비혈연간 조혈모세포이식 후 재발한 만성골수성백혈병에서 Gleevec에 의한 완전관해 및 공여자 조혈 재건 1예

박사라,김우건,이제환,최성준,형철호,손희정,강혜진,지형석,이정신,이규형 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2

저자들은 만성골수성백혈병으로 동종 골수이식 후 림프구성급성전환으로 재발한 환자에서, Gleevec 투약 후 DLI (donor lymphocyte infusion) 없이 공여자 조혈(donor hematopoiesis)의 재건이 이루어지고, 세포유전학적, 분자생물학적 기준에서 모두 완전관해에 이르고, 12개월째 관해를 유지하고 있는 환자를 경험하였기에 이를 보고하는 바이다. 본례의 환자에서 Gleevec은 동종 골수이식 후 급성전환기로 재발한 환자에서도 매우 효과적인 것으로 나타났다. Gleevec은 동종 골수이식 후 재발한 만성골수성백혈병에서 Interferon-α, DLI, 2차골수이식 등 기존의 치료의 문제점을 보완할 수 있는 유용한 치료방법으로 사용될 수 있을 것으로 생각되며, 이의 장기적 치료효과의 평가와 기존치료와의 병합요법의 유용성 등에 대한 향후 연구가 필요할 것으로 생각된다. We report a 32-year old woman with chronic myelongenous leukemia (CML) in lymphoid blast crisis, who underwent allogenic bone marrow transplantation (BMT) from HLA phenotype full mached unrelated donor. Her disease relapsed into full-blown blast crisis. Upon treatment with gleevec, she achieved immediate remission of leukemia as well as the donor type hematopoiesis without donor lymphocyte infusion (DLI). Our case suggests the high effectiveness of gleevec in CML relapsed after allogeneic BMT. Further studies are needed to define the role of gleevec (with or without DLI) in the management of CML relapsed after allogeneic BMT.

Al_2O_3를 첨가한 LaFeO_3 박막의 암모니아 가스감지 특성

이복상,조철형,최부천,박기철,마대영,김정규 경상대학교 생산기술연구소 2002 工學硏究院論文集 Vol.2 No.-

LaFeO_3 thin films with 2%, 5% and 10% A1_2O_3 additives were fabricated by r.f. magnetron sputtering method on Al_2O_3 substrates. Structural, electrical and ammonia gas sensing characteristics of the thin films with different heat treatments were examined. From the XRD results, the compound of LaFeO_3 and Al_2O_3 was not found. Thin film with 5% Al_2O_3 additives, heat-treated at 800℃, showed the sensitivities of about 85% for 100ppm ammonia gas at the working temperature of 300℃. The response time to the ammonia gas was several seconds and the thin film showed good selectivity to NH_3 gas.

당밀의 첨가가 갈근탕박 사일리지의 품질과 산양의 기호성에 미치는 영향

김성복,문계봉,이봉덕,오홍록,배형철,이수기 충남대학교 농업과학연구소 2006 농업과학연구 Vol.33 No.1

Two experiments were conducted to investigate the effects of molasses supplementation to silage materials in ensiling Galgeuntang (herbal medicine) meal on the quality of silage, and its palatability in Korean native goats. In experiment Ⅰ, molasses was added at the levels of 0, 0.5, and 1.0% to Galgeuntang meal with three replicates per treatment. In experiment Ⅱ, three 1.5-yr-old Korean native goats were used to measure palatability. In experiment Ⅰ, lactic acid contents in molasses treatments were significantly(p<0.05) higher, and pH and butyric acid contents were lower than those of non-molasses treatment. In addition, molasses treatment increased total microbial cell counts in MRS medium for lactobacillus, but decreased total microbial cell counts in PDA medium for fungi. Molasses supplementation to silage materials increased in vitro dry matter disappearance. Molasses supplementation tended to increase silage intake in Korean native goat (experiment Ⅱ), but the difference was not significant(p>0.05). It is concluded that molasses supplementation to silage materials in ensiling herbal medicine meal could improve its preservability and palatability, the higher the better.

MoSi_2기 복합재료의 소결온도에 따른 미끄럼마모 특성

이광영,박원조,허선철,김형진,박성호 경상대학교 해양산업연구소 2002 해양산업연구소보 Vol.15 No.-

Molybdenum disilicide(MoSi_2) is considered to be a promising high temperature material for turbojet anhypersonic engines in aerospace and various industrial applications, because of a high melting point(2030℃),adequate density(6.3g/cm^3) and an excellent oxidation resistance. Mosi2 powder was evaluated from the variation of fabricating such as preparation temperature 1250℃, 1350℃ and 1500℃ respectively. Abrasion tester used a pin-on-disk type and a Si3N4 ceramic ball which used as machine structural materials. The test condition apply to load of 8kgf at 7.5rpm for 6 hours and the effect of hardness is also discussed. As a result of the tests, the friction coefficient was decreased with sintered MoSi_2 of increasing temperature but the function coefficient did not vary much for all specimens at all temperatures.

