Treatment outcome of postoperative radiotherapy for retroperitoneal sarcoma

Hyun Jin Lee,Si Yeol Song,Tae-Won Kwon,Jeong Hwan Yook,Song-Cheol Kim,Duck-Jong Han,Choung-Soo Kim,Hanjong Ahn,Heung Moon Chang,Jin-Hee Ahn,Eun Jin Jwa,Sang-Wook Lee,Jong Hoon Kim,Eun Kyung Choi,Seong 대한방사선종양학회 2011 Radiation Oncology Journal Vol.29 No.4

Purpose: To evaluate the treatment outcome and prognostic factor after postoperative radiotherapy in retroperitoneal sarcoma. Materials and Methods: Forty patients were treated with surgical resection and postoperative radiotherapy for retroperitoneal sarcoma from August 1990 to August 2008. Treatment volume was judged by the location of initial tumor and surgical field, and 45-50 Gy of radiation was basically delivered and additional dose was considered to the high-risk area. Results: The median follow-up period was 41.4 months (range, 3.9 to 140.6 months). The 5-year overall survival (OS) was 51.8% and disease free survival was 31.5%. The 5-year locoregional recurrence free survival was 61.9% and distant metastasis free survival was 50.6%. In univariate analysis, histologic type (p = 0.006) was the strongest prognostic factor for the OS and histologic grade (p = 0.044) or resection margin (p = 0.032) had also effect on the OS. Histologic type (p = 0.004) was unique significant prognostic factor for the actuarial local control. Conclusion: Retroperitoneal sarcoma still remains as a poor prognostic disease despite the combined modality treatment including surgery and postoperative radiotherapy. Selective dose-escalation of radiotherapy or combination of effective chemotherapeutic agent must be considered to improve the treatment result especially for the histopathologic type showing poor prognosis.

니켈/알루미나 촉매상에서 CO의 플라즈마 촉매 메탄화 반응에 미치는 니켈 함량의 영향

좌은진 ( Eun Jin Jwa ),장두일 ( D. I. Jang ),고란영 ( R. Y. Ko ),이상백 ( S. B. Lee ),목영선 ( Y. S. Mok ) 한국공업화학회 2011 응용화학 Vol.15 No.1

알루미나에 0∼12.5%의 니켈이 담지 된 촉매와 플라즈마를 결합하여 일산화탄소의 촉매 메탄화 반응을 수행하였다. CO와 H2는 1:3의 비율로 반응기에 유입되었으며 H2, CO, CO2, CH4의 농도는 가스 크로마토그래피로부터 측정되었다. 알루미나(bare alumina)를 사용하였을 때는 CO가 CH4로 전환되지 않았지만 니켈이 담지 된 촉매는 메탄화 반응에 영향을 주었고, 촉매상의 니켈 조성이 증가함에 따라 반응 속도가 증가되었다. 저 농도의 니켈이 함량된 촉매를 사용했을 경우 300℃ 이상의 고온에서 반응을 진행했을 경우에는 촉매 자체의 활성이 높아 거의 최대 효율을 나타냈다. 240℃ 이하의 저온영역에서는 다소 메탄화 효율이 낮았지만 저온 플라즈마에 의해 CO와 H2가 들뜬 상태로 활성화되어 촉매적 메탄화 효율은 증가하였다. 고 농도의 니켈이 함량된 촉매를 사용한 반응에서는 촉매 자체의 활성이 저온영역에서 좋았으나 저온플라즈마에 의해 더욱 메탄화 반응이 향상되었다.

Treatment outcome of postoperative radiotherapy for retroperitoneal sarcoma

Lee, Hyun-Jin,Song, Si-Yeol,Kwon, Tae-Won,Yook, Jeong-Hwan,Kim, Song-Cheol,Han, Duck-Jong,Kim, Choung-Soo,Ahn, Han-Jong,Chang, Heung-Moon,Ahn, Jin-Hee,Jwa, Eun-Jin,Lee, Sang-Wook,Kim, Jong-Hoon,Choi, The Korean Society for Radiation Oncology 2011 Radiation Oncology Journal Vol.29 No.4

Purpose: To evaluate the treatment outcome and prognostic factor after postoperative radiotherapy in retroperitoneal sarcoma. Materials and Methods: Forty patients were treated with surgical resection and postoperative radiotherapy for retroperitoneal sarcoma from August 1990 to August 2008. Treatment volume was judged by the location of initial tumor and surgical field, and 45-50 Gy of radiation was basically delivered and additional dose was considered to the high-risk area. Results: The median follow-up period was 41.4 months (range, 3.9 to 140.6 months). The 5-year overall survival (OS) was 51.8% and disease free survival was 31.5%. The 5-year locoregional recurrence free survival was 61.9% and distant metastasis free survival was 50.6%. In univariate analysis, histologic type (p = 0.006) was the strongest prognostic factor for the OS and histologic grade (p = 0.044) or resection margin (p = 0.032) had also effect on the OS. Histologic type (p = 0.004) was unique significant prognostic factor for the actuarial local control. Conclusion: Retroperitoneal sarcoma still remains as a poor prognostic disease despite the combined modality treatment including surgery and postoperative radiotherapy. Selective dose-escalation of radiotherapy or combination of effective chemotherapeutic agent must be considered to improve the treatment result especially for the histopathologic type showing poor prognosls.

The Gingival Subside Effect by Use of the High Pressure Dental Water Jet

Jin-Su Kim,Eun-Kyoung Lee,Su-Kyung Jwa 대한예방치과학회 2016 International Journal of Clinical Preventive Denti Vol.12 No.3

Objective: Water jet is one of the auxiliary oral hygiene devices to eliminating the dental plaque and gingival massage through spraying the high pressure water into the inter proximal site and gum. This clinical test was performed in order to compare the cleansing effect and gingival subside effect between the use of water jet and the using the interdental brush after tooth brushing. Thirty adults volunteers who had early stage of gingivitis were participated. Methods: Such item of index were checked by oral examination and photo taking in the mouth at before experiment, 2 weeks later and 4 weeks later, after sharing the water jet and interdental brush to all subjects with tooth brushing instruction for rolling method. Let them to use the water jet at the left site of the mouth and interdental brush at the right side after tooth- brushing in the evening, for 4 weeks. The clinical experiment was done after achieved the institutional review board certification. The changes of periodontal pocket depth, gingival bleeding index, patient hygiene performance index, gingival index and papillary, marginal and attached gingiva index were checked and compared with the experimental group as left side and the control as right side. Results: There were significantly different in most of items by time passing, both in experimental and the control, but no significantly different between the experimental group and the control. Conclusion: It was recommended to use the water jet for elimination of the dental plaque at the proximal site or gingival sulcus and gingival subside effect for the early stage of gingivitis dental patient.

Squamous odontogenic tumor:

Jwa-Young Kim,Jin-Cheol Kim,Byoung-Ouck Cho,Seong-Gon Kim,Byoung-Eun Yang,Horatiu Rataru 대한구강악안면외과학회 2007 대한구강악안면외과학회지 Vol.33 No.1

A squamous odontogenic tumor (SOT) is an epithelial originated benign tumor. It has been rarely reported and most was intramural type. We observed a case of SOT in the mandible. It was associated with the odontogenic cyst. It was shown positive to pancytokeratin and p53. Considering that the case was free from recurrence for 5 years after surgery, p53 positive did not seem to be related to the prognosis of the disease.

Prognostic value of $^{18}F$-fluorodeoxyglucose positron emission tomography, computed tomography and magnetic resonance imaging in oral cavity squamous cell carcinoma with pathologically positive neck lymph node

Jwa, Eunjin,Lee, Sang-Wook,Kim, Jae-Seung,Park, Jin Hong,Kim, Su Ssan,Kim, Young Seok,Yoon, Sang Min,Song, Si Yeol,Kim, Jong Hoon,Choi, Eun Kyung,Ahn, Seung Do The Korean Society for Radiation Oncology 2012 Radiation Oncology Journal Vol.30 No.4

Purpose: To evaluate the prognostic value of preoperative neck lymph node (LN) assessment with $^{18}F$-fluorodeoxyglucose positron emission tomography ($^{18}F$-FDG PET), computed tomography (CT), and magnetic resonance imaging (MRI) in oral cavity squamous cell carcinoma (OSCC) patients with pathologically positive LN. Materials and Methods: In total, 47 OSCC patients with pathologically positive LN were retrospectively reviewed with preoperative $^{18}F$-FDG PET and CT/MRI. All patients underwent surgical resection, neck dissection and postoperative adjuvant radiotherapy and/or chemotherapy between March 2002 and October 2010. Histologic correlation was performed for findings of $^{18}F$-FDG PET and CT/MRI. Results: Thirty-six (76.6%) of 47 cases were correctly diagnosed with neck LN metastasis by $^{18}F$-FDG PET and 32 (68.1%) of 47 cases were correctly diagnosed by CT/MRI. Follow-up ranged from 20 to 114 months (median, 56 months). Clinically negative nodal status evaluated by $^{18}F$-FDG PET or CT/MRI revealed a trend toward better clinical outcomes in terms of overall survival, disease-free survival, local recurrence-free survival, regional nodal recurrence-free survival, and distant metastasis-free survival rates even though the trends were not statistically significant. However, there was no impact of neck node standardized uptake value ($SUV_{max}$) on clinical outcomes. Notably, $SUV_{max}$ showed significant correlation with tumor size in LN (p < 0.01, $R^2$ = 0.62). PET and CT/MRI status of LN also had significant correlation with the size of intranodal tumor deposit (p < 0.05, $R^2$ = 0.37 and p < 0.01, $R^2$ = 0.48, respectively). Conclusion: $^{18}F$-FDG PET and CT/MRI at the neck LNs might improve risk stratification in OSCC patients with pathologically positive neck LN in this study, even without significant prognostic value of $SUV_{max}$.

Poster Session : PS 1052; Gastroenterology (Gastrointestinal Tract) ; A Case of Esophago Mediastinal Fistula Due to Tuberculous Mediastinal Lymphadenitis

( Jwa Hoon Kim ),( Do Hoon Kim ),( Hee Young Yoon ),( Ji Wan Lee ),( Hyung Woo Cho ),( Soo Min Jeung ),( Eun Jeong Gong ),( Hwoon Yong Jung ),( Jin Ho Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Tuberculosis rarely involves the esophagus, and the most esophageal tuberculosis occurs secondary to adjacent tuberculous lymphadenitis. Esophago-mediastinal fi stula is very rare complication of tuberculous lymphadenitis. A 28-year-old, previously healthy female visited the outside hospital due to nausea, vomiting, and fever. Chest CT(Computed tomography) showed enlargement of multiple, mediastinal lymph nodes with air density in the mediastinum, and thus suggesting an esophago-mediastinal fi stula. Esophagogram showed the extraluminal contrast leakage in cervical esophagus. Esophagogastroduodenoscopy(EGD) showed the deep ulcer with the fi stula opening at 24cm from the upper incisor teeth. Tuberculosis(Tb) polymerase chain reaction(PCR) on the sputum was positive. A biopsy of the right subclavian lymph node revealed necrotizing granuloma with Tb PCR positive. We diagnosed as tuberculous mediastinal lymphadenitis with esophago-mediastinal fi stula. The referring doctor failed to close the fi stula by endoscopic clipping. Therefore, we decided to use anti-Tb medications to treat fi stula via gastrostomy, because of severe nausea and vomiting. After four weeks, EGD and esophagogram showed that the fi stula opening was closed. The present case highlights the importance of anti-Tb medications in treatment of esophago-mediastinal fi stula due to tuberculous mediastinal lymphadenitis. n.

Application of Activation Analysis to geological materials

Mi-Eun Jin,Yong-Joo Jwa,Gwang Min Sun,Seonbok Yi,Zsolt Kasztovszky,Ildiko Harsanyi 한국자기학회 2017 한국자기학회 학술연구발표회 논문개요집 Vol.2017 No.11

Comparable efficacy of silk fibroin with the collagen membranes for guided bone regeneration in rat calvarial defects

Kim, Jwa-Young,Yang, Byoung-Eun,Ahn, Jin-Hee,Park, Sang O,Shim, Hye-Won The Korean Academy of Prosthodonitics 2014 The Journal of Advanced Prosthodontics Vol.6 No.6

PURPOSE. Silk fibroin (SF) is a new degradable barrier membrane for guided bone regeneration (GBR) that can reduce the risk of pathogen transmission and the high costs associated with the use of collagen membranes. This study compared the efficacy of SF membranes on GBR with collagen membranes (Bio-$Gide^{(R)}$) using a rat calvarial defect model. MATERIALS AND METHODS. Thirty-six male Sprague Dawley rats with two 5 mm-sized circular defects in the calvarial bone were prepared (n=72). The study groups were divided into a control group (no membrane) and two experimental groups (SF membrane and Bio-$Gide^{(R)}$). Each group of 24 samples was subdivided at 2, 4, and 8 weeks after implantation. New bone formation was evaluated using microcomputerized tomography and histological examination. RESULTS. Bone regeneration was observed in the SF and Bio-$Gide^{(R)}$-treated groups to a greater extent than in the control group (mean volume of new bone was $5.49{\pm}1.48mm^3$ at 8 weeks). There were different patterns of bone regeneration between the SF membrane and the Bio-$Gide^{(R)}$ samples. However, the absolute volume of new bone in the SF membrane-treated group was not significantly different from that in the collagen membrane-treated group at 8 weeks ($8.75{\pm}0.80$ vs. $8.47{\pm}0.75mm^3$, respectively, P=.592). CONCLUSION. SF membranes successfully enhanced comparable volumes of bone regeneration in calvarial bone defects compared with collagen membranes. Considering the lower cost and lesser risk of infectious transmission from animal tissue, SF membranes are a viable alternative to collagen membranes for GBR.

Prognostic value of 18F-fluorodeoxyglucose positron emission tomography, computed tomography and magnetic resonance imaging in oral cavity squamous cell carcinoma with pathologically positive neck lymph node

Eunjin Jwa,Sang-Wook Lee,Jae-Seung Kim,Jin Hong Park,Su Ssan Kim,Young Seok Kim,Sang Min Yoon,Si Yeol Song,Jong Hoon Kim,Eun Kyung Choi,Seung Do Ahn 대한방사선종양학회 2012 Radiation Oncology Journal Vol.30 No.3

Purpose: To evaluate the prognostic value of preoperative neck lymph node (LN) assessment with 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET), computed tomography (CT), and magnetic resonance imaging (MRI) in oral cavity squamous cell carcinoma (OSCC) patients with pathologically positive LN. Materials and Methods: In total, 47 OSCC patients with pathologically positive LN were retrospectively reviewed with preoperative 18F-FDG PET and CT/MRI. All patients underwent surgical resection, neck dissection and postoperative adjuvant radiotherapy and/or chemotherapy between March 2002 and October 2010. Histologic correlation was performed for findings of 18F-FDG PET and CT/MRI. Results: Thirty-six (76.6%) of 47 cases were correctly diagnosed with neck LN metastasis by 18F-FDG PET and 32 (68.1%) of 47 cases were correctly diagnosed by CT/MRI. Follow-up ranged from 20 to 114 months (median, 56 months). Clinically negative nodal status evaluated by 18F-FDG PET or CT/MRI revealed a trend toward better clinical outcomes in terms of overall survival, disease-free survival, local recurrence-free survival, regional nodal recurrence-free survival, and distant metastasis-free survival rates even though the trends were not statistically significant. However, there was no impact of neck node standardized uptake value (SUVmax) on clinical outcomes. Notably, SUVmax showed significant correlation with tumor size in LN (p < 0.01, R2 = 0.62). PET and CT/MRI status of LN also had significant correlation with the size of intranodal tumor deposit (p < 0.05, R2 = 0.37 and p < 0.01, R2 = 0.48, respectively). Conclusion: 18F-FDG PET and CT/MRI at the neck LNs might improve risk stratification in OSCC patients with pathologically positive neck LN in this study, even without significant prognostic value of SUVmax.