Changes of Sugar Composition and Related Enzyme Activities during Fruit Development of Asian Pear Cultivars ‘Niitaka’ and ‘Whangkeumbae’

Jin-Ho Choi,Jang-Jeon Choi,Chang-Seok Bang,Jung-Sup Lee,Dong-Woog Choi,Hye-Sun Cho,Jun Cheul Ahn 한국원예학회 2009 Horticulture, Environment, and Biotechnology Vol.50 No.6

We report on the seasonal changes of soluble sugar accumulation and several enzyme activities related to sugar metabolism, in two Asian pear cultivars (Pyrus pyrifolia) cultivars ‘Niitaka’ and ‘Whangkeumbae’. Soluble sugar content increased as the fruit developed and its total contents in matured fruits were 104.6 and 95.1 ㎎ㆍg?¹ fresh weight for ‘Niitaka’ and ‘Whangkeumbae’, respectively. However, the fructose-glucose-sucrose-sorbitol ratio was not significantly changed. Sorbitol-6-phosphate dehydrogenase activity was maintained at high level in leaves and low in fruits throughout the fruit development, although the enzyme activity highly fluctuated in young and mature fruits. NAD-dependent sorbitol dehydrogenase activity increased sigmoidally in both leaves and fruits during fruit development, and correlated with accumulation of total sugar in fruits. Sucrose synthase and sucrose phosphate synthase (SPS) activities remained low in leaves, but higher with two peak fluctuations in fruits. The change of soluble sugar contents positively correlated with SPS activity, based on the seasonal fluctuation of SPS activity and soluble sugar accumulation.

NaBr을 첨가한 물소화제의 냉각효과에 관한 연구

방창훈,김종석 한국화재소방학회 2001 한국화재소방학회논문지 Vol.15 No.2

본 연구의 목적은 NaBr(30%, w/w)을 첨가한 물소화제의 냉각효과을 연구하는 것이다. 고온체로는 탄소강과 테프론을 사용하였다. 실험에서 고온체 표면의 온도범위는 70℃∼116℃이며 액적의 크기는 2.6mm이다. 실험결과 고온체 내부의 온도는 재질에 관계없이 순수한 물의 경우가 NaBr수용액보다 낮게 나타났으며, 테프론의 경우가 탄소강보다 온도 변화가 크게 나타났다. 또한 제질에 관계없이, 평균 열유속은 순수한 물의 경우가 NaBr수용액 보다 크게 나타났으며, 겉보기 증발시간은 순수한 물의 경우가 NaBr 수용액보다 짧게 나타났다. The objective of the present work is to examine the cooling effect of a water fire extinguishing agent containing NaBr(30%, w/w). The carbon steel and Teflon were used as a hot solid. The temperature on the hot solid surface ranged from 70℃ to 116℃ and water droplet size was 2.6 mm in the experiments. It is suggested that regardless of the hot solid material, the indepth temperature of the case of NaBr solution is lower than that of pure water and the variation of indepth temperature of teflon is higher than that of carbon steel. Regardless of the hot solid material, the time averaged heat flux of the case of pure water is higher than that of NaBr solution. The apparent evaporation time of the case of pure water is shorter than that of NaBr solution.

A Multicenter Analysis of Clinical Features and Long-Term Outcomes of POEMS Syndrome in Korea

Kook Hye Won,Jang Ji Eun,Min Chang-Ki,Yoon Dok Hyun,Kim Kihyun,Bang Soo-Mee,Park Yong,Lee Jae Hoon,Yoon Sung-Soo,Kim Jin Seok 대한의학회 2024 Journal of Korean medical science Vol.39 No.2

Background: POEMS syndrome is a rare form of plasma cell dyscrasia characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal proteins, and skin changes. Owing to its low incidence, there are few reports regarding this syndrome. This multicenter study included 84 patients diagnosed with POEMS syndrome in South Korea. Methods: We retrospectively evaluated 84 patients diagnosed with POEMS syndrome at 8 hospitals in South Korea between January 2000 and October 2022. The clinical characteristics and treatment outcomes were analyzed. Results: The median patient age was 53 years (range, 26–77 years), and 63.1% of the patients were male. All patients had peripheral neuropathy, and 81 (96.4%) had monoclonal plasma cell proliferation. Plasma vascular endothelial growth factor levels were available for 32 patients with a median of 821 pg/mL (range, 26–12,900 pg/mL). Other common features included skin changes (54.2%), volume overload (71.4%), and organomegaly (72.6%). Of the 84 patients, 75 received initial treatment (local radiotherapy, 6 [8.0%]; chemotherapy, 17 [22.7%]; both chemotherapy and local radiotherapy, 9 [12.0%]), upfront autologous stem cell transplantation (ASCT), 43 (57.3%; with induction chemotherapy, n = 12, 16.0%; without induction chemotherapy, n = 31, 41.3%). The median follow-up duration was 40.7 months. The 5-year overall survival (OS) was 78%, and the 5-year progression-free survival (PFS) was 55%. Patients who underwent upfront ASCT and were diagnosed after 2014 had a longer OS and PFS. Conclusion: The demographics of Korean patients with POEMS syndrome were similar to those reported previously. Because of the introduction of new treatment agents and the reduced rate of transplant-related mortality related to ASCT, the treatment outcomes of Korean patients with POEMS syndrome have improved in recent years.

