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( Na Eun Lee ),( Hong Seon Son ),( Sung Hoon Choi ),( Chang Hun Lee ),( Seung Young Seo ),( Seong Hun Kim ),( Sang Wook Kim ),( Seung Ok Lee ),( Soo Teik Lee ),( Dae Ghon Kim ),( In Hee Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Tenofovir disoproxil fumarate (TDF) is considered as the preferred treatment option for chronic hepatitis B (CHB) patients with treatment failure or resistance to prior nucleos(t)ide analogues (NAs) treatment. We investigated the efficacy of long-term TDF-based therapy in CHB patients with previous NAs-experience. Methods: This study included total 251 patients who had previous history of NAs therapy and were treated with TDF mono (n=173) or TDF combined with other NA (n=78) from August 2012 to March 2017. Virologic response (VR) was defined as undetectable serum HBV DNA by PCR (<20 IU/mL). Results: Mean age of patients was 49.3 years, median duration of TDF therapy was 27.2 months, 75.7% were HBeAg-positive, and median HBV DNA was 3.7 log10IU/mL. The cumulative rates of VR were 188/244 (77.0%), 180/211 (85.3%), and 146/161 (90.7%) at 12, 24, and 36 months, respectively. Multivariate analysis showed that body mass index (OR 0.77, 95% CI 0.61-0.95, p=0.0189) and duration of TDF therapy (OR 1.09, 95% CI 1.02-1.18, p=0.0221) was significantly associated with VR. TDF monotherapy, HBeAg-positivity, platelet count, serum albumin was associated with VR in the univariate analysis, but not significant in the multivariate analysis. In relation to renal safety, patients showed renal impairment (7, 3.0%), mild hypophosphatemia (15, 7.2%), severe hypophosphatemia (1, 0.4%). Conclusions: Long-term TDF-based therapy demonstrated highly effective in viral suppression and relatively favorable renal safety in CHB patients with previous NA-experience. The body mass index and duration of TDF therapy was independent factors associated with VR.
( Hyun Ju Lee ),( Ja Sung Rho ),( Shao Ran Gui ),( Mi Kyung Kim ),( Yu Kyoung Lee ),( Yeon Sook Lee ),( Jeong Eun Kim ),( Eu Na Cho ),( Mong Cho ),( Tae Ho Hwang ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3
Background/Aims: JX-594 is an oncolytic virus derived from the Wyeth vaccinia strain that causes replication-dependent cytolysis and antitumor immunity. Starting with a cross-examination of clinical-trial samples from advanced hepatocellular carcinoma patients having high levels of aldosterone and virus amplification in JX-594 treatment, we investigated the association between virus amplification and aldosterone in human cancer cell lines. Methods: Cell proliferation was determined by a cell-counting-kit-based colorimetric assay, and vaccinia virus quantitation was performed by quantitative polymerase chain reaction (qPCR) and a viral plaque assay. Also, the intracellular pH was measured using a pH-sensitive dye. Results: Simultaneous treatment with JX-594 and aldosterone significantly increased viral replication in A2780, PC-3, and HepG2 cell lines, but not in U2OS cell lines. Furthermore, the aldosterone treatment time altered the JX-594 replication according to the cell line. The JX-594 replication peaked after 48 and 24 hours of treatment in PC-3 and HepG2 cells, respectively. qPCR showed that JX-594 entry across the plasma membrane was increased, however, the changes are not significant by the treatment. This was inhibited by treatment with spironolactone (an aldosterone-receptor inhibitor). JX-594 entry was significantly decreased by treatment with EIPA [5-(N-ethyl-N-isopropyl)amiloride; a Na+/H+-exchange inhibitor], but aldosterone significantly restored JX-594 entry even in the presence of EIPA. Intracellular alkalization was observed after aldosterone treatment but was acidified by EIPA treatment. Conclusions: Aldosterone stimulates JX-594 amplification via increased virus entry by affecting the H+ gradient. (Korean J Hepatol 2011;17:213-219)
( Hong Seon Son ),( Sung Hoon Choi ),( Na Eun Lee ),( Chang Hun Lee ),( Seung Young Seo ),( Seong Hun Kim ),( Sang Wook Kim ),( Seung Ok Lee ),( Soo Teik Lee ),( Dae Ghon Kim ),( In Hee Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Tenofovir (TDF) entecavir (ETV) are considered as the preferred treatment options for treatment-naïve chronic hepatitis B (CHB) patients. We compared the virologic response and renal safety of long-term TDF versus ETV therapy in naïve CHB patients. Methods: This retrospective study included total 432 patients who were treated with TDF (n=205) or ETV (n=227) from August 2012 to March 2017. Virologic response (VR) was defined as undetectable serum HBV DNA by PCR (<20 IU/mL). Results: Mean age of patients, sex, baseline serum levels of AST, ALT, creatinine, and HBV DNA were not significantly different between TDF and ETV groups. The cumulative rates of VR between TDF and ETV groups were 71.6% vs. 61.8% (p=0.477), 88.1% vs. 79.6% (p=0.058), and 84.8% vs. 83.7% (p=0.966) at 1, 2, and 3 years, respectively. The cumulative rates of genotypic resistance between TDF and ETV groups were 0% vs. 0%, 0% vs. 1.5% (p=0.404), and 0% vs. 2.2% (p=0.447) at 1, 2, and 3 years, respectively. Incidences of renal impairment and hypophosphatemia during treatment up to 3 years were not significantly different between two groups. Multivariate analysis showed that HBeAg-positivity (OR 0.27, 95% CI 0.12-0.58, p=0.0012) and serum HBV DNA at 1 year 2000 IU/mL (OR 0.09, 95% CI 0.03-0.25, p<0.0001) were significantly associated with VR. Conclusions: Long-term TDF and ETV treatments appear to have similar virologic response and renal safety in naïve CHB patient. However, long-term ETV therapy might to be associated with genotypic resistance in 2.2% up to 3 years, while none of patients on TDF therapy did.
