악하선 암의 치료성적과 예후인자

임치영(Chi Young Lim),남기현(Kee Hyun Nam),이잔디(Jan Dee Lee),장항석(Hang Seok Chang),정웅윤(Woong Youn Chung),차인호(In Ho Cha),이창걸(Chang Geol Lee),최은창(Eun Chan Choi),박정수(Cheong Soo Park) 대한두경부종양학회 2005 대한두경부 종양학회지 Vol.21 No.2

Purpose: Submandibular gland tumor is rare, less than 6% of head and neck tumor. The purpose of this article is to analysis the clinical experience and treatment outcomes of malignant submandibular gland tumor, suggesting a guideline of management. Methods: We retrospectively evaluated 26 patients who underwent operation for malignant submandibular gland tumor at Severence hospital between 1986 and 2004. Statistical analysis was performed by Kaplan-Meier method, log rank test, Chi-square test, Fisher's exact test using SPSS v12.0 for Windows. Results: They consisted of 18 males and 8 females whose median age was 47 years(range: 20-71). 10 cases of adenocystic carcinoma, 8 cases of carcinoma ex pleomorphic adenoma, 4 cases of mucoepidermoid carcinoma, 1 case each for acinic cell carcinoma, undifferentiated carcinoma, adeno carcinoma, epithelioid hemangioendothelioma. Sialoadenectomy only was performed in 10 cases(36.5%) and sialoadenectomy with neck node dissection was performed in 16 cases(63.5%). Adjuvant radiotherapy was done in 22 cases(84.6%). 10 year disease free survival rate for malignant submandibular gland tumor was 63.1 % and 10 year overall survival rate for malignant submandibular gland tumor was 70.1%. In univariate analysis, prognostic factors affecting recurrence of malignant submandibular gland tumor was initially papable lateral neck node in physical examination and metastasis of lateral neck node in pathologic confirmation. The prognostic factors affecting survival of malignant submandibular gland tumor was tumor size, TNM stage, recurrence and type of recurrence. Conclusion: In this study, prognostic factors affecting recurrence of malignant submandibular gland tumor was initially papable lateral neck node in physical examination and metastasis of lateral neck node in pathologic confirmation. The prognostic factors affecting survival of malignant submandibular gland tumor was tumor size, TNM stage, recurrence and type of recurrence. To prevent recurrence and to improve survival, early diagnosis and aggressive surgery must be considered.

Variation of Bird community and Habitat use after Developing Hangang river Ecological Learning Center

Paik, In-Hwan,Jin, Seon-Deok,Jeon, Byung-Seon,Yu, Jae-Pyoung,Park, Chi-Young,Paek, Woon-Kee national science museum of korea 2010 Journal of Korean nature Vol.3 No.4

The Hangang (Han River) Ecological Learning Center is a river ecosystem park which was completed in December of 2002. The river ecosystem park was created based on the understanding of the problems of standard park-formed river which centers around convenient facilities instead of on the wish to accentuate the innate unique characteristics of a river. Therefore, the study was conducted in order to analyze the changes and habitation usage of the avifauna in the Hangang Ecological Learning Center to provide basic information for the improvement of bird species diversity in an ecosystem park. The study was conducted in July and October of both 2003 and 2005 to study the avian colonies of the same time period, and the habitat usage of four different areas were examined. Main dominant species includes species which preferred waterside and grassland, and 2005 showed higher levels of species, bird count and number of migratory birds. Furthermore, among the four regions used as habitats, the confluence region showed the highest level of increase, and this is predicted to have caused by the shallow depth of the confluence and the stability of the waterside plant colonies.