專門大學 體育舞踊科 敎育課程의 開發硏究

李鐵煥,金泰亨,李任仙,姜信和 진주여자전문대학 1986 論文集 Vol.8 No.-

肝蛭(Fasciola hepatica)의 脂質에 關한 硏究

李純炯,宋哲鏞 중앙대학교 의과대학 의과학연구소 1979 中央醫大誌 Vol.4 No.1

The present study was undertaken to observe the quality and quantity of lipids in the adult worms of sheep liverfluke, Fasciola hepatica. Lipid extract was done by the methods of Folch et al. (1957) and Kenny (1952), and the the extracted lipid fractions of the worms were separated by thin layer chromatography. Those fractions were also subjected to perform the quantitative analyses of glycerides, cholesterols and phospholipids. The results obtained were summarized as follows. 1. Total amount of glyceride was 45.29㎎ per gram wet weight of worm tissue: the amount of monoglyceride was 4.46㎎; diglyceride, 13.59㎎; and triglyceride, 25.63㎎ per gm wet weight of worm tissue. 2. Total amount of cholesterol was 8.10㎎ per gm wet weight of worm tissue, and the amount of esterified cholesterol(5.21㎎/gm) was much more than that of free cholesterol (2.15㎎/gm). 3. The following 10 phospholipids were detected in the worm tissue of F. hepatica, i.e., lysophosphatidylcholine, phosphatidylinositol, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, phosphatidylserine, phosphatidylethanolamine and three species of unknown phospholipides.

캔음료중 epichlorohydrin 의분석법에 관한 연구

이광호,곽인신,최재천,전대훈,김형일,강경모,최병희,김귀정,이철원 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

캔식품중에 잔류하는 epichlorohydrin을 분석하기 위한 pu링e & trap-Cc/uf통D 분석법을 확립하여 캔의 lacauer 코팅제에서 식품으로 이행되어 잔류하는 epichtorohydfn을 측정하고, 식품유사용매에 의한 용출시험을 통해 일일추정섭취량을 산출하였다. epichlorohydrin의 검량선은 y=0.0006x+0.OO6?(R큰0.9983)의 직선성·라 0.05#ga의 검출한계를 나타내었다. 각종 음료 및 식품유사용매에 일정량의 epichlorohydrin을 첨가한 후 분석하였을 때 회수을은 72~91%였으며, 실제 시판되는 f5건의 캔음료 중 잔류하는 epichlorohydrin을 측정한 결과 모든 캔음료에서 검출한계(0.1#94) 이하였다. 제관업체에서 구입한 modifed epoxy, epoxy phenolic, vinyl organosol, epoxy phenol ester 등의 BADGE(bisphenol A diglycidyt ether)형 에폭시수지로 lacquer 코팅된 식품용 캔에 식품윤사용매인 10% 또는 95% 에탄올을 층L진한 후 90~121'c의 드라이오븐에서 30분~2시간동안 용출시켰을 패 캔의 lacquer 코팅재에서 식품유사용매로 이행되는 epichBorollydirn은 코팅재질, 그리고 가열온도 및 시간에 문관하게 모든 캔에서 검출한계(0.4#ga)이하 였다. 위의 용출결과를 FD.f_의 "Recommendation for Chemistry Data for Indirect Food Additive Petition" 윽 일일추정섭취량 산출법에 적용하여 얻은 epichtorohydrin의 일딜추정 섭 취 량은 0.2r조persorday이하였다. A sensitive ana1?~7tical method based on gas cl)romatogFapy~mass spectrometry with a selected ion monitoring (GE/hfS-Slhf) and the purge-and-trap concentrator ))·asdeveloped for determining ot'epicillorohydrin in canr;ed be)#erages coated with eporl· resin. Thecalibration rurve in the ranre of 0.j ~50nr had'correlation coefficient of 0.9983 and detection limit of 0.Osrga. Recoveries of epichlorohydrin spiked to beverages were in the range of 72 ~91% with detection limits of 0.1 #ga. fn survey of epichlorohydff in twenty commercialcanned beverage samples, epichlorohydrin was not found in all the samples with the detectionlimit of 0.1 r9a. In migration test of various cans coated with BADGE-based coating cans;modifed epoxy, epoxy phenolic, vinyl organosol, epox?· phenol ester were exposed to the foodsimulants of 10% ethanol and 95% ethanol. flfo delectable epichlorohydrin migrated to foodsiHulants was found in aTl the cars with detection Jimit of 0.4 #9/L. Using the miEration data,along uTith the applicstion of food and beverage cans complied with FDA's "Recommendationfor Chemlstry Data f,3r Indirect Food Additive Petition" , the potential dietary exposure toepichlorohydrin was estlmated to be under 0.2rf/person/day.

