RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      검색결과 좁혀 보기

      선택해제
      • 좁혀본 항목 보기순서

        • 원문유무
        • 음성지원유무
        • 원문제공처
        • 등재정보
        • 학술지명
        • 주제분류
        • 발행연도
        • 작성언어
        • 저자

      오늘 본 자료

      • 오늘 본 자료가 없습니다.
      더보기
      • 무료
      • 기관 내 무료
      • 유료
      • KCI등재
      • KCI등재

        양 태아 출혈에 대한 적혈구 조혈인자의 반응

        정대영,김진우,신종철,이귀세라,이영,김사진,김수평,Robert A Brace,노승혜,백은정 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.3

        목적: 양 태아 출혈 후 24 시간에 적혈구 조혈 인자의 혈 중 내 농도는 10-20배 증가하며, 출혈 후 48 시간에 정상으로 돌아온다. 이에 저자들은 양 태아 출혈 후 적혈구 조혈 인자의 혈 중 내 농도의 변화를 시간대 별로 정확하게 비교하여 관찰하였다. 방법 및 대상: 제태 후기의 양 태아 12마리를 지속적인 혈관내의 삽관을 이용하여, 2시간 동안에 양 태아 총 혈액양의 40%를 출혈시킨다 (1ml/min for 2hr). 태아 적혈구 조혈인자의 농도는, 처음 출혈 후 1, 2, 4, 6, 8, 10,12, 16, 20, 24, 30, 36시간에 헤파린 처리된 주사기에 의하여 얻어진 혈청에서 원심 분리 후, Radioimmunoassay를 이용하여 측정하였으며. ANOVA로 통계학적인 분석을 시행하였다. 결과: 양 태아에서 출혈이 있은 후, 태아 혈청 내 적혈구 조혈인자의 농도는 4시간 후에 기저 치 농도 보다 2.3 배정도 의미 있게 증가하였고, 16시간 후에 기저 치 농도보다 33.3배 증가하여 최고치를 보인 후에 감소하였다. 결론: 저자들은 양 태아 출혈 후 적혈구 조혈 인자의 농도 변화를 시간대 별로 관찰하였으며, 최근의 연구에 의하면 태아 신장, 간, 그리고, 태반이 적혈구 조혈인자를 발현한다고 알려진 바, 양 태아 출혈 후 적혈구 조혈 인자 증가는 조직 특이성으로 조절되며, 출혈 후 다양한 태아 조직에서 적혈구 조절 인자 mRNA 발현의 정도에 대한 연구가 현재 진행중이다. Objective: The ovine fetus responds to hemorrhage with a 10-20 fold increase in plasma erythropoietin (EPO) concentration at 24 hr and a return toward normal at 48 hr after the hemorrhage. The objective of the present study was more accurately to compare the magnitude and time course of the plasma EPO response after fetal hemorrhage. Methods: Chronically catheterized, 12 of late gestation ovine fetus were gradually hemorrhaged 40% of their blood volume over 2 hr (1ml/min). Plasma was sampled for EPO concentration at 1, 2, 3, 4, 6, 8, 10, 12, 16, 20, 24, 30, 36 hr after initiating the hemorrhage were collected at these times. Radioimmunoassay was used to measure plasma EPO concentrations. Analysis of variance was used for statistical analysis. Result: After a slow hemorrhage in the ovine fetus (1ml/min over 2hr), plasma EPO concentration increased significantly at 4hr (2.3 times basal values), reached a maximum at 16 hr (33.3 times basal values), and declined thereafter. Conclusion: We studied change in time course of the fetal plasma EPO after slow hemorrhage and recent studies have shown that the fetal kidney, liver and placenta express EPO mRNA. These observation suggest that plasma EPO increase may be mediated by a tissue specific up-regulation of EPO transcription in the fetal kidney, liver and placenta. We have studied change in Epo mRNA expression in various fetal tissue after slow haemorrhage.

