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- 발행기관 : Japanese Circulation Society (검색결과 33 건)
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Jeong, Han Saem,Hong, Soon Jun,Park, Jae Hyoung,Kim, Jong-Ho,Choi, Seung Cheol,Ahn, Chul-Min,Kim, Je Sang,Lim, Do-Sun Japanese Circulation Society. 2012 Circulation journal Vol.76 No.5
<P><B><I>Background:</I></B> The correlations between circulating angiogenic cell mobilizations and improvement of microvascular integrity were investigated in patients (n=110) with acute myocardial infarction (AMI) during an 8-month follow up. <B><I>Methods and Results:</I></B> Coronary flow reserve (CFR) was measured at baseline and at 8 months by using an intracoronary Doppler wire. Serial changes in the absolute numbers of circulating angiogenic cells such as CD34+, CXCR4+, CD117+, CD133+ and C-met+ were measured at baseline, day 1, day 5 and at 8 months. The absolute numbers of circulating angiogenic cells at day 1 were significantly higher than those at baseline. A positive correlation was found between the numbers of circulating angiogenic cells of CD34+, CXCR4+, CD117+ and CD133+ cells at day 1 and the CFR changes from baseline. The cut-off value of CFR changes at 8 months by a receiver operating characteristic curve between a circulating CD34+ cell at day 1 and changes of CFR at 8 months was 0. Late-loss showed the positive correlation with the absolute number of C-met+ cells and the negative correlation with the absolute number of CXCR4+ cells after AMI. The negative correlation was found between changes in high-sensitive C-reactive protein and soluble intercellular adhesion molecule-1 and changes in CFR at 8 months. <B><I>Conclusions:</I></B> The recovery of microvascular integrity after acute ischemic injury was expedited by the increases in circulating angiogenic cell mobilization together with the greater decreases in inflammatory cytokines. The improvement in CFR could be predicted by the measurement of circulating angiogenic cells after AMI. (<I>Circ J</I> 2012; <B>76:</B> 1213-1221)</P>
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Hong, Soon Jun,Choi, Seung Cheol,Cho, Jae Young,Joo, Hyung Joon,Park, Jae Hyoung,Yu, Cheol Woong,Lim, Do-Sun Japanese Circulation Society 2015 Circulation journal Vol.79 No.4
<P>Background: Aberrant expression of microRNAs is associated with neointimal hyperplasia (NIH) in type 2 diabetes. We prospectively compared the effects of pioglitazone on coronary NIH and changes in microRNAs according to NIH status in type 2 diabetic patients during 9-month follow-up. Methods and Results: Type 2 diabetic patients were randomly assigned to the pioglitazone (n=36) or control groups (n=36) after coronary stenting. Primary endpoint was the comparison of changes in neointimal volume on OCT and in the level of circulating microRNA-17,-24,-92a,-126 and -145 during 9-month follow-up. Secondary endpoint was the comparison of changes in brachial artery flow-mediated dilation and inflammatory markers such as IL-6, TNF-alpha, hsCRP, adiponectin, sICAM-1, and sVCAM-1 between the 2 groups. Neointimal volume was significantly lower in the pioglitazone group (25.02 +/- 17.78 mm(3) vs. 55.10 +/- 30.01 mm(3), P<0.001) with significant increases in circulating microRNA-24 (0.264 +/- 0.084 vs. 0.006 +/- 0.030, P<0.001) during follow-up. FMD was significantly greater in the pioglitazone than control group at 9 months (0.47 +/- 0.14 mm vs. 0.28 +/- 0.18 mm, P<0.05, respectively). Decreases in inflammatory markers such as IL-6, TNF-alpha, and sVCAM-1 were significantly greater in the pioglitazone than the control group during the follow-up. Conclusions: Pioglitazone significantly decreased NIH with increases in circulating microRNA-24 at 9-month follow-up. The decrease in microRNA-24 could be used as a potential predictor of increases in NIH in type 2 diabetic patients.</P>
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Choi, Eue-Keun,Kim, Hyo-Soo,Park, Kyung-Woo,Kim, Hyung-Kwan,Cho, Joung-Won,Lee, Myoung-Mook,Park, Young-Bae,Choi, Yun-Shik Japanese Circulation Society. 2005 CIRCULATION JOURNAL Vol.69 No.7
