Effects of needleless intradermal injection of multivalent foot and mouth disease vaccine on granuloma formation at neck region in fattening pigs

Chang-Won Im,Wan-Kyu Lee 한국예방수의학회 2021 예방수의학회지 Vol.45 No.3

The abnormal meat could caused by abscess, fibrosis and granuloma in the region of the neck by the adverse effect of foot-and-mouth disease (FMD) vaccination practice for Korean swine. After FMD vaccination was implemented in 2010, the number of incidences of abnormal meat has been increasing. In this study, it was evaluated whether needless intradermal injection (NII) of FMD vaccine reduces abnormal meat at the injection site in comparison to conventional intramuscular injection (IM). In addition, the onset of humoral immunity was analyzed in order to see if NII of this vaccine is able to mount comparable antibody response with IM. This study was carried out in four Korean pig farms. The O-type FMD vaccine was implemented via NII at three farms and the control group was vaccinated via IM. Antibody titers were compared from the serum samples taken from 10 random pigs at age of 8, 12, 16 and 22~24 weeks of age. The O+A type FMD vaccine was also compared with the same protocol. When test animals were slaughtered, incidence, type and size of abnormal meat were recorded. The results of this study showed that the antibody titers between intradermal and intramuscular group were similar but a significant difference in the incidence of abnormal meat formation was observed between two groups (p < 0.05). In summary, needless intradermal injection of FMD vaccination was proven to be effective for the onset of humoral immunity and reducing abnormal meat formation.

A preliminary study in melasma following INMODE forma procedure

( Soon-hyo Kwon ),( Je-byeong Chae ),( Jung-won Shin ),( Jung-im Na ),( Chang-hun Huh ),( Kyoung-chan Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Melasma is a common hypermelanosis that frequently appears on the face. In recent studies, it is suggested that dermal structural alteration, including solar elastosis and basement membrane disruption, may have an important role in the pathogenesis of melasma. Forma device (InMode Inc, Richmond Hill, ON, Canada, North America) is a radiofrequency dermal heating device used on facial wrinkles and rhytides. Objectives: The aim of this study was to evaluate the effects of Forma device on melasma in a small group of volunteers. Methods: All volunteers were treated 4 times at 3 weeks intervals. Every visit, melanin index and erythema index was measured to assess the improvement in hyperpigmentation and erythema. Clinical photos were evaluated to estimate the degree of skin changes. Results: Clinical and instrumental evaluation showed that melasma improved after INMODE forma treatment. Conclusion: We suggest that treatment with Forma device may have beneficial effects on melasma by dermal remodeling and direct heat delivery on melanocytes.

농촌지역 여성고령자의 현미덤벨체조가 체조성, 체력 및 식습관에 미치는 영향

이기철 ( Lee Gi Cheol ),정창주 ( Jeong Chang Ju ),손기수 ( Son Gi Su ),우임수 ( U Im Su ),이원경 ( Lee Won Gyeong ),공무현 ( Gong Mu Hyeon ),이수천 ( Lee Su Cheon ) 한국운동영양학회 2003 Physical Activity and Nutrition (Phys Act Nutr) Vol.7 No.2

The present study evaluated the possibility of dumbbell exercise as to improve the physical fitness and the health starus of old people in rural area. Although eighty seven volunteers of old women (over 64) living in Seonsan, Gumi city were subjected, twenty of them were attended the whole program for 6 months and the data from the twenty was analysed in this study. The results were drawn out from comparison of the body constitutuion, the physical strength, the medical aspectrs, and the questionaires of before and after this program. They showed increased physical fithess tested by grip strength (left), bar gripping reaction time, standing trunk flexibility, on foot standing test through dumbbell exercise for 6 months. Questionaire revealed the betterment of dietary pattem during this program. In the light of in these results, it is possible to conclude that dumbbell exercise had improved the basic physical condition and the health status through the increasement of physical fitness and dietary pattem change. Therefore, dumbbell exercise would be a useful program for the old people in reual area to improved their health status.

