RBF-POD reduced-order modeling of DNA molecules under stretching and bending

Lee, Chung-Hao,Chen, Jiun-Shyan Techno-Press 2013 Interaction and multiscale mechanics Vol.6 No.4

Molecular dynamics (MD) systems are highly nonlinear and nonlocal, and the conventional model order reduction methods are ineffective for MD systems. The RBF-POD method (Lee and Chen, 2013) employed a radial basis function (RBF) approximated potential energies and inter-atomic forces of MD systems under the framework of the proper orthogonal decomposition (POD) method for the reduced-order modeling of MD systems. In this work, we focus on the numerical procedures of the RBF-POD method and demonstrate how to apply this approach to the modeling of ds-DNA molecules under stretching and bending conditions.

Fibroblast-Derived Clusterin Negatively Regulates Pigmentation

Lee, Jiun,Kim, Misun,Park, Tae Jun,Kang, Hee Young Williams & Wilkins 2017 The Journal of investigative dermatology Vol.137 No.8

Biomimicking Hybrid Scaffold Consisting of Compact and Spongy Bone Structure Using Gelatin/α-Tricalcium Phosphate via 3D-Printing and Electrohydrodynamic Jetting Processes

Lee, JiUn,Kim, WonJin,Koo, YoungWon,Choe, YoungEun,Kim, Hyunggun,Kim, GeunHyung American Scientific Publishers 2018 Nanoscience and nanotechnology letters Vol.10 No.5

Three-Dimensional Hierarchical Nanofibrous Collagen Scaffold Fabricated Using Fibrillated Collagen and Pluronic F-127 for Regenerating Bone Tissue

Lee, JiUn,Kim, GeunHyung American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.42

<P>It is well known that a nanoscale fibrous structure can provide a unique stage for encouraging reasonable cell activities including attachment and proliferation owing to its similar topological structure to the extracellular matrix. Hence, the structure has been widely applied in tissue regeneration. Type-I collagen has been typically used as a typical tissue regenerative material owing to its biocompatibility and abundance, although it has potential for antigenicity. In particular, collagen has been fabricated in two different forms, porous spongy and nanofibers. However, although the structures provided outstanding cellular activities, they exhibit disadvantages such as low cell migration capabilities in a spongy scaffold owing to the low degree of interconnected macropores and low processability in fabricating three-dimensional (3D) structures in an electrospun collagen scaffold. Hence, the fabrication of 3D nanofibrous collagen structures with interconnected macropores can be extremely challenging. In this work, we developed a 3D collagen scaffold consisting of multilayered nanofibrous struts fabricated using a 3D printing process and pluronic F-127 (PF-127), which is a thermoreversible polymer. After optimizing various processing conditions, we successfully achieved the 3D nanofibrous collagen mesh structure with fully interconnected macropores. A 3D-printed collagen scaffold that was fabricated using a low-temperature printing process was applied as a control. Through various analyses using physical properties (surface morphology, fibronectin absorption, mechanical properties, etc.) and cell activities using preosteoblasts (MC3T3-E1), we are convinced that the newly designed 3D nanofibrous collagen scaffold can be a new promising scaffold for bone tissue engineering.</P> [FIG OMISSION]</BR>

Development of a tannic acid cross-linking process for obtaining 3D porous cell-laden collagen structure

Lee, JiUn,Yeo, Miji,Kim, WonJin,Koo, YoungWon,Kim, Geun Hyung Elsevier 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.110 No.-

<P><B>Abstract</B></P> <P>Cell-printing is an emerging technique that enables to build a customized structure using biomaterials and living cells for various biomedical applications. In many biomaterials, alginate has been widely used for rapid gelation, low cost, and relatively high processability. However, biocompatibilities enhancing cell adhesion and proliferation were limited, so that, to overcome this problem, an outstanding alternative, collagen, has been extensively investigated. Many factors remain to be proven for cell-printing applications, such as printability, physical sustainability after printing, and applicability of <I>in vitro</I> cell culture. This study proposes a cell-laden collagen scaffold fabricated <I>via</I> cell-printing and tannic acid (TA) crosslinking process. The effects of the crosslinking agent (0–3wt% TA) in the cell-laden collagen scaffolds on physical properties and cellular activities using preosteoblasts (MC3T3-E1) were presented. Compared to the cell-laden collagen scaffold without TA crosslinking, the scaffold with TA crosslinking was significantly enhanced in mechanical properties, while reasonable cellular activities were observed. Concisely, this study introduces the possibility of a cell-printing process using collagen and TA crosslinking and <I>in vitro</I> cell culture for tissue regeneration.</P>

Fabrication of 3D bioceramic/natural polymer biocomposite using low temperature 3D printing system for bone tissue regeneration

