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Bon-Gwon Koo,Dong-Hee Lee,Won-Sub Kim,Jin-Hwan Yoon 한국생활환경학회 2018 한국생활환경학회지 Vol.25 No.1
In the present study, we investigated the effects of 12 weeks resistance exercise on muscle strength, breaking force and serum ALP level in orchiectomized(OCX) rats. Thirty male Sprague–Dawley rats(30 weeks) were used as subjects. The subjects were divided into three groups; control group(CG, n=10), OCX control rats group(OCXC, n=10) and OCXC rats+resistance exercise group(OCXC+RE, n=10). Progressive resistance training using a ladder and tail weights was performed for 12 weeks (3 days/week). After the experiment for 12 weeks, grip strength was significantly higher in OCXC+RE group than OCXC group(p<0.05). Femur breaking force was significantly higher in OCXC+RE group than OCXC group(p<0.05). Serum ALP level was significantly increased in OCXC+RE group compared with OCXC group(p<0.05). In conclusion, theses results suggest that regular resistance exercise training can improve muscle strength, breaking force and markers of bone formation in orchiectomized rats.
1.55-μm DFB lasers over a wide temperature range for analog application
Koo, Bon-Jo,Song, Han-Wook,Kim, Yong-Kwan,Park, Chil-Sung,Ryu, Han-Gwon,Huh, Kwang-Soo,Park, Seung-Bae,Lhee, Zail,Choe, Hyosin,Lee, Seok,Han, Sang-Kook Wiley Subscription Services, Inc., A Wiley Company 2006 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS - Vol.48 No.2
<P>Strained-layer multiquantum-well distributed-feedback (SL-MQW-DFB) lasers at a wavelength of 1.55 μm operating from −40°C to 85°C without any coolers are demonstrated. The average value of IMD3 at 1.8 GHz and 5 mW operating conditions was −71 dBc, and the RIN at 2 mW was measured as 151 dB/Hz. The uncooled DFB lasers we have developed are very useful for mobile applications. © 2005 Wiley Periodicals, Inc. Microwave Opt Technol Lett 48: 273–275, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.21325</P>
Koo, Bon-Kwon,Waseda, Katsuhisa,Kang, Hyun-Jae,Kim, Hyo-Soo,Nam, Chang-Wook,Hur, Seung-Ho,Kim, Jung-Sun,Choi, Donghoon,Jang, Yangsoo,Hahn, Joo-Yong,Gwon, Hyeon-Cheol,Yoon, Myeong-Ho,Tahk, Seung-Jea,Ch Ovid Technologies Wolters Kluwer -American Heart A 2010 Circulation. Cardiovascular interventions Vol.3 No.2
<P>BACKGROUND: We sought to investigate the mechanism of geometric changes after main branch (MB) stent implantation and to identify the predictors of functionally significant 'jailed' side branch (SB) lesions. METHODS AND RESULTS: Seventy-seven patients with bifurcation lesions were prospectively enrolled from 8 centers. MB intravascular ultrasound was performed before and after MB stent implantation, and fractional flow reserve was measured in the jailed SB. The vessel volume index of both the proximal and distal MB was increased after stent implantation. The plaque volume index decreased in the proximal MB (9.1+/-3.0 to 8.4+/-2.4 mm(3)/mm, P=0.001), implicating plaque shift, but not in the distal MB (5.4+/-1.8 to 5.3+/-1.7 mm(3)/mm, P=0.227), implicating carina shifting to account for the change in vessel size (N=56). The mean SB fractional flow reserve was 0.71+/-0.20 (N=68) and 43% of the lesions were functionally significant. Binary logistic-regression analysis revealed that preintervention % diameter stenosis of the SB (odds ratio=1.05; 95% CI, 1.01 to 1.09) and the MB minimum lumen diameter located distal to the SB ostium (odds ratio=3.86; 95% CI, 1.03 to 14.43) were independent predictors of functionally significant SB jailing. In patients with > or =75% stenosis and Thrombolysis In Myocardial Infarction grade 3 flow in the SB, no difference in post-stent angiographic and intravascular ultrasound parameters was found between SB lesions with and without functional significance. CONCLUSIONS: Both plaque shift from the MB and carina shift contribute to the creation/aggravation of an SB ostial lesion after MB stent implantation. Anatomic evaluation does not reliably predict the functional significance of a jailed SB stenosis.</P>
