Three-Dimensional Porous Collagen/Chitosan Complex Sponge for Tissue Engineering

Kim, Sung Eun,Cho, Yong Woo,Kang, Eun Jung,Kwon, Ick Chan,Lee, Eunhee Bae,Kim, Jung Hyun,Chung, Hesson,Jeong, Seo Young The Korean Fiber Society 2001 Fibers and polymers Vol.2 No.2

A three-dimensional, porous collagen/chitosan complex sponge was prepared to closely simulate basic extracellular matrix (ECM) constitutes, collagen and glycosaminoglycan. The complex sponge was prepared by a lyophilization method and had the regular network with highly porous structure, suitable for cell adhesion and growth. The pores were well interconnected, and their distribution was fairly homogeneous. The complex sponge was crosslinked using 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) to increase its boilogical stability and enhance its mechanical properties. The crosslinking medium has a great effect on the inner structure of the sponge. The homogeneous, porous structure of the sponge was remarkably collapsed in an aqueous crosslinking medium. However, the morphology of the sponge remained almost intact in a water/ethanol mixture crosslinking milieu. Mechanical properties of the collagen/chitosan sponge were significantly enhanced by EDC-mediated crosslinking. The potential of the sponge as a scaffold for tissue engineering was investigated using a Chinese hamster ovary cell (CHO-K1) line.

실측유량을 이용한 중랑천 갈수량 산정

권필상 ( Phil Sang Kwon ),신종규 ( Jong Kyu Shin ),조용철 ( Yong Chul Cho ),최경완 ( Kyung Wan Choi ),정우석 ( Woo Seok Jung ),이형진 ( Hyoung Jin Lee ),박수영 ( Soo Young Park ),류덕희 ( Duk Hee Ryoo ) 한국물환경학회 ( 구 한국수질보전학회 ) 2010 공동 추계학술발표회 Vol.2010 No.-

A case of multiple milia on the Labia major

Sang Gab Yoon,Sung Hwan Youn,Young Wook Lee,Suck Joon Jung,Na Reu Seung,Eun Ju Park,Hee Jin Cho,Kwang Ho Kim,Kwang Joong Kim 대한피부과학회 2009 대한피부과학회 학술발표대회집 Vol.61 No.1

Effects of Methanol Extract of Prosomillet on Cholesterol and Fatty Acid Metabolism in Rat

Sung-Hee Cho,Seung-Eun Jung,Hye-Kyung Lee,Tae-Youl Ha 한국식품영양과학회 1999 Preventive Nutrition and Food Science Vol.4 No.3

To study effects of methanol extract of prosomillet on lipid metbolism, five groups of male Sprague-Dawley rats weighing 116±9 g were fed test diets for four weeks. The five diets consisted of one low fat (5% w/w) diet containing starch as carbohydrate source (normal) and four high fat diets (15% w/w) containing 40.5% (w/w) sucrose (control) and additional 80% methanol extract of prosomillet at the levels of 0.3% and 1 % (w/w) or prosomillet powder at the level of 20% (w/w). Serum level of total cholesterol was a little higher but that of triglyceride was 41 % lower in 20% (w/w) prosomillet powder group than in the control group. The cholesterol levels of two groups fed methanol extract were not different from the control but their triglyceride levels tended to be reduced. Liver cholesterol levels were lower and phospholipid levels higher in all three prosomillet groups than the control but triglyceride level was significantly low only in the prosomillet powder group. Fecal excretion of bile acid was most increased in the prosomillet powder group among all five test groups. Activity of liver microsomal 3hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase was significantly lower in 0.3% methanol extract fed group than the control and also appeared to be reduced in 1 % extract fed one, whereas those of 20 cholesterol 7a-hydroxylase were not different among the five groups. Activities of liver cytosolic glucose-6-phosphate dehydrogenase (G6PDH) and malic enzyme were decreased in 0.3% prosomillet methanol extract and 20% powder groups. The results indicate that in addition to fiber, certain active components in prosomillet have potential to exert hypolipidemic effects via regulating hepatic cholesterogenesis and lipogenesis.

Outcome of Achilles Tendon Ruptures Treated by a Limited Open Technique

Jung, Hong Geun,Lee, Keun Bae,Cho, Sang Gwon,Yoon, Taek Rim SAGE Publications 2008 Foot & ankle international Vol.29 No.8

