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Yang, Da-Wun,Kang, Ok-Hwa,Lee, Young-Seob,Han, Sin-Hee,Lee, Sang-Won,Cha, Seon-Woo,Seo, Yun-Soo,Mun, Su-Hyun,Gong, Ryong,Shin, Dong-Won,Kwon, Dong-Yeul Spandidos Publications 2016 International journal of molecular medicine Vol.38 No.6
<P>Salidroside [2-(4-hydroxyphenyl)ethyl beta-D-glucopyranoside (SAS)] has been identified as the most potent ingredient of the plant Rhodiola rosea L. Previous studies have demonstrated that it possesses a number of pharmacological properties, including anti-aging, anti-fatigue, antioxidant, anticancer and anti-inflammatory properties. In this study, to ascertain the molecular mechanisms responsible for the anti-inflammatory activity of SAS, we used phorbol-12-myristate-13-acetate (PMA) plus A23187 to induce inflammation in human mast cell line-1 (HMC-1). The HMC-1 cells were treated with SAS prior to being stimulated with PMA plus A23187. Pro-inflammatory cytokine production was measured by enzyme-linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction (RT-PCR). Western blot analysis was used to examine the activation of mitogen-activated protein kinases (MAPKs) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B). SAS inhibited the mRNA expression and production of interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF). In cells stimulated with PMA plus A23187, SAS suppressed the phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and c-jun N-terminal kinase 1/2 (JNK1/2), but not that of p38 MAPK. SAS suppressed the expression of NF-kappa B in the nucleus. On the whole, our results suggest that SAS exerts an anti-inflammatory effect by inhibiting the production of pro-inflammatory cytokines through the blocking of the NF-kappa B and MAPK signaling pathways.</P>
Effect of blood pressure and glycemic control on the plasma cell-free DNA in hemodialysis patients
( Da Wun Jeong ),( Ju Young Moon ),( Young Wook Choi ),( Haena Moon ),( Kipyo Kim ),( Yu Ho Lee ),( Se Yeun Kim ),( Yang Gyun Kim ),( Kyung Hwan Jeong ),( Sang Ho Lee ) 대한신장학회 2015 Kidney Research and Clinical Practice Vol.34 No.4
Background: The plasma levels of cell-free DNA (cfDNA) are known to be elevated under inflammatory or apoptotic conditions. Increased cfDNA levels have been reported in hemodialysis (HD) patients. The aim of this study was to investigate the clinical significance of cfDNA in HD patients. Methods: A total of 95 patients on HD were enrolled. We measured their predialysis cfDNA levels using real-time EIF2C1 gene sequence amplification and analyzed its association with certain clinical parameters. Results: The mean plasma cfDNA level in the HD patients was 3,884 ± 407 GE/mL, and the mean plasma cfDNA level in the control group was 1,420 ± 121 GE/mL (P < 0.05). Diabetic patients showed higher plasma cfDNA levels compared with nondiabetic patients (P < 0.01). Patients with cardiovascular complications also showed higher plasma cfDNA levels compared with those without cardiovascular complication (P < 0.05). In univariable analysis, the cfDNA level was associated with 3-month mean systolic blood pressure (SBP), white blood cell, serum albumin, creatinine (Cr), normalized protein catabolic rate in HD patients. In diabetic patients, it was significantly correlated with SBP, hemoglobin A1c, and serum albumin. In multivariate analysis, SBP was the independent determinant for the cfDNA level. In diabetic patients, cfDNA level was independently associated with hemoglobin A1c and SBP. Conclusions: In patients with HD, cfDNA is elevated in diabetic patients and patients with cardiovascular diseases. Uncontrolled hypertension and poor glycemic control are independent determinants for the elevated cfDNA. Our data suggest that cfDNA might be a marker of vascular injury rather than proinflammatory condition in HD patients.
( Da Wun Jeong ),( Ju Young Moon ),( Sang Ho Lee ),( Yang Gyun Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Plasma levels of cell-free DNA (cfDNA) are elevated in various proin- fi ammatory or apoptotic conditions. Previously, increased cfDNA levels were reported during hemodialysis. However, there is limited data regarding its clinical relevance in HD patients. The aim of this study was to investigate the clinical signifi cance of cfDNA in patients on maintenance HD. Methods: A total of 95 ESRD patients on Hemodialysis for 49.6±52.4 months were enrolled, we measured the pre-dialysis cfDNA using real-time EIF2C1 gene sequence amplifi cation and analyzed the association with clinical parameters by dividing to cfDNA <2000GE/ml, 2000< cfDNA<3000GE/ml and >3000 GE/ml with underlying disease and higher cfDNA and baseline characteristics and clinical parameters with cfDNA. Results: The mean plasma level of cfDNA of HD patients was 2302.07±2177.52GE/ mL and the mean plasma level of cfDNA of control group was 1420.74±1216.44GE/ mL( p< 0.05). cfDNA levels were signifi cantly higher in patients with diabetes mellitus compared to non-diabetic patients (2214.5±2163.4 vs. 1452.6±1221.3GE/mL, respectively, p < 0.035). CfDNA was signifi cantly correlated with current HbA1c but not associated with those of other time points. Patients with previous history of cerebrovascular disease, hypertension had also higher levels of cfDNA. Among clinical parameters, systolic blood pressure, current WBC counts were signifi cantly correlated with the levels of cfDNA but there was no association with infi ammatory parameters of different time points. finally, other parameters of dialysis adequacy including KT/V, uric acid and Ca, Ca*P, hemoglobin, LDL, age, BMI were not associated with the plasma levels of cfDNA. Conclusions: Our results indicate cfDNA could be a potential biomarker of proin- fi ammatory or apoptotic milieu in maintenance HD patients. However, the underlying reasons for the release of cfDNA and its functional role in uremic condition should be further defi ned for its clinical application.
