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안성훈,조명수,송재수,도진우,김종성,손인철 한국전통의학연구소 2002 한국전통의학지 Vol.12 No.1
This study was designed to investigate the location of Sin-Guel(CV_(8), 神闕) through literature research. We extracted the part about the location of Sin-Guel(CV_(8), 神闕) from ancient and modern oriental medical literature which were used commonly in clinic. The results were summarized as follows; 1. The location of Sin-Guel(CV_(8), 神闕) were generally recorded DangJeJung. 2. Sin-Guel(CV_(8), 神闕) placed in middle of linea alba. 3. Treatment effect of moxibustion on Sin-Guel(CV_(8), 神闕) were recorded as diarrhea, dropsy, prolapse of the anus, stomachache, paralysis etc.. 4. Acupuncture therapy on Sin-Guel(CV_(8), 神闕) is dangerous because of inflammation, it is suggested that acupuncture therapy may be possible if acupuncture therapy do not induce inflammation on Sin-Guel(CV_(8), 神闕).
Seong-Cheol Bang,Hyun-Hee Seo,Hye-Rim Shin,Ki-Cheul Lee,Le Tuan Anh Hoang,Sang-Hun Jung 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
The sugar structures of triterpenoid saponins, such as α-hederin, are intimately associated with their antitumor activities and other biological activities. The α-L-rhamnopyranosyl-(1→2)- α-L-arabinopyranoside group of α-hederin alters the cytotoxicity of its aglycon, hederagenin. This study explored the role of this saccharide unit in the cytotoxic effect of α-hederin and the possibility of its use as a carrier moiety in prodrugs of anticancer agents. A new convenient and practical procedure for the preparation of 4-methoxybenzoyl-2,3,4-tri-O-benzoyl-α-L-rhamnopyranosyl-( 1→2)-3,4-O-dibenzoyl-β-L-arabinopyranoside (2) from 4-methoxybenzoyl-β-Larabinopyranoside was accomplished using four steps with an overall yield of 63%. The use of BF3-OEt2 as a catalyst in the glycosylation step in this procedure had a large advantage over the TMSOTf catalyst used in the usual method. Moreover, the key intermediate obtained in this procedure, 4-methoxybenzoyl-2,3,4-tri-O-benzoyl-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside (7), was selectively transformed to 4-methoxybenzoyl-2,3,4-tri-O-benzoyl-α-L-rhamnopyranosyl-( 1→2)-4-O-acetyl-α-L-arabinopyranoside (9) and 4-methoxybenzoyl-2,3,4-tri-Obenzoyl- α-L-rhamnopyranosyl-(1→2)-3-O-benzoyl-β-L-arabinopyranoside (10). These derivatives did not show any cytotoxicity against human cancer cell lines. Thus the 3-O-α-L-rhamnopyranosyl-( 1→2)-α-L-arabinopyranoside could be used as a nontoxic carrier moiety to enhance the activity of anticancer drugs.
Bang, Seong-Cheol,Seo, Hyun-Hee,Shin, Hye-Rim,Lee, Ki-Cheul,Hoang, Le Tuan Anh,Jung, Sang-Hun 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
The sugar structures of triterpenoid saponins, such as $\alpha$-hederin, are intimately associated with their antitumor activities and other biological activities. The $\alpha$-L-rhamnopyranosyl-($1{\rightarrow}2$)-$\alpha$-L-arabinopyranoside group of $\alpha$-hederin alters the cytotoxicity of its aglycon, hederagenin. This study explored the role of this saccharide unit in the cytotoxic effect of $\alpha$-hederin and the possibility of its use as a carrier moiety in prodrugs of anticancer agents. A new convenient and practical procedure for the preparation of 4-methoxybenzoyl-2,3,4-tri-O-benzoyl-$\alpha$-L-rhamnopyranosyl-($1{\rightarrow}2$)-3,4-O-dibenzoyl-$\beta$-L-arabinopyranoside (2) from 4-methoxybenzoyl-$\beta$-Larabinopyranoside was accomplished using four steps with an overall yield of 63%. The use of $BF_3-OEt_2$ as a catalyst in the glycosylation step in this procedure had a large advantage over the TMSOTf catalyst used in the usual method. Moreover, the key intermediate obtained in this procedure, 4-methoxybenzoyl-2,3,4-tri-O-benzoyl-$\alpha$-L-rhamnopyranosyl-($1{\rightarrow}2$)-$\alpha$-L-arabinopyranoside (7), was selectively transformed to 4-methoxybenzoyl-2,3,4-tri-O-benzoyl-$\alpha$-L-rhamnopyranosyl-($1{\rightarrow}2$)-4-O-acetyl-$\alpha$-L-arabinopyranoside (9) and 4-methoxybenzoyl-2,3,4-tri-Obenzoyl-$\alpha$-L-rhamnopyranosyl-($1{\rightarrow}2$)-3-O-benzoyl-$\beta$-L-arabinopyranoside (10). These derivatives did not show any cytotoxicity against human cancer cell lines. Thus the 3-O-$\alpha$-L-rhamnopyranosyl-($1{\rightarrow}2$)-$\alpha$-L-arabinopyranoside could be used as a nontoxic carrier moiety to enhance the activity of anticancer drugs.