JiUn Lee,WonJin Kim,Minseong Kim,GiHoon Yang,JaeYoon Lee,MijiYeo,YoungWon Koo,HaeRi Kim,YoungEun Choe,JaeHeon Jeong,Myojin Kim,GeunHyung Kim 한국표면공학회 2017 한국표면공학회 학술발표회 초록집 Vol.2017 No.11

하버드 프로젝트 제로(Harvard Project Zero)와 미래 예술교육에 대한 전망

이지언 ( Jiun Lee ) 한국예술교육학회 2016 예술교육연구 Vol.14 No.1

본 논문은 미래의 예술교육에 대한 중요성을 탐구하기 위하여 철학자 넬슨 굿맨이 기획한 하버드 교육 대학원의 < 프로젝트 제로, Harvard Project Zero, 1967~ >를 연구의 핵심으로 삼는다. < 프로젝트 제로 >는 예술에 대한 인지적인 접근이라는 철학적 정신 및 방법론을 기조로 설립되었다. 또한 인지 심리학자인 하워드 가드너를 중심으로 < 프로젝트 제로 >의 예술교육은 인지적, 심리적 측면을 융합하는 다양한 예술교육의 학제적 실험이 진행 중이다. 연구는 < 프로젝트 제로 >의 철학적 정신을 바탕으로 어떻게 앱 세대에 대한 예술교육이 가능하며 필요한지 < 프로젝트 제로 >의 연구 프로그램 분석을 통해 진행된다. 특히 제시카 데이비스의 실제적 사례들 및 가드너와 케이티 데이비스의 앱 세대 연구를 토대로 디지털 기술시대 예술교육의 의미를 분석한다. 이를 통해 예술이 제기하는 질문과 인간의 경험, 공감하는 능력의 향상 등 앞으로 도래할 과학기술시대의 변화에 예술이 어떤 역할을 할 수 있을지 논의한다. 결론적으로 변화하는 세계 속에서 창의적인 생각과 표현으로 문제를 해결하고 새로운 세계를 창조하는데 있어 예술교육은 더욱 요청될 것이며, < 프로젝트 제로 >는 학교와 사회를 연결하는 미래 예술교육의 중요한 대안이 된다. This article explores pedagogical experiments that demonstrate a renewed utility for art education in the future. I will discuss the philosopher Nelson Goodman’s Project Zero, housed at Harvard University’s Graduate School of Education. Project Zero is a long-term study of cognitive effects and scholastic outcomes of greater student exposure to art and philosophical methods in general schooling. Continuing this project into the second generation, Howard Gardener’s cognitive psychology research studies the effects of a wide exposure to art education and interdisciplinary education. Project Zero is one major example how the philosophical spirit is possible in art education even in our digital ‘app generation.’ I will explore associated researcher Jessica Davis and her books “Why Our Schools Need the Arts” and “Why Our High Schools Need the Arts.” In general, I examine the question how art and philosophical education connects to improved empathetic and creative abilities for those in our new digital society. Finally, I argue art education is more important than before due to the cultural needs for greater creative thinking, imagination and problem solving. Project Zero embraces these curricular ideas through this creative education, and so it is a useful alternative model to review for a better connection between school and society.