이민혜,정다운,최미용,이승희 숙명여자대학교 건강·생활과학연구소 2009 生活科學硏究誌 Vol.- No.25
India is a new and popular marker for doing businesses. According to the Kotra and Samsung Economy Research Center, 40% of demands in India hold watch market and it occupies the top. With this data, this research chooses India for the proper market and to deal with unexpected situations, a new brand, Veritas, starts the business directly. In more depth, to enter the foreign market, this research is based on SWOT Strategy, STP, 4P and other marketing thesis. For the final strategies, this research focuses on weaknesses and threats. These points will be solved by the researcher's suggestions. Concretely, because of the special quality of the target market, India, researchers will focus on cultures and religions to develop business strategies. Furthermore, both of localization and globalization will be used.
인간 비만세포에서 PMA와 A23187에 의해 유도된 전염증 매개체에 대한 신효월도산 추출물의 항염증 효과
위경 ( Gyeong Wi ),양다운 ( Da Wun Yang ),강옥화 ( Ok Hwa Kang ),김성배 ( Sung Bae Kim ),문수현 ( Su Hyun Mun ),서윤수 ( Yun Soo Seo ),강다혜 ( Da Hye Kang ),임재수 ( Jae Soo Lim ),김마룡 ( Ma Ryong Kim ),곽남원 ( Nam Won Kwak ) 대한본초학회 2014 大韓本草學會誌 Vol.29 No.6
Objectives : Sinhyowoldo-san (SHWDS) is said to be a traditional medicine used for shigellosis, abdominal pain, diarrhea. But mechanism of SHWDS mediated-modulation of immune function is not sufficiently understood. To ascertain the molecular mechanisms of SHWDS 70% EtOH extract on pharmacological and biochemical actions in inflammation, we researched the effect of pro-inflammatory mediators in phorbol-12-myristate-13-acetate (PMA)+ A23187-activated human mast cell line (HMC-1). Methods : In the present research, cell viability was measured by MTS assay. pro-inflammatory cytokine production was measured by performing enzyme-linked immunosorbent assay (ELISA), reverse transcription polymerase chain reaction (RT-PCR), and western blot analysis to analyze the activation of mitogen-activated protein kinases (MAPKs), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB). The investigation focused on whether SHWDS inhibited the expressions of interleukin-6 (IL-6), interleukin-8 (IL-8), MAPKs and NF-кB in PMA+A23187-activated HMC-1 cells. Results : SHWDS has no cytotoxicity at measured concentration (50, 100, and 250 μg/ml). SHWDS (250 μg/ml) inhibits pro-inflammatory cytokine expression in PMA+ A23187-activated HMC-1 cells. Moreover, SHWDS inhibited cyclooxygenase (COX)-2 expression. In activated HMC-1 cells, SHWDS suppressed phosphorylation of extracellular signal-regulated kinase (ERK 1/2) and c-jun N-terminal Kinase (JNK 1/2). Then, SHWDS suppressed activation of nuclear factor NF-кB in nuclear, degradation of IkB α in cytoplasm. Conclusions : We propose that SHWDS has an anti-inflammatory therapeutic potential, which may result from inhibition of ERK 1/2, JNK 1/2 phosphorylation and NF-кB activation, thereby decreasing the expression of pro-inflammatory genes.
당뇨를 동반한 지속외래복막투석 환자에서 발생한 Neisseria sicca 복막염 1예
이혜민 ( Hyae Min Lee ),양인호 ( In Ho Yang ),이선희 ( Sun Hee Lee ),김선혜 ( Seon Hye Kim ),정다운 ( Da Wun Jeong ),정경환 ( Kyung Hwan Jeong ),이상호 ( Sang Ho Lee ),이태원 ( Tae Won Lee ),임천규 ( Chun Gyoo Ihm ),문주영 ( Ju Yo 전북대학교 의과학연구소 2014 全北醫大論文集 Vol.38 No.2
Neisseria sicca is a Gram-negative diplococcus found in the human oral mucosa and upper respiratory tract. Although colonization generally does not result in severe infection, some cases of infection have been reported, particularly in immunocompromised individuals. However, Neisseria sicca has not been reported as a pathogen of continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis in Korea. Here we describe a case of CAPD-related peritonitis due to Neisseria sicca in a patient with poorly controlled diabetes mellitus undergoing peritoneal dialysis.