中原圈 寺刹風景에 관한 考察

鄭玧洙,秋甲喆,李成基 建國大學校 附設 自然科學硏究所 1992 建國自然科學硏究誌 Vol.3 No.-

Four temples were picked from the central northern area in Chung-Won Zone. And the considered result of the temple scape factors can be conclusion as follows: 1. Most of relics worthy of the buddhist culture and tradition were burnt away and lost out,. There were much difficulties in collection and comparision of bibliographical materials. So urgent is the task of recovering and restoring the relics into their original forms and conditions. 2. When Chung-Won Zone in taken in a view of the military strategic position throughout the ancient triple dynasties rather than a center of cultural creation in the context of historical research, we cannot say that Chung-Won Zone was affected uniquely by a particular one nation among the three dynasties. 3. Virgin forest is completly damaged in general throughout current forest aspect of the each temple and yet forests are reviving and on the way of transition to the original. 4. It is assumed that the plants from the primitive around the temple in common were hard wood forest of mixed forest. To quickly bring up the progress of stable forest growth and development for the purpose of ecological advantage, useful hard wood forest should be well tended in a positive approach as the hard wood forest is potentially surfacing out. 5. Country species which is afforested to be proper to form the temple scape should be planted at many small sized spots so barren lands around. It is recommendable that Quercus aliena BL. stands espceally at the Kakyoon Temple be taken care of concentrating it should be leaded to the balanced selection forest type. 6. Caution should be directed to prevent damage of Theodiplosis Japonensis U. et I. from pinus densiflora S. et Z. stands at Kooin Temple and Konglim Temple and also from pinus densiflora for. multicaulis U. at Kayoon Temple. 7. Forest outside the boundary of the temple should be established as a special protective zone and worning boards should be displayed to the public so that people recognize the forest scapes are the most precious resources and dense forest should be developed to be a model forest in Korea. 8. We should be able to find a place of sight pleasue, rest and recreation through further successful development of natural scape elements surrounding the temples. It is ideal that man can expect to enjoy our mental recuperation in the nature from of the forest.

人蔘이 自然發生高血壓쥐에 있어서 血壓 및 血漿 Renin 活性度에 미치는 影響에 關한 實驗的 硏究

孫宜錫,朴陞哲,許鳳烈,李禎均,林憲吉,咸駿洙,梁忠模,韓哲洙,朴贊雄,金海中 대한의학협회 1979 대한의학협회지 Vol.22 No.9

당뇨병 환자에서 혈장 Thrombin-Antithrombin Ⅲ 및 Plasmin-α_2-Plasmin Inhibitor 복합체의 임상적 의의

김경욱,김은숙,정상수,윤수지,박우일,이준희,남수연,안철우,문병수,김경래,차봉수,송영득,임승길,이현철,허갑범 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.25 No.5