      • KCI등재

        태아 긴박증에서 태아 심장박동의 비선형 동력학 및 카오스 분석

        정대영,신종철,이상훈,김수평,김창이,김사진,심영보 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.6

        Nonlinear Dynamic and Chaotic Analysis of Fetal Heart Rate in Fetal Distress DaeYoung Chung, M.D., YoungBo Sim, M.Sc., SangHoon Yi, Ph.D. JongChul Shin, M.D., SaJin Kim, M.D., ChangYi Kim, M.D., SooPyung Kim, M.D. Department of Obstetrics & gynecology, College of Medicine, Catholic University, Seoul, Korea, Department of Computational and Electronic Physics, Inje University, Kimhae, Kyungnahm, Korea Objectives: For estimating the antenatal fetal wellbeing to develop new analysis method of fetal heart rate(FHR) with electronic Fetal Heart Rate Monitoring(eFHRM) and computer. Methods: Heart rate signal is received from distressed fetus using eFHRM. It is necessary to carry out low pass filtering as a preprocess for the nonlinear method. Nonlinear parameters are calcuated and classified to investigate the ralation between these parameters and values of umbilical cord blood gas. REsults: By diving values of the umbilical cord blood gas into 5 fetuses of acidemic group and 17 getuses of non-acidemic group after 22 neonates who presented fetal distress were born, the following results as compared with nonlinear chaotic analysis result were obtained. Ⅰ. Delay time through AMI for acidemic group was 16.80±3.11, and was higher than 15.51±2.27 for non-acidemic group, and is not significant in statistics. Ⅱ. Embedding Dimension calculated with FNN method was 5.60±2.07 for acidemic group, and 4. 71±1.26 for non-acidemic group, and it was not significant statistically. Ⅲ. Correlation dimension for acidemic group was 1.41±0.20, and was higher than 1.10±0.38 for non-acidemic group, and is not significant in statistics. Ⅳ. Mean crossing value by isoangular return map was 28.80±11.34 for acidemic group, and 16.65±7.00 for non-acidemic group, and it was signficant statistically(P=0.008). Ⅴ. In comparison of information entropy in 1-D ED, acidemic group was 6.32±0.38 and non-acidemic group was 6.20 ± 0.28 and it was not significant statistically. Also, in comparison of value in 2-D ED, acidemic group was 10.20±0.34. It was higher than non-acidemic group of 9.51±0.43 significantly in statistics(P=0.004). But, in comparison of value in 2-D EP, acidemic group was 8.78±0.86 and non-acidemic group is of 9.22±0.74 and it wasn't significant statistically. And, 2-D ED(DI) value was 10.64±0.14 for acidemic group and 10.51±0.18 for non-acidemic group, and it wasn't significant statistically. Conclusions: By the above result, nonlinear dynamics and chaotic analysis of heart rate data with computer can serve as a new diagnosis method which may estimate the fetal wellbeing with real time. Through further studies for establishment of diagnosis standard and computer programming, real time diagnosis method shall be applied to clinical practice.

      • KCI등재

        중증 및 경증 자간전증 태반에서 간세포성장인자 및 수용체의 발현

        정대영,신종철,양동은,이지현,김수평,문희봉,김사진,김창이,백은정 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.8

        Objectives : Hepatocyte growth factor (HGF) is a pleiotrophic cytokine that play an important role in cell migration, proliferation, morphogenesis and angiogenesis in many different cell types. Although the etiology of preeclampsia is still unknown, this disease is characterized by reduced invasion of trophoblastic cells, and as HGF might stimulate the invasion of placental trophoblast through the activation of c-Met, we studied whether difference in the expression of HGF and c-Met is present between placentas of normal and preeclamptic pregnancies, to elucidate the possible relationship between HGF and c-Met expression and the pathogenesis of preeclampsia. Methods : The samples were obtained from human placentas of three groups - normal, mild and severe preeclamptic pregnancies - in third trimester. For evaluation of HGF and c-Met mRNA expression, 25 cycles of reverse transcription-polymerase chain reaction (RT-PCR) using specific primers was performed after isolating total RNA from the placental samples, and then southern blot was used for detection of PCR products. Western blot analysis was performed to measure HGF in protein levels. Results : The HGF mRNA expressions of mild and severe preeclamptic pregnacies were 79% and 39% respectively, compared with that of normal pregnancy. The c-Met mRNA expressions of mild and severe preeclamptic pregnacies increased in 47%와 49% respectively, compared with that of normal pregnancy. The HGF protein expression of mild and severe preeclamptic pregnacies were 58% and 24% respectively, compared with that of normal pregnancy. Conclusion : These results suggest that the lowered expression of placental HGF in preeclampsia might be closely associated to the lack of trophoblast invasion that may be the key in pathogenesis of preeclampsia.

