정신과 환자들의 의료서비스 이용에 관한 연구 : 경기도 연천 지역에서 In Yonchon Area of Kyunggi Province

황성혜,홍진표,권준수,우종인,김중술,조두영,이부영,조맹제,양병국,배재남 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

본 연구는 농촌지역 정신과 환자들의 의료서비스 이용 형태를 알아보고자 하여 행하여졌다. 경기도 연천군 주민중 1993년 1년간 지역 의료보험과 의료보호자료에서 정신과적 진단을 받은 사람들 1295명 중 209명을 대상으로 하였다. 연구자들이 제작한 반구조화된 면담도구를 사용하여 13명의 훈련된 면담자에 의해 증상을 처음 느낀 후 이용한 의료서비스를 차례대로 조사하였다. 결과는 다음과 같다. 정신증적 장애 환자들은 정신과 치료만을 받은 경우가 28.8%이며 처음 방문한 의료서비스는 정신과 45%, 일반의 28%, 약국 6%, 한방치료 5%, 요양원 6%, 기타 10%였다. 비정신증적 장애 환자들은 정신과를 한번이라도 이용한 경우는 32.1%였고 처음 방문한 의료서비스는 정신과 15%, 일반의59%,약국 17%, 한방치료8%, 기타1%였다. 진단에 따라서는, 정신분열병의 경우 64.5%가 처음에 정신과를 방문하였고 정동형 정신병의 경우는 20.8%에 불과했고 64.1%가 일반이나 약국을 처음에 방문하였다. 신경증적 장애(ICD-9 300)는 40.0%가 일반의만을 방문했다. 이상의 결과로 정신분열병 환자들은 대다수가 정신과 치료를 받는 것으로 나타났으나 정동형 정신병과 신경증적 장애는 다수가 일반의를 이용하는 것으로 나타났다. 지역사회 정신보건에서 일반의의 역할이 매우 중요하며 일반의에 대한 정신과 교육이 절실하고, 보다 전문적인 치료환경과 기술을 요하는 경우에는 정신과와의 연계 체계의 필요성도 요구된다. The purpose of this study was to investigate the pathways of health care seeking by the psychiatric patients at a well - defined rural area in Korea. Among 1,295 patients diagnosed to have mental disorders by ICD-9 in a year, all the psychotic patients(184 in number) and randomly selected 15% of nonpsychotic patients(162 in number) were selected as subjects of this study. Thirteen well - trained interviewers collected the data using semi-structurd inter-view instrument developed by the authors. Two hundred nine patients(60.4%) fully responded to the interviews. As for psychotic patients, 28.8% used only psychiatric services, and the first visits for help were psychiatrists, general practitioners, pharmacists, asylums and oriental herb medicine in the order of decreasing frequency. Only 32.1% of nonpsychotic patients used mental health specialties during the course of their illness, and their most common first visits for care were general practitioners(59%) followed by pharmacists(17%) and psychiatrists(15%). Majority(64%) of schizophrenic patient visited psychiatrist first, while 64.1% of affective psychosis patients visited general practitioners and pharmacists first. The forty percent of neurotic patients(ICD-9 300) visited general practitioners only for their health care.