<P>BACKGROUND: The optimal surgical management of Achilles tendon ruptures remains a topic of active debate. Recently, many authors have preferred the limited open method because it afforded sufficient visualization to ensure anatomic apposition of disrupted tendon fibers, minimized local blood supply disturbances, guaranteed free tendon movement, and produced excellent cosmesis. We report our initial experience with this technique and review the literature. MATERIALS AND METHODS: The outcomes of 30 consecutive patients that underwent limited open repair for Achilles tendon rupture using Achillon (Newdeal SA, Lyon, France) from June 2003 to May 2006 were retrospectively reviewed. There were 20 men and 10 women, of average age 38.6 years, and the average followup period was 18.5 months. Twenty of the injuries were sports-related, eight were caused by a fall, and two by a laceration. The clinical results were assessed using patient satisfaction, the ankle-hindfoot scale of the American Orthopaedic Foot and Ankle Society (AOFAS), and the occurrence of complications. RESULTS: At last followup, sixteen patients were very satisfied, 11 were satisfied, and the remaining three were dissatisfied. Mean patient AOFAS score was 93.0 points. Surgical complications noted were re-rupture in two cases, deep infection in one, and sural nerve injury in one. All patients except the three patients with a re-rupture or infection, returned to work 2 months postoperatively and resumed light exercise at 3 months, and previous sporting activities by 6 months. CONCLUSION: The described limited open repair technique for Achilles tendon ruptures provided excellent cosmetic results, satisfactory functional results, and a high level of patient satisfaction.</P>

참다래 와인의 최적 malolactic fermentation 조건과 품질 특성

Sang-Dong Kang(강상동),Yu-Jin Ko(고유진),Eun-Jung Kim(김은정),Yong-Hwi Son(손용휘),Jin-Yong Kim(김진용),Hui-Gyeong Seol(설희경),Ig-Jo Kim(김익조),Hyoun-Kook Cho(조현국),Chung-Ho Ryu(류충호) 한국생명과학회 2011 생명과학회지 Vol.21 No.4

본 연구에서는 참다래를 이용하여 국내산 과실 특유의 강한 산미를 감소시켜 고품질 참다래 와인을 제조하기 위하여 MLF 에 의한 산도 및 malic acid 감소 효과를 연구하였다. MLF가 진행됨에 따라 모든 실험구에서 당도가 점차 감소하는 것으로 나타났으며 25℃에서 발효한 참다래 와인의 당도가 5.90 °Brix로 가장 낮게 나타났다. 총산함량은 발효 전 0.96%에서 발효 20일 후 0.75~0.79%로 모든 실험구에서 발효가 진행됨에 따라 총산 함량이 감소하였으나 발효 온도에 따른 유의적 차이는 없었다. 참다래 와인의 malic acid 함량은 MLF가 진행됨에 따라 감소하였으며 25℃에서 발효시킬 경우 0.05 ㎎/㎖로 가장 낮게 나타났다. 참다래 와인의 초기 pH에 따른 malic acid 함량 변화를 확인한 결과 pH 2.5 실험구에서는 큰 변화를 보이지 않았으며, pH 4.5에서는 발효 완료 시 0.55 ㎎/㎖로 검출되어 약 85% 감소하였다. 또한 초기 pH 3.5로 조절한 실험구는 발효기간이 경과함에 따라 malic acid함량이 급격히 감소하여 발효 완료시 매우 낮게 나타났다. MLF에 의한 malic acid와 lactic acid 함량을 조사한 결과 O. oeni를 첨가하여 MLF를 실시한 실험구의 malic acid는 급격히 감소하여 14일 후에 0.08 ㎎/㎖로 나타났으며 lactic acid의 함량은 점점 증가하여 발효 16일에 3.15 ㎎/㎖로 나타났다. 초기 pH를 3.5로 조절하고 25℃에서 15일간 발효시킨 참다래 와인의 품질특성을 조사한 결과 총산 함량은 0.78%로 대조구의 0.96%보다 다소 낮게 나타났으며 pH는 3.70로 MLF를 실시하지 않은 대조구의 3.45 보다 높게 나타났다. 또한 알코올 함량은 12.75%, 총당 38.72 ㎎/㎖, 총폴리페놀 60.18 ㎎/㎖로 대부분 큰 차이는 보이지 않았다. Oxalic acid는 0.69 ㎎/㎖로 대조구와 유사하게 나타났으며 강한 신맛을 내는 malic acid는 대조구에 비해 크게 감소하여 0.06 ㎎/㎖로 나타났다. 반면 lactic acid는 대조구보다 4.5배 많은 3.12 ㎎/㎖로 나타났고 citric acid는 대조구와 유사한 0.26 ㎎/㎖로 나타났다. 관능평가 결과 MLF를 실시한 와인이 대조구 와인에 비해 떫은맛을 제외한 모든 부분에서 우수한 것으로 나타났으며, 특히 신맛과 전체적 기호도에서 3.8±0.5와 3.9±04로 대조구의 3.5±0.6과 3.5±0.5보다 높게 나타났다. 결과적으로 고품질의 참다래 와인을 제조하기 위한 MLF의 최적 조건은 초기pH 3.5로 조절한 후 MLF 균주인 O. oeni (1×10? CFU/㎖)를 첨가하여 25℃에서 발효시키는 것이 가장 적합할 것으로 생각된다. Maloactic fermentation (MLF) occurs after completion of alcoholic fermentation and is mediated by lactic acid bacteria (LAB), mainly Oenococcus oeni. Kiwi wine more than commercial grape wine has the problem of high acidity. Therefore, we investigated the optimal MLF conditions for regulating strong acidity and improving the quality properties of wine fermented with Kiwi fruit cultivated in Korea. For alcohol fermentation, industrial wine yeast Saccharomyces cerevisiae KCCM 12650 strains and LAB, known as MLF strains, were used to alleviate wine acidity. First, the various experimental conditions of Kiwi fruit, initial pH (2.5, 3.5, 4.5), fermenting temperature (20, 25, 30℃), and sugar contents (24 °Brix), were adjusted, and after the fermentation period, we measured the acidity, pH, and the change in organic acid content by the AOAC method and HPLC analysis. The alcohol content of fermented Kiwi wine was 12.75%. Further, total acidity and pH of Kiwi wine were 0.78% and 3.5, respectively. Total sugar and total polyphenol contents of Kiwi wine were 38.72 ㎎/㎖ and 60.18 ㎎/㎖, respectively. With regard to organic acid content, the control contained 0.63 ㎎/㎖ of oxalic acid, 2.99 ㎎/㎖ of malic acid, and 0.71 ㎎/㎖ of lactic acid, whereas MLF wine contained 0.69 ㎎/㎖ of oxalic acid, 0.06 ㎎/㎖ of malic acid, and 3.12 ㎎/㎖ of lactic acid. Kiwi wine had lower malic acid values and total acidity than control after MLF processing. In MLF, the optimum initial pH value and fermentation temperature were 3.5 and 25℃, respectively. Therefore, these studies suggest that establishment of optimal MLF conditions could improve the properties of Kiwi wine manufactured in Korea.

