Effects of Phenytoin and Diazepam on the Seizure Activity in the Cortical Dysplasia Animal Models

Kim, Si-Hyung,Choi, In-Sun,Cho, Jin-Hwa,Park, Eun-Ju,Jang, Il-Sung,Choi, Byung-Ju,Kim, Hyun-Jung,Kim, Young-Jin,Nam, Soon-Hyeun The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Dysplasia-associated seizure disorders are markedly resistant to pharmacological intervention. Relatively little research has been conducted studying the effects of antiepileptic drugs(AEDs) on seizure activity in a rat model of dysplasia. We have used rats exposed to methylazoxymethanol acetate(MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of AEDs in the dysplastic brain. Pilocarpine was used to induce acute seizure in MAM-exposed and age-matched vehicle-injucted control animals. Field potential recordings were used to monitor amplitude and numbers population spikes, and paired pulse inhibition in response to stimulation of commissural pathway. Two commonly used AEDs were tested: diazepam 5, 2.5mg/kg;phenytoin 40, 60mg/kg. Diazepam(DZP) and phenytoin(PHT) reduced the amplitude of population spike in control and MAM-exposed rats. However, the amplitude of population spike was nearly eliminated in control rats as compared to the MAM-exposed rats. Pharmaco-resistance was tested by measuring seizure latencies in awake rats after pilocarpine administration(320mg/kg, i.p.) with and without pretreatment with AEDs. Pre-treatment with PHT 60 mg prolonged seizure latency in control rats, but not in MAM-exposed animals. The main findings of this study are that acute seizures initiated in MAM-exposed rats are relatively resistant to standard AEDs assessed in vivo. These data suggest that animal model with cortical dysplasia can be used to screen the effects of potential AEDs.

의류상표태도에서의 감정적 인지적 요소

최선형 가톨릭대학교 생활과학연구소 1995 생활과학연구논집 Vol.15 No.1

The study had a twofold purpose : (1) to investigate emotional responses toward the clothing brands, and (2) to investigate the effect of emotional and cognitive responses toward clothing brands on purchase intention. Self-administrated questionnaires were given to 300 female college students in Seoul. Six brands of female clothing were selected as stimuli for the questionnaire. Factor analysis revealed three emotional responses : Pleasure, activation, utilitarian. When estimated using multiple regression analysis, both cognitive and emotional responses influenced the subject's purchase intention. It was found out that the hedonic aspect had more influence on the purchase intention than the utilitarian one and activation aspect influenced on preference and purchase intention through pleasure. The results of the study suggest that both consumer's emotional and hedonic desires and their cognitional responses of attributes play an important role in the consumer behavior.

유행과 초현실주의

최선형 카톨릭대학교생활과학연구소 1993 생활과학연구논집 Vol.13 No.1

精神分裂症患者의 神經學的 異常所見에 대한 硏究

최정선,이형영 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.3

The standard neurologic examination was performed to evaluated prevalence of abnormal findings and their clinical significance for schizophrenic patients. DSM-III-R diagnosed, age-and sex-matched groups of 35 schizophrenic patients, 24 patients with bipolar affective disorder with history of psychosis, 26 patients hospitalized for alcohol dependence or other drug abuse, and 33 normal volunteers were the subjects. All three patient groups had significantly more total abnormalities than normal control group, but there were no significant differences when patient groups were compared with each other. When the findings due to medication or others unrelated to the pathogenesis of psychiatric illness were-excluded, the differences between the following groups, i.e., the schzophrenic group vs normal control group, schizophrenic group vs bipolar affective disorder group, and alcohol dependence and other drug abuse group vs normal control group, remained significant. When those neurologic abnormalities indicating localized dysfunction of the corticospinal tracts, basal ganglia, or cerebellum were considered, only two pairs showed significant differences. They were schizophrenic group vs normal control group and alcohol dependence and other drug abuse group vs normal control group.

유한요소법을 이용한 수직형 롤러 분쇄기용 테이블 라이너의 내구 해석에 관한 연구

최형모,이경영,조석수,이선봉 三陟大學校 産業科學技術硏究所 2002 産業科學技術硏究論文集 Vol.7 No.1

Vertical roller mill, which perform the grinding and parting blending of raw material, is the one of the important machine to produce ordinary portland cement. The table liner belonged to the vertical roller is mill the one of the main parts influencing its grinding efficiency. The life of table liner is estimatede to 4×107cycles in the design stage, but at the field, when its operating time reaches to 4×106 ~ 8×106 cycles, the fracture of table liner being to be found. The fracture of table liner commences from the outside edge of grinding path contacting with the grinding roller. Its maintenance normally take 30% of the total maintenance costs of the roller mill. Therefore, this study shows the clarification of the reasons occuring the fatal destruction of the table liner by fatigue fracture analysis utilizing fracture mechanics and by FEM using ANSYS 5.6.