The Change of Skeletal Muscle Mass Is Associated with Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease

( Do Seon Song ),( U Im Chang ),( Seong Woo Go ),( Jeong Won Jang ),( Si Hyun Bae ),( Seung Kew Yoon ),( Jin Mo Yang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: We aimed to investigate the association between the change of muscle mass and change of fibrosis and steatosis in NAFLD patients. Methods: We analyzed 2,893 NAFLD subjects who had health check-up more than twice in St. Vincent’s Hospital between November 2009 and December 2017. NAFLD was diagnosed by ultrasound, and appendicular muscle mass (ASM) was assessed by Inbody 720, and Sarcopenia index was calculated as ASM divided by weight (SI%) and ASM divided by body mass index (SI-BMI). Non-invasive markers were used to evaluate the severity of hepatic fibrosis and steatosis; NAFLD fibrosis score (NFS), Fibrosis-4 (Fib-4) score, and Forn’s index for fibrosis, and hepatic steatosis index (HSI) and fatty liver index (FLI) for steatosis. Results: The mean age was 47.3±10.4 years, and 1956 subjects (67.6%) were male. Diabetes, hypertension, metabolic syndrome were more prevalent in sarcopenic subjects (P<0.01), and non-invasive fibrosis and steatosis markers were higher in sarcopenic subjects (P< 0.01). The mean interval between two health check-up was 39.8±21.9 months. There was no significant association between the change of NFS, Fib-4, and Forn’s index and the change of SI% and SI-BMI (all P >0.1). However, the changes of HIS and FLI were significantly associated with the change of SI% and SI-BMI (all P<0.01). Multivariate logistic analysis demonstrated the independent association between the change of skeletal muscle mass and the changes of non-invasive steatosis markers after adjusting for other confounding factors (all P< 0.001). However, the changes of non-invasive fibrosis markers did not show an independent association with the change of appendicular muscle mass after adjusting for other confounders (all P >0.1) Conclusions: The change of muscle mass is strongly associated with the change of hepatic steatosis, but not the change of fibrosis.

우황청심원 관련 최근 연구 동향 : 국내 논문에 대한 고찰

이제원,백경민,백영두,임은영,장우석,전우현,정인권,Lee, Je-Won,Baek, Kyung-Min,Baek, Young-Doo,Im, Eun-Young,Chang, Woo-Seok,Cheon, Woo-Hyun,Chung, In-Kwon 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.4

Objectives : Woohwangchungsim-won has been used for acute diseases such as cerebrovascular disease (stroke), heart disease. The aim of this study was to determine the effects, significance & necessity of Woohwangchungsim-won in acute stages of these disease by reviewing Korean articles about Woohwangchungsim-won. Methods : Article searches were performed on 8 major Korean web article search engine from January 1980 to August 2010. There were no restrictions on the types of publication, including grey articles. Results : Forty-three articles were included. Twenty one were efficacy tests, thirteen were comparative efficacy tests, eight were toxicity tests, and one was new method development. Eighteen articles were multicenter studies and twenty five were single center studies. Thirty two articles were animal testing, only ten articles were clinical articles. Thirty seven articles presented the composition and quantity of Woohwangchungsim-won, but six did not. Conclusions : The results of Korean articles about Woohwangchungsim-won can not strongly support the effects, significance & necessity of Woohwangchungsim-won. More rigorous studies are required for determination of the effects of Woohwangchungsim-won.

Pressure-Dependent Structural and Chemical Changes in a Metal–Organic Framework with One-Dimensional Pore Structure

Im, Junhyuck,Seoung, Donghoon,Hwang, Gil Chan,Jun, Jong Won,Jhung, Sung Hwa,Kao, Chi-Chang,Vogt, Thomas,Lee, Yongjae American Chemical Society 2016 Chemistry of materials Vol.28 No.15

<P>Pressure-dependent structural and chemical changes of the metal organic framework (MOF) compound MIL-47(V) have been investigated up to 3 GPa using different pore-penetrating liquids as pressure transmitting media (PTM). We find that at 0.3(1) GPa the terephthalic acid (TPA) template molecules located in the narrow channels of the as synthesized MIL-47(V) are selectively replaced by methanol molecules from a methanol ethanol water mixture and form a methanol inclusion complex. Further pressure increase leads to a gradual narrowing of the channels up to 1.9(1) GPa, where a second irreversible insertion of methanol molecules leads to more methanol molecules being inserted into the pores. After pressure release methanol molecules remain within the pores and can be removed only after heating to 400 degrees C. In contrast, when MIL-47(V) is compressed in water, a reversible replacement of the TPA by H2O molecules takes place near 1 GPa. The observed structural and chemical changes observed in MIL-47(V) demonstrate unique high pressure chemistry depending on the size and type of molecules present in the liquid PTM. This allows postsynthetic nonthermal pressure-induced removal and insertion of organic molecules in MOFs forming novel and stable phases at ambient conditions.</P>

