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전승정,김태헌,류민선,오다연,송명은,이신아,류재인,김혜인,문일환,유권 이화여자대학교 의과학연구소 2011 EMJ (Ewha medical journal) Vol.34 No.2
The causes of pyogenic liver abscess has been known as biliary tract disease or intrabadominal infection but the large proportions of the patients has no apparent underlying disorders. Recently colonic mucosal lesions were reported in patients with cryptogenic liver abscess and it has been suggested that colonic mucosal break may play a role in developing liver abscess in otherwise healthy patients. We experienced a patient of severe recurrent liver abscess complicated with endophthalmitis only 3 months after successful treatment of initial cryptogenic liver abscess and a polypoid colon cancer was discovered by chance. It seems prudent to proceed colonoscopic examination in patients with cryptogenic liver abscess especially when it is recurrent.
Da Eun Kwon,Da Mi Kim,Chang June Song,In Ho Lee,Yong Min Kim 대한영상의학회 2024 대한영상의학회지 Vol.85 No.1
Respiratory epithelial adenomatoid hamartoma (REAH) in the head and neck is a rare benign lesion containing glandular tissue covered with ciliated respiratory epithelium. In the head and neck, REAH of the nasal cavity, paranasal sinuses, and nasopharynx have been reported in literature. Due to rareness of REAH and insufficient knowledge of its imaging features, the diagnosis can be challenging when we encounter a non-specific cystic mass at an uncommon site in the head or neck. Here, we report the case of a pathologically confirmed REAH showing a cystic mass centered at the buccal space (retromaxillary fat pad) with CT and MRI findings.
송다은(Da Eun Song) 단국대학교 상담학연구소 2021 상담교육연구 Vol.4 No.2
본 연구는 국내 심상 연구의 동향을 분석함으로써 연구의 성과를 정리하고 향후 연구에 대한 시사점을 제언하는 데 목적이 있다. 본 연구는 1983년부터 2021년까지 KCI에 등재된 31편의 학술논문을 대상으로 발행연도, 연구대상, 측정도구, 연구방법 및 통계분석, 연구주제, 관련 변인별로 분석하였다. 연구 결과는 다음과 같다. 첫째, 발행연도별로는 2006년을 기준으로 논문 수가 증가하였으며 2016년부터 최근까지 가장 활발히 연구가 이뤄졌다. 둘째, 연구대상별로는 대학(원)생과 특정 임상적 특성을 가진 대상이 많았다. 셋째, 측정도구로는 심상능력척도(QMI)가 가장 많이 사용되었다. 넷째, 연구방법으로는 양적 연구가 가장 많이 이뤄졌으며, 통계는 변량분석계열이 가장 많이 사용되었다. 마지막으로 연구대상을 6개의 범주로 나누었을 때 기타, IR, 집단심상치료 등 순으로 연구가 많이 이뤄졌으며 관련 변인은 표로 제시하였다. 본 연구 결과를 바탕으로 국내 심상연구의 주요 시사점 및 후속 연구에 대한 제언을 논하였다. Objectives: The purpose of this study is to analyze the research trends of the imagery in Korea and review the achievements and present the implications for future studies. Methods: Through the study, 31 academic papers registered in KCI(Korea Citation Index) for the period from 1983 to 2021 were analyzed in terms of year of publication, subjects, research scales, method, research topics and relevant variables. Results: First, the number of the papers has increased since 2006 and the research was conducted most rigorously between 2016 and the recent years. Second, undergraduate/graduate students and those with specific clinical conditions were sampled mostly. Third, as the research scale, the QMI(Questionnaire Upon Mental Imagery) was used most. Fourth, most of the research were quantitative ones, while ANOVA(analysis of variance) was used most for the statistical analysis. Lastly, when the subjects were divided into 6 categories, the category ‘others’ was used most, followed by IR(Imagery Rescripting) and GMIP(The Guided Mental Imagery Psychotherapy) and the relevant variables were presented on the table. Conclusions: Based on the results above, some suggestions for future imagery studies as well as the major implications of the imagery research in Korea were provided.