Gwon, Hyeon-Cheol,Hahn, Joo-Yong,Park, Kyung Woo,Song, Young Bin,Chae, In-Ho,Lim, Do-Sun,Han, Kyoo-Rok,Choi, Jin-Ho,Choi, Seung-Hyuk,Kang, Hyun-Jae,Koo, Bon-Kwon,Ahn, Taehoon,Yoon, Jung-Han,Jeong, Myu Ovid Technologies Wolters Kluwer -American Heart A 2012 CIRCULATION - Vol.125 No.3
<P>The optimal duration of dual antiplatelet therapy (DAPT) after implantation of drug-eluting coronary stents remains undetermined. We aimed to test whether 6-month DAPT would be noninferior to 12-month DAPT after implantation of drug-eluting stents.</P>
Cho, Youngjin,Koo, Bon-Kwon,Song, Young Bin,Hahn, Joo-Yong,Choi, Seung-Hyuk,Gwon, Hyeon-Cheol,Rha, Seung Woon,Yu, Cheol Woong,Park, Jong-Seon,Bae, Jang-Ho,Lee, Jae-Hwan,Jeong, Myung-Ho,Yoon, Jung Han Japanese Circulation Society 2015 CIRCULATION JOURNAL Vol.79 No.3
<P>Background: There are limited data on the relative efficacy of 1st-vs. 2nd-generation limus-eluting stents in bifurcation lesions. Methods and Results: Our analysis of a Korean multicenter registry for bifurcated coronary lesions enrolled 1,762 patients treated with 2nd-generation everolimus-eluting stent (EES, n=348) or 1st-generation sirolimus-eluting stents (SES, n=1,414). In the overall population, EES was comparable to SES regarding major adverse cardiac events (MACE: composite of cardiac death, nonfatal myocardial infarction, and target vessel revascularization (TVR)), cardiac death, and TVR rates within a 2-year follow-up. In 1: 3 propensity score-matched populations, EES showed a significantly lower MACE rate compared with SES (HR [95% CI], 0.53 [0.29-0.97]; P=0.039), mainly through a reduction in repeat revascularization (HR [95% CI], 0.47 [0.24-0.92]; P=0.027). EES was superior to SES in reducing TVR in patients with left main (LM) lesions (HR [95% CI], 0.21 [0.06-0.67]; P=0.008) or in patients treated with 2-stent technique PCI (HR [95% CI], 0.28 [0.09-0.91]; P=0.035). There was no difference in clinical outcomes between 2 stents in a non-LM bifurcation lesion or in patients treated with a 1-stent technique. Conclusions: At 2-year follow-up, 1st- and 2nd-generation limus-eluting stents showed comparable clinical outcomes in general bifurcation lesions. EES was superior to SES after matching by propensity score, especially in patients with LM bifurcation or in those treated by a 2-stent technique.</P>
Shin, Dong-Ho,Park, Kyung Woo,Koo, Bon-Kwon,Oh, Il-Young,Seo, Jae-Bin,Gwon, Hyeon-Cheol,Jeong, Myung-Ho,Seong, In-Whan,Rha, Seung Woon,Yang, Ju-Young,Park, Seung-Jung,Yoon, Jung Han,Han, Kyoo-Rok,Park The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.8
<P>This study compared two-stent strategies for treatment of bifurcation lesions by stenting order, 'main across side first (A-family)' vs 'side branch first (S-family). The study population was patients from 16 centers in Korea who underwent drug eluting stent implantation with two-stent strategy (A-family:109, S-family:140 patients). The endpoints were cardiac death, myocardial infarction (MI), stent thrombosis (ST), and target lesion revascularization (TLR) during 3 years. During 440.8 person-years (median 20.2 months), there was 1 cardiac death, 4 MIs (including 2 STs), and 