http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Wei-Che Lin,Wen-Chieh Chen,Pei-Wen Wang,Yi-Chia Chan,Yen-Hsiang Chang,Harn-Shen Chen,Szu-Tah Chen,Wei-Chih Chen,Kai-Lun Cheng,Shun-Yu Chi,Pi-Ling Chiang,Chen-Kai Chou,Feng-Fu Chou,Shun-Chen Huang,Feng 대한초음파의학회 2023 ULTRASONOGRAPHY Vol.42 No.3
Radiofrequency ablation (RFA) is a minimally invasive management strategy that has been widely applied for benign and recurrent malignant thyroid lesions as an alternative to surgery in Taiwan. Members of academic societies for specialists in interventional radiology, endocrinology, and endocrine surgery collaborated to develop the first consensus regarding thyroid RFA in Taiwan. The modified Delphi method was used to reach a consensus. Based on a comprehensive review of recent and valuable literature and expert opinions, the recommendations included indications, pre-procedural evaluations, procedural techniques, post-procedural monitoring, efficacy, and safety, providing a comprehensive review of the application of RFA. The consensus effectively consolidates advice regarding thyroid RFA in clinical practice for local experts.
Scene Reconstruction using a Pan-Tilt-Zoom Camera with a Moving Spherical Mirror
Chen-Yu Huang,Chieh-Chih Wang 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
3D scene reconstruction from 2D images can serve as a foundation for solving a number of robotics and computer vision problems such as robot navigation and 3D object recognition in which covering a large field of view could be critical. As conventional cameras have limited fields of view, we propose an approach to reconstruct large 3D scene models using a combination of a pan-tilt-zoom (PTZ) camera and a moving spherical mirror. The proposed system provides uncertainty estimates of the scene model. The uncertainty of moving spherical mirror detection and localization is represented using samples. Two images are used to computed a location measurement of a 3D point in the scene in which the combinations of the sample sets of the two mirror locations are exploited and location measurements of 3D points are represented using Gaussian distributions. Localization of 3D points in the scene is done using a Kalman filter. The experimental results demonstrate the feasibility of the proposed system.
Tazarotene-Induced Gene 1 Interacts with DNAJC8 and Regulates Glycolysis in Cervical Cancer Cells
Wang, Chun-Hua,Shyu, Rong-Yaun,Wu, Chang-Chieh,Chen, Mao-Liang,Lee, Ming-Cheng,Lin, Yi-Yin,Wang, Lu-Kai,Jiang, Shun-Yuan,Tsai, Fu-Ming Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.6
The tazarotene-induced gene 1 (TIG1) protein is a retinoidinducible growth regulator and is considered a tumor suppressor. Here, we show that DnaJ heat shock protein family member C8 (DNAJC8) is a TIG1 target that regulates glycolysis. Ectopic DNAJC8 expression induced the translocation of pyruvate kinase M2 (PKM2) into the nucleus, subsequently inducing glucose transporter 1 (GLUT1) expression to promote glucose uptake. Silencing either DNAJC8 or PKM2 alleviated the upregulation of GLUT1 expression and glucose uptake induced by ectopic DNAJC8 expression. TIG1 interacted with DNAJC8 in the cytosol, and this interaction completely blocked DNAJC8-mediated PKM2 translocation and inhibited glucose uptake. Furthermore, increased glycose uptake was observed in cells in which TIG1 was silenced. In conclusion, TIG1 acts as a pivotal repressor of DNAJC8 to enhance glucose uptake by partially regulating PKM2 translocation.
