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張智鉉 고려대학교 민족문화연구소 1969 民族文化硏究 Vol.3 No.-
According to the historical records, though the accurate origins were unknown, the history of Korean "Changs" may date back to about 1200 years ago. The age of early unified Shilla dynasty. The records reveal the first evidence of "Chang"―like soy products in this age. However, since it is generally believed that was imported from China about 2000 years ago, in the beginning of Sam-Kuk-age(三國時期初期) probably "Chang" manufacturing had started earlier. The records on Korean "Changs", however, are available not until the early stage of Yi dynasty. Undoubtedly during these long unrecorded period, the "Changs" manufacturing technology might had developed to certain degrees, since Koreans had been using continuously "Changs" as the basic cereal supplementing foods. But there is noway to know the history. In the records of the early Yi dynasty there appered, for the first time, the separate manufacturing and usage of Toenjang (fermented soybean mash) and Kanjang (soy sauce). Especially the Chinkanjang (陳甘醬―much concentrated or on aged soy sauce including Toenjang within) manufacturing was recorded already. These technology may be undoubtedly the result of long development during the unrecorded period. Later ku-Hwang-Chal-Yo (救荒撮要; a guide book for the relief of farmine) which was published in the age king Myung-Chong (明宗)recorded the various aspects of "Chang" manufacturing technology. According to this book, the "Chang" technology had especially progressed in the age of king Sae-Chong. (世宗). Koreans started to use wheat flour as the raw material of Toenjang meju (메주, soy sauce and soybean mash fermenting startar) in addition to soybean. A new device of expressing of soy sauce from soy sauce waste was also invented at that time. Therefor it can be said that the separate or independent manufacture of Kanjang and Toenjang was Completed in this age. According to the Sa-Si-Chan-Yo (四時纂要; a monthly farm guide) which was published in the year of king Hyo-Chong(孝宗) the "Changs" manufacturing had became one of the annual practices of Korean family and various kinds of characteristic "Changs" Kae-Chang (蟹醬), Jup-Chang (汁醬), Po-Chang (泡醬) were listed as the popular "Changs" at that times. Probably the fundamental technologies of many specific "Changs" manufacturing had been gradually established from the begining of the Yi dynasty to this age together with the development of food substitutes. A large modification in "Chang" manufacturing technology was brought in the middle ages of Yi dynasty. According to San-Lim-Kyung-Chai(山林經濟; a scientific encyclopedia) Chung-Chang (汁醬; the same as Kanjang) and Toenjang were described as the general purpose "Chang" of daily use and Jup-Chang (汁醬), Chung-Kuk-Chang (淸國醬) and Tam-Su-Chang (淡水醬) were listed as the popular specific "Changs" at that time. A new specific "Chang", Man-Cho-Chang (蠻椒醬, red pepper sauce) was deviced also in this age. Amang them the Chung-Chang is basically similar to the Present type of Korean Kanjang. It was described to be prepared entirely from soybean and Toenjang was the by-product of soy-souce, Undoubtedly the Present Korean Kanjang manufacturing technology may derive its origin to this Chung-Chang, using entirely soybean as the sole raw material. Probably further minor modifications, continued to improve "Chang" manufacturing technology and to adapt for home making method and scale, but essentially the similar "Chang" products which originated in the middle ages of Yi dynasty were conveyed to the present. Thus we can list the present day "Changs" as follows.; Chung-Chang, Toenjang, Nam-Cho-Chang (the same as Man-Cho-Chang) Jup-Chang, Chung-Kuk-Chang, Tam-Su-Chang. Among them the Chung-Chang and Nam-Cho-Chang are the only products of extensive general use by Korean of the Present day and others are only for occasional uses for an epicurism etc. The manufacturing procedures of present Korean Kanjang and Toenjang consist of three major steps; that is, the preparation of Meju, Kanjang fermentation, and expressing of sauce. The history of development of these three Kanjang manufacturing procedures are as the follows. I) The history of Kanjang-Meju Preparation method- The first record of Meju is found is San-Lim-Kyung-Jai. In this text it was described as: Cooked soy beans were mashed and made into small