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Impurity Behaviors under Wall Conditioning in HL-2A
Zhengying Cui,Chenghe Cui,Mingxu Wang,Ping Sun,Quanming Wang,Wei Li,Yudong Pan,Zeng Cao 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III
Impurities are one of the key issues of tokamak plasma research, as they are directly related to plasma quality and steady-state operation. The HL-2A device with two close divertor is the first divertor tokamak in China. It was successfully constructed in 2002 and has been operated for three 3 years up to now. In the 2004 campaign, siliconization as a wall conditioning was first done on the HL-2A tokamak by using glow discharge cleaning (GDC) with a gas mixture of SiH4 + He. The effects of siliconization on impurities and recycling are investigated, as well as the lifetime of siliconization, in this paper. The intensity of oxygen line is remarkably decreased after siliconization. Radiation of silicon line rapidly decreases shot by shot just after siliconization, but the effect of siliconization on the plasma properties is present all along and decreases gradually for a large amount of discharges. The effect of the siliconization can be maintained to about 180 discharges with similar discharge parameters.
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Tailoring the Impact Toughness of Sintered NdFeB Magnets via Surface Coating
X. G. Cui,J. X. Pan,C. Y. Cui,P. Mei,X. H. Wang,C. Fang,T. Y. Ma,C. Wang,X. C. Peng 한국자기학회 2018 Journal of Magnetics Vol.23 No.1
Metallic coating by electroplating is commonly attractive for improving the corrosion resistance of sintered NdFeB magnets. However, its tailoring of mechanical characteristics for sintered NdFeB magnets has been seldom concerned. Herein, the impact toughnesses of sintered NdFeB magnets with various metallic coatings (Ni or Ni/Sn) were comparatively investigated. The results indicate that the impact toughnesses of sintered NdFeB magnets are both improved by Ni coating and Ni/Sn bilayer coating. And Ni/Sn bilayer coating exhibits more enhancement of the impact toughness, increased by 41.6% compared with the original magnet. Moreover, the microstructural observations of the metallic coatings and the fracture were conducted, and the enhanced mechanism of impact toughness for the magnet is analyzed. These findings may provide a reference for toughening the brittle materials.
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Pan Yun,Zhang Dong,Zhang Jintao,Liu Xiaofei,Xu Jiawei,Zeng Rong,Cui Wenjing,Liu Tian,Wang Junfei,Dong Liang 대한천식알레르기학회 2024 Allergy, Asthma & Immunology Research Vol.16 No.1
Purpose: Airway remodeling is a critical feature of asthma. Secreted protein acidic and rich in cysteine (SPARC), which plays a cardinal role in regulating cell-matrix interactions, has been implicated in various fibrotic diseases. However, the effect of SPARC in asthma remains unknown. Methods: We studied the expression of SPARC in human bronchial epithelial cells and serum of asthmatics as well as in the lung tissues of chronic asthma mice. The role of SPARC was examined by using a Lentivirus-mediated SPARC knockdown method in the ovalbumin (OVA)-induced asthma mice. The biological processes regulated by SPARC were identified using RNA sequencing. The function of SPARC in the remodeling process induced by transforming growth factor β1 (TGFβ1) was conducted by using SPARC small interfering RNA (siRNA) or recombinant human SPARC protein in 16HBE cells. Results: We observed that SPARC was up-regulated in human bronchial epithelia of asthmatics and the asthmatic mice. The levels of serum SPARC in asthmatics were also elevated and negatively correlated with the forced expiratory volume in one second (FEV1) to forced vital capacity ratio (FVC) (r = −0.485, P < 0.01) and FEV1 (%predicted) (r = −0.425, P = 0.001). In the chronic asthmatic mice, Lentivirus-mediated SPARC knockdown significantly decreased airway remodeling and airway hyper-responsiveness. According to gene set enrichment analysis, negatively enriched pathways found in the OVA + short hairpin-SPARC group included ECM organization and collagen formation. In the lung function studies, knockdown of SPARC by siRNA reduced the expression of remodeling-associated biomarkers, cell migration, and contraction by blocking the TGFβ1/Smad2 pathway. Addition of human recombinant SPARC protein promoted the TGFβ1-induced remodeling process, cell migration, and contraction in 16HBE cells via the TGFβ1/Smad2 pathway. Conclusions: Our studies provided evidence for the involvement of SPARC in the airway remodeling of asthma via the TGFβ1/Smad2 pathway.