      • KCI등재

        일차성 폐성 고혈압 (Primary pulmonary Hypertension)이 동반된 임신 1 예

        정대영,신종철,이귀세라,이지현,문희봉,백은정,김사진,김수평 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.9

        일차성 폐성 고혈압증은 아주 드문 질환으로 임신과 잘 동반되지는 않으나 동반될 경우 높은 모성 사망률과 유병율을 일으키므로 철저한 피임과 조기 진단이 필수적이다.폐고혈압증 환자가 임신이 될 경우 임신의 생리적인 변화로 일어나는 혈액량의 증가로 인해 증가된 폐동맥압을 더욱 악화시키며 심장에 부담이 되어 부전을 일으키게된다. 이로 인한 사망률은 30-50%까지 보고되고 있다. 최근에는 칼슘 통로 차단제나 nitric oxide 같은 혈관 확장제를 사용하여 폐동맥압의 증가를 저지하려는 여러 연구가 시도되고 있으며 좋은 성적을 내고 있다. 저자들은 일차성 폐증 고혈압증을 가진 임신 36주 환자에서 폐동맥의 확장과 저항을 낯추기 위해 adenosine 반응후 nifedipine을 사용하여 약 20%이상의 폐동맥압 감소를 유도하였으나 심한 부작용으로 인해 nitrate 와 hydralazine 으로 대체하여 조절 하다가 건강한 아기를 분만하고 특별한 이상 없이 퇴원한 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Primary pulmonary Hypertension is a rare disorder in pregnant woman but it carries a high risk of maternal morbidity and mortality. Therefore early diagnosis and pregnancy prevention is critical. When pregnancy is combined, physiologic increase in maternal plasma volume aggravates pulmonary pressures causing cardiac decompensation and maternal mortality of 30-50% was reported. But recent trials with vasodilators improved hemodynamic changes and prolonged survival in patients with pulmonary hypertension who respond to high doses of calcium antagonist. We experienced a case of a pregnant woman with primary pulmonary hypertension who after adenosine trial was treated with nifedipine showing more than 20% decrease in pulmonary artery pressure but drug was switched to isosorbide dinitrate and hydralazine because of side effects. Also nitrates showed good results and patient delivered a healthy boy and had an uneventful postpartum period. We reports this case with brief review of literature.

      • KCI등재

        태아에서 발생한 양성 낭성 복막 중피종 (Benign cystic peritoneal mesothelioma) 1 예

        정대영,강대호,신종철,이지현,문희봉,백은정,노승혜,고현선,김수평 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10

        태아나 신생아의 복강내 종괴의 가장 흔한 원인은 수신증과 다낭성신장을 포함한 신장기원의 종괴라고 보고되고 있으며, 그외 의 원인으로는 소화기계, 후복막, 또는 여성생식계를 들수 있으며, 대부분의 경우 양성 경과를 보이나 약 2%에서 악성화를 나타낸다. 양성 낭성 복막 중피종은 복막에서 기원하는 종양으로 양성 중피세포로 둘러싸인 아주 얇은 막으로 구성되어 있다. 국소적인 재발은 흔하나 악성 변성이나 전이가 보고된 적은 없으며 주로 가임기 여성에서 발병하며 남성에서는 매우 드문 것으로 알려져 있다. 저자들은 임신 36주에 시행한 산전초음파에서 복부에 다발성 낭종을 보인 태아에서, 남아에서 드물고 태아에게 더욱 드문 양성 낭성 복막 중피종과 이로 인해 이차적으로 발생한 양측 수신증 1 례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. It is stated in many reports that the most frequent cause among abdominal masses in fetus and neonates is congenital renal lesion including hydronephrosis and multicystic kidneys. Other causes are masses originated from gastrointestinal tract, retroperitoneum, or female genital tract. Which almost are benign but about 2% of cases have malignant course. Benign cytic peritoneal mesotheliomas are tumors of peritoneum characterized by thin-walled cyst lined by benign mesothelial cells. Despite the marked tendency to occur, no malignant degeneration or metastasis was reported. It occurs predominantly in females of reproductive age and is rare in male. We experienced a case of male fetus with a huge abdominal mass and severe secondary hydronephrosis which result to be a benign cytic peritoneal mesothelioma, a rare entity in male fetus and rarer in fetal period.