clumps and they were left in the room covered with brossonetia leaves, straw, grass leaves or morus bombysis leaves: Probably for microorganisms grow. From the middle ages Yi dynasty the Mejus were left piled in straw woven bages. The present day method, hanging the Mejus under the ceiling with straw ropes in the room, had been already described in the above San-Lim-Kyung-Jai also. It had been generally recogniged in the old texts of agriculture that coverage of Meju by yellow molds (黃衣) yielded good results. Without the present knowledge of pure culture technique of microbiology, it might hardly be expected to have a good growth of yellow molds by such primitive methods of Meju preparation, we can imagine. Probably such conditions rather might had favored the growth of bacteria and making Meju to Natto type soy product. We can think only of the effect of grass coverage on a good growth of yellow molds. There appeared many other very specific methods of Meju preparations described in the old texts, but none of them survived to be practiced and accepted among Koreans until to the present day. 2) The history of Kanjang fermentation- Until the middle age of Yi-dynasty Chin-Kanjang fermentation method which had been a device chiefly to obtain much concentrated soysauce so that it used small quantities of brine compared to the amount of Meju had been practiced. Later the tendency had come to obtain more quantities of dilute soy sauce and from the end of Yi dynasty the present day Chung-Chang fermentation method had emerged. This method has been using Meju: salt: water in the quantity ratio of 1 : 1 : 4. 3) History of method of expressing soy sauce- In the beginning the soy sauce had not been expressed from soybean mash but the whole mixtures had been consumed as "Chang". From the beginning of Yi dynasty as the need of soy sauce alone had become large the expressing method started to develope. In Ku-Hwang-Chal-Yo expressing by wood curtain was already described. In the middle ages of Yi dynasty, a hole was made in "Chang" and sauce exeeded in the hole was scooped out, or Yong-Su (a bamboo woven basket) were used to separate soy sauce from "Chang". From the end of Yi dynasty the present filtration method (for ex. using sive) were started to be used.
Cho, Yong-Chan,Lee, Chang-Seok,Cho, Hyun-Je,Lee, Kyu-Song,Park, Pil-Sun The Ecological Society of Korea 2011 Journal of Ecology and Environment Vol.34 No.1
Various responses of forest ecosystems to climate change underscore the need to improve our understanding of the environmentally-driven changes in forests, most effectively by long-term monitoring protocols. We have explored vegetation dynamics based on changes in community structure, species composition, diversity and demographics in four Korean National Long Term Ecological Research (KNLTER) sites--Mt. Nam, Mt. Jeombong, Mt. Worak, and Mt. Jiri--between 2004 and 2009. Most of the sites and forests studied exhibited increments in total basal area, but this was not observed in Quercus mongolica forests in Mt. Nam and Mt. Worak. Stem density exhibited various changes. Altitude gradient was the representative factor in differences in species composition. Two patterns of compositional change--convergence and divergence--were detected. The vegetation of Mt. Nam and Q. mongolica community of Mt. Work showed relatively larger changes in composition. However, in the other sites, few changes were observed. Changes of species richness were not notable except for Mt. Nam, where three species were added in the pine forest, whereas one species disappeared in the oak forest. In the oak forests, mortality rate was as follows (in descending order): Mt. Nam (25.5%), Mt. Jeombong (24.3%), Mt. Worak (16.4%) and Mt. Jiri (0.8%). In the pine forest, the recruitment rate was as follows (in descending order): Mt. Nam (63.7%), Mt. Worak (12.9%), Mt. Jeombong (7.6%) and Mt. Jiri (7.3%). The mortality rate and change rate of basal area were strongly negatively correlated (r = -0.9, P = 0.002), and the recruitment rate and change rate of density were positively correlated (r = 0.77, P = 0.026). In the KNLTER sites, larger vegetation changes were attributed to anthropogenic activities such as salvage logging. Suppression or competition for resources would also affect these changes. Research suggestions such as monitoring to clarify the causes of species mortality were discussed.
