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Hypocholesterolemia in Patients with an Amebic Liver Abscess
( Maria S Flores ),( Adriana Obregon Cardenas ),( Eva Tamez ),( Elba Rodriguez ),( Katiushka Arevalo ),( Isela Quintero ),( Rolando Tijerina ),( Francisco Bosques ),( Luis Galan ) 대한소화기학회 2014 Gut and Liver Vol.8 No.4
Background/Aims: Many parasites induce changes in the lipid profiles of the host. Cholesterol increases the virulence of Entamoeba histolytica in animal models and in vitro culture. This study aimed to determine, in patients with an amebic liver abscess, the correlation between cholesterol and other features, such as the size and number of abscesses, standard hematological and serum chemistry profiles, liver tests, and duration of hospital stay. Methods: A total of 108 patients with an amebic liver abscess and 140 clinically healthy volunteers were investigated. Cholesterol and triglycerides were measured in the sera. The data from medical observations and laboratory tests were obtained from the clinical records. Results: A total of 93% of patients with an amebic liver abscess showed hypocholesterolemia not related to any of the studied parameters. Liver function tests correlated with the size of the abscess. The most severe cases of amebic liver disease or death were found in patients whose cholesterol levels continued to decrease despite receiving antiamebic treatment and hospital care. Conclusions: Our results show that the hypocholesterolemia observed in patients with an amebic liver abscess is not related to any of the clinical and laboratory features analyzed. This is the first study relating hypocholesterolemia to severity of hepatic amebiasis. (Gut Liver 2014;8:415-420)
( Salas Marina Miguel Angel ),( Miguel Angel Silva Flores ),( Mayte Guadalupe Cervantes Badillo ),( Maria Teresa Rosales Saavedra ),( Maria Auxiliadora Islas Osuna ),( Sergio Casas Flores ) 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.7
To deal with pathogens, plants have evolved sophisticated mechanisms including constitutive and induced defense mechanisms. Phytohormones play important roles in plant growth and development, as well as in the systemic response induced by beneficial and pathogen microorganisms. In this work, we identified an Aspergillus ustus isolate that promotes growth and induces developmental changes in Solanum tuberosum and Arabidopsis thaliana. A. ustus inoculation on A. thaliana and S. tuberosum roots induced an increase in shoot and root growth, and lateral root and root hair numbers. Assays performed on Arabidopsis lines to measure reporter gene expression of auxin-induced/ repressed or cell cycle controlled genes (DR5 and CycB1, respectively) showed enhanced GUS activity, when compared with mock-inoculated seedlings. To determine the contribution of phytohormone signaling pathways in the effect elicited by A. ustus, we evaluated the response of a collection of hormone mutants of Arabidopsis defective in auxin, ethylene, cytokinin, or abscisic acid signaling to the inoculation with this fungus. All mutant lines inoculated with A. ustus showed increased biomass production, suggesting that these genes are not required to respond to this fungus. Moreover, we demonstrated that A. ustus synthesizes auxins and gibberellins in liquid cultures. In addition, A. ustus induced systemic resistance against the necrotrophic fungus Botrytis cinerea and the hemibiotrophic bacterium Pseudomonas syringae DC3000, probably through the induction of the expression of salicylic acid, jasmonic acid/ethylene, and camalexin defense-related genes in Arabidopsis.
The MAK16 Gene of Entamoeba histolytica and Its Identification in Isolates from Patients
Maria del Pilar Crisostomo-Vaz,Victor Alberto Marevelez-Acost,Andres Flores-Luna,Enedina Jimenez-Cardoso 대한기생충학열대의학회 2014 The Korean Journal of Parasitology Vol.52 No.4
To identify sequences of Entamoeba histolytica associated with the development of amebic liver abscess (ALA) in hamsters, subtractive hybridization of cDNA from E. histolytica HM-1:IMSS under 2 growth conditions was performed: 1) cultured in axenic medium and 2) isolated from experimental ALA in hamsters. For this procedure, 6 sequences were obtained. Of these sequences, the mak16 gene was selected for amplification in 29 cultures of E. histolytica isolated from the feces of 10 patients with intestinal symptoms and 19 asymptomatic patients. Only 5 of the 10 isolates obtained from symptomatic patients developed ALA and amplified the mak16 gene, whereas the 19 isolates from asymptomatic patients did not amplify the mak16 gene nor did they develop ALA. Based on the results of Fisher’s exact test (P<0.001), an association was inferred between the presence of the mak16 gene of E. histolytica and the ability to develop ALA in hamsters and with the patient’s symptoms (P=0.02). The amplification of the mak16 gene suggests that it is an important gene in E. histolytica because it was present in the isolates from hamsters that developed liver damage.