<P><B>Background</B> There is a paucity of information regarding the impact of the coronary collaterals on prognosis in type 2 diabetic (T2DM) patients. We developed a novel index, which considers not only the degree of collateral circulation but also the stimulus of collateral development, and investigated its prognostic value in T2DM patients with coronary artery disease (CAD). <B>Methods and Results</B> One hundred and ninety four consecutive T2DM patients were analyzed and followed for an average of 30 months. We measured the diameter stenosis (DS; %), corrected TIMI frame count (CTFC) and Rentrop score at 3 major epicardial coronary arteries. The collateral development (CD) score was calculated by: (Σ Rentrop score +1)/Σ [DS (%) × CTFC] ×1,000. During the follow-up, acute cardiovascular events occurred in 49 patients. By multivariate analysis, the CD score was an independent predictor of adverse events not only in the total population (p<0.001), but in all 3 subgroups (p=0.020 for coronary artery bypass grafting, p=0.030 for percutaneous transluminal coronary angioplasty (PTCA) and p=0.003 for the medical group). Furthermore, patients in the tertile with the highest CD score showed improved survival by Kaplan-Meier analysis in the total population, the PTCA and the medical group. <B>Conclusions</B> The CD score, a novel index of collateral development, may be a useful predictor of clinical outcome in T2DM patients with CAD. (<I>Circ J</I> 2005; <B>69:</B> 786 - 792)</P>
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Lee, Sak,Chang, Byung-Chul,Youn, Young-Nam,Kwak, Young-Lan,Yoo, Kyung-Jong Japanese Circulation Society. 2007 CIRCULATION JOURNAL Vol.71 No.10
<P><B>Background</B> An association of mitral regurgitation (MR) with ischemic cardiomyopathy (I-CMP) increases the risk of heart failure and its surgical management remains controversial. <B>Methods and Results</B> Between July 2001 and June 2006, a total of 49 patients with I-CMP underwent surgical ventricular restoration (SVR) and coronary revascularization with or without concomitant mitral annuloplasty (MAP). The mean age was 59.8 years, and all patients had New York Heart Association (NYHA) class III or IV heart failure (mean left ventricular ejection fraction (LVEF) = 24.8%). Nineteen patients had MR >grade 3 (MR group). SVR and coronary artery bypass grafting were performed in all patients, and concomitant MAP was performed in the MR group. Echocardiography was performed preoperatively, postoperatively, and at mean of 19 months after operation. Preoperative left ventricular (LV) end-diastolic and end-systolic dimensions, left atrial volume index, and MR grade were statistically significantly increased in the MR group. On the early postoperative echocardiogram, mean LVEF was significantly improved, with reduction of LV dimensions, in both groups; however, at follow up, these parameters were more significantly improved in the MR group, but unchanged in non-MR group, reaching almost the same levels as the non-MR group. <B>Conclusion</B> In patients with I-CMP, MR increases early and late mortality; however, after SVR and concomitant MAP, LV function seems to continuously improve with more significant reduction in the LV dimensions than in the non-MR group. (<I>Circ J</I> 2007; <B>71:</B> 1516 - 1520)</P>
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On, Young Keun,Park, Hyeong Kyu,Hyon, Min Su,Jeon, Eun-Seok Japanese Circulation Society. 2007 CIRCULATION JOURNAL Vol.71 No.6
<P><B>Background</B> Resistin is an adipocyte-secreted hormone. The relationship between circulating resistin concentrations and atherosclerotic coronary artery disease (CAD) in type 2 diabetic patients, if any, remains poorly understood. Serum resistin concentrations were investigated in type 2 diabetic patients with CAD (DMCAD), and compared with the concentrations in diabetics patients without CAD (diabetes mellitus, DM). Whether resistin levels are associated with increased restenosis rates in diabetic patients with CAD after successful coronary stenting was also investigated. <B>Methods and Results</B> Fasting serum resistin, adiponectin, and leptin concentrations were measured in 45 DMCAD patients and 47 DM controls. The percutaneous coronary intervention study included 70 DMCAD patients, who underwent elective and successful coronary bare metal stent (BMS) implantation for the treatment of de novo lesions. Serum resistin concentrations were higher in the DMCAD patients than in the DM controls (5.75±3.21 vs 2.53±2.47 ng/ml, mean ± SEM, p<0.001), and these differences were persistent regardless of age or body mass index. Insulin resistance indices, as assessed via homeostasis model assessment (HOMA-IR) correlated significantly with resistin concentrations (r=0.4, p<0.001). Resistin was an independent factor, and was associated with DMCAD in the multivariate analysis. In the percutaneous coronary intervention study, HOMA-IR was not associated with subsequent restenosis rates after BMS implantation in DMCAD patients. Pre-procedural serum resistin concentrations were higher in restenosis group than in the patients without restenosis. <B>Conclusions</B> Serum resistin may prove to be a useful biological marker for CAD and restenosis in patients with type 2 DM. (<I>Circ J</I> 2007; <B>71:</B> 868 - 873)</P>