프래그머티즘 미학과 대중예술

이지언 ( Lee Jiun ) 한국예술교육학회 2017 예술교육연구 Vol.15 No.1

과학기술 사회에서 대중예술은 새로운 인간의 조건으로서 유의미한 철학적 논의를 형성하고 있다. 철학의 영역에서 노엘 캐롤은 대중예술에 대한 성찰을 통해 기존의 논쟁에 반박하고 있으며 나아가 리처드 슈스터만은 프래그머티즘 미학을 통해 삶과 예술이 어떻게 밀접하게 연결되고 있는지 포스트모던 논의를 통해 구성한다. 특히 슈스터만은 미국의 랩 음악을 분석함으로써 대중예술이 하위문화가 아니라 주류문화로서 논의될 수 있음을 주장하고 있다. 논자는 슈스터만이 주장하는 프래그머티즘 미학의 원리인 삶과 예술의 결합이라는 측면에 주목하고, 삶의 영역을 과학에 초점을 두어 포스트휴먼 시대의 예술로 확장하고자 한다. 이렇게 될 때 미디어 대중을 의미하는 `매스(mass)`의 철학적 함의는 디지털 미디어로 확장할 수 있을 것이다. 앞으로 대중예술은 가상공간에서 이루어지는 디지털 미디어에 의해서 더욱 변모할 것이며, 디지털 예술에 대한 논의도 더욱 활발해질 것이다. 본 논문의 목표는 첫째 철학의 맥락에서 대중예술의 정체성을 재점검하고, 둘째 삶과 예술을 통합하여 설명하고자 한 슈스터만의 프래그머티즘 미학을 살펴봄으로써 포스트휴먼 시대의 대중문화가 과학기술과 결합하여 디지털 시대 새로운 예술로서 논의할 수 있는 이론적 토대를 제공할 수 있다는 것을 입증하는 것이다. Mass culture is very important to mainstream culture in our era. Previous arguments about mass culture and mass art argued that `mass art` was entirely the same as `popular art.` I am challenging this formulation due to recent artistic developments, while I accept it for the past. What has changed? There is a quality about current mass art that is less studied if such a formulation is accepted. I think that the difference between mass art and popular culture is that mass art in our current era has become highly dependent upon digital mediation through developments in science and technology whereas popular culture loses this important new nuance. I draw upon different aesthetic philosophers to build this viewpoint. From Noel Carroll, I accept his criticism of others that the increasing dependence on science and technological mediation in our basic culture can be a positive or beneficial aspect, instead of previous philosophers viewing such developments more negatively. Second, drawing on Richard Schusterman`s Pragmatist Aesthetics which holds important the interaction of life and art, this is a way to bring a greater understanding that lived technology and science have to be integrated into our sense of a mass art instead of categorized as outside of culture and art in our digital era. For example, the digital aspects of the phenomenon of Korean `k-pop` mass art is hard philosophically to analyze in its aesthetics or its global impact without a deep appreciation of its highly technological and mediated aspects for building the culture of mass art through internet devices worldwide. So I would consider definitions of science and technology now can be considered very important material aspects of mass art, while in the term popular culture this is unaddressed. First, I will use Schusterman`s Pragmatist Aesthetics for how we can connect art and life. Second, this is a foundation for analysing a digital mass art that draws on previous thinkers though makes a new statement from them.

코로나 19 상황에서 교육용 SNS 앱의 유아 원격교육 활용 가능성 탐색

이지운(Lee, Jiun),강은진(Kang, Eun Jin) 한국열린유아교육학회 2020 열린유아교육연구 Vol.25 No.6

코로나19 사태로 유아교육기관에도 디지털 매체를 활용한 교수학습방법에 대한 요구가 커지고 있다. 본 연구에서는 유아교육기관에서 가정과 부모의 소통도구로 사용되었던 SNS 앱의 특징을 분석함으로써 유아-부모-기관의 상호작용을 통해 유아의 복합양식 문식성을 길러주는 교수매체로서의 가능성을 살펴보기 위해 수행되었다. 이를 위해, 유아교육기관에서 사용되는 4개의 교육용 SNS 앱을 선정하여, 앱의 안전성, 인터페이스, 상호작용을 중심으로 분석하였다. 본 연구에서 분석한 교육용 SNS 앱은 시소, 플립그리드, 클래스팅이었다. 연구결과 모든 앱이 개인정보 보안을 고려하고 있었으나, 광고제한 기능이 있는 앱은 2개였다. 인터페이스에서 유아를 고려한 교육용 SNS 앱은 복합양식 문식성교육에 활용되기 좋은 매체이며, 교사와 부모의 소통뿐만 아니라 유아와의 상호작용도 고려한 교육용 SNS 앱은 가정과 유아교육기관을 연계한 교수매체로 활용될 수 있음을 알 수 있었다. 이러한 결과를 통해 교육용 SNS 앱이 원격교육 상황에서 활용될 수 있음을 제안하였다. The COVID-19 epidemic brought unprecedented remote learning in Korean Early Childhood Educational institutions. This situation evoked the needs for the new teaching methods in early childhood classroom utilizing digital tools. This study analyzes characteristics of social networking applications which have been used in early childhood educational settings as a communication tool between parents and educators. Therefore, the possibility of using an educational social networking application as an interaction tool among child, parents, and educators and as an educational tool to foster multimodal literacy learning for children are explored. To serve this purpose, four educational social networking applications (Flipgrid, SEESAW, Classting, Kids Note) were analyzed by their safety features, interfaces, and interactions. The results implied following suggestions. First, all educational social networking applications are in consideration of securing privacy while only two applications restrict the exposure of advertisements. Second, the interface analysis suggested that educational social networking applications considering children as users could be utilized as fine tools for multimodal literacy education. Third, this study recognized the possibility that educational social networking applications, which consider not only communication between parents and teachers but also interactions with and among children, could be used as educational tools that connect families and early childhood institutions. These results suggest that educational social networking applications can be utilized in remote learning situations.

Synergistic effect of highly porous microstructured support and co-solvent assisted interfacial polymerization on the performance of thin-film composite FO membranes

Jaewoo Lee,Yu Jie Lim,Jiun Hui Low,Somin Lee,Chung-Hak Lee,Rong Wang,Tae-Hyun Bae 한국막학회 2022 한국막학회 총회 및 학술발표회 Vol.2022 No.11