우리나라 노인여성의 골다공증성 척추골절로 인한 경제적 부담 추계

강혜영,강대룡,장영화,박성은,최원정,문성환,양규현,Kang, Hye-Young,Kang, Dae-Ryong,Jang, Young-Hwa,Park, Sung-Eun,Choi, Won-Jung,Moon, Seong-Hwan,Yang, Kyu-Hyun 대한예방의학회 2008 예방의학회지 Vol.41 No.5

Objectives : To estimate the economic burden of osteoporotic vertebral fracture (VF) from a societal perspective. Methods : From 2002 to 2004, we identified all National Health Insurance claims records for women ${\geq}50$ years old with a diagnosis of VF. The first 6-months was defined as a "clearance period," such that patients were considered as incident cases if their first claim of fracture was recorded after June 30, 2002. We only included patients with ${\geq}$ one claim of a diagnosis of, or prescription for, osteoporosis over 3 years. For each patient, we cumulated the claims amount for the first visit and for the follow-up treatments for 1 year. The hospital charge data from 4 hospitals were investigated to measure the proportion of the non-covered services. Face-to-face interviews were conducted with 106 patients from the 4 study sites to measure the out-of-pocket spending outside of hospitals. Results : During 2.5 years, 131,453 VF patients were identified. The patients had an average of 3.38 visits, 0.40 admissions and 6.36 inpatient days. The per capita cost was 1,909,690 Won: 71.5% for direct medical costs, 20.6% for direct non-medical costs and 7.9% for indirect costs. The per capita cost increased with increasing age: 1,848,078 Won for those aged 50-64, 2,084,846 Won for 65-74, 2,129,530 Won for 75-84and 2,121,492 Won for those above 84. Conclusions : Exploring the economic burden of osteoporotic VF is expected to motivate to adopt effective treatment options for osteoporosis in order to prevent the incidence of fracture and the consequent costs.

지시약의 등흡광점을 이용한 용액의 pH측정(제2보)

최원형,박민수,허호장 경성대학교 1989 論文集 Vol.10 No.1

지시약 Bromo Cresol Green(BCG) 용액을 시료 용액에 첨가하고 지시약의 염기성 최대 흡수 파장과 등흡광점에서 이 시료액의 흡광도를 측정하였다. 이들 측정한 흡광도로부터 용액의 pH를 계산하였다. 등흡광점에서 흡광도의 범위를 0.1내지 0.17로 유지하고 시료 용액의 pH가 pK₁±1내에서, pH측정 오차는 ±0.07pH 단위 이내이었다. The Bromo cresol Green (BCG) stock solution was added to Sample solution and the absorbance of this solution was measured at the maximum absorption wavelength of basic form and the isosbertic point of the indicator. From these measurements of absorbance, the pH of this solution was calculated. The range of absorbance at the isobestic point was maintained with in 0.1∼0.17. The errorof pH measurement was within ±0.07pH unit in the pH range sample solution of pK₁±1

Ciprofloxacin 제제의 생물학적 동등성에 관한 연구

최철희,신재국,신완균,유호진,이경훈,정원석,장인진,신상구 대한화학요법학회 1991 대한화학요법학회지 Vol.9 No.1

국내 시판중인 ciprofloxacin 제제인 Citopcin®(250㎎ tablet)의 동등성을 검토하기 위해 제조원인 Bayer사의 Citopcin®(250㎎ tablet)를 기준제제로 하여 18명의 건강한 남성 피험자를 대상으로 500㎎ 1회 교차 경구 투여후 약동학적 성상을 분석비교한 결과는 다음과 같다. 시험제제의 생체 이용율의 지표인 AUC, C_(mao), T_(max) 및 MRT들의 평균치는 백분율차이에 있어 모든 기준제제 지표의 ± 20% 이내였으며, 이들 생체 이용율 지표들은 분산분석 검정에서 차이를 인지할 수 없었다.생체 이용율 지표들의 기준제제에 대한 백분율 90% 대칭 신뢰구간 검토시 모든 경수들에서 ± 20% 이내의 조건을 만족하였으며 AUC의 경우에는 대칭형 신뢰구간으로 변환시 95% 신뢰구간에서도 동등성의 조건을 만족하였다, 이상의 시험결과로 시험제제인 Citopcin®은 기준제제인 Ciprobay®와 생물학적 동등한 제제로 판단되었다. The pharmacokinetics of ciprofloxacin was studied for the evaluation of the bioequivalence of the generic ciproflocacin products. Two single doses of 500㎎ each of ciprofloxacin(Ciprobay® 250㎎ tablet as a reference compound and Citopcin® 250㎎ tablet s a test compound) were administered orally to ighteen male volunteers in a balanced, randomized crossover design. Pek plasma levels of ciprofloxacin were observed about 1 hour after the doses and the peak concentrations of both products were similar(Ciprobay®, 3.18㎍/㎖; Citopcin®, 2.89㎍/㎖). The values of other pharmacokinetic parameter of ciprofloxacin computed for Ciprobay® are presented in that order: AUC=13.53:12.47㎍·h/㎖, T_(max)=1.28:1.14 hours; MRT=5.30:5.08 hours; t_(1/2)β=3.65:3.47 hours. No satistically significant, differences were detected when AUC and the other parameters were compared with the method of ANOVA. Using the criteria of 90% confidence interval for the assessment of bioequivalence al the parameters were acceptable. The products were found to be equivalent on the premise that no significant difference was detected when the relevant pharmacokinetic parameters were compared, and the confidence limit analysis showed acceptable results.