骨格筋 Protein Methylase Ⅱ에 關한 硏究

洪承元,郭相太,林圭,黃炳斗 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2

Protein methylase Ⅱ (S-adenosy-L-methionine : protein-carboxyl 0-methyltransferase) has been, purifed 6,600-fold from bovine skeletal muscle and characterized. The purification procedures involved ammonium sulfate fractionation, Sephadex G-75 chromatography, S-adenosyl-L-homocysteine-Sepharose 4B chromatography, and hydroxyapatite chromatography. The enzyme showed an optimal pH around 6.0. It was heat-labile, being inactivated by heattreatment at 60℃ for 6 minutes. However, storage of the enzyme at -20℃ in the presence of 10% glycerol prevented the activity loss for 6 months. The apparent Km for S-adenosyl-L-methionine was 2.86 × 10 exp (6) M. Copper(Cu^2+) ion was potent noncompetitive inhibitor, the activity being completely inhibited b) 0.25 mM Cu^2+ and 1 mM Zn^2+. Most of the activity loss by copper and zinc ions were recovered by the addition of ethylenediamine tetracetate. The enzyme was also completely inhibited by 0.5 mM phydroxymercuribenzoate, which could be reversed by the addition of 10 mM 2-mercaptoethanol. The molecular weight of the enzyme was 24,000, as determined by Sephadex G-75 chromatography. Histone IIA, immunoglobulin A and soybean trypsin inhibitor were efficiently carboxylmethylated by the enzyme. Sarcoplasmic reticulum(SR) and sarcolemma(SL) of the skeletal muscle were also efficiently carboxylmethylated by the enzyme at a rate of 0.96 and 0.63 pmolesl mg protein/min of 3^H-CH_3, incorporation, respectively. Polyacrylamide gel electrophoresis of the carboxylmethylated SR and SL revealed multiple carboxylmethylated subfactions : SR resolved into the subfractions with molecular weight 100,000, 55,000, 22,000 and 14, 400, and SL into the subfractions with molecular weight 48,000, 22,000 and- 14, 400. Of these subfractions those with Mr=22, 000 were most strongly carboxylmethylated. Endogenous cAMP-dependent phoshorylation of SR occurred in the subfractions with Mr=55, 000, Mr=27, 000 and Mr=~14, 400, of which the fraction with Mr=27, 000 was most strongly phosphorylated. When SR was carboxylmethylated, the endogenous cAMP-dependent phosphorylation was decreased. SR exhibited relatively high Ca^2+-ATPase activity and oxalate-facilitated ATP-dependent 45^Ca^z+uptake. The carboxylmethylation and cAMP-dependent phosphorylation of SR increased the Ca^2+TATPase activity by 15% and by 29%, respectively. However, cAMP-dependent phosphorylation of SR which had been previously carboxylmethylated led to only 23% increase in the Ca^2+-ATPase activity. Both the carboxylmethylation and cAMP-dependent phosphorylation enhanced the steady-state rate as well as the initial rate of ^45Ca^2+-uptake. Kinetic analysis showed that the apparent Km and Vmax of Ca^2+ for ATP-dependent Ca^2+-uptake were 45μM and 35 nmoles/mg protein, respectively. Both the carboxylmethylation and cAMP-dependent phosphorylation of SR decreased the Km and increased the Vmax for the Ca^2+-uptake. These results suggest that protein methylase II might have some regulatory role in the calcium transport of sarcoplasmic reticulum.

初等學敎施設의 色彩計劃 合理化 試論 : 6개 新築學敎에 대한 문-스펜서 色彩調和와 PCCS 色調調和에 바탕하여 Based on Moon & Spencer and PCCS Harmonization Theory

張聖浚,崔斗源,黃仁煥 대한건축학회 2003 대한건축학회논문집 Vol.19 No.12

The study deals with color environment of some new primary school buildings to suggest alternative strategy for rationalization of color planning. We introduced two analytic methods. Firstly, we measured present color schemes in and outside the building, and checked if the colors satisfy theory of harmony suggested by Moon & Spencer, and PCCS. Secondly, we conducted enquete survey to find out preference on color samples and satisfaction on color environment of the new building. In case of exterior colors, half of them were in disharmony in respect to main color. The respondents presented conflict attitude in color combination preference in the color sample and the real color environment. The study suggests appropriate strategy for color planning to promote color satisfaction; .enhancement of harmony condition, simple checking of harmony between primary color and secondary or accent color, cheking of bipolar attitude, care of color maintenance.