Wang Hui-Ching,Moi Sin-Hua,Chan Leong-Perng,Wu Chun-Chieh,Du Jeng-Shiun,Liu Pei-Lin,Chou Meng-Chun,Wu Che-Wei,Huang Chih-Jen,Hsiao Hui-Hua,Pan Mei-Ren,Chen Li-Tzong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Personalized genetic profiling has focused on improving treatment efficacy and predicting risk stratification by identifying mutated genes and selecting targeted agents according to genetic testing. Therefore, we evaluated the role of genetic profiling and tumor mutation burden (TMB) using next-generation sequencing in patients with head and neck squamous cell carcinoma (HNSC). The relapse mutation signature (RMS) and chromatin remodeling mutation signature (CRMS) were explored to predict the risk of relapse in patients with HNSC treated with concurrent chemoradiotherapy (CCRT) with platinum-based chemotherapy. Patients in the high RMS and CRMS groups showed significantly shorter relapse-free survival than those in the low RMS and CRMS groups, respectively (p < 0.001 and p = 0.006). Multivariate Cox regression analysis showed that extranodal extension, CCRT response, and three somatic mutation profiles (TMB, RMS, and CRMS) were independent risk predictors for HNSC relapse. The predictive nomogram showed satisfactory performance in predicting relapse-free survival in patients with HNSC treated with CCRT.
Tazarotene-Induced Gene 1 Interacts with DNAJC8 and Regulates Glycolysis in Cervical Cancer Cells
Chun-Hua Wang,Rong-Yaun Shyu,Chang-Chieh Wu,Mao-Liang Chen,Ming-Cheng Lee,Yi-Yin Lin,Lu-Kai Wang,Shun-Yuan Jiang,Fu-Ming Tsai 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.6
The tazarotene-induced gene 1 (TIG1) protein is a retinoid-inducible growth regulator and is considered a tumor suppressor. Here, we show that DnaJ heat shock protein family member C8 (DNAJC8) is a TIG1 target that regulates glycolysis. Ectopic DNAJC8 expression induced the translocation of pyruvate kinase M2 (PKM2) into the nucleus, subsequently inducing glucose transporter 1 (GLUT1) expression to promote glucose uptake. Silencing either DNAJC8 or PKM2 alleviated the upregulation of GLUT1 expression and glucose uptake induced by ectopic DNAJC8 expression. TIG1 interacted with DNAJC8 in the cytosol, and this interaction completely blocked DNAJC8-mediated PKM2 translocation and inhibited glucose uptake. Furthermore, increased glycose uptake was observed in cells in which TIG1 was silenced. In conclusion, TIG1 acts as a pivotal repressor of DNAJC8 to enhance glucose uptake by partially regulating PKM2 translocation.
Cheng-Shang Lee,Chun-Chieh Wu,Tai-Chi Chen Wang,Russell L. Elsberry 한국기상학회 2011 Asia-Pacific Journal of Atmospheric Sciences Vol.47 No.3
Typhoon Morakot (2009) produced 2855 mm of rain and was the deadliest typhoon to impact Taiwan with 619 deaths and 76missing persons, including a landslide that wiped out an entire village. While Morakot did not exceed the heaviest 24-h rain record,the combination of heavy rain and long duration that led to the record accumulation is attributed to the southwest summer monsoon influence on the typhoon. Thus, a special combination of factors was involved in the Morakot disaster: (i) Strong southwesterly monsoon winds; (ii) Convergence between the typhoon circulation and monsoon flow to form an east-west oriented convective band over the Taiwan Strait that was quasi-stationary and long-lasting; (iii) A typhoon in a specific location relative to the Central Mountain Range and moving slowly; and (iv) Steep topography that provided rapid lifting of the moist air stream. The contributions of each of these four factors in leading to the Morakot disaster are reviewed primarily based on new research presented at the International Conference on Typhoon Morakot (2009). Historical data sets, new Doppler radar observations, and numerical modeling have advanced the understanding of the special conditions of monsoon-influenced typhoons such as Morakot. This research is also leading to modifications of existing and development of new forecasting tools. Gaps in scientific understanding, limits to the predictability, and requirements for advanced forecast guidance tools are described that are challenges to improved warnings of these extreme precipitation and flooding events in monsoon-influenced typhoons.