다발성 연조직 종괴를 동반한 급성 림프구성 백혈병의 증례 보고

장정용,허경회,이원진,허민석,이삼선,최순철 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.2

A 15-year-old patient, who had been diagnosed and treated as Burkitt cell type acute lymphoblastic leukemia (ALLL3) already, visited our department. He complained of gingival enlargement and loosening teeth 1 month ago. The clinical examination revealed anterior open bite, gingival enlargement, and nontender swelling particularly in molar regions of both jaws. Deep periodontal pockets and severe mobility was shown on most of the teeth. The panoramic radiographs showed severe bone destruction and extrusion of the molars. The contrast enhanced CT showed multiple enhanced mass and bone marrow obliteration in both jaws. Chemotherapy was done and the swelling was subsided at 1 month later. In conclusion, radiologic findings of leukemia with soft tissue mass, known as chloroma or granulocytic sarcoma, mimic those of lymphoma, so blood test may be needed for the final diagnosis.

몬테카를로 방법을 이용한 고강도콘크리트 구조물에 대한 휨변형의 해석적인 연구

최광진,장일영,송재호,홍원기 金烏工科大學校 1995 論文集 Vol.16 No.-

The object of this thesis is an analytical study on flexural deformation of high strength concrete structures using Method. Using the established experimental data that has been presented in various documents the stress-strain relationship curves of high strength(500㎏f/㎠) models are proposed. Based on both methods of logarithm regression analysis and multiple regression analysis adopted in order to establish the relationships between design parameters, responsed random variables and flexural deformation analyzed using monte carlo simulation and simpson composite formula. Additional random variables are introduced to incorporate both the confidence in the analytical accuracy of engineering mechanics associated with structural response quantities and the uncertainty in the construction quality control. The result is expected to accomodate other important design parameter of high strength concrete design in treating reliability theory that practicing engineers and structural engineering.

충전층 반응기에서 전분의 고정화 동시당화발효법에 의한 ETHANOL제조

최동진,원성호,김장규,김남기 成均館大學校 科學技術硏究所 1992 論文集 Vol.43 No.2

Kinetic data of immobilized Saccharomyces cerevisiae, Zymomonas mobilis, and S. cerevisiae-Z. mobilis with amylase from Aspergillus shirousamii(SimultaneousSaccharification-Fermentation of starch) in packed bed reactor were investigated with 10%, 15%, 20%, and 25% water-soluble starch solution at 30 ℃ and initial pH 5.0. For the comparison of ethanol productivity, Z mobilis ATCC 10988, S. cerevisiae ATCC 26603, and dual organisms(Z. mobilis-S. cerevisiae) were immobilized with 3%[W/V] agar-agar gel respectively on the styrofoam bead. The results were that the volumetric ethanol productivity of dual organisms was better than that of Z. mobilis and of S. cerevisiae. And the volumetric ethanol productivity of 25% soluble starch solution was better than that of the others.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

신상아에서 후족부 모세 혈액 검사 이후에 발생한 종골 골수염

최장석,김정원 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.3

In neonate, osteomyelitis of the calcaneus is extremely rare and various reports have indicated that it accounts for 3~8% of all bone infections among neonates, infection can result from hematogenous seeding or direct inoculation, as seen in puncture wounds (accidental or for blood sampling), open fracture, degloving injuries. and extension of pressure ulceration. Although direct inoculation has been reported to be the more frequent cause, other reports suggest a hematogenous etiology in the majority. We compared our experience that neonate calcaneal osteomyelitis after hind foot capillary blood sampling for cogenital metabolic deficiencies test and follow up of bilirubin level at Paik Hospital, Inje University, Pusan, Korea to that reported in the literature to determine if the experience at this institution was similar to that previously reported. Additionally, characteristics of the clinical presentation, laboratory investigation, treatment, and outcome were studied to determine if any factors might be helpful in making an earlier diagnosis, improving outcome, or both.

동양 전통과학의 탐구방법론 연구 : 朱子의 格物致知論을 중심으로

최영제,이우붕,정원우,김용수,문장수,방경곤,김기정 경북대학교사범대학과학교육연구소 2005 科學敎育硏究誌 Vol.29 No.-

경추수술의 골이식 재료로서 장골과 Biocompatible Orthopaedic Polymer(BOP)에 대한 평가

신원한,박진규,김범태,최순관,변박장 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.6