연구배경:당뇨병 환자에서 혈액응고 및 섬유소용해 체계의 이상경향이 있어 그 결과로 여러 혈관합병증의 발생위험이 높다는 사실은 널리 알려져 있다. 그 기전은 아직 확실히 밝혀지지 않았으나, 고혈당으로 인한 혈장 단백질들의 비효소성 당화작용이나 산화성 스트레스로 인한 유리 라티칼 작용으로 응고항진이나 섬유소용해 활성의 저하를 유발하는 것으로 생각되고 있다. 최근 응고 및 용해인자와 그 억제자의 복합체들의 증가가 이 상태를 비교적 예민하게 반영한다고 알려져 있다. 방법:본 연구에서는 당뇨병 환자 101명과 정상 대조군 20명에서 혈장내 thrombin­antithrombin complex(TAT)와 plasmin­α₂­plasmin inhibitor complex(PIC)를 측정하여 비교하고, 당뇨병 환자에서 미세혈관 합병증과 대혈관합병증의 유무에 따른 차이와, 이미 혈관 질환의 위험인자로 알려져 있는 인자들간의 상관성을 알아보고자 하였다. 결과:1. 환자의 분포를 살펴보면 혈관합병증이 있는 군은 85명, 혈관합병증이 없는 군은 16명이었고, 평균연령은 각각 57.9±14.1세, 49.9±16.6세로 혈관 합병증이 있는 군에서 더 나이가 많았고, 체질량지수는 23.2±3.4㎏/㎡, 24.1±3.4㎏/㎡로 두 군간 유의한 차이는 없었다. 또 두 군간의 혈압 및 HbA1c, 공복혈당 및 인슐린과 C­peptide, 총 콜레스테롤, 중성지방, HDL­콜레스테롤, Lp⒜는 유의한 차이가 없었고, 미세혈관합병증이 있는 군에서 당뇨병의 유병기간이 길었다. 2. TAT 및 PIC의 농도는 정상 대조군에서는 2.8±1.2 ng/mL, 240.4±69.7 ng/mL이었고, 당뇨병 환자군에서는 9.5±22.6 ng/mL, 472.2±258.7 ng/mL이었다. TAT와 PIC 모두 당뇨병 환자군에서 정상 대조군에 비해 유의하게 증가되어 있었고(p<0.001), TAT/PIC ratio는 두 군간 차이가 없었다. 3. 당뇨병 환자의 혈관합병증에 따른 TAT 및 PIC, fibrinogen 농도는 합병증이 없는 군은 각각 4.1±2.4ng/mL, 362.2±272.0ng/mL, 322.7±102.4mg/mL으로 PIC와 fibrinogen의 증가를 보였으나, 연령을 보정한 후에는 통계학적 유의성은 없었다. 또 대혈관 합병증군에서는 각각 6.0±4.9 ng/mL, 507.4±321.6 ng/mL, 427.1±194.7 mg/dL이었으며 미세·대혈관 합병증군에서는 10.4±6.4 ng/mL, 484.8±269.7 ng/mL, 388.4±132.4 mg/dL으로 TAT의 증가를 보였으나 역시 연령을 보정한 후에는 통계학적 유의성은 없었다. 4. 미세혈관합병증군에서 HbA1c(>8%)가 높은 군의 PIC 농도가 유의하게 높았고(p=0.049), 대혈관합병증군에서 HbA1c(>8%)가 높은 군의 총 콜레스테롤 농도가 유의하게 높았다(p=0.042). 5. 총 당뇨병 환자군에서 PIC는 fibrinogen과 HbA1c와 양의 상관관계를, BMI와 음의 상관관계를 보였으며(r=0.47, 0.31,-0.25), 혈관 합병증이 없는 당뇨병 환자군에서만 TAT는 HbA1c와 양의 상관관계를 보였다(r=0.67). 결론:이상의 결과에서 혈장 TAT 및 PIC 농도는 당뇨병 환자에서 정상 대조군에 비해 의미있게 증가되어 있었고, 당뇨병 환자군에서는 연령의 증가와 유병기간이 혈액응고항진 및 용해의 장애에 큰 역할을 함을 알 수 있었으며, 총 당뇨병 환자군에 PIC와 HbA1c와 양의 상관관계를, BMI와 음의 상관관계를 보였으며 혈관 합병증이 없는 당뇨병 환자군에서만 TAT는 HbA1c와 양의 상관관계를 보였다. 따라서 당뇨병 환자에서 혈액응고 및 용해의 장애가 동반되어 있다고 볼 수 있으며, 혈장 TAT 및 PIC는 혈관합병증으로의 진행을 예측하는 지표로서 유용하리라 생각된다. 또 혈당조절정도와 상관성이 있으므로 혈당조절후에 추적검사를 시행하여 합병증의 예방이 가능한지 추후 연구가 필요하리라 생각된다. Background : Abnormality of coagulation and fibrinolystic system is known as a predisposing factor of vascular complication in diabetes. Although the pathogenesis is not well known, non-enzymatic glycation reaction and the increase in production of free radicals due to an increased oxidative stress may be linked to the hypercoagulibility and hypofibrinolytic activity. As indices of abnormality in coagulation and firinolysis in peripheral blood, plasma thrombin-antithrombin Ⅲ complex (TAT) and plasmin-α_2-plasmin inhibitor complex (PIC) were measured. The purpose of this study was to clarify whether hypercoagulability exists in diabetic patients with or without vascular complication. Methods : In our study, we measured plasma thrombin-antithrombin Ⅲ compelx (TAT) and plasmin-α_2-plasmin inhibit or complex (PIC) in 101 diabetic subjects and 20 controls. Comparing TAT and PIC levels in diabetic microvascular complication group, diabetic macrovascular complication group and controls, we examined correlation between risk factors associated with diabetic vascular complication. Results : 1. The group with diabetic vascular complication was older than group without complication. There was no significant difference in BMI, blood pressure, HbA_ic, blood sugar level, insulin, C-peptide, serum creatinine, total cholesterol, triglyceride, HDL-cholesterol, Lp (a) between two groups. The group with diabetic microvascular complication had longer duration of diabetes. 2. Concentration of TAT and PIC were 2.8±1.2 ng/ mL, 240.4±69.7 ng/ mL in controls and 9.5±22.6 ng/ mL, 472.2±258.7 ng/ mL in diabetic patients, respectively. TAT and PIC were significantly higher in diabetic patients than in control (p<0.001). But TAT/PIC ratio was no significant difference between two groups. 3. In diabetic patients, concentration of TAT and PIC and fibrinogen were respectively 4.1±2.4 ng/ mL, 362.2±272.0 ng/ mL, 322.7±102.4 mg/ dL in group without vascular complication and 5.3±4.1 ng/ mL, 529.5±258.7 ng/ mL, 374.9±106.2 mg/ dL in group with microvascular complication, which group had increase in PIC and Fibrinogen but no significance after correction of age. Concentration of TAT and PIC and Fibrinogen were 60.±4.9 ng/ mL, 507.4±321.6 ng/ mL, 427.1±194.7 mg/ dL in macrovascular complication, and 10.4±6.7 mg/ mL, 484.8±269.7 ng/ mL, 388.4±132.4 mg/ dL in combined vascular complication which group showed increase of TAT but also had no significant increase after correction of age. 4. In diabetic microvascular complication patients, group of high HbA_1c (>8%) (p=0.049) had significant high PIC concentration. In diabetic macrovascular complication patients, group of high HbA_1c (>8%) (p=0.042) had significant high total cholesterol concentration. 5. In all diabetic patients, PIC was positively correlated with fibrinogen and HbA_1c and negatively correlated BMI (r=0.47, 0.31, -0.25). Only in daibetic patients without angiopathy, TAT was positively correlated with HbA_1c (r=0.67). Conclusion : In this study, plasma TAT and PIC concentration significantly increased in diabetic patients compared with controls, and PIC was increased in group with microvascular complication, TAT were increased in group with combined micro macrovascular complication. However, there was no significance relationship existed when correctinf for age. PIC was correlated with HbA_1c. TAT was correlated with HbA_1c only in the group without angiopathy. Abnormality of coagulation and fibrinolysis were combined in diabetes, plasma TAT and PIC can be used as an index of vascular complication. Also we found the correlation with the degree of the blood glucose control. Therefore we need follow up study for the possibility of prevention of vascular complication after controlling the blood glucose to age-matched patients (J Kor Diaabetes Asso 25:354~363, 2001).

