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Lee, Seong-Cheol,Bang, Du-Yeol,S. Chonan,H. Inooka 한국정밀공학회 1992 한국정밀공학회지 Vol. No.
This paper provides the end-point positioning of a single-link flexible robot arm by inverse dynamics. The system is composed of a flexible arm, the mobile ballscrew stage as an arm base, a DC servomotor as an actuator, and a computer. Actuator voltages required for the model of a flexible arm to follow a given tip trajectory are formulated on the basis of the Bermoullie-Euler beam theory and solved by applying the Laplace transform method, and computed by the numerical inversion method proposed by Weeks. The mobile stage as the arm base is shifted so that the end-point follows the desired trajectories. Then the trajectory of end-point is measured by the laser displacement sensor. Here, two kinds of functions are chosen for the given tip trajectories. One is what is called the bang-bang acceleration profile and the other is the Gaussian velocity profile.
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방성민,송왕철 濟州大學校 情報通信硏究所 2000 情報通信硏究所論文集 Vol.3 No.-
The networked environment has the possibility of the illegal access to the private informations and the attacks via networks. Therefore. security management technologies to protect networks from intrusions and network attacks have been given much attention. Intrusion detection system is an important component of the security management system for large network. It is hard to adapt to the heterogeneous internet environment because of the conventional intrusion detection system depends on the specific system environments. The new intrusion detection architecture with mobile agent technology is proposed in the paper. The mobile agent is an itinerary software program that autonomously runs on behalf of its operator in a network environment. It helps the adaptability in the intrusion detection system and decrease the network traffic. For the purpose. we analyze the attack patterns and design the new intrusion detection architecture.
김성훈,방중철 금오공과대학교 산업기술개발연구원 2001 産業技術開發硏究 Vol.17 No.-
The combustion process of diesel engine is very complex because there are many factors which have effects on it. The study on these factors is necessary in order to improve diesel combustion. So, the effects of intake air temperature, cavity geometry and fuel injection timing on combustion characteristics were investigated in this paper with the visualized diesel engine. When the intake air temperature was increased, it was proved that the point of ignition nuclei was fasten in plate type combustion chamber. Also, it was turned out that the most effective fuel injection timing in engine power was BTDC 22° CA.
Seong-Cheol Bang,Hyun-Hee Seo,Hye-Rim Shin,Ki-Cheul Lee,Le Tuan Anh Hoang,Sang-Hun Jung 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
The sugar structures of triterpenoid saponins, such as α-hederin, are intimately associated with their antitumor activities and other biological activities. The α-L-rhamnopyranosyl-(1→2)- α-L-arabinopyranoside group of α-hederin alters the cytotoxicity of its aglycon, hederagenin. This study explored the role of this saccharide unit in the cytotoxic effect of α-hederin and the possibility of its use as a carrier moiety in prodrugs of anticancer agents. A new convenient and practical procedure for the preparation of 4-methoxybenzoyl-2,3,4-tri-O-benzoyl-α-L-rhamnopyranosyl-( 1→2)-3,4-O-dibenzoyl-β-L-arabinopyranoside (2) from 4-methoxybenzoyl-β-Larabinopyranoside was accomplished using four steps with an overall yield of 63%. The use of BF3-OEt2 as a catalyst in the glycosylation step in this procedure had a large advantage over the TMSOTf catalyst used in the usual method. Moreover, the key intermediate obtained in this procedure, 4-methoxybenzoyl-2,3,4-tri-O-benzoyl-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside (7), was selectively transformed to 4-methoxybenzoyl-2,3,4-tri-O-benzoyl-α-L-rhamnopyranosyl-( 1→2)-4-O-acetyl-α-L-arabinopyranoside (9) and 4-methoxybenzoyl-2,3,4-tri-Obenzoyl- α-L-rhamnopyranosyl-(1→2)-3-O-benzoyl-β-L-arabinopyranoside (10). These derivatives did not show any cytotoxicity against human cancer cell lines. Thus the 3-O-α-L-rhamnopyranosyl-( 1→2)-α-L-arabinopyranoside could be used as a nontoxic carrier moiety to enhance the activity of anticancer drugs.
Synthesis of Water Soluble Analogs of Arylsulfonylimidazolidinone (JSH-2282)
Bang, Seong-Cheol,Lee, Ki-Cheul,Sharma, Vinay K.,Sharma, Niti,Yang, Hyun-Sun,Jung, Sang-Hun Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.7
To improve the water solubility of arylsulfonylimidazolidinone (JSH-2282), a potent anti-cancer agent, two urea derivatives, sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline-1-carbonyl)-phenyl)ureido)succinate (2a) and sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline-1-carbonyl)phenyl)ureido)pentanedioate (2b), were synthesized and studied for solubility and anti-cancer activity.