網狀織內皮細胞系統이 胸腺『아렐기-』性變化에 미치는 影響에關한 實驗的硏究
柳昌鉉 최신의학사 1958 最新醫學 Vol.1 No.1
Series of studies regarding to the relation of the R.E.S. to allergic changes were carried out by many investigators. Boyd, Topley and Wilson, Wilson and Bloom, Hayashi and Maruyama described the produc- tion of antibody in the R.E.S.. Oka found that anaphyla ctic shock was inhibited by splenectomy. Prof.Yun, Far- mer reported that anaphylactic shock was inhibited by thymusectomy: Meanwhile, Ogawa and Isida recogni- zed that , anaphylactic shock was aggrevated by the administration of thymic substance. Juiigeblut and Berlot, Gay and Clark, Tuft, Oka, Sakurai, Watanave, Hirakawa and Ozima and Iwaii also recognized inhibition of anaphylactic shock in !he R.E.S. blockaded animals. Akahoshi, Apitz, Klinge and Umasugi reported that the main hyperallergic changes in liver were changed' in the stellet cells. Haedel and,Karsue have reported that anaphylactic- shock was inhibited by the-injection of a large dose of India ink solution and was aggrevated by a small dose of India ink solution: Prof. Yun, Moldovan, Slavoacet et Zolog found a protective substance against anaphylactic shock in the serum of the R. E. S. blockaded animal and claimed that the protective substance seems to be corresponded by the endocrine function in the R.E.S..Seul has reported that allergic in the liver were inhibited either by the injection of India ink solution or serum from the R. E. S. blockaded animal. 'Song also has recognized that the injection of India ink solution or serum from the R. E. S. blockaded animal inhibited allergic changes in the lungs. The experiment to be reported in this paper was to study the influence of the R.E.S. on allergic changes in thymus. Experimental material and method Normal rabbit weighing around 800 grams were used. I cc. of normal horse serum per kilogram of horse serum per kilogram of body weight given' locally . in thymus parencyma two weeks later.: For blockading the R.E.S., India ink solution obtained by the sterili- zation of i0% of BOPIL MUkJIP saline. solution was used. 1. Nonsensitizing group. The normal horse serum was injected locally in'the thymus parenchyma without sensitization. 2. Sensitizing group. The normal horse serum was injected subcutaneo 4 times for sensitizing. For reinjection, O.I cc, of normal horse serum per kilogram of body weight was given to the thymus parenchyma two weeks later. 3. Single injection of 50c. India ink solution. Allergic changes were observed in rabbits into which India ink solution, 5 cc. per kilogram of body Weight, was injected- intravenously 24 hours before sensitization. 4. Plural injection of 5 cc. India ink solution. Allergic changes were observed An rabbits into which India, ink :solution, 5 cc. per kilogram of body weight, was injected intravenouslly 6 times with 12 hours intervals 24 hours before sensitization. 5. Injection of the serum from normal rabbits. Allergic changes in. the thymus were observed in rabbits into which normal rabbit serum, 2 cc. per kilogram of body weight was injected intravenously 24 hours before sensitization. 6. Injection of the serum from single injection of 5 cc. India ink solution. Serum from rabbits, 2 cc. per kilogram of body weight,' into 'which 5 cc, of India ink solution per kilogram. of body weight had,,been injected was given 24 hours before sensitization. ` 7. Injection' of the serum from "plural injection of 5 cc. India ink solution. "The serum from rabbits, ,2 cc. per kilogram of body weight, into which 5, cc, of India ink solution per Kilogram of body weight " had been `injected 6 times with 12 hours intervals was given 24 hours before sensitization. Discussion Moldvan, Slovoaca of Zolog, Prof. Yun claimed the existance of inhibitory substance against allergic changes in the serum of the R.E,S. blockade. As ohs erved in these experiment, the 'injection of serum from rabbits blockaded with India ink solution, especially in the group receiving the serum from single iniection of India ink solution inhibited markedly allergic changes in thymus. It is quite apparent that the serum of the R. E. S. blockaded rabbits contain an inhibited subst- ante against allergic changes. Allergic changes in thymus were slightly inhibited. in rabbits directly blockaded with India ink solution. Jungeblut and Berlot, Gay and. Clark, Siegmond and Okazaki previously descrived the inhibition of allergic changes in the R.E.S. blockade. That is the inhibitory substance against allergic' changes were secreted from the R. E. S.. Conclusions. Studies on the relation between allergic changes in thymus and the R. E. S. are reported. 1) The injection of serum from the R.E.S. blockade with India ink solution inhibited allergic changes in thymus. 2) Direct blockade of the R. E. S. slightly, inhibited, allergic changes in thymus.
