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송지영,김은기 한밭대학교 정보통신전문대학원 2003 정보통신전문대학원 논문집 Vol.1 No.1
In this paper, we have implemented the new protocol, LB_UDP, that can be used for multimedia data transmission. The implemented LB_UDP can control a burst multimedia data and regulate traffic having a constant rate at regular intervals. LB_UDP protocol maintains the basic actions of UDP and controls bursty data using the Leaky Bucket algorithm. We have test a implemented LB_UDP in Linux Kernel. When traditional UDP was used, we could find that the data transmission rate changes variably. But when LB_UDP was used, we could find that the change of data transmission rate is a little. The designed LB_UDP can be used to transmit a multimedia data without network congestion.
박용관,박치영,조은택,조기섭,박찬국,송창훈,이미자,기근홍 朝鮮大學校 附設 醫學硏究所 1995 The Medical Journal of Chosun University Vol.20 No.2
Hepatocellular carcinoma frequently metastasizes through direct extension, lymphatic, and hematogenous routes. The most common sites of metastasis are the lungs and the lymph nodes, glands, bones, spleen, kidneys, colon, and pleura are the sites of metastasis in decreasing order of frequency. But metastasis to the ovary is very rare. It is thought that metastasize to the ovary occurs through infiltration or dissemination. However, we observed ovarian metastasis of primary hepatic tumor in a 34-year old female who suffered from lower abdominal pain. At first, it was diagnosed as a primary ovarian tumor. But histologically, it presented sinusoidal pattern surrounded by the tumor cells and contained rounded by the tumor cells and contained round hyaline globules in minority of the cytoplasm. Then, the histologic features of percutaneous, sono-guided liver biopsy speecimen of the liver mass are similar to those of resected ovarian tissues. Therefore, we concluded that ovarian tumor was originated from hepatocellular carcinoma. In summary, this report examines a case of hepatocellular carcinoma with ovarian metastasis in a female and reviews the literature.
ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis
Song, Eun Kyung,Jeon, Jimin,Jang, Dong Gil,Kim, Ha Eun,Sim, Hyo Jung,Kwon, Keun Yeong,Medina-Ruiz, Sofia,Jang, Hyun-Jun,Lee, Ah Reum,Rho, Jun Gi,Lee, Hyun-Shik,Kim, Seok Jung,Park, Chan Young,Myung, K American Association for the Advancement of Scienc 2018 Science translational medicine Vol.10 No.462
<P>Developing and mature chondrocytes constantly interact with and remodel the surrounding extracellular matrix (ECM). Recent research indicates that integrin-ECM interaction is differentially regulated during cartilage formation (chondrogenesis). Integrin signaling is also a key source of the catabolic reactions responsible for joint destruction in both rheumatoid arthritis and osteoarthritis. However, we do not understand how chondrocytes dynamically regulate integrin signaling in such an ECM-rich environment. Here, we found that developing chondrocytes express integrin-beta-like 1 (Itgbl1) at specific stages, inhibiting integrin signaling and promoting chondrogenesis. Unlike cytosolic integrin inhibitors, ITGBL1 is secreted and physically interacts with integrins to down-regulate activity. We observed that Itgbl1 expression was strongly reduced in the damaged articular cartilage of patients with osteoarthritis (OA). Ectopic expression of Itgbl1 protected joint cartilage against OA development in the destabilization of the medial meniscus-induced OA mouse model. Our results reveal ITGBL1 signaling as an underlying mechanism of protection against destructive cartilage disorders and suggest the potential therapeutic utility of targeting ITGBL1 to modulate integrin signaling in human disease.</P>
Stewart-treves syndrome following chronic leg lymphedema of the lower extremity
( Sung Eun Song ),( Seung Woo Lee ),( Seung Gi Hong ),( Ki Woong Ro ),( Eun Phil Heo ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Stewart-Treves syndrome (STS) is a rare cutaneous angiosarcoma that develops in chronic lymphedema. The majority of STS are described in the upper extremity after aggressive locoregional therapy for breast cancer. A 68-year-old woman presented with diffuse purpuric coalescent plaques on right posterior thigh. She has a history of radical hysterectomy with lymph node dissection due to uterine cervical cancer. She received total hip replacement surgery due to hip joint avascular necrosis. After hip surgery, she has suffered from chronic right leg edema. The skin biopsy on right posterior thigh showed irregular, anastomosing vascular channels lined by atypical endothelial cells. Special stains showd positivity for factor VIII, anti-CD34 and anti-CD31 antibodies which are vascular markers. She showed bone and pelvis metastasis from primary leg lesion on radiologic staging work up. She refused any treatment such as surgery, radiotherapy, and chemotherapy except pain control. She died 2 months after diagnosis of this highly malignant tumor. Herein, we report a case of Stewart-Treves syndrome following chronic leg lymphedema in Korea.
