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Chi, Hee-Jun,Park, Jun-Sang,Yoo, Chang-Seok,Kwak, Su-Jin,Son, Ho-Jeong,Kim, Seok-Gi,Sim, Chae-Hee,Lee, Kyeong-Ho,Koo, Deog-Bon The Korean Society for Reproductive Medicine 2020 Clinical and Experimental Reproductive Medicine Vol.47 No.4
Objective: This study investigated whether adding outer-well medium to inhibit osmotic changes in culture media in a dry-type incubator improved the clinical outcomes of in vitro fertilization-embryo transfer (IVF-ET) cycles. Methods: In culture dishes, the osmotic changes in media (20 µL)-covered oil with or without outer-well medium (humid or dry culture conditions, respectively) were compared after 3 days of incubation in a dry-type incubator. One-step (Origio) and G1/G2 (Vitrolife) media were used. Results: The osmotic changes in the dry culture condition (308 mOsm) were higher than in the humid culture conditions (285-290 mOsm) after 3 days of incubation. In day 3 IVF-ET cycles, although the pregnancy rate did not significantly differ between the dry (46.2%) and humid culture (51.0%) groups, the rates of abortion and ongoing pregnancy were significantly better in the humid culture group (1.5% and 49.5%, respectively) than in the dry culture group (8.3% and 37.8%, respectively, p<0.05). In day 5 IVF-ET cycles, the abortion rate was significantly lower in the humid culture group (2.2%) than in the dry culture group (25.0%, p<0.01), but no statistically significant difference was observed in the rates of clinical and ongoing pregnancy between the dry (50.0% and 25.0%, respectively) and humid culture groups (59.5% and 57.3%, respectively) because of the small number of cycles. Conclusion: Hyperosmotic changes in media occurred in a dry-type incubator by evaporation, although the medium was covered with oil. These osmotic changes were efficiently inhibited by supplementation of outer-well medium, which resulted in improved pregnancy outcomes.
Chae, Yoon‐,Jee,Lee, Kyeong‐,Ryoon,Noh, Chi‐,Kyung,Chong, Saeho,Kim, Dae‐,Duk,Shim, Chang‐,Koo,Chung, Suk‐,Jae Wiley Subscription Services, Inc., A Wiley Company 2012 Journal of Pharmaceutical Sciences Vol.101 No.3
<P><B>Abstract</B></P><P>The objectives of this study were to investigate the allele frequencies and linkage disequilibrium (LD) in the organic anion transporting polypeptide 1B3 (OATP1B3) in the Korean population and to examine the functional consequences. Using samples from 48 Koreans, direct sequencing was carried out to determine the allele frequencies and LD of OATP1B3 in a representative Korean population. Thirty‐six genetic variations in the transporter were found in Koreans; among them, five undocumented variations (i.e.,−6436G>C in the 5′‐upstream region, 26A>C and 586A>G in the protein coding region, and IVS6‐72A>T and IVS12‐80A>T in intron regions) were identified. In the upstream region, −5035G>A was found to have lowered gene expression, as determined by a reporter gene assay, suggesting that this variation reduces the expression of OATP1B3 in humans. The functional relevance of the genetic variations in the protein coding region was determined by an uptake study involving representative substrates in human embryonic kidney 293 cells expressing wild type or variant forms. Variations involving 699G>A showed a reduced uptake activity for testosterone, but not for estradiol 17β‐<SMALL>d</SMALL>‐glucuronide or methotrexate, indicating that the functional impact of the variations is substrate specific. Considering the kinetic relevance of OATP1B3, the functionally affected variations may be therapeutically important. © 2011 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:1302–1313, 2012</P>
매개변수 불확실성을 가지는 특이시스템의 강인 관측기 기반 $H_\infty$ 제어기 설계방법
김종해,안성준,안승준,오도창,지경구,Kim Jong-Hae,Ahn Seong-Joon,Ahn Seung-Joon,Oh Do-Chang,Chi Kyeong-Koo 대한전기학회 2005 전기학회논문지 D Vol.54 No.1
This paper considers a robust observer-based H/sub ∞/ controller design method for singular systems with parameter uncertainties using an LMI condition. The sufficient condition for the existence of controller and the controller design method are presented by a perfect LMI condition in terms of all variables using singular value decomposition, Schur complement, and change of variables. Therefore, one of the main advantages is that a robust observer-based H/sub ∞/ controller can be established by solving one LMI condition compared with existing results. Numerical example is given to illustrate the effectiveness of the proposed controller design method.