RKO 대장암세포에서 3-헵틸아미노-6-알릴티오피리다진과 3-디펜틸아미노-6-알릴티오피리다진의 항암기전

임현경,권유미,송지윤,김경미,김채원,박명숙,정주희,Lim, Hyun Kyung,Kwon, Yumi,Song, Jiyun,Kim, Kyoung Mee,Kim, Chaewon,Park, Myung-Sook,Jung, Joohee 대한약학회 2016 약학회지 Vol.60 No.3

Allylthiopyridazine derivatives were synthesized and evaluated for anti-proliferative activities in the previous study. In this study, selected two allylthiopyridazine derivatives (compound I, 3-heptylamino-6-allylthiopyridazine and compound II, 3-dipentylamino-6-allylthiopyridazine) were assessed for cytotoxicity and chronic proliferation in human colon carcinoma RKO cells. Two derivatives dose-dependently inhibited cell viability and proliferation. To elucidate the anticancer mechanism of two derivatives, we investigated the expression level of apoptosis-related proteins in RKO cells. Compound I induced the activation of JNK and expression of p53 and p21. On the other hand, compound II showed no change of p53 level. Interestingly, compound II inhibited the nuclear translocation of NF-${\kappa}B$. This result suggested that compound II suppressed cell proliferation. These different mechanisms of these compounds might have occurred through different steric conformation.

중국 여대생의 한국에 대한 국가이미지 인지가 한국 패션브랜드 인지도와 구매의도에 미치는 영향

임현경 ( Hyun Kyung Lim ),이정우 ( Jung Woo Lee ),김미영 ( Mi Young Kim ) 한국의류학회 2013 한국의류학회지 Vol.37 No.4

This study used Chinese female college students as subjects to classify the components of the Korean national image as well as understand the recognition difference of country image factors and Korean fash-ion images; in addition, it examined the differences of the effect of Korean national image factors on the Korean fashion attitudes of Chinese female college students. A SPSS 18.0 statistic program with factor ana-lysis, Cronbach`s α, paired t-test, multiple regression analysis, frequency analysis and χ²-test was used. The results are: First, it was shown that there are six factors: culture-society, economy, products, sports, politics, and technology. Second, the recognition difference on the six factors were significantly higher for products, politics, technology, economy, culture-society, and sports, respectively. Third, the difference of Korean fa-shion images showed that they recognize design uniqueness and diversity to choose styles preferentially. Fourth, the purchase intention was significant in the order of culture-society, products, politics, and sports, and recognition affects culture-society, sports, and products, respectively. Fifth, they prefer THE E-LAND GROUP, Beaucre Merchandising, and The Basic House the most and show a strong purchase intention. The analysis also showed that other various brands that are also recognized. These study results can provide Korean fashion companies with useful implications for marketing.

두개골 핀고정시 Lidocaine과 Fentanyl 정주가 뇌척수액압과 뇌관류압에 미치는 영향에 대한 비교 연구

임현경 ( Hyun Kyung Lim ),한정욱 ( Jung Uk Han ),이춘수 ( Choon Soo Lee ),송장호 ( Jang Ho Song ),이경훈 ( Kyung Hoon Lee ),박현선 ( Hyun Sun Park ),박혜진 ( Hae Jin Park ),박지선 ( Ji Sun Park ),정종권 ( Chong Kweon Chung ) 대한마취과학회 2003 Korean Journal of Anesthesiology Vol.44 No.1

대장천공의 임상적 고찰

임현경(Hyun Kyung Lim),박경환(Kyung Hwan Park),배진선(Jin Sun Bae),채병도(Byung Do Chae) 대한외과학회 2006 Annals of Surgical Treatment and Research(ASRT) Vol.71 No.6

다문화 교사 연수 프로그램의 사례 분석

모경환 ( Kyung Hwan Mo ),최충옥 ( Chung Ok Choi ),임현경 ( Hyun Kyung Lim ) 한국사회과교육학회 2010 시민교육연구 Vol.42 No.4

The present study examines the effects of a teacher training program for multicultural education on teachers` multicultural efficacy and their beliefs about diversity. The sample for this study consists of 68 elementary and high school teachers in Gyeonggi Province. The 60 hour training program was conducted at the Gyeongi Center for Multicultural Education. The questionnaire is comprised of questions regarding multicultural efficacy and beliefs about diversity. The pretest and posttest scores were analyzed through paired t-test for 54teachers` data. The results of the study are as follow. First, the teacher training program of this study was effective both for enhancing the teachers` multicultural efficacy and their positive beliefs about diversity. Second, the results of study imply that future in-service training programs for multicultural education should focus more on enhancing teachers` problem solving ability and developing teaching materials.

