아세틸 콜린 유발 검사시 허혈성 심전도 변화와 흉통의 발생이 내피세포 기능장애에 미치는 영향

최철웅(Cheol Ung Choi),나승운(Seung-Woon Rha),김선원(Sun Won Kim),나진오(Jin Oh Na),임홍의(Hong Euy Lim),김진원(Jin Won Kim),김응주(Eung Ju Kim),한성우(Seong Woo Han),박창규(Chang Gyu Park),서홍석(Hong Seog Seo),오동주(Dong Joo Oh) 대한임상노인의학회 2010 대한임상노인의학회지 Vol.11 No.4

연구배경: 아세틸 콜린 유발 검사시 발생하는 흉통과 허혈성 심전도 변화가 아세틸 콜린에 의해 발생하는 관상동맥의 내피세포 기능에 어떤 영향을 주는지 알아보고자 했다. 방법: 흉통으로 내원하여 관상동맥 조영술과 아세틸 콜린 유발검사를 시행받은 1,085명의 환자를 대상으로 하였다. 아세틸 콜린 유발 검사를 하는 동안 허혈성 심전도 변화 및 흉통의 발생 유무에 따른 관상동맥 내피세포 기능의 특징을 비교하였다. 결과: 539명의 환자에서 아세틸 콜린 검사시 내피세포 기능 장애가 발생 하였다. 허혈성 심전도 변화가 있었던 그룹이 심전도 변화가 없었던 그룹보다 흉통이 더 많았고(78.1% vs. 60.8%, P=0.007), 관상동맥 조영술상 다발성 관상동맥 경련이 빈번하였고(59.4% vs. 40.6%, P=0.004), 관상동맥의 경련 정도도 더 심하였다(64.1% vs. 46.5%, P=0.006). 흉통이 있었던 그룹이 흉통이 없었던 그룹보다 허혈성 심전도 변화의 빈도가 더 높았다(14.7% vs. 7.5%, P=0.007). 또한 흉통이 있었던 그룹이 관상동맥 경련이 다발성으로 발생하는 경우가 많았고 (50.7% vs. 29.5%, P<0.001), 미만성으로 발생하는 경우가 많았고(87.1% vs. 75%, P<0.001), 관상동맥의 경련의 정도도 더 심하였다(51.6% vs. 43.5%, P=0.041). 결론: 아세틸 콜린 유발검사시 발생하는 허혈성 심전도 변화와 흉통은 관상동맥 경련의 정도와 경련이 발생하는 관상동맥 개수와 연관이 있다. Background: ECG changes and chest pain during acetylcholine (Ach) provocation tests may constitute important clinical parameters for Ach-induced endothelial dysfunction. We investigated the association between ischemic ECG changes and chest pain during the Ach-provocation test and angiographic characteristics of Ach-induced endothelial dysfunction. Methods: A total of 1,085 patients with anginal symptoms underwent diagnostic coronary angiography (CAG) and Ach-provocation tests. We compared angiographic characteristics of Ach-induced endothelial dysfunction according to the presence of ECG change and chest pain. Results: A total of 539 patients experienced Ach-induced endothelial dysfunction. Patients who experienced ECG change group suffered more frequent chest pain (78.1% vs. 60.8%, P=0.007), angiographically more frequent multiple coronary artery spasm (59.4% vs. 40.6%, P=0.004), and more severe coronary artery spasm (64.1% vs. 46.5%, P=0.006) than patients without ECG change. However, there was no difference in the length of endothelial dysfunction between the groups. The incidence of ischemic ECG changes in patients with chest pain was higher than in patients without chest pain (14.7% vs. 7.5%, P=0.007). Patients who experienced chest pain more often experienced multiple (50.7% vs. 29.5%, P<0.001), diffuse (87.1% vs. 75%, P<0.001), and severe coronary artery spasm (51.6% vs. 43.5%, P=0.041) than patients without chest pain. Conclusion: Ischemic ECG changes and chest pain during the Ach-provocation test are associated with multi-vessel involvement and severe coronary artery spasm. Chest pain is associated with the length of endothelial dysfunction, but ischemic ECG change is not.