조직문화 변화 상황에서 구성원 태도와 행동 변화의 영향요인
현창혁(Hyun, Chang Hyuk),이호선(Lee, Hosun) 한국인사관리학회 2013 조직과 인사관리연구 Vol.37 No.2
본 연구에서는 조직문화 변화 상황에서 구성원의 태도와 행동 변화에 초점을 두었다. 즉 기업이 새로운 조직문화를 구축하기 위해 행동지침으로서의 공유가치를 조직 내에 정착시키는 데 있어서 구성원이 변화에 참여하고 지원하는 행동에 영향을 미치는 요인이 무엇인지를 구명하려 하였다. 구체적으로는 Herscovitch & Meyer(2002)의 변화몰입과 변화지지행동의 개념을 적용하여 구성원의 공유가치 실천 행동에 영향을 미치는 요인을 분석하였다. 그리고 변화몰입에 영향을 미치는 요인을 상사의 변혁적 리더십 요인과 구성원 자신이 지각하는 변화관련 인지적 요인으로 구분하고, 인지적 요인은 다시 변화관련 자기효능감, 변화결과 호의도, 조직의 변화준비성 등으로 세분화하여 영향의 정도를 파악하고자 하였다. 분석 결과, 변혁적 리더십과 지각된 변화관련 인지적 요인(변화관련 자기효능감, 변화결과 호의도, 조직의 변화준비성)이 모두 정서적 변화몰입과 공유가치실천 행동에 정의 영향을 미치는 것으로 드러났다. 아울러 정서적 변화몰입이 변혁적 리더십과 공유가치실천 행동 간의 관계를 매개하며, 변화관련 인지적 요인과 공유가치실천 행동 간의 관계에서도 매개효과가 있음이 밝혀졌다. This study is focused on attitudinal and behavioral changes of organizational members under context of organization cultural changes. That is, it tries to identify the factors that affect organizational members' behavior for participating and supporting in relation to organization changes when companies plan to settle down shared values as the code of conduct into the organizations so as to establish new organization culture. Data were collected from 748 full-time employees during Sep. and Oct. 2011, but 702 questionnaires were used to for analysis. Results indicate both transformational leadership and cognitive factors related to changes(change-related self-efficacy, positive expectancies to change outcome, and readiness for organizational change) have positive influence on organizational members' emotional commitment to organization change and behaviors of practicing shared values. Furthermore, organizational members' emotional commitment to organization change has mediating effect on the relationships between transformational leadership and their behaviors of practicing shared values. It also has mediating effect on the relationships between cognitive factors related to changes and organizational members' behaviors of practicing shared values. Finally, some implications of these findings are discussed and directions for future research are suggested.
흰쥐의 위산 분비 및 실험적 괴양에 미치는 향정신성물질의 영향
白尙昌 大韓神經精神醫學會 1974 신경정신의학 Vol.13 No.1
Introduction of psychotropic agents to the field of psychiatry brought tremendous change and new implication in the therapeutic aspect as well as the concept of psychosomatic medicine. Reserpine was introduced by Sen & Bose(1931), and Vakil(1949) and Hakim(1953) has proved it to release biogenic amine (serotonin, norepinephrine, epinephrine, dopamin) at brain cell and peripheral tissues. Chlorpromazine was proved to have tranquilizing effect by Laborit et al(1952), and tremendons therapeutic effect to treat the psychiatric patient was shown by Delay (1952 a&b) and Courvoisier(1653). Jn 1961, Gey and Pletscher, and Axelrod found that chlorpromazine reduced the permeability of granular membrane, where the biogenic amine was stored. Haloperidol, a derivative of butyrophenone was synthesized by Janssen(1958). In 1966 Glowinski and Axelrod and in 1967 Janssen and Schildkraut et.al. reported that haloperidol reduced the shift of catecholamine from neuron and granular membrane. Meprobamate, one of the minor tranquilizers, has been used widely as an antianxiety agent and antiulcer agent as well. But recently it seemed that the derivatives of benzodiazepine replaced meprobamate as antianxiety and antiulcer agent. In 1952, Delay reported the iproniazid showed anti-depressive effect and Zeller explained that iproniazid