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( Eun Hye Cho ),( Do Hwa Im ),( Da Hyun Kim ),( Young Nam Kim ),( Jung Mi Byun ),( Moon Su Sung ),( Kyung Bok Lee ),( Dae Hoon Jeong ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Objective: This study aimed to investigate the correlation of sarcopenia with chemotherapy-ralated complications and oncological outcomes in endometrial cancer patient Methods: We collect the data from January, 2015 to August, 2021 by electronic medical records(EMR) and reviewed the pateints who underwent chemotherapy during those periods retrospectively. We assessed patients who had abdominopelvic computerized tomography(APCT) as part of follow up. We measured L3 vertebra skeletal muscle index(L3SMI) using Slice-O-Matic program(Tomovision) and sarcopenia was defined as L3SMI < 41cm2/m2. Results: Total 117 patients were underwent chemotherapy in our hospital and 97 patients were included our study finally. There are 28 patients in sarcopenia group, 69 patients in non-sarcopenia group. In the sarcopenia group, body mass index(BMI) before chemotherapy is lower than non-sarcopenia group (26.85±4.52 vs. 22.55±2.38; P < 0.0001). The prevalence of neutropenic fever in sarcopenia group was higher than non-sarcopenia group (42.9% vs. 18.8%, P = 0.0148). Whereas recurrence rate and prevalence of anemia after 1st chemotherapy were not associated with sarcopenia. Conclusion: In endometrial cancer, the patients with sarcopenia who underwent chemotherapy have increased chemotherapy- related complication as neutropenic fever. Neutropenic fever is mortal in patients who should be treated for malignancy by chemotherapy. Based on this result, it is necessary to use the Granulocyte-Colony Stimulating Factor(G-CSF) and pegfilgrastim prophylactically after chemotherapy for endometrial cancer patients with sarcopenia to prevent neutropenic fever. Additionally we should counsel about diet and exercise to prevent sarcopenia.
Im, Chang-Nim,Kim, Byeong Mo,Moon, Eun-Yi,Hong, Da-Won,Park, Joung Whan,Hong, Sung Hee Korea Genome Organization 2013 Genomics & informatics Vol.11 No.4
A radioresistant cell line was established by fractionated ionizing radiation (IR) and assessed by a clonogenic assay, flow cytometry, and Western blot analysis, as well as zymography and a wound healing assay. Microarray was performed to profile global expression and to search for differentially expressed genes (DEGs) in response to IR. H460R cells demonstrated increased cell scattering and acidic vesicular organelles compared with parental cells. Concomitantly, H460R cells showed characteristics of increased migration and matrix metalloproteinase activity. In addition, H460R cells were resistant to IR, exhibiting reduced expression levels of ionizing responsive proteins (p-p53 and ${\gamma}$-H2AX); apoptosis-related molecules, such as cleaved poly(ADP ribose) polymerase; and endoplasmic reticulum stress-related molecules, such as glucose-regulated protein (GRP78) and C/EBP-homologous protein compared with parental cells, whereas the expression of anti-apoptotic X-linked inhibitor of apoptosis protein was increased. Among DEGs, syntrophin beta 2 (SNTB2) significantly increased in H460R cells in response to IR. Knockdown of SNTB2 by siRNA was more sensitive than the control after IR exposure in H460, H460R, and H1299 cells. Our study suggests that H460R cells have differential properties, including cell morphology, potential for metastasis, and resistance to IR, compared with parental cells. In addition, SNTB2 may play an important role in radioresistance. H460R cells could be helpful in in vitro systems for elucidating the molecular mechanisms of and discovering drugs to overcome radioresistance in lung cancer therapy.
