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Aspergillus sensitization associated with current asthma in children: NHANES 2005-2006
Wen Hui-Ju,Wang Shu-Li,Li Ming-Chieh,Guo Yue Leon 한국역학회 2022 Epidemiology and Health Vol.44 No.-
OBJECTIVES: To investigate the association between allergen sensitization and current asthma in children from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. METHODS: Children from the NHANES 2005-2006, aged 6 to 19 years, were included in this study. A structured questionnaire was used to assess asthma status, including without asthma, asthma in remission, and current asthma. Nineteen specific IgE (sIgE) levels were measured using the Pharmacia Diagnostics ImmunoCAP 1000 System (Kalamazoo, Michigan, USA). A machine-learning method was applied to select important sIgEs related to childhood asthma. Multivariate regression analysis was used to test this hypothesis. RESULTS: A total of 2,875 children were recruited. The prevalence of ever having asthma and current asthma was, 16.5% and 5.6%, respectively. Six specific IgE levels were found to contribute to asthma using bootstrap forest selection. After adjusting for child’s sex, age, and family income, children with the double of sIgE levels of Dermatophagoides farinae, dog, and Aspergillus were related to current asthma, as compared to children without asthma [odds ratio (95% confident interval)= 1.11 (1.04-1.19), 1.30 (1.16-1.46), and 1.54 (1.38-1.72), respectively]. CONCLUSIONS: Our findings suggested that allergen sensitization, especially to Aspergillus, is associated with current asthma in children. Strategies to reduce sensitization may help prevent and manage asthma.
Wang Hui-Ching,Moi Sin-Hua,Chan Leong-Perng,Wu Chun-Chieh,Du Jeng-Shiun,Liu Pei-Lin,Chou Meng-Chun,Wu Che-Wei,Huang Chih-Jen,Hsiao Hui-Hua,Pan Mei-Ren,Chen Li-Tzong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Personalized genetic profiling has focused on improving treatment efficacy and predicting risk stratification by identifying mutated genes and selecting targeted agents according to genetic testing. Therefore, we evaluated the role of genetic profiling and tumor mutation burden (TMB) using next-generation sequencing in patients with head and neck squamous cell carcinoma (HNSC). The relapse mutation signature (RMS) and chromatin remodeling mutation signature (CRMS) were explored to predict the risk of relapse in patients with HNSC treated with concurrent chemoradiotherapy (CCRT) with platinum-based chemotherapy. Patients in the high RMS and CRMS groups showed significantly shorter relapse-free survival than those in the low RMS and CRMS groups, respectively (p < 0.001 and p = 0.006). Multivariate Cox regression analysis showed that extranodal extension, CCRT response, and three somatic mutation profiles (TMB, RMS, and CRMS) were independent risk predictors for HNSC relapse. The predictive nomogram showed satisfactory performance in predicting relapse-free survival in patients with HNSC treated with CCRT.
Huan-Kan Tseng,Chieh-Chen Wang,Jung-Cheng Chen,Hui-Chieh Li,Chuan-Chung Hsieh 한국교육개발원 2022 KEDI Journal of Educational Policy Vol.19 No.1
The purpose of this qualitative study is to present and shape successful indigenous school principal leadership in Taiwan. We focus particularly on a principal’s attitudes to change, how this influences principal leadership practice and ultimately its contribution to improving school performance. The study captures and analyzes opinions of the stakeholders of an indigenous school on principal leadership to understand how the principal leads the school to successful transformation. The results show that indigenous principal leadership emphasizes harmonious collective relationships, equality of power, spiritual satisfaction and collectivism. The ancestral soul is especially rooted in the principal’s philosophy and values, such that the principal makes good use of the blood ties between schools and tribes, and creates a community of a shared future, facing difficulties together. The findings contribute to the body of knowledge on shaping successful indigenous school principal leadership, which transforms the internal and external environmental factors into the forces for successful school change and benefits the stakeholders.
Chuan-Chung Hsieh,Imam Gunawan,Hui-Chieh Li 한국교육개발원 2023 KEDI Journal of Educational Policy Vol.20 No.1
This study aimed to examine the mediating effects of teacher professional community on the relationship between perceived instructional leadership and teacher self-efficacy of online teaching in Taiwan. Data were collected from elementary and middle school teachers via an online survey using a questionnaire designed with well-developed scales. Analysis showed that perceived instructional leadership has no direct effect on teacher self-efficacy and that teacher professional community mediates fully the relationship between perceived instructional leadership and teacher self-efficacy. Among the four teacher professional community components examined, shared norms showed the most significant mediating effect. Results also revealed no significant difference in the relationships between variables across teachers in elementary and middle schools. Implications for school leadership and teacher learning are discussed.
Ta-Hsin Chou,Kuei-Yuan Cheng,Chih-Chieh Su,Tien-Li Chang,Chih-Wei Hsieh,Jen-Hui Tsai 한국정밀공학회 2010 International Journal of Precision Engineering and Vol.11 No.4
The transparent conducting oxide (TCO) film is a significant component in flat panel display industry, applied for flexible display, e-paper, and touch panel. The TCO materials have high refractive index, so the phenomenon of high reflectance is the major issue and needs solved in present and future market. In this study, the structure and process of new lower reflection TCO hybrid film is introduced. The laser interference lithography and UV nanoimprint are combined for fabrication of sub-wavelength structures on PET film, then the tin-doped indium oxide (ITO) deposited on structures. Finally, the best result of this hybrid film is reflectance reduced to 3.3% at wavelength 550nm, just 13% of the original film, and the resistance of ITO layer is 1.05x10-3 Ω-cm. This result is useful for the TCO film applied in low reflection demand products in the future.
Chuan-Chung Hsieh,Si-Hsien Lin,Hui-Chieh Li 한국교육개발원 2022 KEDI Journal of Educational Policy Vol.19 No.1
This study explores the impact of principals’ spiritual leadership on teachers’ organizational commitment (OC) and psychological capital (PsyCap) in a high-school environment. We tested the conceptual model using structural equation modeling (SEM) of data collected from a sample of 803 high-school teachers in Taiwan. The results revealed that principals’ spiritual leadership had significant and positive impact on teachers’ PsyCap and that teachers’ PsyCap enhanced their OC. However, principals’ spiritual leadership had no direct effect on teachers’ OC. Teachers’ PsyCap was found to mediate fully the impact of principals’ spiritual leadership on OC. Discussion and implications of the results are presented.