had M.A.O. inhibitory action (1952). In 1958, Kuhn reported imipramine, which has similar chemical structure of phenothiazine, showed M.A.O. inhibitory action and antidepressive action. Until recently many psychotropic agents has been introduced and used widely in the field of psychiatry. Author tried to find the influence of various psychotropic agents on gastric secretion and experimentally-induced peptic ulcer in rat. White male rat, average 180g of body weight was used as experimental animal. Experiment on gastric secretion was carried out with the method of Shay(1945), With the centrifuged gastric secretory material, the P.H. was measured by Radiometer, Titrator TTT₂(Copenhagen), and gastric secretion amount was measured by Autoburett, ABU11 (Radiometer). Experiment of artificial gastric ulcer was carried out through the stress givent by ① pyloric ligation ② shaking ③ restraint with upside down position. Pathological change on the mucous membrane of rat stomach including hemorrhage, erosion and perforation etc. was observed by Stereoscope. Result (1) Diazepam inhibited gastric secretion (especially gastric acid) and lowered the acidity. Yet meprobamate on the contrary, raised gastric secretion and acidity, which might possibly be due to its peripheral effect. (2) Chlorpromazine markedly depressed the gastric secretion. But Prochlorperazine, Haloperidol, and Reserpine did not show any significant change on gastric secretion, which might be due to their limited dosage to influence on gastric secretion. (3) Tranylcypromine, and M.A.O. inhibitor, markedly reduced gastric secretion and gastric acidity. The Imipramine, tricyclic antidepressant with similar chemical structure of chlorpromazine, lowered the free acid of stomach in rat. (4) The stress of pyloric ligation showed ulcerative change on rumen of stomach. Diazepam and Chlorpromazine premedicated rat did not reveal much change. But Tranylcypromine premedicated rat showed severe degree of ulcer change on all experimented rats and two of them were dead of perforation of stomach, which seemed to be the result of stomach, which seemed to be the result of stomach, which seemed to be the result of peripheral effect or decreased mucus of gastric secretion as an effect of relax action. (5) The stress of shaking the rat brought erosion and edematous change on rumen but no ulcerative change took place. Diazepam premedicated group has not showed change on mucous membrane. Chlorpromazine premedicated group showed mild degree of change. But Reserpine treated group showed marked degree of ulcer change on the rumen and 4 of this group died of gastric perforation. (6) The stress of restraint of rat with upside down position revealed marked degree of erosion and hemorrhage on glandular portion, but no change on rumen. But Diazepam, Chlorpromazine and Imipramine premedicated group of rats showed lesser degree above changes. As shown above, varions psychotropic agents influenced on gastric secretion and experimentally induced gastric ulcer in rats. It might be explained that most of the psychotropic agents could influence on biogenic amine metabolism of brain and on regulating anxiety, which prevent hypersecretion of stomach. But as a few of the exception for instance. Tranylcypromine and Reserpine brought severe degree of ulcer change, which might possible be due to the peripheral effect. Above two psychotropic agents are to be alarmed to use to the patient with peptic ulcer.