Primary Malignant Pericardial Mesothelioma Presenting as Acute Pericarditis

Won-Suk Choi,Moon-Sun Im,Ji-Hun Kang,Yun-Gi Kim,In-Chang Hwang,Ju-Myung Lee,Soryung Lee,Hyo-Sun Shin,Seung-Pyo Lee,Goo-Yeong Cho 한국심초음파학회 2012 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.20 No.1

We report on a 21-year-old man with fever, dyspnea, and pleuritic chest pain. An electrocardiography showed ST elevation in multiple lead and thoracic echocardiography revealed moderate pericardial effusion. He was initially diagnosed with acute pericarditis,and treated with nonsteroidal anti-inflammatory drugs and colchicines with clinical and laboratory improvement. After 1 month of medication, his symptoms recurred. An echocardiography showed constrictive physiology and the patient was treated with steroid on the top of current medication. The patient had been well for 7 months until dyspnea and edema developed, when an echocardiography showed marked increased pericardial thickness and constriction. Pericardial biopsy was performed and primary malignant pericardial mesothelioma was diagnosed. Malignancy should be considered in the differential diagnosis of recurrent pericarditis.

Progress report on CQUEAN (Camera for QUasars in EArly uNiverse)

Won-Kee Park,Eun bin Kim,Chang su Choi,Ju hee Lim,Jin oung Kim,Hyeon ju Jeong,Hee young Oh,Soo jong Pak,Myung shin Im 한국천문학회 2010 天文學會報 Vol.35 No.1

An unsupervised eye blink artifact detection method for real-time electroencephalogram processing

Chang, Won-Du,Lim, Jeong-Hwan,Im, Chang-Hwan IOP 2016 PHYSIOLOGICAL MEASUREMENT Vol.37 No.3

<P>Electroencephalogram (EEG) is easily contaminated by unwanted physiological artifacts, among which electrooculogram (EOG) artifacts due to eye blinking are known to be most dominant. The eye blink artifacts are reported to affect theta and alpha rhythms of frontal EEG signals, and hard to be accurately detected in an unsupervised way due to large individual variability. In this study, we propose a new method for detecting eye blink artifacts automatically in real time without using any labeled training data. The proposed method combined our previous method for detecting eye blink artifacts based on digital filters with an automatic thresholding algorithm. The proposed method was evaluated using EEG data acquired from 24 participants. Two conventional algorithms were implemented and their performances were compared with that of the proposed method. The main contributions of this study are (1) confirming that individual thresholding is necessary for artifact detection, (2) proposing a novel algorithm structure to detect blink artifacts in a real-time environment without any <I>a priori</I> knowledge, and (3) demonstrating that the length of training data can be minimized through the use of a real-time adaption procedure.</P>

Automatic Identification of Interictal Epileptiform Discharges in Secondary Generalized Epilepsy

Chang, Won-Du,Cha, Ho-Seung,Lee, Chany,Kang, Hoon-Chul,Im, Chang-Hwan Hindawi Publishing Corporation 2016 Computational and mathematical methods in medicine Vol.2016 No.-

<P>Ictal epileptiform discharges (EDs) are characteristic signal patterns of scalp electroencephalogram (EEG) or intracranial EEG (iEEG) recorded from patients with epilepsy, which assist with the diagnosis and characterization of various types of epilepsy. The EEG signal, however, is often recorded from patients with epilepsy for a long period of time, and thus detection and identification of EDs have been a burden on medical doctors. This paper proposes a new method for automatic identification of two types of EDs, repeated sharp-waves (sharps), and runs of sharp-and-slow-waves (SSWs), which helps to pinpoint epileptogenic foci in secondary generalized epilepsy such as Lennox-Gastaut syndrome (LGS). In the experiments with iEEG data acquired from a patient with LGS, our proposed method detected EDs with an accuracy of 93.76% and classified three different signal patterns with a mean classification accuracy of 87.69%, which was significantly higher than that of a conventional wavelet-based method. Our study shows that it is possible to successfully detect and discriminate sharps and SSWs from background EEG activity using our proposed method.</P>