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Siqi Li,Zhipeng Su,Chengjun Zhang,Zhuofei Xu,Xiaoping Chang,Jiawen Zhu,Ran Xiao,Lu Li,Rui Zhou 한국유전학회 2018 Genes & Genomics Vol.40 No.8
Porcine pleuropneumonia caused by Actinobacillus pleuropneumoniae has led to severe economic losses in the pig industry worldwide. A. pleuropneumoniae displays various levels of antimicrobial resistance, leading to the dire need to identify new drug targets. Protein–protein interaction (PPI) network can aid the identification of drug targets by discovering essential proteins during the life of bacteria. The aim of this study is to identify drug target candidates of A. pleuropneumoniae from essential proteins in PPI network. The homologous protein mapping method (HPM) was utilized to construct A. pleuropneumoniae PPI network. Afterwards, the subnetwork centered with H-NS was selected to verify the PPI network using bacterial two-hybrid assays. Drug target candidates were identified from the hub proteins by analyzing the topology of the network using interaction degree and homologous comparison with the pig proteome. An A. pleuropneumoniae PPI network containing 2737 non-redundant interaction pairs among 533 proteins was constructed. These proteins were distributed in 21 COG functional categories and 28 KEGG metabolic pathways. The A. pleuropneumoniae PPI network was scale free and the similar topological tendencies were found when compared with other bacteria PPI network. Furthermore, 56.3% of the H-NS subnetwork interactions were validated. 57 highly connected proteins (hub proteins) were identified from the A. pleuropneumoniae PPI network. Finally, 9 potential drug targets were identified from the hub proteins, with no homologs in swine. This study provides drug target candidates, which are promising for further investigations to explore lead compounds against A. pleuropneumoniae.
Zhang Ying,Qiu Chengjun,Li You,Zhang Wenlong,Wang Xuan 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.10
In the terahertz (THz) science research field, electro-optic (EO) polymer possesses many superior characters compared with mineral crystal. Two kinds of the side group EO polymer, polyphosphazene with plmaol grained by 2, 4-dinitroaniline and polyphenylacrylate containing p-nitro bisazo group, are synthesized and characterized. For higher EO coefficient, the double EO molecules polymer thin films are prepared by mixing a small nonlinear optical (NLO) molecule into the side group EO polymer. The principles of preparation are given and the EO coefficients are tested. The effect on the EO coefficients by different mixing proportion and different poling temperature are analyzed in details. Experiments results show that the double EO molecules polymer has fine stability, higher EO coefficient and can be easily processed. This kind of material has the potential to be widely applied in the emission and detection of THz radiation.
Mechanism of Packing Rigidity Gain in Sand Aging: From the Perspective of Structural Order Evolution
Chengjun Liu,Pei Tai,Zhaofeng Li,Wenbiao Hu 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.6
Rigidity gain can be observed in sand aging but is usually accompanied by minute densification.This phenomenon is inconsistent with the conventional diagram of rigidity/jamming transition for granules and therefore too enigmatic to be utilized in the field by engineers. Therefore, this study aims to reveal the mechanism of rigidity gain and reconcile the inconsistency in sand aging. The aging processes of two sand packings with the same mono-sized spheres but different initial densities were reproduced via discrete element method simulations. In the simulations, sudden increases in the solid fraction destroyed the similarity between the evolution processes of rigidity gain and densification, confirming the inadequacy of explaining this gain considering densification alone. The bond-orientational order remained almost unchanged, while the contact-force order generally increased over time with distinct drops, similar to the change in rigidity gain. This evolution pattern is attributed to the laws of thermodynamics, which require the Gibbs energy of the sand packing to decrease over time, and contact-force order reduction assists with this decrease. Simultaneously, this reduces the nonaffinity under shear and rigidity demolition, consequently dominating the rigidity gain mechanism in sand aging. Based on these findings, the conventional diagram of rigidity transition was modified to jointly consider the effects of the solid fraction and structural orders. The proposed diagram can depict how the sand packing rigidity is enhanced over time and can better guide the consideration of the sand aging effect in the field.