Synthesis of Water Soluble Analogs of Arylsulfonylimidazolidinone (JSH-2282)
Bang, Seong-Cheol,Lee, Ki-Cheul,Sharma, Vinay K.,Sharma, Niti,Yang, Hyun-Sun,Jung, Sang-Hun Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.7
To improve the water solubility of arylsulfonylimidazolidinone (JSH-2282), a potent anti-cancer agent, two urea derivatives, sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline-1-carbonyl)-phenyl)ureido)succinate (2a) and sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline-1-carbonyl)phenyl)ureido)pentanedioate (2b), were synthesized and studied for solubility and anti-cancer activity.
Bispectral Index 감시장치로 경막외마취의 진정효과를 평가할 수 있는가?
신병철,이혜원,신혜원,조헌,임혜자,윤석민,장성호 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.6
Background: Epidural anesthesia has been shown to a have direct sedative effect and to markedly reduce the amount of hypnotic agents required for sedation. A Bispectral Index (BIS) is a useful of the level of sedation and loss of consciousness for several anesthetics including propofol. In this study, we investigated whether BIS monitoring could detect the sedative effect of epidural anesthesia during propofol induction. Methods: Twenty patients scheduled for elective lower abdominal surgery were included. A Target controlled infusion (target effect concentration 5㎍/ml, induction time 3 min) of propofol was administered to the patients with or without epidural anesthesia (2% lidocaine 15 ml) at the L_2-3 level. The OAA/S scale and BIS were evaluated 20 min after epidural injection. Hypnotic requirements of propofol were determined using loss of eye opening in response to verbal command as an epidural. At the time of induction of hypnosis, the target concentration, target effect concentration and BIS were recorded. Results: Epidural lidocaine significantly decreased the hypnotic dose of propofol (1.0±0.2㎍/ml vs. 1.3±0.1㎍/ml; p=0.0008), hypnotic calculated concentration (3.3±0.6㎍/ml vs. 4.1±0.3㎍/ml; P=0.0007), and the hypnotic effect concentration (0.7±0.3㎍/ml vs. 1.1±0.1㎍/ml; P=0.0007). In the patients with epidural anesthesia, the OAA/S scale was decreased without a change of the BIS after epidural anesthesia and BIS recorded at the time of induction of hypnosis was much higher in patients with epidural anesthesia than in patients without in epidural anesthesia (92.7±2.2㎍/ml vs. 85.5±6.2㎍/ml; P=0.0029). Conclusions: Epidural anesthesia included a sedative effect without a change of the BIS and then induced the hypnosis with lesser dose of propofol. At the time of hypnosis, a higher BIS was noticed with epidural anesthesia. These results concluded that BIS monitoring could not detect the sedative effect induced with epidural anesthesia. (Korean J Anesthesiol 2002; 43: 698~703)
Evaluation of Anticancer Activity of 4-Vinyl-1-Arylsulfonylimidazolidinones
Kwak, Son-Hyok,Bang, Seong-Cheol,Seo, Hyun-Hee,Shin, Hye-Rim,Lee, Ki-Cheul,Hoang, Le Tuan Anh,Jung, Sang-Hun The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.9
To continue exploration of structure activity relationship of novel 1-(indoline-5-sulfonyl)-4-phenylimidazolidinones (1) reported as anticancer agent with broad spectrum, three 1-(arylsulfonyl)-4-vinylimidazolidinones (2) were synthesized from methyl serinate (3) in 8 steps. Reaction of intermediate 2-phenoxycarbonylaminobut-3-enyl p-toluenesulfonate (10) with arylsulfonamide in the presence of potassium carbonate produced corresponding 2 and N-(4-vinyloxazolidin-2-yl)arylsulfonamide 11 in approximately equal ratio. This reaction is believed to undergo through urea intermediate 16 as shown in scheme 3. 1-Arylsufonyl-4-vinylimidazolidinones 2 show much reduced activity against human colon carcinoma (Colo205), human chronic myelogenous leukemia (K562), and human ovarian adenocarcinoma (SK-OV-3) and compatible activity against human lung carcinoma (A549) compared to 1. Therefore phenyl at 4-position should be the optimum planar motif for the activity of 1.
고연석 ( Youn Seok Ko ),박상훈 ( Hun Sang Park ),이정한 ( Jung Han Lee ),차윤엽 ( Yun Yeop Cha ),정원석 ( Won Suk Chung ),신병철 ( Byung Cheul Shin ),전찬용 ( Chan Yong Jeon ),고호연 ( Ho Yeon Go ),선승호 ( Seong Ho Sun ),장보형 ( 한방재활의학과학회 2013 한방재활의학과학회지 Vol.23 No.2
Objectives :The purpose of this study is to analyze internal research trends of work-related musculoskeletal disorders(WMSDs) and provide problems of researches forward.Methods :6 Korean databases were searched for articles of WMSDs published from 2000 to 2012, and 264 research were systematic reviewed. An analytical method was used descriptive statistics, an actual number and percentage.Results :The results of distribution by year were reported more than 20 articles after 2004, and 45 articles in 2009. Industrial classification distribution of research subjects the manufacturing industry was many most at the 84. Research contents in most description were 147 whether it was risk factor and relation. Research design type of articles was most description survey research 226. In the research field 89 articles were reported to the journal related to technologies.Conclusions : It is considered to be necessary that ergonomic approach would cooperate with other approaches such as integrated health management system as well as industrial medicine considering psychosocial factors.