물-에너지-식량-탄소 넥서스를 이용한 통합물관리 모델 평가 연구 - 영산강 수계를 중심으로 -

나라 ( Na Ra ),박진현 ( Park Jin-hyeon ),주동혁 ( Joo Donghyuk ),김하영 ( Kim Hayoung ),유승환 ( Yoo Seung-hwan ),오창조 ( Oh Chang-jo ),이상현 ( Lee Sang-hyun ),오부영 ( Oh Bu-yeong ),허승오 ( Hur Seung-oh ) 한국농촌계획학회 2023 농촌계획 Vol.29 No.1

Active attention and effort are needed to develop an integrated water management system in response to climate change. In this study, it proposed models for cross-use of agricultural water and river maintenance water using sewage treatment water as an integrated water management system for the Yeongsan River. The impact of the integrated water management models was assessed by applying the concept of Nexus, which is being presented worldwide for sustainable resource management. The target year was set for 2030 and quantitatively analyzed water, energy, land use and carbon emissions and resource availability index by integrated water management models was calculated by applying maximum usable amount by resource. An integrated water management system evaluation model using the Nexus concept developed in this study can play a role that can be viewed in a variety of ways: security and environmental impact assessment of other resources. The results of this research will be used as a foundation for the field of in the establishment of a policy decision support system to evaluate various security policies, as we analyzed changes in other factors according to changes in individual components, taking into account the associations between water, energy, food, and carbon resources. In future studies, additional sub-models need to be built that can be applied flexibly to changes in the future timing of the inter-resource relationship components. 1)

O/W형 microemulsion의 생성영역과 입자크기 및 안정성에 관한 연구

오주영 ( Joo-young Oh ),한창규 ( Chang-gew Han ),조춘구 ( Choon-ku Zhoh ) 대한화장품학회 1995 대한화장품학회지 Vol.21 No.2

본 연구에서는 ME의 각 성분의 구조가 그들의 생성영역, 입자의 크기 및 안정성에 미치는 영향을 고찰하고자 surfactant로서 POE sorbitan fatty acid 계를 사용하였고, oil로는 포화탄화수소계인 liquid paraffin, squalane, 방향족계열인 alkyl benzoate, Isostearyl benzoate를 그리고 cosurfactant로는 glycerine, propylene glycol, sorbitol, 1, 3-butanediol을 사용하여 4성분계 ME을 제조하고, 이 계에서 cosurfactant의 구조적 특성이 ME 생성영역에 미치는 영향과 그리고 oil과 surfactant의 구조 특성이 제조된 ME 입자크기 및 안정성에 미치는 영향을 고찰한 결과, cosurfactant로 polyol류를 사용했을 때, polyol 분자 중 탄소가 같은 경우 OH수가 많을 때, OH기 수가 같을 경우 탄소수가 적을 때 ME생성영역이 크게 나타남을 알 수 있었으며 제조된 ME의 입자 크기를 비교했을 때 oil의 극성이 클수록, surfactant 소수부분의 alkyl chain의 탄소수가 클수록 입자크기가 작게 나타났다. 또한 분산상으로 사용된 oil 중 alkyl benzoate나 Isostearyl benzoatbenzoate 에 비해서 포화탄수소계인 liquid paraffin, squalane으로 구성된 ME의 경시 안정성이 더 양호하였다. This study was investigated to search for the effects of the structure of each component in four-component O/W microemulsion system on its formation region, droplet size and stablilty. The results was that the more number of OH site, the shorter carbon chain length of polyol, the larger formation region of microemulsion was showed. The small microemulsion droplet was obtained on condition that the polatry of oil was large and carbon chain length of hydrophobic group of surfactant was long. In using satrated hydrocarbon (such as liquid paraffin, squalane) as dispersed phase, the stability of microemulsion was better than aromatic oil phase.

