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종양 표지 인자로서 혈장 Transforming Growth Factor-β1에 대한 연구
신훈,임창기,최인영,이두연,노동영,류민희,이효석,방영주,박종섭,진승원,Shin, Hoon,Lim, Chang Ki,Choi, In Young,Lee, Doo Yun,Noh, Dong Yong,Ryu, Min Hee,Lee, Hyo Suk,Bang, Yung Jue,Park, Jong Sup,Jin, Seung Won 대한면역학회 2001 Immune Network Vol.1 No.2
Background : Many investigators have found transforming growth factor-${\beta}1$ (TGF-${\beta}1$) to be elevated in tumors. Changes in responsiveness to TGF-${\beta}1$ have been linked to malignant transformation, tumor progression and tumor regression. Many malignant cell lines of epithelial or hematopoietic origin are refractory to the antiproliferative effects of TGF-${\beta}1$. However, a little is known about the association of TGF-${\beta}1$ with progression of malignant tumor. Methods : In this study, we measured the plasma level of TGF-${\beta}1$ in various cancer patients and evaluated the utility of plasma TGF-${\beta}1$ as a possible tumor marker. Plasma TGF-${\beta}1$ levels were measured using enzyme-linked immunosorbent assay in cancer patients and normal controls. Carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP) as tumor marker were compared with TGF-${\beta}1$ in the aspects of sensitivity and specificity. Results : The mean of plasma TGF-${\beta}1$ levels was $1.219{\pm}0.834ng/ml$ in normal controls, $5.491{\pm}3.598ng/ml$ in breast cancer, $12.670{\pm}10.386ng/ml$ in lung cancer, $5.747{\pm}3.228ng/ml$ in hepatocellular carcinoma and $10.854{\pm}7.996ng/ml$ in cervical cancer. In comparison with CEA and AFP, TGF-${\beta}1$ is more sensitive. Conclusion : We conclude that the high levels of TGF-${\beta}1$ are common in the plasma of cancer patients. These results suggest that the plasma TGF-${\beta}1$ level can be a potent tumor marker in various cancer patients.
간장 ( 肝臟 ) 및 담도 ( 膽道 ) : 원발성 간세포암 환자의 수술 후 생존에 영향을 미치는 예후 인자들 - 단변량 및 다변량 분석 -
김수태(soo Tae Kim),이홍주(Hong Joo Lee),노동영(Dong Yong Noh),이상전(Sang Jeon Lee) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.4
N/A The prognostic importance of 13 faetors were analysed using univariate and multivariate regression models in 217 patients with hepatocellularcarr.inoma who had curative ar pailiative hepatic resections during 10 year period sinee l978. There were 239 patients who had hepatic reseetion due to primary hepatocellular carcinoma and we could fallow up 217 patients among them. Male to female ratio was 5 to l and their average age was 51. Thirteen variables were subject to univariate analysis and their survivals were calculated using the actuarial method of Kaplan and Meier. The significance level of difference between curves was assessed with the logrank test. The factors with a P-value below 0.05 in the univariate analysis were submitted to multivariate analysis using Cox's regreasion model. Among the patients, 66.3% had liver cirrhosis and HiBsAg positive rate was 74.8%. The operative mortality was 7.5% and 72% of the patients had over 20 ng/ml of AFP. These features are similar to the reports from Japan. Some of the prognostic factors such as tumor size, capsule formation, transfueional amount had different views of significance. The 2 year and 5 year survival of the curatively resected patients were 47.1% and 33.3% resepectively. Univariated analysis of curatively resected cases revealed that Childs classification, resectional type, encapsulation and microangi.oinvasion affected significantly to the longterm survival (p<0.05) but sex, age, size, AFP, cirrhosis, transfusional amount, histopathologic subtype didnt have statistical meareings. Multivariate analysia showed that microangioinvasian, Childs classification and encapsulation were the most valuable factors in predicting survival in decreasing orders.
Sclerosing Adenosis Diagnosed by Needle Biopsy
Heon Jin Jung(정헌진),Won Shik Han(한원식),Hyeong-Gon Moon(문형곤),Soo Kyung Ahn(안수경),Ji-Sun Kim(김지선),Dong-Yong Noh(노동영),Jung-Min Chang(장정민),Nariya Cho(조나리야),Woo Kyung Moon(문우경),In-Ae Park(박인애),Hee-Chul Shin(신 대한종양외과학회 2012 Korean Journal of Clinical Oncology Vol.8 No.2
목적 : 본 연구는 침생검을 통해 진단 받은 경화성 선증에 대해 추가적인 수술 없이 경과 관찰했을 때의 잠재적 안정성을 알아보고자 하였다. 방법 : 1996년 1월부터 2010년 5월까지 침생검을 통해 경화성 선증으로 진단된 143명의 환자의 145개 병변을 대상으로 (core-needle biopsies 118례, vacuum-assisted biopsies 27례) 의무기록 검토를 토대로 한 후향적 고찰이다. 결과 : 환자들의 BI-RADS(The American College of Radiology Breast Imaging Reporting and Data System) 분류는 다음과 같다: C3(n=8), C4a(n=123), C4b(n=11), C4c(n=e), C5(n=1). 그 중 14명은 조직검사를 재시행하였고 BI-RADS 분류 C5이면서 영상의학적 소견과 병리학적 소견의 불일치를 보인 1명의 환자가 침윤성 유방암으로 진단되어 수술을 시행하였다. 나머지 환자들은 정기적인 초음파 검사 및 유방촬영술을 통해 경과 관찰하였고, 평균 추적관찰 기간 40개월 동안 144개의 병변의 최종 BI-RADS 분류는 다음과 같다: C1(n=5), C2(n=107), C3(n=32), 경과 관찰기간 동안 142명의 환자에서 악성 유방질환이 발견된 환자는 없었다. 결론 : 침생검을 통해 경화성 선증으로 진단된 환자에 있어서 추가적인 수술 없이 정기적인 검진을 통하여 경과 관찰하는 것은 잠재적 안전성을 가지고 있다. 하지만 조직검사와 영상검사 결과의 불일치 소견을 보이는 경우 수술적 생검을 통한 최종 진단이 필요하다. Background : The aim of this study was to assess the potential safety of follow up for patients diagnosed with sclerosing adenosis through needle biopsies without additional surgery. Patients and Methods : From January 1996 to May 2010, 145 lesions in 143 sclerosing adenosis patients who underwent core-needle biopsies (n=118), vacuum-assisted biopsies (n=27) in our institution were followed. Results : The American College of Radiology Breast Imaging Reporting and Data System (BI-BADS) classification in these patients was as follows : C3(n=8), C4a(n=123), C4b(n=11), C4c(n=e) and C5(n=1). After sclerosing adenosis was diagnosed by needle biopsy, 14 patients underwent re-biopsy. Only 1 patient who had BIRAD C5 sonographic features was diagnosed with invasive ductal carcinoma and surrounding ductal carcinoma in situ. The remaining 142 patients received regular medical exam with ultrasonography and/or mammography. 144 lesions’ BI-RADS category were C1(n=5), C2(n=107) and C3(n=32). With the median follow-up period of 40 months, none of the patients developed breast malignancy. Conclusions : Our study suggest that patients with sclerosing adenosis diagnosed by needle biopsies can be safely followed without additional surgery. However, in case of discordance with images and biopsy result, surgical excision for definite diagnosis is recommended.