혼합형 자가면역성용혈성빈혈과 동반된 Evans 증후군 1례

선길홍,윤찬영,박상곤,박경희,우정주,한경택,김진화,김영훈,정춘해,박치영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Evans syndrome is defined as a simultaneous or sequential occurrence of autoimmune hemolytic anemia and autoimmune thrombocytopenia. Autoimmune hemolytic anemia (AIHA) is usually induced by IgG warm autoantibody or cold-active IgM antibodies reacting specifically with antigens associated with a patient's RBC. AIHA is a fairly uncommon disorder, with estimates of the incidence at 1 to 3 cases per 100,000 per year. Mixed-type AIHA is a relatively uncommon form of AIHA, with studies noting the incidence of 7-8% among cases of AIHA. We experienced a patient, 46-year-old woman who was diagnosed having a very rare clinical presentation of mixed warm and cold antibody mediated Evans syndrome. She was treated with corticosteroid therapy only and has been maintaining a complete response for 15 weeks. 저자들은 혼합형의 자가면역성 용혈성 빈혈과 자가면역성 혈소판 감소증이 동시에 발생한 혼합형 Evans 증후군으로 진단하고 스테로이드 요법 후 혈액학적으로 회복된 상태로 15주가 지난 현재 steroid 5 mg/일 까지 감량한 상태에서 추적 관찰 치료중인 46세 여자 환자를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

von Willebrand's diseasee 1예

박치영,모성환,문철호,곽재정,김태종,전용준,박유환,정춘해 조선의대 1995 The Medical Journal of Chosun University Vol.20 No.2

암성통증의 약물적 치료

박치영 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S

평창 지역 상업의 발전과정에 관한 연구

박치영 관동대학교 기업경영연구소 2004 경영논집 Vol.22 No.-

생산자와 소비자 간에 재화와 서비스를 원활히 유통시키는 행위를 상업이라 하고, 원래 상업은 생산자와 소비자의 욕구를 충족시켜주는 매매업을 말하였다. 협의 상업은 매매업을 의미하지만, 광의의 상업은 보조적 상업인 운송업, 보험업, 창고업, 통신업까지를 포함시킨다. 전술한 상업을 평창 지역을 중심으로 그 발달과정을 고찰한 결과 우리나라 타 지역의 상업 변천과정과 비슷한 추세로 장시를 중심으로 발달하였다. 특히 광복 후부터 시장장려정책의 계속적인 추진과 도로, 통신 등 사회간접자본의 확충으로 괄목할 만큼 신장되었다. 평창 지역은 산이 많아 청정 지역이지만 반면 시장들이 상대적으로 협소하기 때문에 지속인 지원과 성장정책이 필요하다.

상고생의 직업관 제고를 위한 효율적인 지도방안

朴稚英,李鍾根 관동대학교 경영경제연구소 2002 경영논집 Vol.21 No.-

태백지역 상업계고등학교 학생들의 직업관 제고를 위한 효율적인 지도방안을 모색하기 위하여 재학생과 재직교사들을 대상으로 설문조사 하여 국가와 사회가 요구하는 올바른 직업인을 양성하고 장래 직업인인 학생들이 자기의 능력과 적성에 맞는 직업을 선택하여 질 높은 삶을 영위하도록 하기 위한 방안을 제시하였다. 설문 분석 결과에 따른 제고방안을 고찰하면 먼저 건전한 직업관을 가지고 자신의 소질과 적성에 맞는 직업을 선택하도록 가치관 교육을 강화해 나가야 하며, 다음으로 수요자들의 요구와 관심에 부응하는 계획적이고 체계적인 교육과정을 설정, 교수 학습 모형을 개발 활용되어 져야 하고, 그리고 직업교육과 관련하여 개인적인 측면과 사회적인 측면에서 기초 능력 배양 및 인성교육, 가정교육도 이루어져야 한다. 더 나아가서 교사의 사기 진작, 지역사회와의 협력시스템 개발, 전문적인 산학협동 프로그램개발 등도 요망되는 것으로 분석되었다.

벌 자상에 의해 발생한 횡문근융해증과 급성신부전

박상곤,김영대,강지은,신정현,신병철,박차영,정춘해 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2

Rhabdomyolysis is a syndrome characterized by muscle necrosis and release of intracellular muscle constituents into the circulation. The spectrum of causes is quite broad and included disorders of traumatic, metabolic, infectious and toxic origin. However, rhabdomvolvsis and acute renal failure following bee sting is rare and its pathogenesis is not well known. We experienced a case of 63-year-old man with acute renal failure and rhabdomyolysis caused by bee sting. He was stung by bee on scalp and neck. Oliguria was developed within several hours. He has fully recovered after general supportive care including fluid therapy and diuretics. This case demonstrates that rhabdomvolysis with consequent acute renal failure are able to developed by bee sting.