Maternal risk factors for recurrent small-for-gestational age at term neonates in South Korea
( Eun Hye Cho ),( Young Nam Kim ),( Dae Hoo Jeong ),( Kyung Bok Lee ),( Moon Su Sung ),( Da Hyun Kim ),( Do Hwa Im ),( Geum Joon Cho ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Objective: The objective of this study is to analyze the associated maternal pre-pregnancy and pregnancy factors that affect SGA at term neonates in South Korea. Methods: This study enrolled pregnant women who had two full-term singleton deliveries from 2006 to 2016, and who had undergone a national health screening examination through the National Health Insurance during the 1 year before their delivery. We compared the pregnancy and pre-pregnancy characteristics between the SGA group and non-SGA group, and between the recurrent SGA group (second SGA delivery) and non-recurrent SGA group (second non-SGA delivery) among the women who delivered their first SGA neonate. Results: We enrolled 887,902 term singleton deliveries during the study periods. SGA neonates were delivered in 2.84% of term singleton pregnancies. Mean birth weight were 2.18 ± 0.64 kg in the SGA group and 3.28 ± 0.38 kg in the non-SGA group (p<0.001). The prevalence of pre-gestational hypertension and gestational hypertension were higher in SGA group than non-SGA group (3.99% vs. 2.85%; <0.001, and 5.88% vs. 1.22%; p<0.001, respectively). Maternal pre-gestational mean BMI and fasting glucose were lower in SGA group than non-SGA group (20.46 ± 2.58 vs. 21.08 ± 2.74, p<0.001, and 86.62 ± 10.52 mg/dl vs. 87.33 ± 11.23 mg/dl; <0.001, respectively) For the women who recurrently delivered SGA neonates, the prevalence of gestational hypertension during the second pregnancy were higher than non-recurrent SGA group (5.88% vs. 1.65%; p<0.0001), and pre-gestational fasting glucose were lower (86.31 ± 10.29 mg/dl vs. 87.76 ±11.36 mg/dl; p=.0388) than non-recurrent group. Conclusion: Pregnant women who delivered SGA neonates had more gestational and pre-gestational hypertension and lower pre-gestational BMI and fasting glucose level. Moreover, women who recurrently delivered SGA neonates had more gestational hypertension during second pregnancy. Based on this results, the management and counseling for pregnant women is necessary to prevent SGA neonates.
지은경(Eun-Kyung Ji),유임주(Im Joo Rhyu),전용혁(Young Hyuck Cheon),이은경(Eun-kyung Lee),김용민(Yong Min Kim),신다영(Da Young Shin),황승준(Seung Jun Hwang) 대한체질인류학회 2001 해부·생물인류학 (Anat Biol Anthropol) Vol.14 No.4
뇌들보는 뇌의 좌우를 연결하는 신경성유호 성별에 따라 형태학적 특정이 다르게 나타난다고 한다. 성인을 대상으로 한 연구결과 뇌들보 팽대 (Splenium) 의 생김새가 여성의 경우 남성에 비해 더 불촉한 형태를 띠 고, 뇌들보의 뒤 115 의 연적도 여성에서 큰 경향을 보여 생별에 따라 특성 있게 나타나는 두뇌활동과 관련지어 설명하려는 경향이 있다. 발생 과정중 성에 따른 뇌들보의 두 형태에 관한 연구 또한 그리 많지 않고, 논란의 여자가 있어 한국인 신생아를 대상으로 본 연구를 수행하였다. 임신 38-42 주로 정상분만 된 신생아의 뇌들보 정중시상 초음파 영상을 앞숫구멍을 창으로 하여 얻었으며, 남아 100 명, 여아 100 명의 뇌들보 전체면적 및 5 등분한 각 부분의 연적 그리고 뇌들보의 너비 및 높이의 길이를 NIB imagε풀그림을 이용하여 분석하였다. 전체 뇌들보의 평균연적은 남아 97.61±21.05mm²( 평균土표준현차 ), 여야 99.54±20 .82 mm² 로 남녀간의 차이 를 보아지 않았고 ,5 등분한 각 부위의 연석 차도 관찰되지 않았다. 뇌들보 너비는 남아 45.06±4.51 mm, 여아는 44.46±3.72 mm 였고, 높이는 남아에서는 14.06±l.86mm², 여아 13.4±1.75 mm²로, 남아의 뇌들보 높아가 여아에 비하여 통계적 3 로 높게 나타났다. 본연구 결과 성별에 따른 뇌들보의 연석의 차이를 관찰 할 수 없었지만, 뇌들보의 높아가 성벌에 따라 다르게 나타나 남아와 여아의 뇌들보의 공간 분포가 다르게 나타남을 알 수 있었다.