Pedigree Analysis of 17 High Quality Korean Rice Cultivars Using Web Database Systems
Yi, Gi-Hwan,Park, Dong-Soo,Chung, Eun-Sook,Song, Song-Yi,Jeon, Nam-Soo,Nam, Min-Hee,Kim, Doh-Hoon,Han, Chang-Deok,Eun, Moo-Young,Ku, Yeon-Chung The Korean Society of Crop Science 2006 Korean journal of crop science Vol.51 No.6
It is important to understand pedigree of rice cultivars commonly used for breeding. In this paper, pedigree tables for tracking the pedigree of 17 representative rice cultivars recommended by Rural development Adminstration (RDA) were completed and analyzed using two kinds of web database system; 'IRIS' and 'RRDB'. Seven cultivars, namely, 'Sangmibyeo', 'Ilpumbyeo', 'Saegewhabyeo', 'Surabyeo', 'Shindongjinbyeo', 'Ilmibyeo' and 'Jungwhabyeo' had 'Koshihikari' on the pedigree of their ancestor. Besides 'Koshihikari', the most feguently used ancestral germplasms among the high quality rice cultivars were 'Fujisaka 5', 'Kameno o' and 'Asahi', 'Fujisaka 5' was used as ancestral parent in 12 out of 17 cultivars. Interestingly, 'Kameno o' was used in pedigree of 16 out of 17 high quality varieties and 'Asahi' was used in the ancestral pedigree of all 17 varieties. 'Hwayeongbyeo' was used as one of parent in the breeding of 'Dongjin 1', 'Hwabongbyeo', 'Saegewhabyeo' and 'Junambyeo'. 'Ilpumbyeo' was used in the breeding pathway of 'Junambyeo' and 'Saegewhabyeo', 'Mangeumbyeo' itself was not enlisted as one of high quality rice cultivars, but was used as a breeding parent of three high quality varieties, namely, 'Saegewhabyeo', 'Hwabongbyeo' and 'Nampyeongbyeo'. Incorporated with evaluation data, pedigree will provide a valuable chance to genealogical tracking of agronomic traits such as disease resistance, grain quality and etc.
알코올성 지방간 유발 마우스에서 다슬기 유래 가수분해물의 간 보호 효과
송은진 ( Eun Jin Song ),조경환 ( Kyoung Hwan Cho ),추호진 ( Ho Jin Choo ),양은영 ( Eun Young Yang ),정윤경 ( Yoon Kyoung Jung ),서민균 ( Min Gyun Seo ),김종철 ( Jong Cheol Kim ),강은주 ( Eun Ju Kang ),류기형 ( Gi Hyung Ryu ),박범 한국산업식품공학회 2017 산업 식품공학 Vol.21 No.4
본 연구는 다슬기의 간 보호 효능을 확인하고자 하였다. 다슬기를 단백질 가수분해효소인 alcalase를 이용하여 가수 분해물을 얻은 후 실험을 수행하였다. HepG2 세포에 다슬기 가수분해물을 처리하였을 때 세포독성이 나타나지 않음을 확인하였다. 그리고 다슬기 가수분해물과 에탄올(1 M)을 가하여 24시간 후 세포생존율을 확인했을 때, 세포가 알코올 독성으로부터 보호되는 것을 확인할 수 있었다. 다음으로 다슬기 가수분해물의 간 손상 보호 효과를 Liber-DeCarli 알코올 액체 식이 급여와 동시에 경구 투여를 통한 알코올 단회 폭음(single binge)으로 알코올성 지방간과 염증을 유발시킨 마우스모델(NIAAA)을 사용하여 확인하고자 하였다. 이들 마우스 모델에서 알코올 식이 급여 후 초기에 체중이 감소하는 경향을 보이나 점차 비알코올 식이 급여군과 유사한 체중으로 회복하였다. 조직학적 관찰에서 알코올로 유도된 간 세포내 지방 축적과 지방성 염증이 에탄올과 함께 다슬기 가수분해물을 투여한 군에서 개선되는 것을 관찰 할 수 있었다. 또한, 알코올 투여에 의한 AST, ALT 및 ALP의 효소활성 증가가 다슬기 가수분해물 처리에 의해 억제되었으며, 만성 알코올 섭취에 의한 염증 매개 효소와 염증성 사인토카인의 발현 증가는 다슬기 가수분해물을 투여한 군에서 양성대조군에 비하여 유의하게 감소하였다. 이상의 연구결과를 종합해 보면 다슬기효소 가수분해물 소재는 알코올성 지방간의 예방 및 개선을 위한 기능성식품용 상업적 소재로서 높은 실용화 가능성을 시사한다. Alcoholic steatosis is a fundamental metabolic disorder and may precede the onset of more severe forms of alco-holic liver disease. In this study, we isolated enzymatichydrolysate from Semisulcospira libertine by alcalase hydrolysis and investigated the protective effect of Semisulcospira libertine hydrolysate on liver injury induced by alcohol in the mouse model of chronic and binge ethanol feeding (NIAAA). In an in vitro study, the hydrolysate protects HepG2 cells from ethanol toxicity. Liver damage was assessed by