Study on the Energy Spectrum Response of a CdZnTe Detector
Yuandong Li,Liangquan Ge,Kun Sun,Shangqing Sun,Guoqiang Zeng,Chengjun Tan 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.9
In order to study the energy spectrum response of a CdZnTe detector, we firstly measured the temperature dependence and the bias dependence of the main characteristic parameters for both a quasi-hemispherical detector and a CAPtureTM plus detector. Secondly, we designed a low-noise readout circuit for the CdZnTe detector and measured the noise. Finally, we evaluated the energy spectrum response of the detector to different radioactive sources at different temperatures by connecting the detector to the readout circuit. The research showed that both detectors had low leakage current and junction capacitance, as well as good stability in temperature and bias; the quasi-hemispheric detector had a smaller leakage current and junction capacitance compared to the CAPtureTM plus detector; under zero input capacitor, the noise of the readout circuit was 612e, with the noise slope being 5.44e/pF; at room temperature(20 °C), the energy resolutions of the detector reached 3.84% and 1.36% for X-rays from 241Am (59.5 keV) and gamma-rays from 137Cs (662 keV), respectively; the signal-noise ratio of the output signal reached 31:1 with the rise time being 90 ns; at low temperature, the energy resolution reached 3.41% for the X-rays from 241Am (59.5 keV); the detector achieved an excellent spectrum response and was able to distinguish clearly the energy peaks of 152Eu and 226Ra.
Study of Traveling Partners’ Discovery Algorithm Based Closed Clustering and Intersecting
Kongfa Hu,Jiadong Xie,Chengjun Hu,Tao Yang,Yuqing Mao,Yun Hu,Long Li 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.6
As the rapid development of IOT (the Internet of Things), RFID technology has been widely applied, and it generates a large of RFID trajectory stream data with the spatial-temporal characteristic. Because RFID has many characteristics, it leads to become very difficult that extracting moving objects groups that together moving (ie. traveling partners) in a period of time from RFID trajectory stream data. Existing methods are difficult to efficiently find this model. This paper presents a closed clustering and intersecting algorithm (CCI) for RFID data to detect movement along traveling partners, which is mainly constituted by two steps: first step is clustering sub-trajectory, it generates sub-trajectory clusters; second step is intersecting sub-trajectories with the traveling partners’ candidate set to improve the candidate set, and find out traveling partners. In this process, we use the principle of Closure to accelerate our processing. Through experiments on the RFID synthetic dataset, we demonstrate the effectiveness and efficiency of our algorithm, thus show that our algorithm is suitable for discovering traveling partners in RFID applications.
An Experimental Study on Micro-Grinding Process with Nanofluid Minimum Quantity Lubrication (MQL)
이필호,이상원,남정수,Chengjun Li 한국정밀공학회 2012 International Journal of Precision Engineering and Vol.13 No.3
Nanofluid minimum quantity lubrication (MQL) technique has recently attained a significant attention for mechanical machining processes to reduce environmental loads caused by full usage of metal working fluids (MWF). Nanofluid refers to a fluid containing nanoparticles, which has superior lubrication and cooling characteristics. This paper investigates the characteristics of a nanofluid MQL micro-grinding process through a series of experiments. The miniaturized desktop machine tool system is developed, and a small grinding wheel is used to effectively realize the nanofluid MQL microgrinding process. Nanodiamond and nano-Al2O3 particles are selected, and the base fluid is paraffin oil. The experimental results show that nanofluid MQL is effective for reducing grinding forces and enhancing surface quality. In addition, it is demonstrated that the type, size and volumetric concentration of nanoparticles are critical parameters to have influence on the performances of micro-grinding process.
Lingling Xu,Jie Wu,Nini Li,Chengjun Jiang,Yan Guo,Peng Cao,Dianlei Wang 대한생리학회-대한약리학회 2020 The Korean Journal of Physiology & Pharmacology Vol.24 No.6
The present study aimed to examine the effect of allyl isothiocyanate (AITC) on chronic obstructive pulmonary disease and to investigate whether upregulation of multidrug resistance-associated protein 1 (MRP1) associated with the activation of the PARK7 (DJ-1)/nuclear factor erythroid 2-related factor 2 (Nrf2) axis. Lung function indexes and histopathological changes in mice were assessed by lung function detection and H&E staining. The expression levels of Nrf2, MRP1, heme oxygenase-1 (HO-1), and DJ-1 were determined by immunohistochemistry, Western blotting and reverse transcription-quantitative polymerase chain reaction. Next, the expression of DJ-1 in human bronchial epithelial (16HBE) cells was silenced by siRNA, and the effect of DJ-1 expression level on cigarette smoke extract (CSE)-stimulated protein degradation and AITC-induced protein expression was examined. The expression of DJ-1, Nrf2, HO-1, and MRP1 was significantly decreased in the wild type model group, while the expression of each protein was significantly increased after administration of AITC. Silencing the expression of DJ-1 in 16HBE cells accelerated CSE-induced protein degradation, and significantly attenuated the AITC-induced mRNA and protein expression of Nrf2 and MRP1. The present study describes a novel mechanism by which AITC induces MRP1 expression by protecting against CS/CSEmediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis.