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정대영,신종철,이귀세라,김은중,이종승,이초희,김사진,김수평,진홍기,권인 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.3
연구목적: 이 연구의 목적은 정상 임신부에서 임신 주수의 증가에 따라서 Tumor necrosis factor-α(TNF-α), Vascular cell adhesion molecule-1(VCAM-1) 및 lipid peroxide(지질과산화)의 혈장 내 농도의 변화를 알아보고자 하였다. 연구방법: 건강한 임신부와 임신의 경험이 없는 비임신 여성을 대상으로 하였다. 임신부는 임신 제 1분기(임신 4∼14주), 임신 제 2분기(임신 15∼29주), 임신 제 3분기(임신 30∼41주)로 나누어서 각 해당되는 주수의 임신부로부터 혈액을 채취하여 혈장을 분리한 뒤 TNF-α와 VCAM-1을 immunoassay에 의하여, 지질산화는 colorimetric assay에 의하여 측정하여 통계 분석하였다. 결과 및 결론: 혈장 내 TNF-α는 비임신 여성에 비하여 임신 제 2, 3분기에 유의적인 증가를 보였으며, 혈장 내 VCAM-1의 농도는 비임신 여성에 비하여 임신 제 1분기에 유의적인 증가가 있었다. 지질과산화의 혈장 내 농도는 임신 전기간에 걸쳐서 비임신 여성과 유의적인 차이는 없었다. 결론: 임신 시 혈장 내 TNF-α, VCAM-1 및 지질과산화의 변화는 비임신 여성에 비하여 TNF-α의 경우 제 2, 3 분기에, VCAM-1의 경우 임신 제 1 분기에 증가하며 지질과산화는 임신에 의한 변화는 없었다. 본 연구는 앞으로 문제성 있는 임신의 예측과 중증의 정도를 예견하는 데 있어서 기초 연구가 될 수 있을 것으로 생각된다. Objective: The purpose of study was to assess in a longitudinal study of maternal plasma concentrations of Tumor necrosis factor-α(TNF-α), Vascular cell adhesion molecule-1(VCAM-1), Lipid peroxide (malonaldehyde, MDA) in uncomplicated pregnancy. Methods: Blood was collected from healthy women at 4 to 41 weeks' gestation and non-pregnant women. Plasma samples were measured by immunoassay for TNF-α, VACM-1 and by colorimetric assay for lipid peroxide, and data were statistically analyzed. Results: Plasma concentration of TNF-α was not significantly elevated during first trimester compared with non-pregnant women, but significantly elevated during second and third trimester compared with non-pregnant women. Plasma concentration of VCAM-1 was significantly elevated during first trimester compared with non-pregnant women. Plasma concentration of lipid peroxide was not significantly elevated during pregnancy compared with non-pregnant women. Conclusion: The plasma concentration of TNF-α and VCAM-1 were significantly higher than that of non-pregnant state during second and third trimester in case of TNF-α, and during first trimester in case of VCAM-1. But the plasma concentration of lipid peroxide during pregnancy was not significantly different from that of non-pregnant, and the plasma concentration was kept up constant levels during gestation. These were seems to be meant that abnormal pregnancy would be happened if the level is above or below the measured level.
Thyroid Autoantibody Positive Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Yoori Jung,Soonwon Park,Hwan-Jun Son,정대수,Eun Hi Sa,Sun-Tae Lee,김은수,정나연,김은주 대한치매학회 2016 Dementia and Neurocognitive Disorders Vol.15 No.1
BackgroundHashimoto’s encephalopathy (HE) and anti N-methyl-D-aspartate receptor (NMDAR) encephalitis have clinical overlaps. Case ReportA 70-year-old woman presented with acutely developed confusion, disorientations and psychosis. HE was suspected based on goiter, markedly elevated anti-thyroglobulin and anti-thyroid peroxidase antibody. She was placed on high dose steroid and intravenous immunoglobulins administration, which did not ameliorate her symptoms. After the antibodies to the NMDAR were identified, weekly 500 mg of rituximab with 4 cycles were started. The current followed up indicated a complete recovery. ConclusionsThe possible associations between NMDAR antibody and autoimmune thyroid antibodies in anti-NMDAR encephalitis with positive thyroid autoantibodies remain unclear. However, a trend toward a higher incidence of NMDAR antibody in patients with autoimmune thyroid antibodies than without has been observed. Cases of encephalitis with only NMDAR antibody (pure anti-NMDAR encephalitis) also occur. Therefore, it is important for clinicians to know the clinical and pathogenic differences between anti-NMDAR encephalitis with positive thyroid autoantibody and pure anti-NMDAR encephalitis for relevant treatment, predicting prognosis, and future follow-up.