骨格筋 S-Adenosyl-L-Methionine : Protein-Carboxyl O-Methyltransferase의 精製 및 特性 Protein-Carboxyl O-Methyltransferase from Bovine Skeletal Muscle

林圭,洪承元,郭相太,黃炳斗 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.2

S-Adenosyl-L-methionine : protein-carboxyl 0-methyltransferase(prorein methylase II) has been purified from bovine skeletal muscle approximately 6,600-fold with a 7% yield by combination of ammonium sulfate precipitate, Sephadex G-75 chromatography, S-adenosyl-L-homocysteine-Sepharose 4B chromatography and hydroxyapatite chromatography, and then its characterizations and possible roles were investigated. The enzyme showed a optimum pH around 6.0. It was heat labile, inactivated by heat-treatment at 60℃ for 6 minutes, and when stored at -20℃ in the presence 10% glycerol, its activity has almost stabilized in 6 months. Copper ion(Cu^2+)and zinc ion(Zn^2+)were a potent inhibitors, the activity being completely inhibited at 0.25 mM and 1 mM respectively, The inhibition of copper and zinc ions were recovered 94%, 75% of its activity by adding 4 mM of EDTA, respectively. The apparent Km value for S-adenosyl--L-methionine was 2.86 x 10^-6 M. Kinetic analysis of enzyme in the presence of 30 uM copper ion showed that the nature of the inhibition to the enzyme was noncompetitive considering that Km was constant and Vmax was decreased. Histone IIA, immunoglobulin A and trypsin inhibitor were relatively good substrates for the enzyme. The enzyme activity was completely inhibited by 0.5 mM p-hydroxymercuribenzoic acid, but all of the activity was recovered in adding 10 mM mercaptoethanol, and the molecular weight of the enzyme was 24,000. Sarcolemma and sarcoplasmic reticulum of the skeletal muscle were good substrates for this enzyme and ^3H-CH_3 group was incorporated to 0.63 and 0.96 pmoles/mg protein/min, respectively. The carboxylmethylation of the sarcolemma of the skeletal muscle occurred in the 5 protein fractions(M. W. : 45,000, 22,000, below 14,400etc.) and that of sarcoplasmic reticulum occurred in the 7 protein fractions (M. W. : 100,000, 45,000, 22,000, below 14, 400 etc) by SDS/polyacrylamide gel electrophoresis. Among these molecular weight 22,000 was strongly methylated. These results discuss that protein methylase Il may play some roles in regulating physiological function of sarcolemma and sarcoplasmic reticulum of skeletal muscle.