Trends in incidence and survival of esophageal cancer in Korea: Analysis of the Korea Central Cancer Registry Database

Shin, Aesun,Won, Young‐,Joo,Jung, Hye‐,Kyung,Kong, Hyun‐,Joo,Jung, Kyu‐,Won,Oh, Chang‐,Mo,Choe, Sunho,Lee, Jihyun John Wiley and Sons Inc. 2018 Journal of gastroenterology and hepatology Vol.33 No.12

<P><B>Abstract</B></P><P><B>Background and Aim</B></P><P>The diagnostic and therapeutic modalities of esophageal cancer have recently improved in Asia, and its prognosis is expected to change. This study provides a population‐based report on the epidemiology of esophageal cancer in Korea.</P><P><B>Methods</B></P><P>Cancer incidence data from 1999 to 2013 were obtained from the Korea Central Cancer Registry, covering the entire population. Age‐standardized incidence rates and annual percent changes were calculated according to subsites and histological types. Five‐year relative survival rates were estimated for cases diagnosed between 1993 and 2013. Relative excess rates were compared between patients diagnosed from 2009 to 2013 and 2006 to 2008.</P><P><B>Results</B></P><P>The age‐standardized incidence rates decreased from 8.8 per 100 000 populations in 1999 to 5.9 in 2013 with an annual percent change of −2.6% in men and −2.2% in women. The most common histological type was squamous cell carcinoma, accounting for 90.2% of all esophageal cancers in 2013, followed by adenocarcinomas (3.1%), and their incidences decreased. The proportion of localized and regional cancer tended to increase compared with that of distant cancer. Five‐year relative survival of squamous cell carcinoma improved from 12.1% (1993–1995) to 34.6% (2009–2013). Relative excess rate was 0.72 (95% confidence interval 0.65–0.80) in localized stage and 0.88 (95% confidence interval, 0.82–0.95) in regional stage comparing patients diagnosed from 2009 to 2013 and 2006 to 2008.</P><P><B>Conclusions</B></P><P>The incidence of esophageal cancer has decreased in Korea for the past 15 years, and 5‐year survival rates have improved significantly. These increases may be attributable to more effective detection of early‐stage disease.</P>

pH, 이온종류 및 농도, 퇴적물의 성분에 따른 하천 내 불소의 거동특성

이동민(Dong Min LEE),주광진(Kwang Jin Joo),최이송(ISong Choi),장광현(Kwang Hyeon Chang),오종민(Jong Min Oh) 응용생태공학회 2018 Ecology and resilient infrastructure Vol.5 No.1

하천에 유입된 오염물질은 다양한 환경 조건에 의하여 수체 및 퇴적물의 상호작용에 따라 수체의 수질에 영향을 미친다. 특히 최근 수체의 수리학적 체류시간이 상대적으로 긴 정체수역 내에서는 퇴적물의 축적량이 증가하고 있어 퇴적물과 수체 내에서의 물질적 거동특성 파악은 중요한 수질적 관점 요소이다. 본 연구에서는 하천 내 pH, 이온종류 및 농도, 퇴적물의 점토함량에 따라 불소의 거동이 어떻게 변화하는지 검토하기 위하여 경기도에 위치한 중소하천을 대상으로 조건별 실험을 실시하였다. pH에 따른 흡착 및 용출특성 실험결과, pH가 높을수록 불소의 흡착량이 감소하였고, 용출되는 불소량은 증가하는 경향을 나타냈다. 이온농도 및 종류에 따른 흡착 및 용출특성 실험결과, Cl<SUP>-</SUP>, SO₄<SUP>2-</SUP> 이온은 불소의 흡착능에 큰 영향을 주지 않는 것으로 나타났으나, 불소와의 활발한 이온경쟁효과를 지닌 OH<SUP>-</SUP>와의 반응에서는 흡착량이 줄고, 용출량이 늘었음을 알 수 있었다. 퇴적물의 성분에 따른 흡착 및 용출특성 실험 결과 상대적으로 입경이 작은 Silt와 Clay 성분이 많이 포함된 시료에서 불소의 흡착량이 많고 용출되는 불소량이 줄어드는 것을 알 수 있었다. 이는 수체의 환경조건이 퇴적물 내 불소의 흡착 및 용출에 크게 영향을 미치기 때문에, 퇴적물 내 불소를 적절하게 관리하기 위해서는 수체의 환경조건에 대한 이해가 선행되어야 한다는 것을 의미한다. Water quality is affected by the pollutants flowing into rivers since the interaction between water bodies and sediments in various environmental conditions. Especially, accumulation of sediments increases in the stagnant water areas due to a relative long hydrological retention time in the water bodies. Therefore, it is an important factor of water quality to understand characterization of the material behavior in water bodies and sediments. In this study, the objective of the conditional experiments was small and medium sized streams located in Gyeonggi-do. To estimate how the changes of fluoride behavior, depending on the pH, ion type, concentration, and clay contents. The pH results showed a trend that adsorption amount of fluorine decreased and the dissolution of fluorine increased following by pH increasing. The concentration and type of ions results showed that Cl<SUP>-</SUP> and SO₄<SUP>2-</SUP> ions had no significant effect on the adsorption ability of fluorine, the amount of dissolution was increased because OH<SUP>-</SUP> ion had active competition with fluorine in the reaction. The ingredient of sediment results showed that the amounts of fluoride adsorption and dissolution were reduced in samples, which contain relatively large amounts of Silt and Clay components. This means that the environmental conditions of water bodies greatly affect the adsorption and dissolution of fluoride in the sediments, so that proper management of fluoride in the sediments must precede an understanding of the environmental conditions of the water bodies.

