http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, Wan-Jin,Ko, Tae Hoon,Seo, Min-Kang,Chung, Yong-Sik,Kim, Hak-Yong,Kim, Byoung-Suhk THE KOREAN SOCIETY OF INDUSTRIAL AND ENGINEERING 2018 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY -S Vol.59 No.-
<P><B>Abstract</B></P> <P>A binder-free electrode for flexible supercapacitor applications was fabricated using carbon fiber papers (CFPs) via a facile paper making method. CV curves and galvanostatic charge/discharge profiles exhibited ideal capacitive behavior and linear voltage–time function with small <I>IR</I> drop. O<SUB>2</SUB> activation process greatly affected the porosity and surface structures. The CFP electrodes activated at 325°C for 45min by O<SUB>2</SUB> oxidizing gas showed highest specific capacitance of 156.9Fg<SUP>−1</SUP> and excellent cycle stability (∼90.2%) after 5000 cycles at 1.0Ag<SUP>−1</SUP> in 1.0M H<SUB>2</SUB>SO<SUB>4</SUB>, which presented the possibilities as flexible electrodes with excellent electrochemical performances for EDLCs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Core/shell structured flexible carbon fiber paper electrodes are prepared. </LI> <LI> The O<SUB>2</SUB> activation effects of the core/shell strucuted carbon fibers is studied. </LI> <LI> It delivers the highest specific capacitance of 156.9Fg<SUP>−1</SUP>. </LI> <LI> It shows the excellent cyclic stability with retention of 90.2% after 5000 cycles. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Byoung Wan Lee,Junho Ryeom,Jae-Hyeon Ko,Dong Wook Kim,Chan-Hum Park,Jaehoon Park,Young Ho Ko,Kwang Joo Kim 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.69 No.2
The elastic properties of a biocompatible silk film were investigated under temperature and pressure variations by using Brillouin spectroscopy. The Brillouin frequency shift decreased monotonically upon heating and showed a sudden change at the glass transition temperature. The existence of water molecules in the film increased the longitudinal modulus by approximately 10% and induced a relaxation peak in the hypersonic damping at 60 C. The pressure dependences of the sound velocities of the longitudinal and the transverse acoustic modes and the refractive index were determined for the first time at pressures up to 15.5 GPa. All these properties increased upon compression; these changes indicated that the free volume in the silk film collapsed at a pressure of about 3 GPa.
Bacterial Composition of Respiratory Organs and Intestine in Mice and Rats
Byoung Chun Lee,Mee Kyung Jang,Jong-Kun Seo,Jin-Ho Kang,Kab Ryong Chae,Dae Youn Hwang,Byoung Guk Kim,Seung Wan Jee,Sun Bo Shim,Su Hae Lee,Ji Soon Sin,Chang Jun Bae,Jong-Min Woo,Chuel Kyu Kim 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.1
The change of microbial flora in intestine and respiratory organs make some effects on animal health, which can cause some aberrations to experiment data. Therefore, it is an important factor to maintain the homogeneity of the bacterial composition of each organ. In this study, the bacterial distribution of respiratory organs and intestine were analyzed from 247 mice and 200 rats by analyzing biochemical properties and 16S rDNA sequencing. The total of 1,075 isolates were classified to 35 species of 17 genera. In case of rats, intestinal microbial flora were composed of 5 major bacteria including E. coli, P. mirabilis, M. morganii, C. freundii, and P. vulgaris, and 5 bacteria such as E. coli, P. mirabilis, S. aureus, S. cohnii, and M. morganii also mainly consisted of the microbial flora of respiratory organs. In case of mice, intestinal microbial flora were composed of 4 major bacteria including E. coli, P. mirabilis, A. lwoffi, and L. adecarboxylata, and 5 bacteria such as E. coli, B. sphaericus, S. auricularis, A. lwoffi, and L. adecarboxylata also mainly consisted of microbial flora of respiratory organs. This study suggested that B. sphaericus, G. morbillorum, S. paucimobilis, Staphylococcus spp. were specific in respiratory organs, and that M. morganii and Citrobacter spp. were almost specific in intestine. This study also can give some basic information to understand the relationship between animal care environment and microbial composition of animal organs.