      • KCI등재

        자간전증 태반에서 인슐린유사 성장인자-II 및 인슐린유사 성장인자 결합단백질-1의 발현

        정대영,신종철,양동은,유영옥,이지현,김수평,문희봉,김창이,백은정,박철훈 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.12

        목적 : 정상임신과 자간전증이 동반된 임신의 태반에서의 IGF-II와 IGFBP-I 발현에 차이가 있는지 알아봄으로써 IGF-II 및 IGFBP-1과 자간전증 사이의 연관성 알아보기 위해 본 연구를 시행하였다. 방법 : 임신 제 3분기에 제왕절개술을 시행한 정상임신 4예, 경증 자간전증 임신 9예 및 중증 자간전증 5예의 태반으로부터 조직을 얻었다. IGF-II 와 IGFBP-1 의 mRNA발현을 관찰하기 위하여 태반조직에서 총RNA를 추출한 후 IGF-II 및 IGFBP-1의 primer를 이용하여 RT-PCR을 시행하였고, IGFBP-1의 단백질 발현을 관찰하기 위해서 western blot을 시행하였다. 결과 : 1. 경증 및 중증 자간전증에서의 IGF-II mRNA 발현은 정상임신에 비해 모두 유의하게 감소되었으나(p$lt;0.05, respectively) 경증 및 중증 자간전증 사이에는 별 차이가 없었다. 2. 경증 및 중증 자간전증에서의 IGFBP-1 mRNA 발현은 정상임신에 비해 모두 증가되었을 뿐 아니라 중증도가 심할수록 많이 발현되었으며, 특히 중증 자간전증의 경우에는 정상임신에 비해 유의하게 증가하였다(p$lt;0.05). 그러나 경증 자간전증에서는 정상임신에 비해 유의하게 증가하지는 않았다. 3. IGFBP-1 mRNA의 발현양상과 유사한 결과를 보였다. 즉, 경증 및 중증 자간전증에서의 IGFBP-1 단백질의 발현이 정상임신에 비해 모두 증가되었을 뿐 아니라 중증도가 심할수록 많이 발현되었다. 결론 : IGF-II 및 IGFBP-1은 자간전증의 발생기전 및 중증도에 관계가 있을 것으로 생각된다. Objective : To elucidate the possible relationship between IGF and pathogenesis of preeclampsia we studied whether expression of IGF-II and IGFBP-1 differs in preeclamptic placentas compared with normal ones. we also studied the differential expression of IGF-II and IGFBP-1 according to the severity of preeclampsia. Methods : The placental samples were obtained from 4 cases of normal pregnancy, 9 cases of mild preeclampsia, and 5 cases of severe preeclampsia terminated by cesarean section in the third trimester. For evaluation of IGF-II and IGFBP-1 mRNA expression, we isolated total RNA from placental samples and then performed RT-PCR using specific primers. Western blot was also done to identify IGFBP-1 protein expression. Results : The expressions of IGF-II mRNA in mild and severe preeclamptic placentas were significantly decreased than those in normal placentas (p$lt;0.05, respectively). The expression of IGFBP-1 mRNA in severe preeclamptic placentas was significantly increased than that in normal placentas (p$lt;0.05). However, although the expression of IGFBP-1 mRNA in mild preeclamptic placentas was increased than that in normal placentas, there was no significant difference between them. The results on expressions of IGFBP-1 protein among normal, mild preeclamptic and severe preeclamptic placentas showed the similar patterns with the results of IGFBP-1 mRNA. Conclusions : These results suggest that IGF-II and IGFBP-1 are might be associated with pathogenesis of preeclampsia.

      • KCI등재

        자궁외임신에서 내 외과적 치료의 비용 절감 효과 비교

        정대영,이영,신종철,유영옥,김대훈,백은정,이종건,김창이,김수평 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.12

        The incidence of ectpic pregnancy has increased rapidly over the past decade. Currently, the complications of this disorder make it one of the leading causes of maternal mortality and morbidity. In the late 1980s, reports of successful use of methotrexate (MTX) as a non surgical treatment for ectopic pregnancy (EP) also began to appear in the literature. With MTX emerging as a possible alternative management of selected women with an EP, an analysis of its comparative costs is now needed. We examined retrospectively the costs associated with management of EP in our hospital. We selected 30 women with EPand divided them into two groups of MTX treated group (n= l0) and surgically treated group (n=20). There were no statistically significant differences in the doctors fee, room, charge and cost of laboratory and radiologic examination between two groups. But We found significant reduction in cost with regard to pharmacy, injection, procedure and operation of MTX treated group compared to surgically treated group (p$lt;0.05). Consequently the use of MTX for EP should still be considered investigational; we recognize and agree that the evolution of this remedial option should be based primarily on its ability to decrease morbidity and mortality rather than on its ability to reduce costs. If medical treatment proves to be effective, the potential cost savings demonstrated in this report will become an important influential factor on selecting alternative remedy.

