151종 생약제 추출물이 B형 간염 바이러스 표면 항원(HBsAg)과 항체(HBsAb)의 결합반응 그리고 HBV DNA polymerase 활성에 미치는 효과 : 한국산 각종 생약제를 이용한 B형 간염치료제의 개발

정태호,김정철,김문규,이인선,채성철,김승래,정준모,이인수,김승호,함경수 慶北大學校 醫科大學 1992 慶北醫大誌 Vol.33 No.3

세계인구 43억명 중 B형 간염 바이러스 보균자는 2억 1천 5백만명이며 이중 78%인 1억 6천만명 이상이 아시아 대륙에 집중되어 있다. 한국도 B형 바이러스 간염의 침윤지대이다. 본 연구는 B형 바이러스 보균자 혹은 만성간염을 치료할 수 있는 생약제를 탐색할 목적의 일환으로 한국에서 시판하는 생약제 151종을 구입하여 증류수로 추출하고 여과한 후 냉동건조하여 HBs 항원에 대한 결합능, HBV DNA polymerase억제능, tumor necrosis factor(TNF) 유리에 미치는 영향, 그리고 galactosamine 유발 간염에 대한간장보호 작용을 조사하였다. 151종의 생약제중 0.16㎍/㎖ 농도에서 간염 vaccine 내에 함유된 HBs 항원과 결합하는 생약제는 지유, 가자, 복분자, 대황, 정향, 빈량, 산수유, 소목, 마황, 쇄양, 후박, 목과, 양강, 오약, 산사, 목단피 등 16종이었다. 이들 생약제중 대황(Rheum palmatum L. 大黃), 가자(Terminalia chebula R. 訶子), 지유(Sanguisorba officinalis L. 地楡), 복분자(Rubus coreanus M. 覆盆子)는 HBV DNA polymerase 활성도를 비교적 강하게 억제하였으며 빈량(Areca catechu L. 빈랑), 정향(Eugenia caryophyllata T. 丁香), 목과(Chaenomeles japonica L. 木瓜), 산수유(Cornus officinalis S. 山茱萸)는 약하게나마 HBV DNA polymerase 활성을 억제하였다. 또한 HBV DNA polymerase를 억제한 대황, 가자, 지유, 복분자, 빈량, 정향, 마황, 소목, 산수유를 대상으로 TNF 유리에 미치는 영향을 조사한 결과 소목을 제외한 8종의 생약제 모두가 대식세포를 자극하여 TNF를 유리시켰다. 그리고 장차 임상에 사용함을 전제로 HBV DNA polymerase를 억제한 대황, 가자, 지유, 복분자, 빈량, 정향, 마황, 소목, 산수유를 galactosamine 유발 간염(백서)에 투여하여 간기능 검사에 미치는 효과를 조사하였으나 간기능 검사상으로는 특별한 보호작용을 나타내지 못하였으며 생약제 단독 투여로서는 간기능에 대하여 나쁜 영향을 주지 않았다. Hepatitis B virus infection is major cause of acute and chrome hepatitis, cirrhosis of liver, and hepatocellular carcinoma. There are over 200 million carriers of hepatitis B virus in the world, nearly 80 % of whom live in the South East Asia, Korea is also highly endemic area of hepatitis B virus infection. This study was performed to evaluate the effect of extracts of traditional Korean herbal medicines on hepatitis B virus. 151 traditional herbs were extracted, filtered and lyophilized. Using 151 herbal extracts we tested binding capability to the HBs Ag, inhibition of HBV DNA polymerase, release of tumor necrosis factor (TNF), and protection against galactosamine induced liver damage. Among 151 herbs, 16 herbs (Sanguisorba officinalis L., Terminalia chebula R., rubus coreanus M., Rheum palmatum L., Eugenia caryophyllata T., Areca catechu L., Cornus officinalis S., Caesalpinia sappan L, Ephedra sinica S., Cynomorium songaricum R., Machilus thunbergii S., Chaenomeles japonica L., Alpinia officinarum H., Lindera strychnifolia V., Crataegus pinnatifida B., Paeonia suffruticasa A. ) had binding capability to HBs Ag which contained in the commercial hepatitis vaccine, at 16 ug/㎖ of concentratioa Among the above 16 herbs, Rheum palmatum L., Terminalia chebula R., Sanguisorba officinalis L., Rubus coreanus M. significantly inhibited the HBV DNA polymerase activity, and Areca catechu L., Eugenia caryophyllata T., Ephedra sinica S., Caesalpinia sappan L., Chaenomeles Japonica L., Cornus officinalis S. also inibited the HBV DNA polymerase activity but less effective. All of the herbs, except Caesalpinia sappan L., which inhibited the HBV DNA polymerase activity, actively stimulated the mononuclear cells to release tumor necrosis factor(TNF) in whole blood culture system. The herbs which inhibited the HBV DNA polymerase activity, did not show any protective effect in galactosamine-induced hepatitis in rats, but there was no direct toxic effect when herbs were administered alone.