의류상표 전략을 위한 컨조인트 분석의 활용

최선형 가톨릭대학교 생활과학연구소 2002 생활과학연구논집 Vol.22 No.1

The Purpose of this study is to introduce conjoint analysis techniques for Brand strategy of fashion market. A conjoint measurement of brand equity is developed in Korean men's casual market which is composed of A, B, C, D company. Four product attributes such as brand name, price, style, distribution are reported as choice factors. 4(brand name)×3(price)×2(style)×3(distribution) fractional factorial design is set up to originally. Through the orthogonal array, the final 12 profiles are used for full-profile stimulus cards method. 100 visitors of Brand which are major target customers are participated in conjoint experimentation. Using a conjoint analysis, we can estimate the utility value in each attributes, the importance rates of each attributes, the combination of ideal attributes, the market share rate according to the combination of attributes, develop new product, and calculate brand equity in terms of monetary value and segment the market.

고체상 추출과 GC/MSD를 이용한 금속가공유중 다핵 방향족 탄화수소류 및 그 유도체의 분석

최호춘,김강윤,안선희,문형중 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1

This study was performed to confirm an analytical method for polyunclear aromatic hydrocarbons (PAHs) in metalworking fluids(MWFs) which were used in metalworking factories. To ensure the analysis with accuracy and precision the fesults of PAHs in MMFs, this study was tried to use solid phase extraction(SPE) and gas chromatography/mass selective detector(GC/MSD). Also, this study was examined the concentrations of PAHs in MMF bulks and the qualitative analysis polycyclic aromatic compounds(PACs)excluding PAHs. 21 bulk samples were sampled in 7 metalworking factories. 21 bulk samples were 18 cutting oil(13 straight oils and 5 soluble oils) and 3 others(lubricating oil, discharge oil. compresses oil). 6 SPE cartridges were used to analyze PAH in MMFs and GC/MSD(satum 2000, Varian, U.S.A). Among the the 6 SPE cartridgesm this study was selected strong cation exchanger(SCX, aromatic benzene sulfonic acid functional group) cartridge for PAHs extraction in MMFs. Also the recovery test was performed. 1. The appropriated cartridge of SPE for analysis of PAHs in MWFs was found to be SCX. 2. The detected PAHs in MWFs were naphthalene(n=2). acenaphthylene(n=1). phenanthree(n=1), anthracene(n=2), fluoranthene(=7), pyrene(n=11) benzo[b]fluoranthene(n=1), chrysene(n=1), benzo[k]fluoranthene(n=1), benzo[k]fluoranthene(n=1).benzo[a]pyrene(n=1), dibenz[a,h]anthracene(n=2) and benzo[ghi] perylene(n=8). Total PAH(n=12) concentrations range were lower than LOD-270.03ug/ml. 3. The component of the PACs excluding PAHs were naphthalenes, acenaphthenes, chrysenes, anthracenes, indenes, fluoranthenes, fluorenes, pyrenes, benzopyrenes, phenantherenes and others volitile organic compounds(VOCs)were amines, phenols, aldehydes and others. For the results, SCX cartridge was better than other 5 SPE cartridges. 13 of 16 PAHs components were detected in MWFs. However recovry rate in this study should be improved analytical techniques on PAHs in MWFs. Also this study was need for further investigation for more MWFs samples and environmental monitoring and evaluation of MWFs exposed workers.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

의복쇼핑가치 측정에 관한 연구

최선형 가톨릭대학교 생활과학연구소 1996 생활과학연구논집 Vol.16 No.1

Consumer researchers' growing interest in consumer experiences has revealed that many consumption activities produce both hedonic and utilitarian outcomes. Thus there is an increasing need for scales to assess consumer perceptions of clothing shopping values including both hedonic and utilitarian values. This article describes the development of a scale measuring values obtained from the pervasive consumption experience of apparel shopping. The author develops and validates the scale using a multistep process. The result demonstrates that the distinct hedonic, informational and utilitarian shopping value dimensions exist and are related to a number of important consumption variables.

패션명품에 대한 태도 연구

최선형 服飾文化學會 2001 服飾文化硏究 Vol.9 No.6

The purposes of this study are to find out the factors of consumers attitude toward Fashion luxury products, to identify the effects of demographics to influence on consumer's attitude toward fashion luxury products; to identify the effects of the attitude toward fashion luxury to influence on the concern for fashion luxury. The subjects were Korean 445 women from 20's to 50's living in Seoul. The mean, ANOVA, factor analysis, regression analysis, Duncan test were used for statistics analysis. The results are as follows; Seven factors of the attitude toward fashion luxury products were identified: the involvement for fashion luxury, the quality of fashion luxury, the negative response toward the consumption of fashion luxury, the luxurious aspect of fashion goods, the traditional value of fashion luxury, the rarity of fashion luxury. Among demographics, age and income influenced on fashion luxury products involvement, the quality of luxury products. The perception of good quality and hedonic consumption of luxury good influence highly on the involvement for the luxury products.