Wilfredo Flores-Paredes,Nestor Luque,Roger Albornoz,Nayade Rojas,Manuel Espinoza,Maria J. Pons,Joaquim Ruiz 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.3
Backgound: The members of the so-called ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) are a frequent cause of severe infection, ranking among the most relevant causes of hospital infections. In Peru, few studies, often focused in a single ESKAPE microorganism, have been performed, but none providing an overall and comprehensive long-time analysis of the antibiotic resistance of ESKAPE microorganisms. In the present study, the evolution of antimicrobial resistance levels of ESKAPE microorganisms isolated during 2009 - 2010 (Period 1) and 2012 - 2014 (Period 2) in a IV-level hospital in Lima was analyzed. Materials and Methods: ESKAPE microorganisms were isolated from inpatients clinical samples. Bacterial identification, as well as antimicrobial susceptibility levels for up to 29 antimicrobial agents and presence of Extended-Spectrum β-Lactamases (only established in K. pneumoniae) were determined using automatic methods. Results: Of 9,918 clinical isolates, 1,917/3,777 (50.8%) [JAN/2009-JUN/2010 (Period 1)] and 4764/6141 (46.4%) [JAN/2012-DEC/2014 (Period 2)] belonged to the ESKAPE group (P <0.0001). ESKAPE were more frequent in the intensive care unit (ICU) (P <0.0001). E. faecium decreased from 5.1% to 4.1% (P <0.5), S. aureus from 10.5% to 7.0% (P <0.05), and P. aeruginosa from 12.9% to 11.6% (P <0.05), while, A. baumannii increased from 5.0% to 6.7% (P <0.05), mainly related to an increase in ICU isolates (8.4% vs. 17.1%; P <0.05). Overall, high levels of antimicrobial resistance were detected, but with few exceptions (e.g. vancomycin in E. faecium), antibiotic resistance levels remained stable or lower in Period 2. Contrarily, A. baumannii showed significantly increased resistance to different cephalosporins, carbapenems and amoxicillin plus sulbactam. Conclusion: The introduction of a successful extensively drug-resistant A. baumannii clone in the ICU is suspected. The isolation of ESKAPE and levels of antibiotic resistance levels have reduced over time.
JaeHyuk Lee,Maria Celeste Flores Gimenez,BumChul Yoon 대한스포츠물리치료학회 2017 정형스포츠물리치료학회지 Vol.13 No.1
Prolonged sitting is a high-risk factor for chronic neck pain. McKenzie exercises are commonly used in clinics. Mobile app-based care is increasingly popular, and providesaccess to health information. This study examined the effect of mobile app-based McKenzie exercise on pain intensity, functional disability, exercise adherence, fear avoidance, and quality of life. Twenty graduate students participated in the study to completion. Neck exercise was performed as directed by the mobile app in the workplace environment for at least 10 min/day, 3 days/week for 8 weeks. The Visual Analog Scale (VAS) score for pain intensity, the Neck Disability Index (NDI) for functional disability, the level of exercise adherence, the Fear-Avoidance Belief Questionnaire (FABQ), and the 36-Item Short-Form Health Survey (SF-36) for the quality of life were used to evaluate outcomes. After an 8-week intervention, the VAS (p < .001) and NDI(p < .001) scores were significantly improved with app-based neck exercise. The work-related subscale (p = 0.023) in the FABQ and physical component summary (p < .001) of the SF-36 showed significant improvement in psychological and physical health. The exercise adherence rate was 87.5 %. In conclusion, this study showed that app-based neck exercise can reduce pain intensity and functional disability.
Dynamic Effects of MERCOSUR: An Assessment for Argentina
( German Calfat ),( Renato G. Flores Jr. ),( Maria Florencia Granato ) 세종대학교 경제통합연구소 2003 Journal of Economic Integration Vol.18 No.3
We evaluate the potential dynamic effects of MERCOSUR on the Argentinean economy. Two approaches, already used with other regional integration agreements, are applied for measuring medium and long-term effects. Special care has been taken in separating intra from extra zone effects. All estimations are carefully checked and have their magnitudes contrasted with other figures derived from different sources. Besides, complementary empirical assessments are done. The diverse empirical evidences found support the argument that Argentina experienced growth effects due to MERCOSUR.