Superior Electrical-Optical Properties of Organic Light-Emitting Diodes through Applying Embedded Interlayers

Sang-Geon Park(박상건),Ji-Yun Lee(이지윤),Cho-Rong Ju(주초롱),San Kim(김산),Seung-Yeol Lee(이승열),Jung-Ju Lee(이정주),Seung-Ro Lee(이승노),Yoon-Su Hwang(황윤수),Hyeog-Ju Kim(김혁주),Kyung-Won Seo(서경원),Ho-Joon Park(박호준),Su-Kan 대한전기학회 2015 대한전기학회 학술대회 논문집 Vol.2015 No.10

Medical Care Utilization During 1 Year Prior to Death in Suicides Motivated by Physical Illnesses

Cho, Jaelim,Lee, Won Joon,Moon, Ki Tae,Suh, Mina,Sohn, Jungwoo,Ha, Kyoung Hwa,Kim, Changsoo,Shin, Dong Chun,Jung, Sang Hyuk The Korean Society for Preventive Medicine 2013 예방의학회지 Vol.46 No.3

Objectives: Many epidemiological studies have suggested that a variety of medical illnesses are associated with suicide. Investigating the time-varying pattern of medical care utilization prior to death in suicides motivated by physical illnesses would be helpful for developing suicide prevention programs for patients with physical illnesses. Methods: Suicides motivated by physical illnesses were identified by the investigator's note from the National Police Agency, which was linked to the data from the Health Insurance Review and Assessment. We investigated the time-varying patterns of medical care utilization during 1 year prior to suicide using repeated-measures data analysis after adjustment for age, gender, area of residence, and socioeconomic status. Results: Among 1994 suicides for physical illness, 1893 (94.9%) suicides contacted any medical care services and 445 (22.3%) suicides contacted mental health care during 1 year prior to suicide. The number of medical care visits and individual medical expenditures increased as the date of suicide approached (p<0.001). The number of medical care visits for psychiatric disorders prior to suicide significantly increased only in 40- to 64-year-old men (p=0.002), women <40 years old (p=0.011) and women 40 to 64 years old (p= 0.021) after adjustment for residence, socioeconomic status, and morbidity. Conclusions: Most of the suicides motivated by physical illnesses contacted medical care during 1 year prior to suicide, but many of them did not undergo psychiatric evaluation. This underscores the need for programs to provide psychosocial support to patients with physical illnesses.

A Cell Assembler for VTOA ( Voice and Telephony over ATM )

Sung Rae Cho,Sung Jae Lee,Jung Sik Kim 대한전자공학회 1996 ITC-CSCC :International Technical Conference on Ci Vol.- No.-

Streamlining Disaster Information Management for Reducing Impact of Natural Disasters

Jung-Pyo Seo,Won-Cheol Cho,Tae Sung Cheong 한국방재학회 2016 Journal of Disaster Management Vol.1 No.2

To elevate for disaster prevention, this paper assumes extreme importance for preventive, application-driven, and efficient disaster prevention information management for reducing impact of natural disasters. It analyzes and discusses the task from three different perspectives: content, process and circumstances. The content perspective includes i) disaster prevention information network infrastructure, ii) deployment of urban and rural disaster prevention systems and iii) information concurrency and coexistence. The process perspective includes i) application of ICT technologies, ii) enhancement of disaster prevention data collection and analysis capabilities, iii) improved decision-making and onsite command structures and iv) acceleration of recovery system informatization. The circumstances perspective includes i) disaster-information-related laws and acts, ii) definition of disaster prevention tasks, iii) improved situation assessment capability, iv) consolidation and feedback and v) the role of the media. Achieving efficient disaster prevention information management by satisfying the requirements will contribute greatly to reducing the impact of natural disasters.