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Pan Xiaoming,Gu Yinger,Zhang Xian,Shi Biwei,Cui Long,Wang Fangfang,Qu Fan 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.1
Background: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory infertility. Chinese herbal medicine (CHM) has many advantages in treating PCOS. We conducted a retrospective cohort study to investigate the effects of CHM (Bu-Shen-Tian-Jing Formula, BSTJF) on the outcomes of IVF in Chinese patients with PCOS and the potential underlying mechanism. Methods: A total of 111 patients with PCOS who undergone IVF between November 2009 and July 2018 were included. Fifty-four patients received a three-month BSTJF therapy before controlled ovarian hyperstimulation, while the other 57 patients didn't. The data of the PCOS patients was collected. Anti-Müllerian hormone (AMH), growth differentiation factor-8 (GDF-8) levels in the follicular fluid were evaluated. Results: BSTJF helped patients with PCOS to get more retrieved oocytes (P<0.05) and fertilized oocytes (P<0.05). The clinical cumulative pregnancy rate, live birth rate, and term delivery rate were significantly higher in the same stimulated cycle of the PCOS patients with BSTJF treatment (P<0.05). No significant differences existed between the two groups in the rate of fertilization, hospitalization rate of ovarian hyper stimulation syndrome and obstetrical or neonatal complications. BSTJF significantly decreased the AMH levels in the follicular fluids (P<0.05). Conclusion: BSTJF significantly may improve the outcomes of IVF in Chinese patients with PCOS through decreasing AMH levels in follicular fluids. However, the evidence is limited due to the small sample size and the several potential bias. Background: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory infertility. Chinese herbal medicine (CHM) has many advantages in treating PCOS. We conducted a retrospective cohort study to investigate the effects of CHM (Bu-Shen-Tian-Jing Formula, BSTJF) on the outcomes of IVF in Chinese patients with PCOS and the potential underlying mechanism. Methods: A total of 111 patients with PCOS who undergone IVF between November 2009 and July 2018 were included. Fifty-four patients received a three-month BSTJF therapy before controlled ovarian hyperstimulation, while the other 57 patients didn't. The data of the PCOS patients was collected. Anti-Müllerian hormone (AMH), growth differentiation factor-8 (GDF-8) levels in the follicular fluid were evaluated. Results: BSTJF helped patients with PCOS to get more retrieved oocytes (P<0.05) and fertilized oocytes (P<0.05). The clinical cumulative pregnancy rate, live birth rate, and term delivery rate were significantly higher in the same stimulated cycle of the PCOS patients with BSTJF treatment (P<0.05). No significant differences existed between the two groups in the rate of fertilization, hospitalization rate of ovarian hyper stimulation syndrome and obstetrical or neonatal complications. BSTJF significantly decreased the AMH levels in the follicular fluids (P<0.05). Conclusion: BSTJF significantly may improve the outcomes of IVF in Chinese patients with PCOS through decreasing AMH levels in follicular fluids. However, the evidence is limited due to the small sample size and the several potential bias.
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Pan Ying-Hua,Nong Bao-Xuan,Chen Lei,Yang Xing-Hai,Xia Xiu-Zhong,Zhang Zong-Qiong,Qing Dong-Jin,Gao Ju,Huang Cheng-Cui,Li Dan-Ting,Deng Guo-Fu 한국유전학회 2023 Genes & Genomics Vol.45 No.7
Background Cold damage stress significantly affects rice growth (germination and seedling) and causes serious losses in yield in temperate and high-altitude areas around the globe. Objective This study aimed to explore the cold tolerance (CT) locus of rice and create new cold-tolerant germplasm. We constructed a chromosome segment substitution line (CSSL) with strong CT and fine mapped quantitative trait loci (QTLs) associated with CT by performing the whole-genome resequencing of CSSL with phenotypes under cold treatment. Methods A chromosome CSSL, including 271 lines from a cross between the cold-tolerant wild rice Y11 (Oryza rufipogon Griff.) and the cold-sensitive rice variety GH998, was developed to map QTLs conferring CT at the germination stage. The whole-genome resequencing was performed on CSSL for mapping QTLs of associated with CT at the germination stage. Results A high-density linkage map of the CSSLs was developed using the whole-genome resequencing of 1484 bins. The QTL analysis using 615,466 single-nucleotide polymorphisms (SNPs) led to the identification of 2 QTLs related to germination rate at low-temperature on chromosome 8 (qCTG-8) and chromosome 11 (qCTG-11). The qCTG-8 and qCTG-11 explained 14.55% and 14.31% of the total phenotypic variation, respectively. We narrowed down qCTG-8 and qCTG-11 to 195.5 and 78.83-kb regions, respectively. The expression patterns of important candidate genes in different tissues, and of RNA-sequencing (RNA-seq) in CSSLs, were identified based on gene sequences in qCTG-8 and qCTG-11 cold-induced expression analysis. LOC_Os08g01120 and LOC_Os08g01390 were identified as candidate genes in qCTG-8, and LOC_Os11g32880 was identified as a candidate gene in qCTG-11. Conclusions This study demonstrated a general method that could be used to identify useful loci and genes in wild rice and aid in the future cloning of candidate genes of qCTG-8 and qCTG-11. The CSSLs with strong CT were supported for breeding cold-tolerant rice varieties.