소절개선을 이용한 심장수술의 임상고찰

김광호,김정택,이서원,김혜숙,임현경,이춘수,선경,Kim, Kwang-Ho,Kim, Joung-Taek,Lee, Seo-Won,Kim, Hae-Sook,Lim, Hyun-Kung,Lee, Choon-Soo,Sun, Kyung 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery (J Chest Surg) Vol.32 No.4

배경: 최근에 시작된 소절개선을 이용한 심장수은술 환자에게 미용상 효과가 좋으며, 통증이 적으며 빠른 회복을 가져온다. 본 교실에서는 그간 실시한 소절개심장수술의 현황을 임상고찰하였다. 대상 및 방법: 1997년 2월 흉골좌연종절개선으로 관상동맥우회술을 실시한 이후 1998년 11월까지 총 31례의 소절개술을 이용한 심장수술을 실시하였다. 남녀 비는 17:14였으며, 1세에서 75세까지의 연령분포를 보였다. 흉골좌연종절개술을 실시한 예는 9례로 관상동맥 질환으로 인공심폐기의 사용없이 박동상태에서 내유동맥으로 좌전행지관상동맥에 우회술을 실시하였는데, 그 중 1례는 내유동맥의 비꼬임으로 술 후 1주일 째 재수술한 경우였다. 흉골우연종절개는 1례로 승모판교련절개술 후 재발된 협착증에 대해 승모판치환술을 실시한 경우였다. 소흉골절개선으로 수술한 예는 21례로, 승모판치환 및 삼첨판성형술이 6례, 승모판치환술 5례, 중복판치환술 2례, 대동맥판치환술 1례, 좌심방점액종 1례, 심방중격결손증 2례, 심실중격결손증 2례, 우심실 자창 1례였다. 처음 5례는 T형의 흉골소절개를 실시하였으나 경험이 쌓이면서 대동맥기저부의 노출이 좋고 흉골 봉합시 안정감이 높은 화살모양의 흉골소절개를 실시하였다. 결과: 수술시간, 인공심폐 구동시간, 대동맥차단시간, 인공호흡기 사용기간, 수술 1일까지의 흉관배액양, 흉관 거치기간, 집중치료실 입원기간 등은 기존의 정중흉골절개선 예들에 비하여 큰 차이가 없었다. 수술 후 사망 예는 2례였으며 1례는 흉골소절개선으로 승모판치환 수술 1일에 대동맥 삽관부위의 파열로 출혈 사망하였고, 다른 1례는 흉골좌연종절개선으로 관상동맥우회술 후 2일에 부정맥으로 사망하였다. 사망의 원인과 수술절개선의 선택과는 직접적인 관련이 없었다. 합병증은 뇌색전증 1례, 창상의 혈종 1 례가 있었다. 결론: 소절개선으로도 정중흉골절개선과 마찬가지로 심장 수술을 효과적으로 실시할 수 있을 것으로 생각된다. Background: Minimally invasive technique for various cardiac surgeries has become widely accepted since it has been proven to have distinct advantages for the patients. We describe here the results of our experiences of minimal incision in cardiac surgery. Material and Method: From February 1997 to November 1998, we successfully performed 31 cases of minimally invasive cardiac surgery. Male and female ratio was 17:14, and the patients age ranged from 1 to 75 years. A left parasternal incision was used in 9 patients with single vessel coronary heart disease. A direct coronary bypass grafting was done under the condition of the beating heart without cardiopulmonary bypass support(MIDCAB). Among these, one was a case of a reoperation 1 week after the first operation due to a kinked mammary artery graft. A right parasternal incision was used in one case of a redo mitral valve replacement. Mini-sternotomy was used in the remaining 21 patients. The procedures were mitral valve replacement and tricuspid annuloplasty in 6 patients, mitral valve replacement 5, double valve replacement 2, aortic valve replacement 1, removal of left atrial myxoma 1, closure of atrial septal defect 2, repair of ventricular septal defect 2, and primary closure of r ght ventricular stab wound 1. The initial 5 cases underwent a T-shaped mini-sternotomy, however, we adopted an arrow-shaped ministernotomy in the remaining cases because it provided better exposure of the aortic root and stability of the sternum after a sternal wiring. Result: The operation time, the cardiopulmonary bypass time, the aorta cross-clamping time, the mechanical ventilation time, the amount of chest tube drainage until POD#1, the chest tube indwelling time, and the duration of intensive care unit staying were in an acceptable range. There were two surgical mortalities. One was due to a rupture of the aorta cannulation site after double valve replacement on POD#1 in the mini-sternotomy case, and the other was due to a sudden ventricular arrhythmia after MIDCAB on POD#2 in the parasternal incision case. Postoperative complications were observed in 2 cases in which a cerebral embolism developed on POD#2 after a mini-sternotomy in mitral valve replacement and wound hematoma developed after a right parasternal incision in a single coronary bypass grafting. Neither mortality nor complication was directly related to the incision technique itself. Conclusion: Minimally invasive surgery using parasternal or mini-sternotomy incision can be used in cardiac surgeries since it is as safe as the standard full sternotomy incisions.