완두 F_1세대의 조합능력 검정

정원복,오주성,황필성,황영현,신두철,한원영,김수경 동아대학교 교육대학원 2002 동아교육논총 Vol.28 No.-

완두의 이면교잡에 의한 F_1세대에 대한 조합능력을 검정한 결과는 다음과 같다. 9개 형질에 대한 GCA, SCA, RCA효과를 검정한 바 조합능력은 전 형질에서 GCA, SCA, RCA가 모두 유의하였고, 분지수·경직경·엽장·주당협수·협당립수·주당립수·100립중·주당립중은 GCA가 SCA보다 크고, 품종간 GCA효과는 고성종1호가 경직경과 100립중에서, 고성종2호가 경장·분지수·엽장에서, 김해종이 주당협수·주당립수·100립중·주당입중에서, 진해종이 협다립수에서 각각 정(+)으로 높았다. SCA효과에서 경장은 1×2(고성종1호×고성종2호)조합과 1×3(고성종1호×김해종)조합이, 분지수는 4×5(고성종3호×진해종)조합이, 경직경과 엽장은 1×3(고성종1호×김해종)조합이, 주당협수는 1×2(고성종1호×고성종2호)조합과 4×5(고성종3호×진해종)조합이, 협당립수는 1×2(고성종1호×고성종2호)조합·1×4(고성종1호×고성종3호)조합·2×3(고성종2호×김해종)조합이, 주당립수는 1×2(고성종1호×고성종2호)조합과 4×5(고성종3호×진해종)조합이, 100립중은 3×4(김해종×고성종3호)조합이, 주당립중은 1×2(고성종1호×고성종2호)조합·3×4(김해종×고성종3호)조합·4×5(고성종3호×진해종)조합이 각각 정으로 높았다. RCA효과에서 경장·엽장·주당협수·주당립중은 1×2(고성종1호×고성종2호)조합이, 주당협수·주당립수·100립중·주당립중은 2×4(고성종2호×고성종3호)조합이 각각 정으로 높았다. Five pea varieties in F₁ generation of the possible crosses among them were used to estimate the combining ability for nine characters, i. e., stem length, number of branches per plant, stem diameter, leaf length, number of pods per plant, number of seeds per pod, number of seeds per plant, 100-seed weight and seed weight per plant. Data for F₁ hybrid and parents were subjected to the analysis method proposed by Griffing. The results obtained were summarized as follows. Mean squares of general combining ability(GCA), specific combining ability(SCA) and reciprocal combining ability(RCA) were significant for all characters observed. Mean squares of GCA were higher than those of SCA and RCA in number of branches per plant, stem diameter, leaf length, number of pods per plant, number of seeds per pod, number of seeds per plant, 100-seed weight and seed weight and seed weight per plant. Variety Gimbae showed the highest GCA effect for number of pods per plant, number of seeds per plant and seed weight per plant and positively high effects of GCA were observed from variety Gosung#1 in stem diameter, 100-seed weight, and from variety Gosung#2 stem length, number of branches per plant, leaf length, from Jinhae in number of seeds per pod In SCA effects, hybrids in Gosung#1×Gosung#2 were wxhibited positively high for stem length, number of pods per plant, number of seeds per pod, number of seeds per plant and seed weight per plant, and high SCA effects for number of branches per plant, number of pods per plant, number of seeds per plant and seed weight per plant were found positively in Gosung#3×jinhae. In RCA effects, hybrids in Gosung#2×Gosung#3 were exhibited positively high for number of pods per plant, number of seeds per plant, 100-seed weight and seed weight per plant and high RCA effects for stem length, leaf length, number of pods per plant, and seed weight per plant were found positively in Gosung#1×Gosung#2.

농작물 해충 및 진균류 방제를 위한 방선균의 분리 및 동정

이은정,강경돈,황교열,김두호,김신덕,성수일 한국잠사학회 1998 한국잠사곤충학회지 Vol.40 No.1

Twenty seven out of ca. 5,000 actinomycete strains, which were isolated from soil collected throughout the country, showed antimicrobial effects against fungi, Rhizopus stronifer (ATCC6227a), Rhizoctonia solani (KCCM 11271) and yeast, Candida albicans(ATCC10231). From these antifungal microorganisms, we further selected seven strains which seemed to produce insecticidal substances with in vivo test, using silkworm, Bombyx mori and beet armyworm, Spodoptera exigua. Morphological and biochemical experiments revealed that three strains out of seven were streptomyces. Further investigations on the physical and chemical properties of these antifungal and insecticidal substances are now in progress.

Treatment of off-gas evolved from thermal decomposition of sludge waste

Hwang, Doo-Seong,Choi, Yun-Dong,Jeong, Gyeong-Hwan,Moon, Jei-Kwon Springer-Verlag 2013 JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY Vol.295 No.3

모의 방사성 용액에서 은함침 활성탄에 의한 (131)I의 흡착 분리

황두성 ( Doo Seong Hwang ),정영주 ( Young Ju Choung ),정원명 ( Won Myoung Choung ),박진호 ( Jin Ho Park ),박경배 ( Kyoung Bae Park ),박소진 ( So Jin Park ) 한국공업화학회 2001 응용화학 Vol.5 No.1

근권제한 및 단근 처리가 ‘서촌조생’ 감나무의 수체생육, 수량 및 과실 품질에 미치는 영향

최성태(Seong-Tae Choi),박두상(Doo-Sang Park),윤영황(Young-Hwang Yoon),송원두(Won-Doo Song),손길만(Gil-Man Shon),노치웅(Chi-Woong Rho),강성모(Seong-Mo Kang) 한국원예학회 2005 원예과학기술지 Vol.23 No.2

