보조호르몬요법을 받는 여성 유방암 환자의 모발 변화와 치료 실태에 대한 기초 연구

이재경 ( Jae Kyung Lee ),김창현 ( Chang-hyun Kim ),홍동균 ( Dongkyun Hong ),정경은 ( Kyung Eun Jung ),서영준 ( Young-joon Seo ),김창덕 ( Chang-deok Kim ),이진선 ( Jin Sun Lee ),권인선 ( In Sun Kwon ),박상현 ( Sanghyun Park ),이영 대한피부과학회 2021 대한피부과학회지 Vol.59 No.7

Background: Hormone therapy, which includes tamoxifen and aromatase inhibitors, is the most common adjuvant therapy used for breast cancer. However, only a few studies have reported endocrine therapy induced alopecia. Objective: We investigated the effects of long-term adjuvant hormone therapy on hair in patients with breast cancer, in addition to patients’ concerns and current treatment for hair loss. Methods: Patients completed a questionnaire that included information on self-perceived hair changes after each adjuvant therapy session, distress, and current treatment for hair loss. Using a folliscope, we measured hair density and thickness in each patient and in healthy controls. Results: The study included 93 patients with breast cancer (mean age 51.9±9.8 years). The density and hair thickness were 106.36±21.85 hairs/cm2 and 0.07±0.01 mm in the patient group and 147.86±30.67 hairs/cm2 and 0.07±0.01 mm in the control group (n=98, mean age 52.10±8.40 years), respectively. The mean hair density was significantly lower in the patient group than in the control group; however, no statistically significant intergroup difference was observed in hair thickness. Among 76 patients who perceived hair changes after adjuvant therapy, 71.1% (n=54) were distressed with regard to hair changes. However, only 7.8% of the patients, including two who were treated by dermatologists, currently received treatment for hair changes. Conclusion: Dermatologists should be familiar with hair changes in patients with breast cancer and provide appropriate education to encourage patients to consult dermatologists for hair loss and thinning after breast cancer treatment. (Korean J Dermatol 2021;59(7):521∼526)

항공사진을 이용한 방포항 인근 해빈의 장기간 해안선 변화 분석

김백운 ( Baeck Oon Kim ),윤공현 ( Kong Hyun Yun ),이창경 ( Chang Kyung Lee ) 대한원격탐사학회 2013 大韓遠隔探査學會誌 Vol.29 No.5

장기간 해안선 변화 자료의 구축을 통해 해안선의 시·공간적인 변화 양상을 분석하고, 이에 근거하여 해안침식의 향후 경향을 파악하는 일은 연안관리에 매우 중요한 역할을 한다. 본 연구에서는 수치항공사진을 이용하여 방포항 인근 해안지역의 장기간(1985년 ~ 2009년) 해안선 변화 탐지를 위해 항공삼각측량, 지상기준점측량, 수치도화, 그리고 해안선 변화율을 산정하였다. 그 결과 방포해빈과 꽃지해빈의 해안선은 각각 0.2 m/yr와 최대 0.8 m/yr로 침식된 것으로 파악되었다. 또한 등고선 변화 통하여 꽃지 해빈의 북부지역에서 침식현상이 가장 뚜렷하게 나타났으며 표고 1 m 간격의 등고선은 최대 45 m 후퇴하였음을 알수 있었다. 이러한 변화는 다양하고 복합적인 요인에 의해 발생할 수 있으며 주된 요인은 1990년대 말에 설치된 해변 옹벽이 해안침식을 일으키는 주요 원인으로서 추정되고 있다. To analyze tendency of temporal and spatial change of shorelines and to estimate rate of shoreline changes using long-term shoreline change data is very important for the coastal environmental management. In this study, investigation was conducted to estimate the rate of shoreline changes using long-term shoreline change data from the year 1985 to 2009 aerial photographs. In this process aerial triangulation, GPS surveying and digital mapping was done for the estimation of changes. As the results, shorelines of Bangpo and Kkotji Beach retreated at a maximum rate of 0.2 m/yr and 0.8 m/yr, respectively. The shoreline could be changed by various factors. However, it was presumed that coastal erosion has been mainly affected by retaining wall constructed in the late 1990s.