전방 기관성형술 -2례 보고-

선경,이서원,김정택,김광호,임현경,Sun, Kyung,Lee, Seo-Won,Kim, Joung-Taek,Kim, Kwang-Ho,Lim, Hyun-Kyoung 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery (J Chest Surg) Vol.32 No.7

소아의 흉부기관협착증 2례에 대해 자가심막을 이용해 전방 기관성형술을 실시\ulcorner였다. 증례 1은 9세된 여 아에서 발견된 선천성 기관협착증의 경우로 인공폐의 보조 아래 기관성형과 동반된 좌폐동맥 기시이상을 동 시에 근치하였다. 환아는 이식된 심막편이 종격조직에 고정될 때까지 수술 후 10일 간 기계호흡을 실시하였 다. 증례 2는 8세된 남아에서 기관절개술 후 하부기관협착이 발생한 경우로, 심막편 바깥을 늑연골편으로 보 강함으로써 수술 직후 기도삽관을 제거할 수 있었다. 2례 모두 수술 후 1년 이상의 관찰기간 동안 기관내경 이 잘 유지되고 있으며, 기관재건부위가 성장하는 소견을 보인다. We describe here two cases of anterior tracheoplasty utilizing an autologous pericardial patch. One patient was a 9 year-old female who had a congenital long tracheal stenosis associated with major vascular anomalies including pulmonary artery sling. One-stage correction was done under the support of an extracorporeal membrane oxygenation system. She required a prolonged ventilation support for 10 days postoperatively until the implanted pericardium was fixed to the mediastinal structures. The other patient was a 8 year-old male who had acquired tracheal stenosis following a complicated tracheostomy. By applying additional support over the pericardial patch with the costal cartilage, an endotracheal tube could be removed immediately after the operation. Both patients have been doing well in a postoperative follow-up of over a year, and there have been evidences of growth in the reconstructed trachea.

기관재건술 후 발생한 심부 종격염 -흉골 절제, 위망 이식, 근피성형을 병합한 근치술-

이서원,김정택,김광호,이충재,김영모,임현경,선경,Lee, Seo-Won,Kim, Jung-Taek,Kim, Kwang-Ho,Lee, Choong-Jae,Kim, Young-Mo,Lim, Hyun-Kyoung,Sun, Kyung 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery (J Chest Surg) Vol.32 No.2