投票行動의 社會心理學的 硏究

鄭喆洙 慶北大學校 文理科大學 1973 文理學叢 Vol.1 No.-

This is a report on a study of the voting behavior of city-dwellers and village-dewellers in Korea. This study was carried out in Taegu, the third largest city in Korea and in four villages in Kyungsangbuk-do Province in August, 1972, one year and three month after the seventh presidential election of Korea. In order to obtain a heterogeneous sample, 550persons (urban area 300, rural area 250) were selected by a systematic random sampling method from the list of voters in Nam-ku Taegu and rural areas, 470 of them urban area 255, rural area 215) answered the questionaires which we distributed. The result of the research has been analyzed and compared with the research (sample 487) at Jongro-ku, Seoul and four other villages in the Youngnam area which was conducted in 1968 by the author. The studies are similar in research contents and analysis viewpoints. Generally speaking the studies show consistency in the tendency of voting dispositions and political consciousness, although there is some variety and a few differences in the number of questionaire items and in the statistical significance of the results of the two studies. The results of the study are summerized as follows 1) City-dwellers have more political information available to them, and thus a higher level of political knowledge and keener interest in elections or politics, as compared to their rural counterparts. City-dwellers have a more autonomous attitude than rural-dwellers in their voting motives and also in their choice of candidate. City-dwellers are more politically sophisticated. 2) City-dwellers are exposed to the mass medea more frequently than rural-dwellers. They get political information mainly from the mass media and are more influenced by the mass media than by personal contacts in their voting decision. Meanwhile rural-dwellers also get more political information by mass media than personal conmunication, but they are much more readily influenced by personal contacts, especially by the opinions of their own family members. 3) We have confirmed through research that city-dwellers showed a lower rate of voting, even though their political consciousness and interest were higher, while though the rural-dwellers had a lower interest and consciousness about poliics, they showed a higher voting rate. The contradictory phenomenon between political consciousness and voting behavior is one of the most remarkable special characteristics of voting behavior in Korea. 4) One of the special contrastive features between the urban and rural areas is that city-dwellers tend do refuse to cast ballots in spite of their feelings and information about political affairs; On the contrary, rural-dwellers show a tendency of casting their ballots, often without information on proper knowledge of politics. It seems that such villagers' voters were only influence by acquaintances with community leaders, or persuaded by the local government authorities, or attracted by material incentives (money or liquor, etc.). In short there are two kinds of political apathy in Korean society, the new style in the urban and the old style in the rural areas. 5) In general, the relationship between the voter's voting disposition or political consciousness and socio-demographic factors varies more or less according to variables. However, generaly speaking, there are highly positive correlations between political consciousness and sex and level of education, but weak relations with age and standard of living. Meanwhile, the difference in political consciousness between male and female voters is generally higher in rural areas than in urban areas.

