studie beschäftigt sich mit der gegenteiligen Entwicklung - Plosiv-Splits -, einem relativ raren akustischen Phänomen, dem in der phonetischen Literatur weniger Aufmerksamkeit geschenkt wurde, und das im 20. Jahrhundert im österreichischen Deutsch stattgefunden hat. Eine vormals kleine phonetische Unterscheidung zwischen fortis und lenis Plosiven hat sich ab der Mitte des 20. Jahrhunderts in einen klaren phonetischen Kontrast entwickelt. Voice-Onset Time von Anlaut-Plosiven und Pitch Skip von nachfolgenden Vokalen wurden in zwei Generationen von österreichischen Sprechern (geboren in den 1910/20ern und in den 1940/50ern) gemessen und ein phonetischer Split, der lenis VOT gekurzt und fortis VOT verlängert hat, konnte skizziert werden. Diese Ergebnisse geben Einblicke in rezente diachronische Entwicklungen des österreichischen Deutsch in Bezug auf Lautwandel in wort-initialen Plosiven und deren Einfluss auf ihr phonemisches Umfeld.

Hypocholesterolemia in Patients with an Amebic Liver Abscess

( Maria S Flores ),( Adriana Obregon Cardenas ),( Eva Tamez ),( Elba Rodriguez ),( Katiushka Arevalo ),( Isela Quintero ),( Rolando Tijerina ),( Francisco Bosques ),( Luis Galan ) 대한소화기학회 2014 Gut and Liver Vol.8 No.4

Background/Aims: Many parasites induce changes in the lipid profiles of the host. Cholesterol increases the virulence of Entamoeba histolytica in animal models and in vitro culture. This study aimed to determine, in patients with an amebic liver abscess, the correlation between cholesterol and other features, such as the size and number of abscesses, standard hematological and serum chemistry profiles, liver tests, and duration of hospital stay. Methods: A total of 108 patients with an amebic liver abscess and 140 clinically healthy volunteers were investigated. Cholesterol and triglycerides were measured in the sera. The data from medical observations and laboratory tests were obtained from the clinical records. Results: A total of 93% of patients with an amebic liver abscess showed hypocholesterolemia not related to any of the studied parameters. Liver function tests correlated with the size of the abscess. The most severe cases of amebic liver disease or death were found in patients whose cholesterol levels continued to decrease despite receiving antiamebic treatment and hospital care. Conclusions: Our results show that the hypocholesterolemia observed in patients with an amebic liver abscess is not related to any of the clinical and laboratory features analyzed. This is the first study relating hypocholesterolemia to severity of hepatic amebiasis. (Gut Liver 2014;8:415-420)