대표농도경로 (RCP) 시나리오에 따른 회야강 유역의 미래 유출 및 유사 변화 분석
황창수(Hwang, Chang Su),최철웅(Choi, Chul Uong),최지선(Choi, Ji Sun) 대한공간정보학회 2014 대한공간정보학회지 Vol.22 No.3
본 연구는 미래 기후변화 및 토지피복변화가 유역 내 유출량과 유사량의 거동에 가져올 영향을 분석하는데 목적이 있다. 기상자료는 IPCC 5차 평가보고서를 위해 새롭게 논의된 RCP 시나리오 중 서로 상반되는 4.5 및 8.5 시나리오의 기후전망 (2011~2100년) 이 사용되었으며, 토지피복지도는 RCP 4.5 및 8.5 시나리오의 사회ㆍ경제 스토리라인과 로지스틱 회귀모형 (LR)을 이용하여 개발 된 모델에 의해 구축되었다. 기후변화만 고려한 경우, 토지피복변화만 고려한 경우, 기후변화 및 토지피복변화 모두 고려한 경우의 세 가지 시나리오를 설정하고, 각 시나리오에 따른 유출량 및 유사량을 모의한 결과 계절적으로 매우 명확한 변화를 나타내었다. 기후변화는 봄과 겨울에 유출량을 증가시키고 여름과 가을에 유출량을 감소시키는 것으로 나타났으며, 유사량 역시 유출량과 동일한 변화의 양상을 보였다. 토지피복변화는 유출량을 증가시키는 반면 유사량은 감소시키며, 이는 도시화로 인한 불투수 면적의 증가에 의한 것으로 판단된다. 토지피복변화는 기후변화에 비해 유출량에 적은 영향을 끼치나, 기후변화에 의해 초래된 유출량 문제를 더욱 극대화 시킬 수 있다. 따라서 지속적인 수자원 관리를 위하여 기후변화의 잠재적 영향을 파악하고, 토지피복변화에 따른 적절한 수자원 대응 정책 마련이 필요할 것으로 판단된다. This study is analyze future climate and land cover change affects behaviors for amount of streamflow and sediment discharge within basin. We used the climate forecast data in RCP 4.5 and 8.5 (2011-2100) which is opposite view for each other among RCP scenarios that are discussed for 5th report for IPCC. Land cover map built based on a socialㆍeconomic storyline in RCP 4.5/8.5 using Logistic Regression model. In this study we set three scenarios: one scenario for climate change only, one for land cover change only, one for Last both climate change and land cover change. It simulated amount of streamflow and sediment discharge and the result showed a very definite change in the seasonal variation both of them. For climate change, spring and winter increased the amount of streamflow while summer and fall decreased them. Sediment showed the same pattern of change steamflow. Land cover change increases the amount of streamflow while it decreases the amount of sediment discharge, which is believed to be caused by increase of impervious Surface due to urbanization. Although land cover change less affects the amount of streamflow than climate change, it may maximize problems related to the amount of streamflow caused by climate change. Therefore, it"s required to address potential influence from climate change for effective water resource management and prepare suitable measurement for water resource.
장순복,최연순,강희선,박소미,Chang, Soon-Bok,Choi, Yun-Soon,Kang, Hee-Sun,Park, So-Mi 대한간호협회 1997 대한간호 Vol.36 No.2
This study was performed to provide preliminary data for the development of a useful instrument to measure the effect of sex education. The study was conducted with the voluntary participation of 155 college students enrolled in the course "Sexuality and Relationship" at Y university in Seoul. At the end of that course, they were asked to write freely about the change they had experienced on sexuality. All meaningful statements were elicited and classified into 7 categories; "Change of Knowledge", "Enlightenment", "Change of Attitude on Sexuality", "Buildup of Ability", "Buildup of. Identity", "Change of Emotion", "Change of Behavior:' There were significant changes in the areas of knowledge(28. 6%), enlightenment(27.4%), and attitudes(20.3%) about sexuality among these 7 categories. The Change of Knowledge category consists of 3 areas: "concretion of knowledge", "increase of information", and "correction of misunderstanding." In the category of Enlightenment, total 12 areas are included: "sex role", "erception of lack of knowledge", "importance of family", "life plan", "parent role", "value of life", "equality", "sexual autonomy", "importance of sexuality", "freedom of sexuality", "perception of sexual problem", and "meaning of love." The Attitude Change category consists of 8 areas. These are "being natural", "being progressive", "being sensitive", "being truthful", "being expressive", "being cautious", "being responsible", and "being confident". The category of Buildup of Ability includes 4 areas: "problem solving", "sex education", "relationship", and "communication". The category of Buildup of Identity includes "sexual identity", and "value of sexuality". The Emotional Change category includes 3 areas: "positive feeling", "negative feeling", and "breaking from negative feeling on sexuality". The Behavior Change category includes "sex-related behavioral change". In conclusion, up to now most researches on sex education effect measures only changes of knowledge, attitude, and behavior. But we believe the changes in "Enlightenment", "Buildup of Ability", "Buildup of Identity", "Change of Emotion", should be included in addition to knowledge, attitude, and behavior in the development of an instrument to measure the sex education effects. And the effect of sex education should measure the degree of learning of autonomy, enlightenment, and ability of behavior and so on rather than studying the simple changes in sexuality.enment", "Buildup of Ability", "Buildup of Identity", "Change of Emotion", should be included in addition to knowledge, attitude, and behavior in the development of an instrument to measure the sex education effects. And the effect of sex education should measure the degree of learning of autonomy, enlightenment, and ability of behavior and so on rather than studying the simple changes in sexuality.ng the simple changes in sexuality.