Expression of cellular retinoic acid-binding protein-I (CRABP-I) in the cerebrospinal fluid of adult onset moyamoya disease and its association with clinical presentation and postoperative haemodynamic change

Jeon, Jin Sue,Ahn, Jun Hyong,Moon, Youn-joo,Cho, Won-Sang,Son, Young-Je,Kim, Seung-Ki,Wang, Kyu-Chang,Bang, Jae Seung,Kang, Hyun-Seung,Kim, Jeong Eun,Oh, Chang Wan BMJ Publishing Group Ltd 2014 Journal of neurology, neurosurgery and psychiatry Vol.85 No.7

<P><B>Objective</B></P><P>The elevation of cellular retinoic acid-binding protein-I (CRABP-I) has been suggested as a candidate in the pathogenesis of paediatric moyamoya disease (MMD). However, few studies have addressed CRABP-I in adult onset MMD. The aim of this study was to examine the expression of CRABP-I in the cerebrospinal fluid (CSF) of adult onset MMD, and to evaluate its association with clinical presentation and postoperative haemodynamic change.</P><P><B>Methods</B></P><P>This study examined the CSF from 103 patients: bilateral MMD, n=58 (56.3%); unilateral MMD, n=19 (18.4%); atherosclerotic cerebrovascular disease (ACVD), n=21 (20.4%); and control group, n=5 (4.9%). The intensity of CRABP-I was confirmed by western blotting and expressed as the median (25th–75th percentile). The differences in CRABP-I expression according to disease entity (unilateral MMD vs bilateral MMD vs ACVD), initial presenting symptoms (haemorrhage vs ischaemia) and postoperative haemodynamic change (vascular reserve in single photon emission CT and basal collateral vessels in digital subtraction angiography) were analysed.</P><P><B>Results</B></P><P>CRABP-I intensities in bilateral MMD (1.45(0.86–2.52)) were significantly higher than in unilateral MMD (0.91(0.78–1.20)) (p=0.044) or ACVD (0.85(0.66–1.11)) (p=0.004). No significant differences were noted based on the initial presenting symptoms (p=0.687). CRABP-I was not associated with improvement in vascular reserve (p=0.327), but with decrease in basal collateral vessels (p=0.023) postoperatively.</P><P><B>Conclusions</B></P><P>Higher CRABP-I in the CSF can be associated with typical bilateral MMD pathogenesis in adults. Additionally, postoperative basal collateral change may be related to the degree of CRABP-I expression.</P>

Effects of Dietary Fatty Acids on Serum Lipids and Fatty Acid Composition of Serum Phospholipids in Men