      • KCI등재

        성별에 따른 태아 심장 박동 분석

        정대영,이영,신종철,김수평,백은정,문희봉,김창이,이종승 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.1

        목적: 태아 심박동(fetal heart rate; FHR)은 자율신경계의 조절로 나타나는 현상으로 정상 심박동은 자체의 주기성, 교감 신경 또는 미주 신경 및 부교감 신경으로부터 영향을 받는다. 자율신경 하에 조절되는 심장박동은 성인의 경우 나이 성별에 따른 차이가 있으며, 성별에 따른 자율신경의 생리 작용이 다르다는 것을 알 수 있다. 이에 저자들은 태아 성별에 따른 임상적 여러 변수들 그리고 태아 심박동과 차이를 연구하였다. 연구 방법: 가톨릭 의과대학 산부인과학 교실에 산전 진찰 및 분만을 위해 내원한 산모 중 전자식 태아감시 장치를 시행하였고, 본원에서 분만하여 신생아 임상 소견을 알 수 있었던 317명의 667개의 태아 심박동 자료를 대상으로 하여, 기초 태아 심박동수, 태아 심박동 증가, 태아 심박동 감소, Percent acceleration time(PAT) 및 Percent deceleration time(PDT)를 계산하였고, 변이도로 표준 편차, Mean minute range(MMR)의 장기변이도(LTV) 및 단기변이도(STV)를 계산하였다. 결과: 분석 결과 남아 분만군과 여아분만군의 비교에서 기초 태아 심박동수 137.64±13.68 bpm, 140.51±12.43bpm(P=0.007), PAT는 6.10±4.00bpm, 4.90±3.34bpm(P=0.001), 그리고 PDT는 7.50±8.70bpm, 6.18±7.70bpm(P=0.039)으로 유의한 차이가 있었으나, 표준 편차는 8.84±10.11bpm, 8.11±3.56bpm, LTV는 80.38±62.79msec과73.65±54.60msec, STV는 14.06±9.79msec과 13.33±12.32msec로 차이가 없었다. 결론: 위의 결과로 남아와 여아의 태아 심박동은 차이가 있으며, 이는 발생 시기부터의 부교감 신경과 교감 신경의 발달 차이로 인한 심장 및 체강의 연결계의 차이가 임신 기간 중에 발생한는 것이 원인으로 사료 된다. Objectives: The purpose of this study is to analyze the previously unreported effect of fetal sex on the fetal heart rate and to measure its magnitude in relation to the effects of other independent clinical variables. Methods: Three hundred and seventeen pregnant women who were able to provide electronic fetal heart rate monitoring were evaluated. On the basis of fetal sex after birth, 167 pregnant women who delivered male neonate were for males group and 146 examples who delivered female neonate were for female group. We analyzed fetal heart rate data using the Catholic Computer Assisted Obstetric Diagnosis System(CCAOD). Results: Female fetuses had significantly faster basal heart rate(140.51±12.43bpm) than male fetuses(137.64±13.68 bpm).(P=0.007) Percent acceleration time(PAT) increased significantly for males(6.10±4.00bpm), comparing to females(4.90±3.34bpm).(P=0.001) Also percent deceleration time(PDT) was significantly higher in male fetuses(7.50±8.70bpm) than female fetuses(6.18±7.70bpm).(P=0.039) But there was no differences in standard deviation(SD)(8.84±10.11bpm, 8.11±3.56bpm), long term variation(LTV)(80.38±62.79msec, 73.65±54.60msec), and short term variation(STV)(14.06±9.79msec, 13.33±12.32msec) between male and female fetuses. Conclusion: The fetal heart rate of female fetuses differ from that of male fetuses. Computerized linear analysis and nonlinear analysis of antepartum fetal heart rate will need to take into account the multiple factors that influence the fetal heart rate to identify precisely which pattern predict clinical outcome.

      연관 검색어 추천

      활용도 높은 자료

      이 검색어로 많이 본 자료

      해외이동버튼