Brain SPECT 영상의 Attenuation Correction 방법들에 대한 비교
조진우,김창호,나수경,이귀원,Jo, Jin U,Kim, Chang Ho,Na, Soo Kyung,Lee, Gui Won 대한핵의학기술학회 2012 핵의학 기술 Vol.16 No.2
이 연구의 목적은 Brain SPECT (Single Photon Emission Computed Tomography)의 Non-attenuation correction (AC-non) 영상에 대한 attenuation correction(AC) 방법 중 Chang's method와 CT based attenuation correction(AC-CT) 사이의 count를 비교하기 위함이다. phantom study는 증류수로 채워진 hoffman 3D phantom에 $^{99m}Tc$ 37Mbq을 투여하였고, patient study는 normal volunteer에 $^{99m}Tc$-HMPAO 750Mbq를 정맥주입하고 Siemens사의 Symbia T6로 Brain SPECT 영상을 획득하였고 뇌 정량 분석을 하였다. 각각의 방법들을 적용한 transverse image는 같은 위치에서 재구성 되었으며 각각 10, 20, 30번째 slice에서 6개의 region of interest(ROI)를 그려 AC-non 과 AC-CT 그리고 Chang's method의 count를 비교하였다. phantom study에서 AC-non, AC-CT, Chang's method의 각각 평균 count는 $4606.8{\pm}511.3$, $16794.6{\pm}2429.4$, $8752.6{\pm}896.5$이었으며 patient study에서 $5460.8{\pm}519.6$, $15320{\pm}1171.6$, $12795{\pm}1422.1$이었다. phantom study에서 AC-CT와 AC-non 사이의 비는 3.70이고 Chang's method와 AC-non 사이의 비는 1.92였으며 patient study에서는 각각 2.85, 2.38이었다. 우리는 이 연구를 통하여 AC-CT가 Chang's method보다 더 높은 AC을 해준다는 걸 알 수 있었다. 그리고 Chang's method는 patient study에서의 AC 값이 phantom study에서의 AC값보다 더 높다는 것을 알 수 있었다. brain SPECT/CT를 시행하는 경우 scatter correction을 같이 시행하고 bone에 의한 감쇠 정보를 반영할 수 있는 AC-CT가 chang's method보다 정확하다 할 수 있겠다. Purpose : The purpose of this study was to compare count between Chang's method and CT-based attenuation correction (AC-CT) among the attenuation correction (AC) methods for non-attenuation correction (AC-non) images of Brain SPECT (Single Photon Emission Computed Tomography). Materials and Methods : We injected $^{99m}Tc$ 37Mbq in a Hoffman 3D phantom filled with distilled water in the phantom study, and injected intravenously $^{99m}Tc$-HMPAO 740Mbq in a normal volunteer in the patient study, and then obtained Brain SPECT images with Symbia T6 of Siemens and conducted quantitative brain analysis. Transverse images to which each method was applied were rebuilt at the same position, and 6 regions of interest (ROI) were drawn on each of Slice No. 10, 20 and 30 and then the counts of AC-non, AC-CT and Chang's method were compared. Results : The mean counts of AC-non, AC-CT and Chang's method were $4606.8{\pm}511.3$, $16794.6{\pm}2429.4$, and $8752.6{\pm}896.5$, respectively, in the phantom study and $5460.8{\pm}519.6$, $15320{\pm}1171.6$ and $12795{\pm}1422.1$, respectively, in the patient study. In the phantom study, the ratio of AC-CT to AC-non was 3.70 and the ratio of Chang's method to AC-non was 1.92, and in the patient study, they were 2.85 and 2.38, respectively. Conclusion : From this study, we found that AC-CT makes higher AC than Chang's method. In addition, when Chang's method was used, AC in the patient study was higher than that in the phantom study. These results need to be considered also in other examinations.