Oh,Eun-Joo,Kwon,Jong-Sook,Chang,Yu-Kyung 韓國營養學會 1997 Journal of Nutrition and Health Vol.30 No.4

마이크로파 수분 측정장치용 L대역 전력증폭기의 설계

오경석,강석규,주창복 경남대학교 신소재연구소 1995 論文集 Vol.5 No.-

본 논문에서는 마이크로파 수분측정장치를 위한 센서용 전력증폭기를 마이크로파 회로 설계용 CAD Tool인 Harmonica를 사용하여 최적화 시키고 컴퓨터 시뮬레이션 실험을 통하여 동작 주파수 대역에서의 제 동작특성이 설계사양을 만족하는 결과를 얻었으며 증폭기의 전력 고효율화에 관한 특성을 설명하였다. Cripp의 방법을 이용하여 최적 부하임피던스를 결정하고 출력단을 Wilkinson형 전력분배기/결합기를 이용한 2단 증폭기를 구성하였다. 정합회로의 설계는 집중정수 소자와 마이크로스트립 선로를 이용하여 구현하고 동작 주파수대역에 대하여 설계사양에 대해 최적화시켜 회로를 구성하였다. 바이어스 전압조정을 통하여 출력전류와 전압파형이 이상적 파형이 되도록 하여 전력부가효율 특성의 고효율과를 기하였다. 본 논문에서 설계된 전력증폭기는 주파수 0.8∼2.0(GHz)대역에서 전력 1.0[W]정도의 출력을 가지며 60%이상의 높은 전력효율 특성을 갖는다. In this paper, the power amplifier for microwave moisture measurement system over the frequency band of 0.8-2.O[GHz] is designed using the microwave circuit CAD simulator, Harmonica, and described the higher power added efficiency characteristic of the designed power amplifier through the simulated result of its current and voltage waveforms by controlling the operating bias voltage near to pinch-off. Cripp's method is used to design the optimum output load impedance and the Wilkinson type power coupler/divider is used to schematic of the output power stage to obtain appropriate output power level. The designed power amplifier using the microstrip lines and lumped elements properly on the teflon substrate (ε_{γ} =2.54 , h=0.64mm) show the output power is 1.0[W] and the power added efficiency is greater than 60% across the frequency band of 0.8∼2.0[GHz]. This amplifier designed in this paper is considered generally suitable to the microwave moisture measurement system which is required output power level about l.0[W].

일차적 비확공성 골수강 고정술로 치료한 제3형 개방성 경골 골절

오창욱,경희수,김도헌,박일형,김풍택,인주철,우연기,이정엽 대한골절학회 2004 대한골절학회지 Vol.17 No.2

DS/CDMA 무선 광전송시스템 모델에서의 IMD와 다사용자 간섭

周昌福,吳經錫 慶南大學校 附設 工業技術硏究所 1998 硏究論文集 Vol.16 No.-

비동기 DS/CDMA 무선광전송시스템모델에서 레이저다이오드의 비선형성에 의한 상호변조왜곡(IMD)과 다사용자 간섭관계를 해석적으로 구하였다. 또한 본 논문에서는 IMD와 다사용자 간섭 경감의 한 방법으로 1칩시간 지연의 (N-1)개 탭지연선에 의한 LMS 알고리즘의 트랜스버설필터를 구성하고 상관기에 의한 신호검출에서의 IMD와 BER 경감특성이 비교, 분석되었다. The intermodulation distortion(IMD) and multi-user interference due to laser diode nonlinearity in the asynchronous direct sequence code division multiple access(DS/CDMA) wireless-optical transmission system model is analyzed. In DS/CDMA wireless-optical transmission system, only one harmonic of the third-order intermodulation term falls on the signal frequency band due to laser diode nonlinearity and influences the system performance characteristics. In this paper a transversal filter of LMS algorithm with N-taps of (N-1) tap delay of 1 chip time delay line is used to reduce IMD and multi-user interference in a DS/CAMA wireless-optical transmisson system model. The computer simulation results show that the IMD and BER reducing characteristics are very better then that of correlation detector with one bit slot time.