Poster Session : PS 0770 ; Upper GI Tract : Effect of Intragastric Injection of Botulinum Toxin a for the Treatment of Obesity: A Systematic Review and Meta-Analysis

( Chang Seok Bang ),( Gwang Ho Baik ),( Hyo Sun Kim ),( Sang Hyun Park ),( Eun Jin Kim ),( Jin Bong Kim ),( Ki Tae Suk ),( Jai Hoon Yoon ),( Yeon Soo Kim ),( Dong Joon Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Controversies regarding effect of intragastric injection of botulinum toxin A for the treatment of obesity still remain. Methods: A systematic literature review was conducted using the core databases (PubMed, EMBASE, and the Cochrane Library). Pre- and post-treatment body weight data were extracted and analyzed using Hedges`s g. The analysis was performed divided by 2 ways which are pre-post comparative approach in botulinum injected group and comparison with placebo injected group. A random effect model was applied. The methodological quality of the enrolled studies was assessed by the Risk of Bias table and Newcastle-Ottawa Scale. Publication bias was evaluated through the funnel plot, trim and fi ll method, Egger`s test, and rank correlation test. Results: A total of 139 patients was enrolled from 8 studies (91 treated vs. 49 placebo group) and followed up for median 12 weeks (IQR: 6.5-16 weeks). Overall, treatment group was associated with weight loss in a pre-post comparative approach and compared to the placebo group (Hedges`s g: -0.619, 95% CI: -1.090, -0.148, P = 0.01; Hedges`s g: -0.650, 95% CI: -1.035, -0.265, P = 0.001). Wide area injection including fundus or body rather than the antrum only injection was associated with weight loss. Multiple injection number (above 10) was associated with weight loss. However, large amount of botulinum (more than 500 IU) was not associated with weight loss. Sensitivity analyses showed consistent results. Publication bias was not detected. Conclusions: In this analysis, intragastric injection of botulinum toxin A is effective for the treatment of obesity.

EDITORIAL : Time to learn from the past and prepare for the future in Helicobacter pylori eradication

( Chang Seok Bang ),( Gwang Ho Baik ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.6

Immunological Assay of Lysozymes from Larval Haemolymph of Cabbage Butterfly, Artogeia rapae

Bang, In Seok,Kim, Jong Wan,Chang, Byung Soo,Lim, Do Seon,Kim, Ju Sung,Yoe, Sung Moon 한국곤충학회 2000 Entomological Research Vol.30 No.4

배추흰나비의 5령 유충의 혈림프로부터 2개의 Iysozyme을 분리하여 아미노산 서열을 분석한 결국 두 Iysozyme의 아미노산 조성의 차이에도 불구하고 20번 아미노산잔기까지 동일하였다. 이러한 Iysozyme의 체내 분포와 발생 단계별 농도 변화 및 다른 종과의 상호관계를 면역학적 방법으로 분석하였다. We have previously isolated two Iysozymes, Iysozymes I(LI) and II(LII) from the immune haemolymph of the fifth instar larvae of cabbage butterfly, Afogeia rapae [Yoe, S.M., Bang,I.S., Kang, C.S. and Kim, H.J. (1996) Mot. Cells 6,609-614]. Lysozymes with hinnavins are the main types of the antibacterial proteins of cabbage butterfly. The N-terminal sequences of the two Iysozymes were determined by the automated Edman degradation and their N-terminal sequences up to the 20th residue were completely identical, although LI and LII show considerable differences in amino acid compositions. Organ distribution, developmental change and immunological relationship of these enzymes were investigated through immunoelectrophoresis test and Western blot analysis.

Pitfalls in the Interpretation of Publications about Endoscopic Submucosal Dissection of Early Gastric Cancer with Undifferentiated-Type Histology

Chang Seok Bang,백광호 대한소화기내시경학회 2019 Clinical Endoscopy Vol.52 No.1

Endoscopic submucosal dissection (ESD) is a standard treatment for patients with gastrointestinal neoplasms with a negligible risk oflymph node metastasis. ESD enables en bloc resection of gastrointestinal neoplasms and organ preservation, thereby, avoiding surgicaltreatment. Although small (<2 cm) intramucosal early gastric cancer with undifferentiated-type histology (EGC-UH) without ulcerationis included in the expanded criteria for ESD, controversies remain due to different biology and characteristics compared to EGC withdifferentiated-type histology. The authors previously presented studies about the technical feasibility of ESD for these lesions using ameta-analysis and retrospective multicenter analysis. However, many pitfalls were identified in the interpretation of studies analyzinghistologic discrepancy, mixed-type histology, criteria-based analysis of therapeutic outcomes, interpretation of curative resection, andlong-term clinical outcomes. In this review, the authors discuss pitfalls in the interpretation of publications on ESD for EGC-UH.