측두하악장애 치료 후 하악 안정위의 고경 변화에 관한 연구

김창현,한경수 원광대학교 치의학연구소 2003 圓光齒醫學 Vol.12 No.3

This study was performed to investigate the change of the mandibular vertical dimension, especially at the several rest positions, induced by speech and swallowing after treatment of temporomandibular disorders and to compare the vertical dimemion among those several mandibular rest positions. Thirty patients with temporomandibular disordem participated in this study, and the mean follow-up period after the first visit was 9.7 months. Clinical parameters related to pain, mandibular mobility, occlusion, and parafunction were examined. Subjects were asked to sit upright with relaxed natural head posture and then the two mandibular movements were performed, and recorded with BioEGN of Biopak system(Bioresearch Inc., Milwaukee, USA). A sentence of 'Sue is missing her house' was used to record the speech pattern. The positions observed and named in speech movement were rest, 'ssi', 'her', 'ha', and 's' position, and in swallowing movement were rest before swallowing, swallowing-early, swallowing-late, 0.5 sec. after swallowing, and rest after swallowing. Data obtained were processed and analysed by SPSS windows(ver. 10.0) program, and the results of this study were as follows: The mandibular positions showing vertical difference between before and after treatment were 'her', 'ha', and 's' in speech, and were swallowing-late, 0.5 sec. after swallowing, and rest after swallowing in swallowing. All these positions were located in the late half of the movements and the vertical dimension of rest positions in swallowing were increased after treatment. Rest positions in both of the movements did not show any significant difference for the vertical distance from habitual intercuspal position among them before treatment, however, which were changed and allowed differentiation after treatment. The vertical dimension of rest positions ranged 1.0-2.5mm in both of the movements. The ratio of the maximum opening range at the swallowing-late position in swallowing movement to the maximum Opening range at the 'ha' position in speech before and after treatment were 31% and 36%, respectively. Correlation between the vertical dimension of rest positions and the clinical maximum opening range were significantly negative at the 'mi' and 's' position only in speech movement before treatment. In conclusion, it was not easy to decide which position of all the mandibular positions observed in speech and in swallowing was the optimal mandibular rest position. However, the author suggested that the optimal mandibular rest position could be induced by and after swallowing movement.

말단비대증 환자에서의 수술전 Octreotide 투여 효과

박경수,김현규,조보연,이홍규,고창순,민헌기,김성연,고경수,이석인,한대희,최길수,정희원,김현집 대한내분비학회 1993 Endocrinology and metabolism Vol.8 No.1

Seven patients with previously untreated acromegaly and invasive pituitary macroadenomas were treated with the long-acting somatostatin analog, octreotide (San- dostatin*, Sandoz) for 3~6 months, before transsphenoidal pituitary adenomectomy. Preoperatively, treatment with octreotide for 3 months reduced the pituitary tumor size by 55~60% in 2 patients, 20~39% in 3 patients and little in the remaining 2 patients. Six patients were treated for another 3 monts, but the size of the pituiary tumor showed no further remarkable changes. Mean basal serum GH concentration fell from 251.6(53.0~470.0) ng/ml to 80.1(9.5~308.0) ng/ml after 3~6months treatment with octreotide. Postopercentrationn of one patient whose pituitary tumor size decreased 65% fell into the normal range. Thus, preoperative administration of octreotide induced shrinkage of GH-producing pituitary rumors in some patients and might have favorable effects on the remission rate in the treated patients. (J Kor Endocrinol 8:35~41, 1993)

백서에서 동종 신경이식시 항 T임파구 단일클론항체 분포에 관한 조직화학적 연구

홍창섭,김경욱,임창준,정대현 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-

Nerve allografts as a bridge through which lost nerve can regenerate is useful in the repair of peripheral nerve defect resulting from trauma, neoplasm and leprosy. But immunological rejection and complicated scar formation is an unaboidable problem in the application of allogenic nerves. This article is intended to study histopathological and immunohistochemical response after fresh allogenic sciatic nerve grafts in rats. 12 male Sprague- Dawley rats were used as the experimental animals. A 2cm skin incision was made on the lateral aspects of limb, parallel to the femur. 1cm-long sciatic nerve trunk taken from the one rat was resected at the middle of the to high, and it was transplanted to the same area of the other rat with perineural suture method. Observation was made at the postoperative 1, 3, 8, 16 day. The results were as follows. 1. Histopathologically, destruction of the perineural sheath was observed only in 1-day group. 2. Mild degenerative changes of the nucleus and cytoplasm of Schwann cells were ovserved in the 1-day and 3-day groups. These changes gradually resolved. 3. Hollow space phenomena of the nucleus and cytoplasm of schwann cells were observed. The response was mild in the 1 day and 3 day groups, and moderate in the 8 day group. The phenomena were not identified in the 16 day group. 4. Immunohistochemical studies revealed pan T cells and cytotoxic T cells in the 1 day group. Increased numbers of cytotoxic T Cells and helper T cells were observed in the 3 and 8 day groups. 5. According to these results, after transplantation of fresh allogenic sciatic nerve an inflammatory response was observed up to 8 days and then gradually resolved. Degenerative changes were more severe up to 8 days, but an the 16th day they had resolved histopathologically and immunopathologically.