韓國農村 새마을 運動의 社會學的 評價

鄭喆洙,朴宗祐 慶北大學校 東洋文化硏究所 1975 東洋文化硏究 Vol.2 No.-

The New Village Movement in Korea was initiated in 1970 to bring about the modernization of Korean rural society through innovations of various kinds. The movement, that is social change, is not an immanent change arising from the social system itself but a contact change from the outside of the system. Nor is it a selective contact change but a direct contact change or a planned change by the government. More than five years have passed since its initiation. Therefore, this paper aims at present to evaluate the present status of the New Village Movement and to measure cultural, technological, and environmental changes, if any, of rural society. Consequently, the study is concerned with the sociological and social psychological examination of the present status of adoption of the innovations within the community. The methods utilized for aquiring data are: formal or informal interviews with the persons concerned, examination of the existing records and the previous studies available, and finally a survey of 439 households. The survey was conducted in February 1975. The sample approximates a systematic random sample of 430 farm households within the boundary of North and South Kyungsang Provinces (220 from Community Development village, 210 from Non-Community Development village), with 420 households sufficiently complete to process. Major findings of the study are summarized as follows: (1) Among the farmers in general, the adoption rate of agricultural innovation programs encouraged by the agricuiture supervising authorities seems to be very high. 18 items were used for this measure such as the planting of recommended seeds, the practice of seed sterilization, the use of weed spray before making the rice seed-bed, the use of vinyl cover on the rice seed-bed to keep the bed warm, the use of fertilizer at a proper time after transplantation, the spraying of preventive chemicals after transplanting, the spraying of a proper amount of preventive chemicals prior to the occurrence of large numbers of insects, the use of compost for rice growth last year, the practice of testing the degree of the acidification of the soil, early plantation of the rice plant, the renewal of rice seeds every three years, a deep plowing of the paddy-field, the adjustment of the amount of the use of nitrogenous fertilizer to prevent rice plant fever, the planting of bean plants along ridges between paddy-fields, and so on. In these 19 items, the rate of adoption of the innovations was higher than 70% for 13 items, and more than a half of the farmers respsnded positively for all of the items above except one, the practice of testing the degree of the acidification of the soil. In addition, the rate of the adoption of agricultural innovations is higher among the members of C·D village than members of Non-C·D village. (2) Farmers' living conditions seem to have been improved. Four of the six items such as replacement of thatch rooves by slate, fence and road repairs, and the modernization of the kitchen were adopted by more than a half of the farmers. Especially, more than 80% of the farmers showed favorable attitudes toward the items for the replacement of thatch rooves by slate and road repairs. And members of C·D village than those of Non-C·D village in general show a higher adoption rate for improving in their living conditions. (3) The rational life index measured by 16 items for the use or non-use of the farming plan mannual, subscription of a magazine on farming, listening to radio programs on farming, etc. seemed to be considerably high among the farmers surveyed in general. More than a half of the farmers adopted all the items. Higher rates of adoption of rational life techniques are seen among the members of C·D village. (4) The standard of living of the majority of the farmers has been improved since 1970. Higher improvement is seen among the members of C·D village. (5) Although 84.8% of the farmers have favorable attitudes toward family planning(C·D village: 88.1%, Non-C·D 81.2%), the proportion of actual practice of family planning among the farmers is much lower campared to their attitude. By camparison of two villages in terms of the knowledge about, attitude toward, and practice of family planning, much higher proportion of members of C·D village than those of Non-C·D village keep positive values. (6) Among the farmers, a great gap is found between the attitudes toward and practice of standardized and abridged procedures of family rites which are highly encouraged by the government. That is, most of the farmers regardless of the members either of C·D or Non-C·D, show a favorable attitude toward it, but a significant part of them hesitate to practice it. (7) Approximately 90% of the farmers participate at least in one group activity. (the rate of participation is slightly higher among tne members of C·D village than Non-C·D village.) (8) Achivement motivation in general is higher among the members of C·D than those of Non-C·D village. (9) Great change is seen in the farmers' traditional value orientation. Greater changes were found in C·D village than in Non-C·D village. This was measured by the examination of their attitudes toward such items as: fatalism, kinship ties, locality consciousness, dependency upon kinsmen, traditional distinction between the sexes, family determined marriage, preferential attitude toward boys, devination to decide if a proposed marriage is possible, seniority the idea of putting government officials above the citizens, the idea of distinction between the gentry and peasantry, dominance of men over women, magic, etc, Of the 12 items there has been least change in those items concerned with attitudes toward seniority and family determined marriage. (10) The rate of adoption of innovations among the farmers both cultural and technological is highly correlated with their acreage under cultivation. (11) Farmers who have a higher rate of adoption of innovations are more likely than those with a lower rate to have favorable attitudes toward improvement in their living conditions, rationalization of their daily life, and the participation in group activities. They also have a higher achievement motivation than those of the less adopting group. (12) When farmers were asked the meaning of the few Village Movement, the majority of them replied that it meant improvement in the living environment and an increase in income. (13) More than 90% of the farmers responded positively to the New Village movement since they were certain that it greatly contributed to development of their community.