histopathological examination, as well as by quantitating activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). After the administration of S. libertina hydrolysate, fat accumulation and infiltration of inflammatory cells in liver tissues were significantly decreased in the NIAAA mouse model. The elevated levels of serum AST, ALT, and ALP activities, along with the lipid contents of a damaged liver, were recovered in experimental mice administrated with S. libertina hydrolysate, suggesting its role in blood enzyme activation and lipid content restoration within damaged liver tissues. Moreover, treatment with S. libertine hydrolysate reduced the expression rate of cyclooxygenase (COX-2), interleukin (IL)-1β, and IL-6, which accelerate inflammation and induces tissue damage. All data showed that S. libertine hydrolysate has a preventive role against alcohol-induced liver damages by improving the activities of blood enzymes and modulating the expression of inflammation factor, suggesting S. libertine hydrolysate could be a commercially potential material for the restoration of hepatotoxicity.
간암 환자에서 발생한 위장관 운동장애 및 소장내 세균과증식
이은희 ( Lee Eun Hui ),이광재 ( Lee Gwang Jae ),김도현 ( Kim Do Hyeon ),송현주 ( Song Hyeon Ju ),최준혁 ( Choe Jun Hyeog ),송영준 ( Song Yeong Jun ),김진홍 ( Kim Jin Hong ),조성원 ( Jo Seong Won ),윤준기 ( Yun Jun Gi ) 대한소화기기능성질환·운동학회 2003 Journal of Neurogastroenterology and Motility (JNM Vol.9 No.2
Gastrointestinal (GI) symptoms such as nausea, vomiting, abdominal pain, and diarrhea are common in patients with advanced liver disease. Changes of the GI function can be caused by malabsorption, GI motility disturbances, small intestinal bacterial overg
P058 A clinical study of cutaneous squamous cell carcinoma and their metastasis
( Sung Eun Song ),( Seung Gi Hong ),( Seung Woo Lee ),( Ki Woong Ro ),( Eun Phil Heo ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: The rate of metastasis in cutaneous squamous cell carcinoma has been estimated to range from 2% to 5%. Despite its low distant metastatic potential, the presence of distant metastasis is associated with a dismal prognosis. Objectives: In this study we investigated the recent trend of the cutansous squamous cell carcinoma metastasis in clinical and histopathological aspects. Methods: Two-hundreds two cases of SCC who had visited the Samsung Changwon Hospital during the last 10 years(between 2006.1.1 and 2015.12.31) were reviewed retrospectively. Results: The possible etiologic factor were Bowen``s disease (24 cases), actinic keratosis (15 cases), burn scar (3 cases), chronic inflammatory skin disorders such as anal fistula, chronic eczema (3 cases), arsenical keratosis, previous radiotherapy, operative scar and immune suppression (1 case each). Most commonly involved sites were the head and neck (157 cases), upper extremities (21 cases), lower extremities (11 cases), trunk (6 cases), perineum (5 cases) in decreasing order. In histopathologic aspects, poorly differentiated histological characteristics and invasion beyond subcutaneous tissue have the potency of metastasis. Regional lymph nodes were the mainly affected sites of metastasis(4 cases) of primary cutaneous SCC. Conclusion: Herein, we suggest a close follow-up plan such as every 3 months and a lymph node ultrasound in high risk group of SCC metastasis.