Ting-Yu Hu,Chieh Wang,Kai-Chieh Yang,Li-Jen Chen 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.106 No.-
Ring-like residual deposits are often observed after drying suspension droplets on surfaces. That introducesa crucial defect in practical applications, such as ink-jet printing that requires a uniform deposit. In this study, depositions after drying sessile/pendant droplets with silica/polystyrene particles wereexamined to identify the effect of gravitational sedimentation of particles on self-pinning and depositionpattern. The suspension droplet with larger polystyrene (or silica) particles would trigger the self-pinningat larger (or smaller) particle concentrations. The deposition pattern of pendant drops with silica particlesis hill-like. This is due to the large density difference between silica and water to induce high sedimentationvelocity, and the particles would precipitate and aggregate along the air–liquid interface to form ahollow shell deposit. The depositions for suspensions with bi-dispersed particles, the larger silica particleswould accumulate at the bottom of the deposit due to the higher sedimentation velocity, in contrastto the well-mixed in the deposits for bi-dispersed polystyrene particles. The sedimentation and capillaryflow velocities were calculated and discussed. These new findings reveal that the particle density (gravityeffect) can be used to adjust the sedimentation velocity to control the deposition morphology and particlesize distribution even to suppress the coffee-ring effect.
Huan-Kan Tseng,Chieh-Chen Wang,Jung-Cheng Chen,Hui-Chieh Li,Chuan-Chung Hsieh 한국교육개발원 2022 KEDI Journal of Educational Policy Vol.19 No.1
The purpose of this qualitative study is to present and shape successful indigenous school principal leadership in Taiwan. We focus particularly on a principal’s attitudes to change, how this influences principal leadership practice and ultimately its contribution to improving school performance. The study captures and analyzes opinions of the stakeholders of an indigenous school on principal leadership to understand how the principal leads the school to successful transformation. The results show that indigenous principal leadership emphasizes harmonious collective relationships, equality of power, spiritual satisfaction and collectivism. The ancestral soul is especially rooted in the principal’s philosophy and values, such that the principal makes good use of the blood ties between schools and tribes, and creates a community of a shared future, facing difficulties together. The findings contribute to the body of knowledge on shaping successful indigenous school principal leadership, which transforms the internal and external environmental factors into the forces for successful school change and benefits the stakeholders.
Tazarotene-Induced Gene 1 Enhanced Cervical Cell Autophagy through Transmembrane Protein 192
Shyu, Rong-Yaun,Wang, Chun-Hua,Wu, Chang-Chieh,Chen, Mao-Liang,Lee, Ming-Cheng,Wang, Lu-Kai,Jiang, Shun-Yuan,Tsai, Fu-Ming Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.12
Tazarotene-induced gene 1 (TIG1) is a retinoic acid-inducible protein that is considered a putative tumor suppressor. The expression of TIG1 is decreased in malignant prostate carcinoma or poorly differentiated colorectal adenocarcinoma, but TIG1 is present in benign or well-differentiated tumors. Ectopic TIG1 expression led to suppression of growth in cancer cells. However, the function of TIG1 in cell differentiation is still unknown. Using a yeast two-hybrid system, we found that transmembrane protein 192 (TMEM192) interacted with TIG1. We also found that both TIG1A and TIG1B isoforms interacted and co-localized with TMEM192 in HtTA cervical cancer cells. The expression of TIG1 induced the expression of autophagy-related proteins, including Beclin-1 and LC-3B. The silencing of TMEM192 reduced the TIG1-mediated upregulation of autophagic activity. Furthermore, silencing of either TIG1 or TMEM192 led to alleviation of the upregulation of autophagy induced by all-trans retinoic acid. Our results demonstrate that the expression of TIG1 leads to cell autophagy through TMEM192. Our study also suggests that TIG1 and TMEM192 play an important role in the all-trans retinoic acid-mediated upregulation of autophagic activity.