ORiginal Article : Additive Effect of Pronase on the Eradication Rate of First-Line Therapy for Helicobacter pylori Infection

( Chang Seok Bang ),( Yeon Soo Kim ),( Sang Hyun Park ),( Jin Bong Kim ),( Gwang Ho Baik ),( Ki Tae Suk ),( Jai Hoon Yoon ),( Dong Joon Kim ) The Editorial Office of Gut and Liver 2015 Gut and Liver Vol.9 No.3

Background/Aims: Helicobacter pylori colonizes on the apical surface of gastric surface mucosal cells and the surface mucous gel layer. Pronase is a premedication enzyme for endoscopy that can disrupt the gastric mucus layer. We evaluated the additive effects of pronase combined with standard triple therapy for H. pylori eradication. Methods: This prospective, single-blinded, randomized, controlled study was conducted between June and October 2012. A total of 116 patients with H. pylori infection were enrolled in the study (n=112 patients, excluding four patients who failed to meet the inclusion criteria) and were assigned to receive either the standard triple therapy, which consists of a proton pump inhibitor with amoxicillin and clarithromycin twice a day for 7 days (PAC), or pronase (20,000 tyrosine units) combined with the standard triple therapy twice a day for 7 days (PACE). Results: In the intention-to-treat analysis, the eradication rates of PAC versus PACE were 76.4% versus 56.1% (p=0.029). In the per-protocol analysis, the eradication rates were 87.5% versus 68.1% (p=0.027). There were no significant differences concerning adverse reactions between the two groups. Conclusions: According to the interim analysis of the trial, pronase does not have an additive effect on the eradication of H. pylori infection (ClinicalTrial.gov: NCT01645761). (Gut Liver 2015;9:340-345)

The Korean Society of Gastroenterology & SIDDS 2027 : Slide Session ;K-UG-30 : Upper GI Tract ; Effect of Helicobacter pylori Eradication on the Development of Metachronous Gastric Cancer After Resection of Early Gastric Cancer: A Systematic Review and Me

( Chang Seok Bang ),( Gwang Ho Baik ),( Hyo Sun Kim ),( Sang Hyun Park ),( Eun Jin Kim ),( Jin Bong Kim ),( Ki Tae Suk ),( Jai Hoon Yoon ),( Yeon Soo Kim ),( Dong Joon Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: There still remains controversies about effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer (EGC). The aim of this study was to assess the effi cacyof Helicobacter pylori eradication for the prevention of metachronous recurrecne after endoscopic resection of EGC. Methods: A systematic literature review was conducted using the core databases (PubMed, EMBASE, and the Cochrane Library). Metachronous gastric cancer recurrence rates between Helicobacter pylori eradicated vs. non-eradicated group were extracted and analyzed using risk ratios (RRs). A random effect model was applied. The methodological quality of the enrolled studies was assessed by the Risk of Bias table and Newcastle-Ottawa Scale. Publication bias was evaluated through the funnel plot, trimand fi ll method, Egger`s test, and rank correlation test. Results: A total of 5914 patients with EGC or dysplasia was enrolled from 10 studies. Overall, Helicobacter pylori eradicated group showed a RR of 0.467 (95% CI: 0.362- 0.602, P<0.001) for the development of metachronous recurrence after endoscopic resection of EGC. Sensitivity analyses showed consistent results. Publication bias wasnot detected. Conclusions: In this analysis, Helicobacter pylori eradication reduces the occurrence of metachronous gastric cancer after endoscopic resection of EGC.

Endoscopic submucosal dissection of gastric subepithelial tumors: a systematic review and meta-analysis

( Chang Seok Bang ),( Gwang Ho Baik ),( In Soo Shin ),( Ki Tae Suk ),( Jai Hoon Yoon ),( Dong Joon Kim ) 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.5

Background/Aims: To evaluate the therapeutic outcomes of the endoscopic sub­mucosal dissection (ESD) technique for the treatment of gastric subepithelial tu­mors (SETs). Methods: A systematic literature review was conducted using the core databases. Data on the complete resection rates and the procedure-related perforation rates were extracted and analyzed. A random effects model was then applied for this meta-analysis. Results: In all, 288 patients with 290 SETs were enrolled from nine studies (44 SETs originated from the submucosal layer; 246 SETs originated from the mus­cularis propria layer). The mean diameter of the lesions ranged from 17.99 to 38 mm. Overall, the pooled complete resection rate was estimated to be 86.2% (95% confidence interval [CI], 78.9 to 91.3). If the analysis was limited to the lesions that originated from the submucosal layer, the pooled complete resection rate was 91.4% (95% CI, 77.9 to 97). If the analysis was limited to the lesions that originated from the muscularis propria, the pooled complete resection rate was 84.4% (95% CI, 78.7 to 88.8). The pooled procedure-related gastric perforation rate was 13% (95% CI, 9.4 to 17.6). Sensitivity analyses showed consistent results. Finally, publication bias was not detected. Conclusions: ESD, including endoscopic muscularis dissection, is a technically feasible procedure for the treatment of SETs. However, selection bias is suspected from the enrolled studies. For the development of a proper indication of ESD for SETs, further studies are needed.