기관재건술 후 발생한 심부 종격염 2례에 대해 흉골절제, 대위망 자유이식 혹은 전치술, 근피성형술을 병행하여 좋은 결과를 얻었기에 보고한다. 증례 I은 8세된 남아에서 흉골 정중절개로 전방기관성형술을 실시한 후 심부 종격염과 흉골 골수염이 발생한 경우였으며, 증례 II는 50세된 여자에서 상부 흉골의 부분 정중절개로 기관절제 및 단단문합을 실시한 후 종격농양과 흉골 골수염이 발생한 경우였다. 치료는 두례 모두 배농을 시키고 일정기간 세척한 다음, 골수염이 생긴 흉골을 광범위 절제하고 대위망으로 종격을 덮은 후 양측 대흉근을 피부와 함께 박리하여 전흉벽을 재건하였다. 이때 증례 I의 경우는 대위망을 분리한 뒤 횡격막을 통해 종격부위에 위치시켰으며 (in-situ pedicled grafting), 증례 II의 경우는 대위망을 자유이식편으로 만들어 우횡경동맥과 외경정맥에 연결한 후 피하출구을 통해 상부종격에 위치시켰다 (free grafting). 양례 모두 술후 쾌회복하였으며 외래를 통해 추적관찰 중이다. We report here 2 cases of deep-seated mediastinitis combined with sternal osteomyelitis after tracheal reconstruction which were successfully treated with sternectomy, in-situ or free omental transfer, and pectoralis major myocutaneous flap. In case I, an 8 year-old boy with deep seated mediastinitis and sternal osteomyelitis that developed after anterior tracheoplasty through a standard midline sternotomy. In case II, a 50 year-old female patient with mediastinal abcess and sternal osteomyelitis that developed after resection and end-to-end anastomosis of the trachea through an upper midline sternotomy. Treatments consisted of drainage and irrigation followed by wide resection of the infected sternum, placement of the viable omentum into the anterior mediastinal space, and chest wall reconstruction with a pectoralis major myocutaneous flap. The omentum was transferred as an in-situ pedicled graft in case I and a free graft in case II. Both patients have recovered smoothly wit out any events and have been doing well postoperatively.

종격에 자유이식된 대공막의 혈관조영 및 전산화 단층촬영 추적결과 - 1례 보고 -

선경,김정택,김광호,이충재,김영모,임현경,Sun, Kyung,Kim, Jung-Taek,Kim, Kwang-Ho,Lee, Choong-Jae,Kim, Young-Mo,Lim, Hyun-Kyoung 대한기관식도과학회 1998 大韓氣管食道科學會誌 Vol.4 No.1

Partial splitting of the upper sternum provides an excellent surgical view in reconstruction of the intrathoracic trachea. However, when deep-seated mediastinitis develops postoperatively, it is difficult to manage especially when combined with sternal osteomyelitis. It also needs an additional consideration compared to the usual treatment modality applied to mediastinitis following a standard median stemotomy because the lower part of the stemum remains intact. We treated a 50 year old female patient with deep-seated mediastinitis and sternal osteomyelitis following resection and end-to-end anastomosis of the trachea through an upper midline sternotomy. The patient underwent extensive stemectomy, omental free grafting, and pectoral myocutaneous flap. Postoperative viability of the free-grafted omentum was evaluated by angiography and CT scan.

수산화마그네슘과 팽창흑연 복합 첨가 셀룰로오스 건축 마감 소재의 화재성능 및 독성평가 연구

박동인(Dong In Park),김용주(Yong Joo Kim),이세진(Sae Jin Lee),임현경(Hyun Kyung Lim),이동호(Dong Ho Rie) 한국화재소방학회 2022 한국화재소방학회 학술대회 논문집 Vol.2022 No.추계

셀룰로오스 건축마감소재는 화재 시 셀룰로오스의 가연 특성상 높은 열방출량과 연소 가스의 발생으로 인하여 화재에 취약하다는 단점이 있으며, 이러한 단점을 보완하여 셀룰로오스 소재에 난연제를 첨가하여 발열량 및 총방출열량을 감소시키는 난연 건축 마감 소재 개발에 많은 관심을 기울이고 있다. 본 연구는 셀룰로오스 건축마감소재의 화재성능의 향상을 목표로 팽창흑연과 수산화마그네슘이 혼합된 2중 난연 혼합 셀룰로오스 소재를 대상으로 수산화마그네슘 첨가비율 변화에 따른 총열방출량(THR)과 CO, CO2 발생량에 대해 콘칼로리미터를 사용하여 측정하였으며, 연소 가스는 NES 713 실험을 통하여 측정하였다. 실험 결과 2중 난연 셀룰로오스의 수산화마그네슘 첨가비율 변화에 따른 총열방출량의 상관관계 및 CO, CO2 발생량의 변화 및 연소가스의 데이터베이스로부터 개발된 소재의 현장 적용 시 성능 위주 화재 위험성 평가의 기초 자료로써 활용할 수 있다.