Peripheral, soft tissue odontoma에 관한 증례보고

이종갑,최병재,최형준,이광출 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.1

1. Peripheral odontoma는 매우 드문 질환으로 확진을 위해서는 생검이 필수적이다. 2. Peripheral odontoma는 치은의 종창을 동반하며 서서히 성장하는 임상적 특징을 가진다. 3. 골내 치아종과 마찬가지로 Peripheral odontoma의 치료로는 완전한 외과적 절제가 추천되고 예후 또한 양호하다. Odontomas, hamartomas of odontogenic origin, are composed of all the structures that make up teeth. The WHO distinguishes odontoma into two types. The complex odontoma is defined as "a malformation in which all the dental tissues are represented, individual tissues being mainly well-formed but occurring in a more or less disorderly pattern." The compound odontoma is defined as "a malformation in which all the dental tissues are represented in a more orderly pattern than in the complex odontoma, so, that the lesion consists of many toothlike structures. Most of these structures do not resemble morphologically the teeth of normal dentition, but in each one enamel, dentine, cementum, and pulp are arranged as in the normal tooth." Almost all odontomas are located intraosseously, but they have occasionally been reported in extrabony location. Peripheral or soft tissue odontomas, those arising outside of the alveolar bone, are very rare. Peripheral or soft tissue odontoma are defined as tumors that demonstrate the histologic characteristics of their intraosseous counterparts but occur solely in the soft tissue covering the toothbearing portion of the mandible and maxilla, When they mature, they appear as a radiopaque mass without the peripheral halo. The final diagnosis should be confirmed by biopsy. The origin of peripheral odontoma is probably related to remnants of the dental lamina in the gingiva. The treatment of choice is complete surgical excision, similarly to intraosseous odontoma and it does not tend to recur. This report presents a case of 5-year-old boy with swelling on labial gingiva of primary central incisor. And it was diagnosed as peripheral odontoma by excisional biopsy.

Bacillus thuringiensis var. darmstadiensis 와 var. sotto의 내독소와 Bacillus thuringiensis var. kurstaki가 생산하는 아밀라제의 연구

이형환,김삼찬,황광현,임창로,조용칠,정인명 건국대학교 교육대학원 1991 敎育論叢 Vol.15 No.-

Endotoxin crystals produced by B.thuringiensis var. darmstadiensis cultured in modified GYS medium over 72 h were ovoidal in shape and separated using Renografin gradient centrifugation. The crystal protein bands were observed. When B.thuringiensis var sotto was grown in the modified GYS broth, it entered stationary phase at 8-9 h after inoculation. Proteinaceous crystals were banded at the position in 40% of Renografin gradient. The solubilized crystal proteins were formed by two bands, 130 Kd and 68 Kd in the SDS-PAGE. One plasmid was observed in B.thuringiensis var darmstadiensis and no plasmid in var. sotto in this study. Enzyme activity of amylase produced B.thuringiensis var kurstaki strain in the basal medium was 0.4 units per ml, and was enhanced to 0.6 units per ml in the basal medium contained soluble starch, Ca^++, Mg^++ and Mn^++ ions. Amylase production medium containing soluble starch was suitable for the amylase production and the highest activity appeared at 4-6 h after cultivation at 32℃. The amylase activity obtained by ethanol precipitation was 0.20 units per ml in 0.1 M phosphate buffer. The band of the molecular weight of 50 Kd was observed by SDS-PAGE analysis. Km value of the amylase for the soluble starch was 6.80 mg per ml.

부산지역 모 공단 및 인근지역 사업체의 산업보건 실태에 관한 조사연구

이동영,손혜숙,이채언,박형종,김대환,엄상화,최성용,유병철 인제대학교 1993 仁濟醫學 Vol.14 No.4

부산지역 공단 및 인근지역 사업체의 산업보건실태를 파악하기 위하여 205개 사업체의 보건담당자를 대상으로 1990년도의 보건실태에 관한 설문조사를 하였다. 조사내용을 일반사항, 보건관리실태에 관한 사항, 작업장 유해환경 및 보호구 지급사항, 건강관련 사항 및 근무조건에 관한 사항 등으로 대별하여 분석ㆍ관찰하였다. In order to obtain the fundamental data for developing more effective and acceptable programs of public health manegement in an industrial complex, 205 health manager in the plants answered the questionaire of the status of industrial health during 1990. The questionaire consisted of general charateristics, health care status, environmental problems, health problems, and others. 72.4% of 205 plants had less than 100 workers. Fabricated metal manufacture was 32.4%. Although Footwear manufacture was 6.4%, the percentage of workers was 33.1% of total workers. The percentage(56.2) of retired women was higher than that(38.2) of men. 51.9% of total plants has recieving group health care services. 85.4% of plants was exposed to noise, 66.5% was exposed to dust. Ear plug and mask were given to prevent noise and dust in 69.2% and 68.6%, respectively. Among 22,299 workers, 618(2.8%) were diagnosed as suspected non-occupatinal disease. 85.9% of them worked on continuously and had their disease treated. The cases suspected for occupational disease was 100 workers. 82.5% of them changed their post. 45% had the compensation for their occuaptional disease. The rate of working: accidents was 2.3%.