치관보철용 글라스 세라믹 재료에서 조성비 변화에 따른 기계적 특성에 관한 연구

정인성,김형일,박성수,최경남,안진모,박희찬 대한치과기재학회 1999 대한치과재료학회지 Vol.26 No.1

Glass ceramics for dental crown prosthesis were prepared by heat-treatment of CaO-MaO-SiO₂-P₂O -TiO₂glasses. The crystallization behaviors of samples have been investigated as a function of heat-treated temperature, holding time and chemical composition with their mechanical properties. From the experiment, the following results were obtained: The nucleation rate of apatite increased with increasing CaO or P₂O and decreasing MgO or TiO₂. Vickers hardness and bending strength of samples increased with increasing MgO or TiO₂ and decreasing CaO or P₂O. Vickers hardness of samples increased due to the precipitation of apatite, whitlockite, β-wollastonite, magnesium titanate, and diopside crystal phases within glass matrix. The final crystalline phase assemblages and the microstructures of the samples were found to be dependent on glass compositions, heat-treatment temperature, and holding time.

광조사 시간에 따른 복합레진과 Ormocer의 중합수축에 관한 연구

정연정,민경산,이해형,조경모,조용범 大韓齒科保存學會 2003 Restorative Dentistry & Endodontics Vol.28 No.4

Ormocer has organic-inorganic compound polymers. One of advantages of ormocer is reduced polymerization shrinkage. The purpose of this study was to compare the amount of contraction shrinkage of composite resins and ormocers. Additionally, the time of each material when there is no further change of contraction shrinkage was analysed. Four brands of composite resins (P-60, Surefil, Z-250 and Denfil) and two brands of ormocers (Definite and Admira) were used. 20 seconds, 40 seconds and 60 seconds of curing times were given. Contraction shrinkage of them were measured using a linometer for 80 seconds. The effect of material and curing time to contraction shrinkage at the time of 80 seconds was analysed by two-way ANOVA. The effect of time to contraction shrinkage was analysed by one-way ANOVA, and the time when there was no further change of the contraction shrinkage was analysed. The results are as follows : 1. P-60, Dfinite, Z-250 and Denfil had no further change of contraction shrinkage from the time of 20 seconds, and Surefil and Admira had no further change of contraction shrinkage from the time of 10 seconds. 2. Statistical analysis revealed volumetric shrinkage varied among material (p<0.05). No significant difference of contraction shrinkage among different curing times was found, and there was no effect of interaction between materials and curing times to contraction shrinkage. 3. Dfinite and Admira showed the statistically same contraction shrinkage with those of Z-250 and P-60, which is higher than that of Surefil and lower than that of Denfil (p<0.05).

Centerless Feeder 장치의 개발

강형모,권경우,김기길,정의식,허영환 한밭대학교 산업과학기술연구소 1994 논문집 Vol.2 No.-

This paper presents results of the development of centerless feeding system which are applicable to bearing metal processes. As a result, the feeding system can be applied to automatic surface finishing on the bearing metal process such as bush, and has greatly effects on the increase of the prodnctiving and the decrease of the man power an effect on increase the productivity and decrease the man power and effect on increase the productivity and decrease the man power of the bush machining process.

검도 머리치기 유형에 따른 상지의 근전도 비교 분석

장언량,박영훈,염창홍,서국웅,이경순,강영택,양충모 釜山大學校 附設 體育科學硏究所 2004 體育科學硏究所 論文集 Vol.20 No.-

Of the fencing club members at D university in B city, the four skilled members and the 4 unskilled members were selected. The MVC of the left brachioradialis, right brachioradialis and left flexor carpi radialis, right flexor carpi radialis each was measured in each group according to the striking directions as they act 'striking left right head'......

Fission yeast-based screening to identify putative HDAC inhibitors using a telomeric reporter strain.

Chung, Kyung-Sook,Ahn, Jiwon,Choi, Chung-Hae,Yim, Nam Hui,Kang, Chang-Mo,Kim, Chun-Ho,Lee, Kyeong,Park, Hee-Moon,Song, Kyung-Bin,Won, Misun Korean Society for Molecular Biology 2008 Molecules and cells Vol.26 No.1