근권제한과 단근 처리가 ‘서촌조생’ 감나무의 수체생장, 수량, 과실 품질에 미치는 영향을 구명하기 위하여 1997년부터 2004년까지 본 시험을 수행하였다. 1997년 3월에 근권을 제한하기 위하여 폭 50㎝, 깊이 45㎝의 도랑식 구덩이를 파고 비닐(비닐 근권제한구) 또는 부직포(부직포 근권제한구)를 구덩이 옆과 아래에 펴고 열간거리 2m, 주간거리 1m로 나무를 심은 근권제한 처리구와 근권제한 조치 없이 재식 이듬해부터 매년 발아 전에 주간 양쪽 50㎝ 거리에서, 45㎝ 깊이로 토양을 파 뿌리를 절단한 단근구, 그리고 무처리의 대조구를 두었다. 근권제한 또는 단근 처리로 수고, 수폭, 주간단면적, 엽면적, 도장지 발생, 지상부 생체중이 재식 4년차부터 뚜렷하게 감소되었는데 부직포 근권제한구에서 그 효과가 가장 컸다. 2003년까지 6년간 총전정량도 부직포 근권제한구가 가장 적었으며, 다음으로 비닐 근권제한, 단근구 순이었다. 재식 8년차 3월에 뿌리를 굴취 해 본 결과, 비닐 및 부직포 근권제한구에서 근권제한 부위 바깥에 세근 및 중근이 부분적으로 뚫고 나간 것이 관찰되었다. 비닐 근권제한구는 근권제한 부위 내에 뿌리 밀도가 가장 높고, 단근구는 단근 부근에서 세근과 중근이 많은 것이 특징이었다. 주당 누적수량은 재식 5년차부터 대조구에서 많았으나 통계적 유의성이 인정될 정도는 아니었으며, 수량효율은 재식 6년차부터 부직포 근권제한구에서 높은 경향이었다. 재식 3년차부터 5년간 평균과중은 대조구 146g에 비해 부직포 근권제한구 142g, 비닐 근권제한구 141g, 단근구 138g 순으로 작았던 반면, 수확일은 대조구보다 각각 3, 4, 2일이 빨랐다. This experiment was conducted to determine the effects of root restriction and root pruning on tree growth, yield, and fruit quality of ‘Nishimurawase’ persimmon from 1997 to 2004. The trees were planted in 50 ㎝-wide, 45 ㎝-deep trenches lined with either polyethylene (PE) film or non-woven fabric. The rows were 2 m apart and the in-row tree spacing was 1 m. A block of trees were root-pruned annually from 1998. The root pruning was done before bud-break by digging and replacing the soil on two sides of the trunk at 50 ㎝ to a depth of 45 ㎝. Root zone of control trees was left untouched until 2004. Root restriction or root pruning significantly decreased tree height, tree spread, trunk cross-sectional area (TCSA), leaf area, number of water sprouts, and fresh weight of above-ground parts. Reductions in tree growth were apparent from the fourth year after planting. The most reduction was found in the trees with non-woven fabric. Cumulative pruning weight was also reduced most in the trees lined with non-woven fabric, followed by the trees with PE film and root-pruned. When excavated in March of the eighth year after planting, it was noted that a few roots were grown through the PE film and the non-woven fabric. Root weight within the restricted zone was the greatest in the trees with PE film, whereas much of fine and medium roots were found near to the cut surface in root-pruned trees. Although not significant, cumulative yield per tree tended to be high in control trees from the fifth year after planting while yield efficiency in the trees with non-woven fabric from the sixth. Average fruit weights during the 5 years from the third year were 146 g in the control, 142 g in non-woven fabric, 141 g in PE film, and 138 g in root-pruned trees, exhibiting some negative effects of root restriction and root pruning on fruit size. However, the fruits matured 3, 4, and 2 days earlier, respectively, than those of the control.

α-Benzoinoxime 에 의한 Molybdenum 의 침전 분리

황두성(Doo Seong Hwang),정원명(Won Myung Choung),김연구(Yeon Ku Kim),이규일(Keu Il Lee),박진호(Jin Ho Park),박경배(Kyung Bae Park),박소진(So Jin Park) 한국공업화학회 2000 공업화학 Vol.11 No.6

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