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Stimulating Effect of a Novel Synthesized Sulfonamido-Based Gallate ZXHA-TC on Primary Osteoblasts
PAN JIN,Li Zheng,Liang Liao,Xiao Lin,Qinggong Guo,Cui-Wu Lin,Huayu Wu,Jinmin Zhao 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.3
Purpose: This study is intended to investigate the effects of plants or plant-derived antioxidants on prevention of osteoporosis through the maintenance of reactive oxygenspecies (ROS) at a favorable level. Materials and Methods: In this study, a novel antioxidant, namely 3,4,5-Trihydroxy-N-[4-(5-hydroxy-6-methoxy-pyrimidin-4-ylsulfamoyl)-phenyl]-benzamide (ZXHA-TC) was synthesized from gallic acid and sulfadimoxine. Its effect on osteoblast metabolism was investigated via the detection of cell proliferation, cell viability, production of ROS, and expression of osteogenic-specific genes including runt-related transcription factor 2 (RUNX2), bone sialoprotein (BSP), osteocalcin (OCN), alpha-1 type I collagen (COL1A1), and osteogenic-related proteins after treatment for 2, 4, and 6 days respectively. Results: The results showed that ZXHA-TC has a stimulating effect on the proliferation and osteogenic differentiation of primary osteoblasts by promoting cell proliferation, cell viability, and the expression of genes BSP and OCN. Productions of bone matrix and mineralization were also increased by ZXHA-TC treatment as a result of up-regulationof COL1A1 and alkaline phosphatase (ALP) at the early stage and down-regulationof both genes subsequently. A range of 6.25×10-3 μg/mL to 6.25×10-1 μg/mL is the recommended dose for ZXHA-TC, within which 6.25×10-2 μg/mL showed the best performance. Conclusion: This study may hold promise for the development of a novel agent for the treatment of osteoporosis.
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Yanhua Cui,Minjia Meng,Dongshu Sun,Yan Liu,Jianming Pan,Xiaohui Dai,Yongsheng Yan 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.3
We developed a simple phase inversion technique to prepare molecularly imprinted membrane (MIM) at room temperature for membrane selective adsorption and separation of methyl p-hydroxybenzoate (M4HB). The prepared SMIP-MIM was characterized by SEM, FT-IR, TGA. Compared with non-imprinted membrane (NIM1-5) adsorbent, SMIP-MIM1-5 adsorbent with high specific surface area and showed higher binding capacity, faster kinetic and better selectively adsorption capacity for M4HB. The maximum isotherm adsorption capacity for M4HB of SMIPMIM4 was 3.519mg·g−1, and the experimental data was well fitted to the slips model by multiple analysis. The maximum kinetic adsorption capacity and equilibrium adsorption time for SMIP-MIM4 were 1.335mg·g−1 and 160 min, respectively. The mechanism for dynamic adsorption of M4HB onto SMIP-MIM4 was found to follow pseudo-firstorder model and pseudo-second-order model. Additionally, the permeability separation factor of SMIP-MIM4 for M4HB compared to a structural analogues methyl 2-hydroxybenzoate (M2HB) could reach 2.847. The adsorption capacity of SMIP-MIM4 for M4HB and M2HB was 0.549mg·cm−2 and 1.563mg·cm−2, respectively. The adsorption behavior of M4HB through SMIP-MIM4 followed the retarded permeation mechanism.
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Prognostic Evaluation of Nasopharyngeal Carcinoma with Bone-Only Metastasis after Therapy
Jianji Pan,Tianzhu Lu,Qiaojuan Guo,Xiaofei Cui,Zhuhong Chen,Shaojun Lin,Luying Xu,Jin Lin,Jingfeng Zong 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.4
Purpose: To evaluate the prognosis of nasopharyngeal carcinoma (NPC) patients who developed bone-only metastasis after primarytreatment and the stratification of these patients into different risk groups based on independent prognostic factors. Materials and Methods: Eighty NPC patients who developed bone-only metastasis after definitive radiotherapy from October 2005to December 2010 were enrolled. All these patients received palliative treatment for bone metastasis, including chemotherapyand/or radiotherapy. Clinical features, treatment modality, and laboratory parameters were examined with univariate and multivariateanalyses. Results: The median follow-up time was 15.5 months (range, 2–67 months) for the whole cohort. The median overall metastaticsurvival (OMS) time and the 2-year estimate OMS rate were 26.5 months and 52%, respectively. Multivariate analysis indicated thatpatients with short metastases-free interval, multiple bone metastases sites, high serum lactic dehydrogenase levels, and treatedwith radiotherapy or chemotherapy alone had significantly worse outcomes. Patients were stratified into three different risk groupsbased on the number of adverse factors present. The OMS curves of the three groups were all significantly different (p<0.001). Conclusion: Severl prognostic factors were found to be associated with worse outcomes. According to the number of adverse factorspresent, bone-only metastasis patients can be stratified into three risk groups with significantly different prognoses. Suchgrouping may help in improving the design of clinical trials and in guiding individualized treatment for NPC patients with boneonlymetastasis.
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