Nam, Da Eun,Jung, Sung‐,Chul,Yoo, Da Hye,Choi, Sun Seong,Seo, Sung‐,Yum,Kim, Gwang Hoon,Kim, Song Ja,Nam, Soo Hyun,Choi, Byung‐,Ok,Chung, Ki Wha Wiley Periodicals, Inc. 2017 Journal of the peripheral nervous system Vol.22 No.3
<P><B>Abstract</B></P><P>Mutations in the <I>NEFH</I> gene encoding the heavy neurofilament protein are usually associated with neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS). Recently, frameshift variants in <I>NEFH</I> (p.Asp1004Glnfs*58 and p.Pro1008Alafs*56) have been reported to be the underlying cause of axonal Charcot‐Marie‐Tooth disease type 2CC (CMT2CC). The frameshift mutation resulted in a stop loss and translation of a cryptic amyloidogenic element (CAE) encoded by the 3′ untranslated region (UTR). This study also identified a <I>de novo</I> c.3015_3027dup frameshift mutation predicting p.Lys1010Glnfs*57 in <I>NEFH</I> from a CMT2 family with an atypical clinical symptom of prominent proximal weakness. This mutation is located near the previously reported frameshift mutations, suggesting a mutational hotspot. Lower limb magnetic resonance imaging (MRI) revealed marked hyperintense signal changes in the thigh muscles compared with those in the calf muscles. Therefore, this study suggests that the stop loss and translational elongations by the 3′ UTR of the <I>NEFH</I> mutations may be a relatively frequent genetic cause of axonal peripheral neuropathy with the specific characteristics of proximal dominant weakness.</P>
한국인의 나트륨 섭취에 기여하는 주요 음식군 및 식품군의 추이 분석
송다영(Song, Da Young),박종은(Park, Jong Eun),심재은(Shim, Jae Eun),이정은(Lee, Jung Eun) 한국영양학회 2013 Journal of Nutrition and Health Vol.46 No.1
The purpose of this study was to evaluate trends in the sources of dietary sodium intake in a representative Korean population in the Korea National Health and Nutrition Examination Survey (KNHANES) conducted in 1998, 2001, 2005, 2007, 2008, 2009, and 2010. The study consisted of 53,570 men and women aged 7 years or older participating in the KNHANES during the corresponding years. Overall sodium intake and the mean percent contribution of each dish and food group to dietary sodium intake across 1998-2010 were calculated. The means of sodium intake ranged between 4,572.6-5,498.9 mg/d across 1998-2010. The major dish groups contributing to dietary sodium intake were kimchi (1,154.8-1,521.2 mg/d), noodles and dumplings (505.3-760.5 mg/d), soups (465.3-714.8 mg/d), and stews and casseroles (387.0-579.8 mg/d). The combined mean percent contribution from the top four dish groups contributing to dietary sodium intake showed a slight decrease over the period; 64.4% in 1998, 64.5% in 2001, 59.3% in 2005, 58.2% in 2007, 56.3% in 2008, 56.7% in 2009, and 54.4% in 2010. The major food groups contributing to dietary sodium intake were seasonings (1,852.9-2,435.9 mg/d), vegetables (1,425.6-1,792.1 mg/d), grains (482.2-778.1 mg/d), and fish and shellfish (257.2-351.4 mg/d). In addition, the combined mean percent contribution from the top four food groups showed a slight decrease over the period; 92.8% in 1998, 93.2% in 2001, 93.8% in 2005, 92.1% in 2007, 91.7% in 2008, 90.9% in 2009, and 90.7% in 2010. In summary, we did not observe a reduction in dietary sodium intake over time, however, the percent contributions from the top major dish groups or food groups to dietary sodium intake showed a decrease over the last decade. (Korean J Nutr 2013; 46(1): 72 ~ 82)
Da eun Jang,Kyung-A Hwang,In Guk Hwang,Geon Min Noh,Sang Hoon Lee,Jin Song 한국산업식품공학회 2016 학술대회 및 심포지엄 Vol.2016 No.04
This study was performed to investigate the content of carotenoid (α-carotene, β-carotene, β-cryptoxanthin, capxanthin, lutein, lycopene, zeaxanthin) and physicochemical characteristics (size, color, dietary fiber, total tannin content) of unripen and ripen persimmons (Diospyros kaki) by seven cultivars. The length of the unripen and ripen persimmons ranged from 40.87-64.75 and 48.80-80.29 cm, the width were from 44.03 to 66.73 and 57.65 to 91.53 cm, respectively. Ripen persimmons were showed in the highest Hunter’s L, a and b values. Total tannin content were resulted of unripen- and ripen persimmons ranged from 7.58 to 19.80 and 2.36 to 5.85 mg/g. Total carotenoid content were from 1.09 to 6.45 and 7.46 to 29.46 μg/g, respectively. From the above results, unripen- and ripen persimmon fruit could be useful for the health functional food.