Kim, Dong-Wan,Lee, Dae Ho,Han, Ji-Youn,Lee, Jongseok,Cho, Byoung Chul,Kang, Jin Hyoung,Lee, Ki Hyeong,Cho, Eun Kyung,Kim, Jin-Soo,Min, Young Joo,Cho, Jae Yong,An, Ho Jung,Kim, Hoon-Gu,Lee, Kyung Hee,K Elsevier 2019 Lung cancer Vol.135 No.-
<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>The aim of this phase 1/2 study was to evaluate the safety, tolerability, pharmacokinetics and antitumor activity of olmutinib in patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) who had failed ≥ 1 previous line of EGFR-tyrosine kinase inhibitor (TKI) therapy.</P> <P><B>Materials and methods</B></P> <P>Phase 1 consisted of dose-escalation and four dose-expansion parts (1: olmutinib 300 mg once daily; 2A: 800 mg once daily [<I>EGFR</I> T790 M mutation-positive patients]; 2B: 500 mg twice daily [<I>EGFR</I> T790 M mutation-positive]; 3: 800 mg once daily [<I>EGFR</I> T790 M mutation-negative]). In phase 2, <I>EGFR</I> T790 M mutation-positive patients received olmutinib 800 mg once daily. Data from expansion part 2A and phase 2 were integrated (`pooled phase 2′). Each olmutinib cycle was 21 days. Outcomes included: tumor response, treatment-emergent adverse events (TEAEs), pharmacokinetic parameters.</P> <P><B>Results</B></P> <P>Overall, 272 patients received at least one olmutinib dose: dose-escalation (n = 66), expansion parts (n = 165), phase 2 (n = 41). In pooled phase 2, the overall objective response rate, confirmed by independent review, was 55.1% (38/69 evaluable patients; 95% CI, 42.6–67.1). All responses were partial responses; 23 patients had stable disease. Estimated median progression-free survival was 6.9 (95% CI, 5.6–9.7) months; estimated median overall survival was not reached. The most frequent treatment-related AEs were diarrhea (59.2% of patients), pruritus (42.1%), rash (40.8%), and nausea (39.5%).</P> <P><B>Conclusion</B></P> <P>Olmutinib showed effective clinical activity with a manageable safety profile, indicating therapeutic potential for T790M-positive NSCLC patients who have failed ≥ 1 previous line of EGFR-TKI therapy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Olmutinib showed effective clinical activity. </LI> <LI> The safety profile of olmutinib was manageable. </LI> <LI> Olmutinib showed potential in T790M-positive NSCLC after failing ≥1 prior EGFR-TKI. </LI> </UL> </P>
Alterations of Colonic Contractility in Long-term Diabetic Rat Model
Kim, Sun Joo,Park, Jae Hyung,Song, Dae Kyu,Park, Kyung Sik,Lee, Jeong Eun,Kim, Eun Soo,Cho, Kwang Bum,Jang, Byoung Kuk,Chung, Woo Jin,Hwang, Jae Seok,Kwon, Joong Goo,Kim, Tae Wan Korean Society of Neurogastroenterology and Motili 2011 Journal of Neurogastroenterology and Motility (JNM Vol.17 No.4
<P><B>Background/Aims</B></P><P>Dysfunction of the gastrointestinal tract occurs in about 76% of patients who are diabetic for more than 10 years. Although diabetes-related dysfunctions of the stomach such as gastroparesis have been extensively studied over the recent years, studies about the mechanism underlying colonic symptoms in long-term diabetes models are rare. Therefore, the goal of our study was to clarify the nature of colonic dysfunction in a long-term diabetic rat model.</P><P><B>Methods</B></P><P>The characteristics of colonic smooth muscle were investigated in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. These results were compared to those obtained from Long-Evans Tokushima Otsuka (LETO) control rats.</P><P><B>Results</B></P><P>Spontaneous contractility of the proximal colon was significantly decreased in the diabetic rats compared to the controls, while the spontaneous contractility of the distal colon was not. The number of interstitial cells of Cajal networks in the proximal colon was greatly decreased in diabetic rats compared to the controls. Contractility of the proximal colon in response to carbachol, an acetylcholine receptor agonist, was significantly weaker in the diabetic rats. In addition, the degree of relaxation in response to nitric oxide in the proximal colon of diabetic rats also appeared to be attenuated.</P><P><B>Conclusions</B></P><P>The results from our study suggest that the decrease of interstitial cells of Cajal network, cholinergic receptors, and neuronal nitric oxide synthase in the proximal colon plays important roles in diabetes-related dysfunction of colon.</P>
Comparison of simplified model and FEM model in coupled analysis of floating wind turbine
Kim, Byoung Wan,Hong, Sa Young,Sung, Hong Gun,Hong, Seok Won Techno-Press 2015 Ocean systems engineering Vol.5 No.3
This paper compares simplified and finite element method (FEM) models for tower and blade in dynamic coupled analysis of floating wind turbine. A SPAR type wind turbine with catenary mooring lines is considered in numerical analysis. Floating body equation is derived using boundary element method (BEM) and convolution. Equations for mooring line, tower and blade are formulated with theories of catenary, elastic beam and aerodynamic rotating beam, respectively and FEM is applied in the formulation. By combining the equations, coupled solutions are calculated. Tower or blade may be assumed rigid or lumped body for simplicity in modeling. By comparing floating body motions, mooring line tensions and tower stresses with the simple model and original FEM model, the effect of including or neglecting elastic, rotating and aerodynamic behavior of tower and blade is discussed.