地域社會開發과 리더쉽

鄭喆洙 경북대학교 1982 새마을 硏究論叢 Vol.2 No.-

男兒選好思想과 女性의 役割

鄭喆洙 경북대학교 사회과학연구소 1985 社會科學硏究 Vol.1 No.1

The focus of this study is to analyze the origins, the realities and the causes of boy preference in Korea and to examine the results of boy preference and the women's role in eradicating the prejudice. The origin of boy preference in Korea roots in the middle period of Yi Dynasty. Prior to this time, women had considerable power in family life. But since the beginning of Yi Dynasty, economic and social-cultural factors reinforced boy preference. This continued trend lead to the problems of violating equal human right, lacking in the balanced development of society, and the population explosion in Korea. Recently this trend has gradually weakened but the complete eradication of boy preference is an urgent problem for the balanced development of Korean society and for accomplishing equality of human rights regardless of sex. In this context, women's role is vital as an agent of early socialization of children and of eradicating boy preference in this society.

시루봉地域一帶의 森林植生에 關한 硏究 : 天然林 및 人工林의 林分構造를 中心으로 Focused on Forest Stand Structure of Natural Artifical Forests

정윤수,신수철 동국대학교 생명자원과학대학 연습림 1997 연습림논문집 Vol.- No.5

To investigate the structure of the forest vegetation of Mt. Sirubong area in Chungbuk district, fifteen plots of natural forest and five plots of artificial forest were set up. As the result of classification and ordination analysis the study area was divided into six groups, which were Quercus mongolica community, Q. serrata community, Pinus densiflora community, Larix leptolepis community, P, rigida community and P. koraiensis community. Species diversity indices range of each of the communities was 0.8686∼1.2403, Quercus mongolica community showed the highest value and P. rigida community showed the lowest value among the communities. The similarity indices range were 17.14∼81.29%, between Quercus serrata community and Pinus densiflora community showed the highest value while on the other between Quercus serrata community and Larix leptolepis community showed the lowest value among the communities. The comparision of site index between Mt. Sirubong area with nationwide, Pinus koraiensis was the highest site index and P. rigida was above the average and Larix leptolepis was the average. Pinus densiflora showed below the average compared with nationwide was caused by the decline species of successional trends in the middle temperated forest zone. According to analysis of annual ring growth of major tree species by tree ring chronology, growth­decrease was occured in common in the year of 1974∼75, 1983∼85, 1987∼88, 1991 and 1995, this was highly concerned with the amount of precipitation during the period of from march to November.