Eun-Yi Oh,Mira Song,Mi-Hyun Ahn,Da-Young Park,Kyung-Jin Lee,Yangkang So,Zhe Lu,Kwang-Wok Min,Seul-Ki Lee,Jung-Hwan Lee,Doo-Byoung Oh,Youngkwan Kim,Kisung Ko 한국당과학회 2009 한국당과학회 학술대회 Vol.2009 No.1
Insect cell expression system using baculovirus has several benefits from high capacity, flexibility, and safety to humans and glycosylation capability. Thus, the baculovirus insect cell system has been widely used for production of recombinant protein. The HC and LC genes of the mAb CO17-1A were cloned under the control of two different promoters, P10 and PPH, respectively, on baculovirus expression pFastBacTM Dual vector. The gene expression cassettes carrying HC and LC genes were transferred into a parent bacmid in DH10Bac. Immunoflouorescence analyses and Western blot confirmed expression and secretion of mAb CO17-1A in the virus infected insect cells. The optimum condition for mAb expression was optimized at 24, 48 and 72hr after the virus infection with MOI ranging (0.2, 1 and 5). HPLC analysis revealed that the insect-derived mAb CO17-1A had insect specific glycan structures. Cell ELISA showed that the purified mAb from insect cell cultured media had a specific binding activity to SW948 cell. These results indicated that the baculovirus insect cell system is able to express, assemble, and secrete functional full size monoclonal antibody with insect specific glycosylation.
Da-Young Park,Yangkang So,Kyung-Jin Lee,Zhe Lu,Eun-Yi Oh,Kwang-Wok Min,Seul-Ki Lee,Jung-Hwan Lee,Mi-Hyun Ahn,Mira Song,Doo-Byoung Oh,Youngkwan Kim,Kisung Ko 한국당과학회 2009 한국당과학회 학술대회 Vol.2009 No.1
Plant genetic engineering has led to the production of plant-derived mAb (mAbP), which provides a safe and economically feasible alternative to the current antibody expression systems. In this study, the expression levels of mAbP SO57 with or without ER-signal peptides (Lys-Asp-Gly-Leu;KDEL) in transgenic tobacco plants were analysed in transgenic plant. PCR and Reverse Transcription-PCR analyses showed existence of heavy and light chain genes of mAb with or without KEDL and their transcription in plant, respectively. Western blot showed that the expression levels of mAbP SO57 with KDEL were significantly higher than that without KDEL. Flow cytometry analysis showed that the Fc domains of both purified mAbP and mammalian-derived mAb have similar binding activity to the FcγRI receptor. High-performance liquid chromatography analysis showed that the mAbP SO57 with KDEL had glycan profile with both oligomannose and golgi type, whereas the mAbP SO57 without KDEL had only golgi type glycans. Neutralizing analysis with rabies virus CVS-11 showed the similar neutralizing activity between mAbP SO57 with and without KDEL. These results suggest that the potential of mAbP SO57 for rabies immunotherapy is regardless of plant specific glycan structures.