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RISS 인기검색어
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- 저자 : Jianji Pan (검색결과 3 건)
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Prognostic Evaluation of Nasopharyngeal Carcinoma with Bone-Only Metastasis after Therapy
Jianji Pan,Tianzhu Lu,Qiaojuan Guo,Xiaofei Cui,Zhuhong Chen,Shaojun Lin,Luying Xu,Jin Lin,Jingfeng Zong 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.4
Purpose: To evaluate the prognosis of nasopharyngeal carcinoma (NPC) patients who developed bone-only metastasis after primarytreatment and the stratification of these patients into different risk groups based on independent prognostic factors. Materials and Methods: Eighty NPC patients who developed bone-only metastasis after definitive radiotherapy from October 2005to December 2010 were enrolled. All these patients received palliative treatment for bone metastasis, including chemotherapyand/or radiotherapy. Clinical features, treatment modality, and laboratory parameters were examined with univariate and multivariateanalyses. Results: The median follow-up time was 15.5 months (range, 2–67 months) for the whole cohort. The median overall metastaticsurvival (OMS) time and the 2-year estimate OMS rate were 26.5 months and 52%, respectively. Multivariate analysis indicated thatpatients with short metastases-free interval, multiple bone metastases sites, high serum lactic dehydrogenase levels, and treatedwith radiotherapy or chemotherapy alone had significantly worse outcomes. Patients were stratified into three different risk groupsbased on the number of adverse factors present. The OMS curves of the three groups were all significantly different (p<0.001). Conclusion: Severl prognostic factors were found to be associated with worse outcomes. According to the number of adverse factorspresent, bone-only metastasis patients can be stratified into three risk groups with significantly different prognoses. Suchgrouping may help in improving the design of clinical trials and in guiding individualized treatment for NPC patients with boneonlymetastasis.
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Yiting Xu,Jianjie Xie,Lingnan Chen,Conghui Yuan,Yinyin Pan,Ling Cheng,Weiang Luo,Birong Zeng,Lizong Dai 한국고분자학회 2013 Macromolecular Research Vol.21 No.12
A novel organic/inorganic hybrid amphiphilic random copolymer poly(methacrylate isobutyl POSS-co-N-isopropylacrylamide-co-oligo(ethylene glycol) methyl ether methacrylate-co-2-vinylpyridine), poly(MAPOSS-co-NIPAM-co-OEGMA-co-2VP), was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The self-assembly behavior of random copolymers in aqueous solution was investigated by dynamic light scattering (DLS) as well as transmission electron microscopy (TEM). The results indicate the novel random copolymer in water could self-assemble into spherical aggregates and the self-aggregate size displays a remarkable dependence on pH. The stimuli-responsive characteristics of these assembles were tested by means of UV-vis spectra,DLS and TEM. There is a critic Zn2+ concentration over which the aggregates can be coordinated into well-define spherical aggregate clusters. The critic Zn2+ concentration can be tuned finely through adjusting solution concentration or 2VP amount. Results from UV-vis and DLS reveal that the copolymer solutions exhibit a sharp and intensive lower critical solution temperature (LCST). Some factors such as the solution concentration, molecular weight, pH and copolymer generation, which could affect the cloud point, were studied systematically. The essentially predetermined LCST can be achieved by altering the content of 2VP or pH. In addition, these novel hybrid aggregates can undergo an association/disassociation cycle with the heating and cooling of solution and the degree of reversibility shows a strong concentration dependence. As a novel organic-inorganic hybrid material which can respond to multiple external stimuli including temperature, pH, metal ions with sharp stimuli-responsive behaviors, it is potentially used for biomedicine, catalysis, diagnostics, bioseparations, biosensors and for fundamental investigation.
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Youping Xiao,Ying Chen,Yunbin Chen,Zhuangzhen He,Yiqi Yao,Jianji Pan 대한암학회 2019 Cancer Research and Treatment Vol.51 No.1
Purpose Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) was evaluated regarding its ability to preliminarily predict the short-term treatment response of nasopharyngeal carcinoma (NPC) following intensity-modulated radiation therapy. Materials and Methods IVIM-DWI with 14 b-factors (0-1,000 sec/mm2) was performed with a 3T MR system on 47 consecutive NPCs before, during (end of the 5th, 10th, 15th, 20th, and 25th fractions), and after fractional radiotherapy. IVIM parametrics (D, f, and D*) were calculated and compared to the baseline and xth fraction. Patients were categorized into responders and non-responders after radiotherapy. IVIM parametrics were also compared between subgroups. Results After fractional radiations, the D (except D5 and D at the end of the 5th fraction) after radiations were larger than the baseline D0 (p < 0.05), and the post-radiation D* (except D*5 and D*10) were smaller than D*0 (p < 0.05). f0 was smaller than f5 and f10 (p < 0.001) but larger than fend (p < 0.05). Furthermore, greater D5, D10, D15, and f10 coupled with smaller f0, D*20, and D*25were observed in responders than non-responders (all p < 0.01). Responders also presented larger D10, f10, D*20, and D*20 than non-responders (p < 0.05). Receiver operating characteristic curve analysis indicated that the D5, D*20, and f10 could better differentiate responders from non-responders. Conclusion IVIM-DWI could efficiently assess tumor treatment response to fractional radiotherapy and predict the radio-sensitivity for NPCs.
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