Bang, Seong-Cheol,Seo, Hyun-Hee,Shin, Hye-Rim,Lee, Ki-Cheul,Hoang, Le Tuan Anh,Jung, Sang-Hun 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
The sugar structures of triterpenoid saponins, such as $\alpha$-hederin, are intimately associated with their antitumor activities and other biological activities. The $\alpha$-L-rhamnopyranosyl-($1{\rightarrow}2$)-$\alpha$-L-arabinopyranoside group of $\alpha$-hederin alters the cytotoxicity of its aglycon, hederagenin. This study explored the role of this saccharide unit in the cytotoxic effect of $\alpha$-hederin and the possibility of its use as a carrier moiety in prodrugs of anticancer agents. A new convenient and practical procedure for the preparation of 4-methoxybenzoyl-2,3,4-tri-O-benzoyl-$\alpha$-L-rhamnopyranosyl-($1{\rightarrow}2$)-3,4-O-dibenzoyl-$\beta$-L-arabinopyranoside (2) from 4-methoxybenzoyl-$\beta$-Larabinopyranoside was accomplished using four steps with an overall yield of 63%. The use of $BF_3-OEt_2$ as a catalyst in the glycosylation step in this procedure had a large advantage over the TMSOTf catalyst used in the usual method. Moreover, the key intermediate obtained in this procedure, 4-methoxybenzoyl-2,3,4-tri-O-benzoyl-$\alpha$-L-rhamnopyranosyl-($1{\rightarrow}2$)-$\alpha$-L-arabinopyranoside (7), was selectively transformed to 4-methoxybenzoyl-2,3,4-tri-O-benzoyl-$\alpha$-L-rhamnopyranosyl-($1{\rightarrow}2$)-4-O-acetyl-$\alpha$-L-arabinopyranoside (9) and 4-methoxybenzoyl-2,3,4-tri-Obenzoyl-$\alpha$-L-rhamnopyranosyl-($1{\rightarrow}2$)-3-O-benzoyl-$\beta$-L-arabinopyranoside (10). These derivatives did not show any cytotoxicity against human cancer cell lines. Thus the 3-O-$\alpha$-L-rhamnopyranosyl-($1{\rightarrow}2$)-$\alpha$-L-arabinopyranoside could be used as a nontoxic carrier moiety to enhance the activity of anticancer drugs.
Bang, Seong-Cheol,Kim, Yong,Yun, Mi-Young,Ahn, Byung-Zun The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.5
Thirty-eight 5-arylidene-2(5H)-furanone derivatives possessing halo-, methoxy-, oxo-, dioxo-, and thiophenyl groups as well as anthraquinone and naphthquinone moieties were synthesized, and their cytotoxicity was evaluated against various cancer cell lines. The introduction of halogen atoms or nitro group at aromatic ring of 5-arylidene-2(5H)-furanone was shown to increase the cytotoxicity with 5-(3-nitrobenzylidene )-2(5H)-furanone (21) being the most potent. Among anthracenyl or naphthalenyl derivatives, (E)-5-[2-(1 ,4-dimethoxy-9, 10-dioxo) anthracenyl]-2(5H)-furanone (34) showed the most potent cytotoxic activity.
Seong-Cheol Bang,Yong Kim,Mi-Young Yun,Byung-Zun Ahn 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.5
Thirty-eight 5-arylidene-2(5H)-furanone derivatives possessing halo-, methoxy-, oxo-, dioxo-, and thiophenyl groups as well as anthraquinone and naphthquinone moieties were synthesized, and their cytotoxicity was evaluated against various cancer cell lines. The introduction of halogen atoms or nitro group at aromatic ring of 5-arylidene-2(5H)-furanone was shown to increase the cytotoxicity with 5-(3-nitrobenzylidene)-2(5H)-furanone (21) being the most potent. Among anthracenyl or naphthalenyl derivatives, (E)-5-[2-(1,4-dimethoxy-9,10-dioxo) anthracenyl]-2(5H)-furanone (34) showed the most potent cytotoxic activity.
Germination-Inhibitory Effect of Pulsatilla koreana N. Leaves; Protoanemonin as Active Principle
Bang, Seong-Cheol,Kim, Dong-Hwa,Ahn, Byung-Zun The Korean Society for Applied Biological Chemistr 2005 Journal of Applied Biological Chemistry (J. Appl. Vol.48 No.2
The germination of Lactuca sativa seeds was significantly inhibited by the water extract of the fresh leaves of Pulsatilla koreana N. including abundant ranunculin. Germination inhibitory activity increased in a dose-dependantly. Protoanemonin, produced from ranunculin by enzymatic action during maceration process of leaves, was proved to be the active principle with inhibitory activity was above 90% at concentration of 1 mg/ml.