알코올 및 인삼액이 효소활성도에 미치는 영향에 관한 연구

신경현,조만희,김창세 순천향대학교 1994 논문집 Vol.17 No.2

This study was investigated for the change of r-GTP, CPK activity and CPK-isoenzyme by alcohol and Ginseng administration, The normal white S.D rats were classified with four groups; ethanol treated was group A, ethanol pretreated group combined pretreated with Ginseng extract was group B, Ginseng extract treated was group C, and Ginseng extract treated group combined pretreated with ethanol was group D. The white rats of four groups were treated with 20%, 30%, 40% ethanol and/or 1% Ginseng extract. Then enzyme activities such as r-GTP, CPK and CPK-isoenzyme had been measared in serum, hepatic, and renal tissues. The sample was collected by 5 day intervalus for 25 days. The following results were obtained. 1. The changes of serum r-GTP activities were significantly increased in ethanol-treated group, decreased in Ginseng-treated group. 2. The changes of hepatic r-GTP activites were significantly increased in ethanol-treated group, decreased in Ginseng-treated group. 3. The changes of renal r-GTP activites were significantly increased in ethanol-treated group, decreased in ginseng-treated group. 4. The changes of serum CPK activites were significantly increased in ethanol-treated group, decreased in ginseng-treated group. 5. The changes of hepatic and renal tissue CPK activites were not significant. 6. The changes of serum and hepatic tissue CPK-isoengyme were significantly increased in ethanol-treated group, decreased in ginseng-treated group combined pretreated with ethanol. 7. The changes of CPK-isoengyme, CPK 1 and CPK 2 were not significant.

Label-free DNA detection with a nanogap embedded complementary metal oxide semiconductor

Kim, Chang-Hoon,Jung, Cheulhee,Lee, Kyung-Bok,Park, Hyun Gyu,Choi, Yang-Kyu IOP Pub 2011 Nanotechnology Vol.22 No.13

<P>A nanogap embedded complementary metal oxide semiconductor (NeCMOS) is demonstrated as a proof-of-concept for label-free detection of DNA sequence. When a partially carved nanogap between a gate and a silicon channel is filled with charged biomolecules, the gate dielectric constant and charges are changed. When the gate oxide thickness reduces, the threshold voltage is significantly affected by a change of the charges, whereas it is scarcely influenced by a change of the dielectric constant. In the case of DNA, those two factors act on the threshold voltage oppositely in an n-channel NeCMOS but collaboratively in a p-channel NeCMOS because of the negative charges of DNA. Hence, a p-channel NeCMOS with a thin gate oxide is more attractive for DNA detection because it enhances the shift of threshold voltage; that is, it improves the sensitivity of DNA detection. In addition, the shift of threshold voltage according to the nanogap length is also investigated and the longer nanogap shows more shift of the threshold voltage.</P>

2 ㎓ 선형 위상 천이 특성을 갖는 소형 아날로그 위상천이기

오현석(Hyun-Seok Oh),최재홍(Jae-Hong Choi),정해창(Hae-Chang Jeong),허윤성(Yun-Seong Heo),염경환(Kyung-Whan Yeom) 한국전자파학회 2011 한국전자파학회논문지 Vol.22 No.1

본 논문에서는 2 ㎓ 선형 위상 천이 특성을 갖는 위상천이기를 설계 및 제작하여 보였다. 소형의 위상 천이기 구현을 위해 집중소자로 구성된 전통과 회로망(all pass network)을 기반으로 위상천이기를 구성하고, 박막 세라믹 공정을 이용하여 제작하였다. 또한, 선형의 위상 천이 특성을 얻기 위해 버랙터(varactor) 다이오드에 직렬 커패시터를 연결하여, 전압에 대한 커패시턴스를 선형화함으로써 비선형성을 개선하였다. 전통과 회로망에 나타나는 인덕터는 스파이럴 인덕터로 구현하고, 이를 다이오드 바이어스 회로에 활용하여 4 ㎜×4 ㎜ 면적을 가지는 소형 위상천이기를 구성할 수 있었다. 또한, 온-웨이퍼(on wafer)로 측정을 위해 입출력은 CPW(Coplanar Waveguide) 형상으로 구현하였으며, 제작된 위상천이기는 버랙터 조정 전압 0~5 V에 대하여, 2 ㎓에서 삽입 손실은 약 4.2~4.7 ㏈, 위상 변화량은 약 79°였으며, 예상한대로 선형 위상 천이 특성을 보였다. In this paper, we present a 2 ㎓ compact analog phase shifter with linear phase-tune characteristic. The compact phase shifter was designed base on a lumped all pass network and implemented using a ceramic substrate fabricated with thin-film technique. For a linear phase-tune characteristic, a capacitance of the varactor diode for a tuning voltage was linearized by connecting series capacitor and subsequently produced an almost linear capacitance change. The inductor and bias circuit in the all pass network was implemented using a spiral inductors for small size, which results in the size reduction to 4 ㎜×4 ㎜. In order to measure the phase shifter using the probe station, two CPW pads are included at the input and output. The fabricated phase shifter showed an insertion loss of about 4.2~4.7 ㏈ at 2 ㎓ band and a total 79° phase change for DC control voltage from 0 to 5 V, and showed linear phase-tune characteristic as expected in the design.