한국인 주의력결핍 과잉행동장애와 도파민 D5 수용체 유전자 다형성의 관련성 : 가족기반 연구 및 환자-대조군 연구

박태원,김붕년,임명호,유희정,강대희,조수철,유일한,조은정,백소영,배치운,서영주 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.1

Objectives : Recent genetic studies have suggested a preferential transmission of the Dopamine D5 receptor gene (DRD5) 148bp marker allele. The aim of this study is to test the association between DRD5 and ADHD. Methods : 106 Korean children with ADHD and their parents were analyzed using the transmission disequilibrium test (TDT) and haplotype-based haplotype relative risk test (HHRR). And also the ADHD children were compared with 212 ageand gender matched normal controls. Results : We found the evidence for an association of short alleles of DRD5 dinucleotide repeat polymorphism in both Case-control and family based studyies. Additionally, we observed some evidence for biased transmission of allele 152 bp and 144 bp. Conclusion : Our results lend credence to the notion that the relationship between ADHD and DRD5 is complex. The number of cases and informative transmissions in our study were small, therefore it would be premature to make any conclusions Con-ceming the role of DRD5 in ADHD. Further work is needed to support these findings.

제조합균주 E. coli Ck1092가 생산하는 2,3-Dihydroxybiphenyl Dioxygenase의 정제 및 특성

박효남,김영수,김영창,김치경,임재윤 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.3

4-CB 분해균주인 Pseudomonas sp. P20으로부터 pcbC 유전자를 클로닝하여 얻은 E. coli CK1092로부터 2,3-DHBP dioxygenase을 분리, 정제하여 효소적 특성을 조사하였다. 효소의 정제는 acetone 침전, DEAE-Se-phadex A-25 ion exchange chromatography, preparative electrophoresis 방법으로 정제하였다. 2,3-DHBP dioxygenase의 분자량은 약 270 kDa으로 추정되며, SDS-PAGE에 의한 분자량은 34 kDa이였다. 따라서, 동일한 subunit 8개 존재하는 octamer로 추정된다. 이 효소는 2,3-DHBP에 대해 높은 기질특이성을 보였으며, 3-methylcatechol, 4-methylcatechol, 4-chlorocatechol에 대해서는 활성을 보이지 않았다. 2,3-DHBP에 대한 Km 값은 18 μM이였으며 30μM 이상의 기질농도에서 활성이 감소하였다. 효소활성의 최적 pH는 8.0이였으며, pH 7.0~10.0 범위에서는 안정하였고, 최적 활성 온도는 40~60℃이며, 60℃까지는 비교적 안정하였다. 또한, 이 효소는 Cu^2+, Fe^2+, Fe^3+ 이온들에 의하여 효소활성이 저해되었고, H_2O_2와 EDTA에 의해서도 활성이 저해되었으며, 10%의 유기용매에 의해서 안정화되지 않았다. 효소활성부위를 알아보기 위해 화학변형제를 처리해 본 결과 tryosine, tryptophan과 histidine이 효소활성에 관여할 것으로 추정된다. 2,3-DHBP dioxygenase was purified from E. coli CK1092 carrying the pcbC gene, which was cloned from 4-chlorobiphenyl-degrading Pseudomonas sp. P20. Purification of this enzyme was done by acetone precipitation, DEAE-Sephadex A-25 ion exchange chromatography, and preparative gel electrophoresis. The molecular weight of subunit was 34 kDa determined by SDS-PAGE, and that of native enzyme was about 270 kDa. It suggests that this enzyme consist of eight identical subunits. This enzyme was specifically active against only 2,3-DHBP as a substrate with 18 μM of Km value, but not catechol, 3-methylcatechol, 4-methylcatechol and 4-chlorocatechol. The optimal pH and temperature of 2,3-DHBP dioxygenase were pH 8.0 and 40~60℃. The enzyme was inhibited by Cu^2+, Fe^2+ and Fe^3+ ions, and was inactivated by H_2O_2 and EDTA. The lower concentrations of some organic solvents such as acetone and ethanol don't stabilize the activity of 2,3-DHBP dioxygenase. The enzyme was completely inactivated by adding the reagents such as N-bromosuccinimide, iodine and p-diazobenzene sulfonic acid.