만성정신질환자의 계속입원치료 심사에 관한 연구

정인원,박환규,정연복,김수일,원구연,김교형,신철진 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 정신보건법에 근거하여 매월 정기적으로 개최된 충청북도 정신보건심판위원회를 통하여 정신질환자의 계속입원치료 청구 심사의 현황과 문제점을 파악하고 개선사항을 지적함으로써 정신질환자의 효율적인 관리를 유도하고 인권남용의 여지를 차단하고자 한다. 방 법: 충청북도 내의 정신의료기관에서 계속입원치료 심사청구서 및 진단서, 보호의무자의 동의서 등을 제출한 정신질환자들을 대상으로 계속입원치료 청구에 대한 승인 여부를 매달 정기적으로 심사하였다. 1년 6개월여동안 심사한 자료를 정리하여 진단 및 보호의무자, 의료보장별 특성과 불승인률 등을 분석하였다. 결 과: 충청북도 심판위원회에 계속입원치료를 청구한 정신질환자는 21차례의 위원회 동안 총 7,981명이었으며, 진단별로 정신분열병은 80.9%, 알콜중독은 8.1%, 치매 등 기타는 11.0%이었다. 또한 보호의무자는 시장 또는 군수가 29.8%, 부모가 26.9%, 형제가 26.1%, 부부가 6.3%, 자녀가 5.9%, 기타가 5.0%로 나타났으며, 의료보장은 의료보호가 73.0%, 의료보험이 27.0%이었다. 이들 중에서 196명이 계속입원치료를 불승인받아서 전체 불승인률은 2.46%이었으며 정신분열병과 알콜중독 환자의 진단별 불승인률은 각각 0.73%와 17.6%이었다. 결 론: 정신과 병상의 대부분이 장기적으로 입원하는 만성 정신질환자들로 구성되어 있어서 이들에 대한 별도의 대책이 시급하다. 또한 계속입원치료가 불승인되어 퇴원한 환자들의 재활 및 사회적응을 위한 사회적 지지 체계가 부족하며, 특히 환자의 인권보호를 위한 구체적인 기준 등이 필요하다. Objectives: This study was to develop effective managements and to avoid the abuse of human rights in mentally-ill patients. The Mental Health Judgement Board of Chungchongbuk-do province has been held monthly since August, 1997 according to the Mental Health Act. In this study, the procedures and the problems of judging continuing hospitalization of chronic mentally-ill patients were reviewed. Methods: The mentally-ill patients who submitted the request for continuing hospitalization with the certificate of charged doctor and the agreement of caregiver were reviewed by the Mental Health Judgement Board of Chungchongbuk-do province. The analysis of the diagnoses, caregivers, medical care systems, and rejection rate for the patients were done. Results: Total mumber of mentally-ill patients who requested for continuing hospitalization were 7,981 from twenty-one monthly meetings. The diagnostic distributions were 80.9% for schizophrenic patients, 8.1% for alcoholics and 11.0% for others including dementia. As for the caretakers, the rate of majors was 29.8%, parents 26.9%, sibling 26.1%, spouse 6.3%, offspring 5.9%, and others 5.0%. And 73.0% of the patients were on Medicaid and 27.0% were insured. The patients who got the rejection for continuing hospitalization were 196 at the rate of 2.46%. And the rejection rates of schIzophrenic and alcoholic patients were 0.73% and 17.6%, respectively. Conclusions: New policies for decreasing longterm hospitalization of chronic mentally-ill patients are required. And the social support systems for psychiatric rehabilitation and readjustment are presently insufficient for the already discharged mentally-ill. Moreover, the practical guidelines for human rights of patients remains to be suggested.

돌와(Gynostemma pentaphyllum)엑기스가 白鼠의 肝臟障碍에 미치는 影響

丁明鉉,文永熙,姜壽鐵,李炳柱 조선대학교 약학연구소 1989 藥學硏究誌 Vol.11 No.1

This study was attempted to invesigate the effects of extract and crude saponins of Gynostemma pentaphyllum Makino on the activities of S-GPT, S-GOT, Al.P, LDH and the levels of total-bilirubin, total-cholesterol in the serum of nomal rats and experimentally CCl_4-intoxicated rats, and on the effect of body, liver and spleen weight in CCl_4-intoxicated rats. The results were shown as follows; The extract (GE.) and crude saponins were showed a significantly decrease in the activities of S-GPT, S-GOT, Al.P and the level of total bilirubin in the serum elevated by CCl_4, but crude saponins was more decreased than GE. The activities of LDH were significantly decreased of the 4th and the 6th days after administration of GE., and crude saponins was decreased in proportion to the number of days. The level of total cholesterol were significantly decreased in all sample groups. when compared with control group, but remarkably decreased in GE. 500㎎/㎏ and crude saponins 100㎎/㎏. The liver and spleen weight were decreased on the administration of GE. and crude saponins. According to the above results, it is thought that GE. and crude saponins exhibited significant antihepatotoxic activity in the CCl_4-intoxicated rats.