주거공간의 지속가능성 계획 사례 분석

이현창(Hyun-chang Lee),남경숙(Kyung-sook Nam) 한국생활환경학회 2008 한국생활환경학회지 Vol.15 No.3

As pursuit of eco friendly housing, it was came out a requirement to develop sustainable design in housing. Sustainable development is a eco friendly development which meets the needs of the present without compromising the ability of future generations to meet their own needs. This study is to set up the sustainable development in housing which is a countermeasure in the long term of a environmental changing. The purpose of the study is to offer information about sustainable design in housing to residents which is related with solving the problems in housing and considering the future housing. A study would like to contribute to design development for sustainable development in housing. To study sustainable development in housing, we researched and analyzed of brand apartments model which will be completed in 2010 through model house, documents, catalog and internet sites. We knew that the progress are doing consistently to increase energy efficiency design as applying ecological design and make a design for decreasing environment pollution. But convenience design and universal design are not enough in housing. So there need to supply convenience, universal space design with equipment design for sustainable development in housing. Environment-friendly design of housing for health is a obligation and fundamental element in the world. As pursuit of convenience, we also want to request of convenience system which is based on the convenience and development of the machine civilization supports the equipment system development. So interior design and equipment system need of convenience as considering the changing lifestyle and applying the culture, trend.

Endoscopy and Imaging Modalities/Basic Science of Gastrointestinal Disorders/Miscellaneous : Changing Pattern Of Digestive And Liver Disease In Korea, 1990-2006 Year; A Single Center Study

( Jung Hyun Kwon ),( Sang Woo Kim ),( In Sik Chung ),( Myung Gyu Choi ),( Kwan Woo Nam ),( Jung Pil Suh ),( Jae Hyuck Chang ),( Won Haing Hur ),( Yu Kyung Cho ),( Jae Myung Park ),( In Seok Lee ) 대한소화기학회 2007 SIDDS Vol.9 No.-

Background/Aims: Westernization in many Asian countries have changed lifestyles and diets, so once rare diseases have now become prevalent. The aim of this study is to investigate the changing pattern of digestive and liver disease in Korea, from 1990 to 2006. Methods: We extracted data specific gastrointestina (GI) disease based on the International Classification of Diseases code from the in-patients records at the Kangnam St. Mary`s Hospital in 1990, 1996 and 2006. This hospital is a tertiary-care hospital in Seoul, Korea, which has a capacity of 800 beds. Results: The admission rate for GI disease increased between 1990 and 2006. Overall in-patients were 1,623 persons in 1990, 2,368 persons in 1996 and 4,166 persons in 2006. The mean age of in-patients increased as time went by. A stomach cancer was the most common diagnosis during all periods, but its prevalence has decreased. Colon cancer ranked the 7th in 1990, but markedly increased and now ranks the second. The third was a hepatocellular carcinoma. The bile duct and gallbladder cancer, pancreas and esophageal cancer ranking followed with little interval change. In cases of cancer patients, a regular admission dramatically increased for chemotherapy. The number of patients admitted with pre-malignant neoplasm of stomach and colon increased remarkably with the development of endoscopy. The liver transplant, inflammatory bowel discase, and reflux esophagitis emerged form mid-1990s with greater frequencies, yet much below the levels found in the West. The admission rate for peptic ulcer, especially ulcer bleeding remained relatively stable, despite a decreased rate for ulcer perforation. Liver cirrhosis, hepatitis, cholelithiasis with cholecystitis-cholangitis, appendicitis, hemorrhoid and gastritis all decreased. Conclusions: The stomach cancer is the leading cause of admission, despite a recent decline. Colon cancer showed a marked rise. The liver transplant, inflammatory bowel disease and reflux esophagitis were new diagnosis with an increased tendency.