<P>Transcriptional silencing is regulated by promoter methylation and histone modifications such as methylation and acetylation. We constructed a Schizosaccaromyces pombe reporter strain, KCT120a, to identify modifiers of transcriptional silencing, by inserting the ura4(+) gene into a heterochromatic telomere region. Two compounds inhibited the activity of histone deacetylases, induced acetylation of histone H3 and caused apoptotic cell death in HeLa cells. Expression of gelsolin and p21(waf1/cip1) also increased, as it does in response to HDAC inhibitors such as TSA. Therefore, these compounds appear to be potent inhibitors of HDACs, and hence potential anti-cancer drugs. Our observations suggest that a yeast cell-based assay system for transcriptional silencing may be useful for identifying histone deacetylase inhibitors and other agents affecting chromatin remodeling.</P>

Efficient Bulblet Regeneration and Growth from Bulb Scale of Hyacinthus orientalis L. cv. Pink Pearl Cultured in vitro

Kyung Soon Lee(이경순),Chung Han Chung(정정한),Yong Mo Chung(정용모),Doh Hoon Kim(김도훈),Soon Jae Jeong(정순재),Jae Sung Nam(남재성),Gyung Tae Kim(김경태),Young Byung Yi(이영병) 한국생명과학회 2007 생명과학회지 Vol.17 No.10

히아신스 Pink Pearl 품종의 인편배양에서 자구의 재생과 생장은 1.0 ㎎/l와 3.0 ㎎/l의 농도에서 IAA 보다 IBA가 더 효과적이었으며, 절편체의 기부가 배지에 삽식되는 정상적인 치상 방향이 역방향의 치상 방법에 비해 자구의 재생과 뿌리의 생장에 더 효율적인 것으로 나타났다. 계대배양에서 재생된 자구와 뿌리의 생장은 한천배지보다 펄라이트가 첨가된 액체배지에서 증가되었다. 이와 같은 히아신스 Pink Pearl 품종의 기내배양의 경우 자구 재생을 위한 초대배양은 한천 고체배지를, 재생된 자구의 생장은 펄라이트의 액체배지를 사용하는 2 단계의 교대배양 시스템이 더 유용함을 시사한다. The regeneration and growth of bulblets from the bulb scale segments of Hyacinthus orientalis L. cv. Pink Pearl were more efficient in IBA than IAA at the same concentrations (1.0 and 3.0 ㎎/l).. The normal (base-down) orientation of explants was more effective for bulblet regeneration and root growth than the inverted (base-up) orientation. The growth of bulblets and roots was increased higher in the perlite than the agar medium. These results suggested that the alternate culture system, first cultured in the agar medium for bulblet regeneration, and then in the perlite medium for bulblet growth, may be more useful for efficient in vitro culture of hyacinth (H. orientalils) cv. Pink Pearl.

다문화 교사 연수 프로그램의 사례 분석

모경환 ( Kyung Hwan Mo ),최충옥 ( Chung Ok Choi ),임현경 ( Hyun Kyung Lim ) 한국사회과교육학회 2010 시민교육연구 Vol.42 No.4

The present study examines the effects of a teacher training program for multicultural education on teachers` multicultural efficacy and their beliefs about diversity. The sample for this study consists of 68 elementary and high school teachers in Gyeonggi Province. The 60 hour training program was conducted at the Gyeongi Center for Multicultural Education. The questionnaire is comprised of questions regarding multicultural efficacy and beliefs about diversity. The pretest and posttest scores were analyzed through paired t-test for 54teachers` data. The results of the study are as follow. First, the teacher training program of this study was effective both for enhancing the teachers` multicultural efficacy and their positive beliefs about diversity. Second, the results of study imply that future in-service training programs for multicultural education should focus more on enhancing teachers` problem solving ability and developing teaching materials.

논총(論叢) : 장교진급제도(將校進級制度)에 대(對)한 관견(管見) -정규군인(正規軍人) 신분령(身分令)을 중심(中心)으로 하여-

정경모 ( Kyung Mo Chung ) 국방대학교 안보문제연구소 1960 국방연구 Vol.9 No.-

변동축력과 반복 횡하중을 받는 콘크리트충전 각형강관 기둥의 이력거동에 대한 수치해석적 평가

정경수(Chung Kyung-Soo),이재승(Lee Jae-Sung),정진안(Chung Jin-An),최성모(Choi Sung-Mo) 대한건축학회 2008 大韓建築學會論文集 : 構造系 Vol.24 No.6

The cyclic load-deformation relationships in deteriorating range are required to be investigated importantly, in order to prevent collapse of the buildings under earthquake excitation. The aim of this paper is to evaluate the hysteresis behavior of concrete filled steel tube (CFT) columns subjected to combination of cyclic bending and variable axial load including deteriorating range. For this purpose, the nonlinear fiber element method with local buckling was carried out and considered using the uni-axial stress and strain relationship for confined concrete and structural steel. The nonlinear fiber element method developed predicts well the hysteresis loops and cumulative plastic energy. On the basis of analytical results, hysteresis behavior could be evaluated, which is related to that under constant axial load and reversed bending.