12 TLRs. Cumulative incidence of cardiac death, MI and ST was lower in A-family (0% in A-family vs 4.9% in S-family, <I>P</I> = 0.045). However, TLR rates were not different between the two groups (7.1% vs 6.2%, <I>P</I> = 0.682). Final kissing inflation (FKI) was a predictor of the hard-endpoint (hazard ratio 0.061; 95% CI 0.007-0.547, <I>P</I> = 0.013), but was not a predictor of TLR. The incidence of hard-endpoint of S-family with FKI was comparable to A-family, whereas S-family without FKI showed the poorest prognosis (1.1% vs 15.9%, retrospectively; <I>P</I> = 0.011). In conclusion, 'A-family' seems preferable to 'S-family' if both approaches are feasible. When two-stent strategy is used, every effort should be made to perform FKI, especially in 'S-family'.</P>
Park, Kyung Woo,Rhee, Tae-Min,Kang, Hyun-Jae,Koo, Bon-Kwon,Gwon, Hyeon-Cheol,Yoon, Jung-Han,Lim, Do-Sun,Chae, In-Ho,Han, Kyoo-Rok,Ahn, Taehoon UNKNOWN 2018 CIRCULATION JOURNAL Vol.82 No.6
<P>Conclusions: EES and SES had similar efficacy with regard to 3-year outcomes in the EXCELLENT trial, while delayed safety events all trended to favor EES.</P>
-40~85℃ 범위에서 단일모드 동작이 가능한 1.49㎛ 비냉각 DFB-LD의 제작
이우원(Woo-Won Lee),김정호(Jeong-Ho Kim),류한권(Han-Gwon Ryu),박칠성(Chil-Sung Park),피중호(Joong-Ho Pi),구본조(Bon-Jo Koo) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.11
In order to obtain stable single mode operation around 1.49 ㎛ range over -40~85℃, strained layer MQW DFB-LD is fabricated by MOCVD method. Fabricated DFB-LDs have low threshold current of 6.2㎃ and 20.45㎃ at 25℃ and 85℃, respectively. Also, side-mode suppression ratio of them is over 35 ㏈m up to 85℃. Their slope efficiencies are 0.3㎽/㎃ and 0.21㎽/㎃ at 25℃ and 85℃, respectively.
Jihoon Kim,Joo Myung Lee,Seung-Hyuk Choi,Ki Hong Choi,Taek Kyu Park,Sung-Ji Park,Jeong Hoon Yang,Young Bin Song,Joo-Yong Hahn,Mi Ja Jang,Bon-Kwon Koo,Hyeon-Cheol Gwon 대한심장학회 2020 Korean Circulation Journal Vol.50 No.5
Background and Objectives: Although percutaneous coronary intervention (PCI) is recommended to improve symptoms in patients with stable ischemic heart disease (SIHD), improvement of exercise performance is controversial. This study aimed to investigate changes in exercise duration after PCI according to functional completeness of revascularization by comparing pre- and post-PCI exercise stress test (EST). Methods: Patients with SIHD were enrolled from a prospective PCI registry, and divided into 2 groups: 1) functional complete revascularization (CR) group had a positive EST before PCI and negative EST after PCI, 2) functional incomplete revascularization (IR) group had positive EST before and after PCI. Primary outcome was change in exercise duration after PCI and secondary outcome was major adverse cardiac events (MACE, a composite of any death, any myocardial infarction, and any ischemia-driven revascularization) at 3 years after PCI. Results: A total of 256 patients (149 for CR group, and 107 for IR group) were eligible for analysis. Before PCI, exercise duration was not significantly different between the functional CR and IR groups (median 540 [interquartile range; IQR, 414, 602] vs. 480 [402, 589] seconds, p=0.091). After PCI, however, the CR group had a significantly higher increment of exercise duration than the IR group (median 62.0 [IQR, 12.0, 141.0] vs. 30.0 [−11.0, 103.5] seconds, p=0.011). The functional CR group also had a significantly lower risk of 3-year MACE (6.2% vs. 26.1%; adjusted hazard ratio, 0.19; 95% confidence interval, 0.09–0.41; p<0.001). Conclusions: Functional CR showed a higher increment of exercise duration than functional IR.