One-step versus two-step sentinel lymph node mapping techniques in endometrial cancer
( Sang Wun Kim ),( Yoo-na Kim ),( Yong Jae Lee ),( Kyung Jin Eoh ),( Jung-yun Lee ),( Eun Ji Nam ),( Sunghoon Kim ),( Young Tae Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: Fluorescence image-guided sentinel lymph node (SLN) biopsy using two-step mapping technique incorporates sequential injection of indocyanine green into the bilateral uterine cornus, followed by cervical injection. Outcomes were compared between this and the conventional cervical method (one-step). Methods: Patients with FIGO stage I-III endometrial cancer who underwent laparoscopic or robotic staging operation, including SLN biopsy, from May 2014 to December 2018, were retrospectively reviewed. Patient characteristics, preoperative imaging, SLN detection pattern, pathological result, adjuvant treatment, and recurrence locations were analyzed. Results: A total of 199 patients received one-step (n=123) and two-step (n=76) SLN biopsy. Paraaortic SLNs were more frequently identified in the two-step group. Lower and upper paraaortic SLNs were identified in 67.1% and 38.2%, respectively, in the two-step group and in 18.7% and 5.7% in the one-step group (p < 0.001). The number of paraaortic SLNs harvested was superior in the two-step group (p < 0.001). Moreover, trend of a higher proportion of patients with metastatic paraaortic SLN was shown in the two-step group (7.9%) than in the one-step group (1.6%) (p = 0.056). The metastatic paraaortic SLNs were found in 7.9% of the two-step group and 2.4% of the one-step group. In detecting LN metastasis, sensitivities of the one- and two-step methods were 91.7% and 100.0%, negative predictive values were 99.0% and 100.0%, false negative rates were 8.3% and 0%, and accuracy were 99.1% and 100.0%, respectively. The one-step methods identified only 3 out of 8 paraaortic LN metastasis and missed 5 paraaortic LN metastasis. However, there was no missed paraaortic LN metastasis in two-step group. Recurrence was observed in two patients (2.6%; one vaginal vault and one adrenal gland) in the two-step and seven patients (5.7%) including three nodal recurrences in the one-step method. Conclusion: Two-step SLN mapping improved the paraaortic SLN detection rate, a known pitfall of conventional cervical injection. Proper evaluation of aortic nodal status will assist in the tailoring of adjuvant therapy and prevent under-treatment of patients with isolated paraaortic metastasis.
A Korean-American Comparative Study of 3D Scanned Female Anthropometric Data
( Eun Sil Kim ),( Sung Nam Kim ),( Da Na Song ) 한국패션비즈니스학회 2013 패션 비즈니스 Vol.17 No.3
The purpose of this research is to provide useable data for application in American and Korean apparel company. This data was developed by analyzing information of Korean and American body sizes obtained from Size USA Project and Size Korea Project. The Subjects were 6,306 American females and 1,988 Korean females over 18 years old. 30 measurements and 14 computed values were chosen that were considered critical in making garments. And descriptive analysis, percentile analysis and t-test were used as statistical methods for analyzing measurements and computed value between the two countries. The results were as follows. It was determined that American women were larger and bigger than Korean women in all measurements and computed values, except for Shoulder Slope. Based on BMI values, we determined that American women had a distinct tendency towards being overweight. Through the comparison of drop values (i.e. the difference between Hip and Bust Girths or Hip and Waist Girths), ratio values (i.e. waist height divided by height) and Body Mass Index (BMI) between the two countries, we determined that American women`s figures were shapelier than Korean women`s. American women had higher hip heights and longer leg lengths for their height compared to Korean woman. Furthermore, the back shapes of Korean women were flatter than American women and BMI values indicated American women were relatively more overweight than Korean women.