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Cho, In Jeong,Shim, Chi Young,Yang, Woo-In,Kim, Sung-Ai,Chang, Hyuk-Jae,Jang, Yangsoo,Chung, Namsik,Ha, Jong-Won Japanese Circulation Society. 2010 CIRCULATION JOURNAL Vol.74 No.7
<P><B><I>Background:</I></B> Alteration of arterial elastic properties is known to occur in patients with arteritis. Velocity vector imaging (VVI) is a new technology to assess multi-dimensional regional mechanics in terms of velocity, strain, strain rate and displacement. The aim of the present study was to investigate the mechanical properties of the common carotid artery using VVI in patients with Takayasu's arteritis (TA). <B><I>Methods and Results:</I></B> Vascular properties of the carotid artery were assessed in 12 patients with TA (11 female, age 38±10 years) and 12 healthy age- and sex-matched controls. Velocity, strain, strain rate and displacement were decreased significantly in TA compared with controls. Standard deviations, however, of time to peak velocity (Tv), strain (Ts), strain rate (Tsr), and displacement (Td) of multiple arterial wall segments were significantly higher in TA (P<0.0001), suggesting disturbance of symmetric arterial expansion during systole. The severity of carotid stenosis was also positively correlated with standard deviations of Tv, Ts, Tsr and Td. <B><I>Conclusions:</I></B> Arterial assessment using VVI may represent a new noninvasive method for quantifying vascular alteration associated with arteritis. (<I>Circ J</I> 2010; <B>74:</B> 1465 - 1470)</P>
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Lee, Dong-Hyeon,Youn, Ho-Joong,Choi, Yun-Seok,Park, Chul-Soo,Park, Jeong-Hwan,Jeon, Hui-Kyung,Kim, Jae-Hyung Japanese Circulation Society. 2010 CIRCULATION JOURNAL Vol.74 No.7
<P><B><I>Background:</I></B> The aim of the present study was to analyze the parameters related to baseline coronary flow velocity (CFV) and coronary flow reserve (CFR) using Doppler transthoracic echocardiography (TTE), and to assess their associations with components of the Framingham risk score (FRS), which estimates 10-year risk of coronary heart disease, in subjects with chest pain and a normal coronary angiogram. <B><I>Methods and Results:</I></B> A total of 354 individuals (mean age: 55±11 years, M:F ratio =186:168) with angina or angina-like chest pain and a normal coronary arteriogram were enrolled. CFR, using TTE and adenosine or dipyridamole, was measured within 2 weeks after coronary angiogram. The clinical, electrocardiographic, echocardiographic and laboratory parameters related to baseline CVF and CFR were analyzed, and CFR was compared with FRS. There was an inverse correlation between baseline CFV and CFR (r=-0.374, P<0.001). On multivariate analysis the fulfilling of left ventricular hypertrophy criteria on electrocardiography was an independent predictor of baseline CFV for the upper 75% quartile (23.2≥cm/s; odds ratio (OR) = 2.840, 95% confidence interval (CI) =1.155-6.983, P=0.023). On multivariate analysis hemoglobin A<SUB>1c</SUB> level was independently related to a CFR <2.0 (OR = 2.195, 95%CI = 0.920-1.005, P=0.013). CFR had an inverse correlation with FRS (r=-0.222, P<0.001). On multiple regression analysis among the components of the FRS system (FRSS), independent factors related to a CFR <2.0 included age (OR =1.033, 95%CI =1.000-1.067, P=0.041), high-density lipoprotein-cholesterol level (OR = 0.961, 95%CI = 0.933-0.991, P=0.012) and smoking status (OR = 2.461, 95%CI =1.078-5.618, P=0.033), respectively. <B><I>Conclusions:</I></B> CFR can be a comprehensive indicator of cardiovascular risk factors, including parameters of the FRSS, in subjects with chest pain and a normal coronary angiogram. (<I>Circ J</I> 2010; <B>74:</B> 1405 - 1414)</P>
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Change in Ischemia-Modified Albumin and Its Clinical Significance During Exercise Stress Testing
Lee, Dong-Hyeon,Jeon, Hui-Kyung,Park, Hun-Jun,Shin, Woo-Seung,Lee, Seung-Won,Youn, Ho-Joong,Kim, Chul-Min,Lee, Hae Kyung Japanese Circulation Society. 2010 CIRCULATION JOURNAL Vol.74 No.3
<P><B><I>Background:</I></B> There is little data about the additive effects of ischemia-modified albumin (IMA) on the exercise stress test (EST) used for the screening of ischemic heart disease. The relationship between myocardial ischemic burden and the change in IMA (ΔIMA) during EST was investigated. <B><I>Methods and Results:</I></B> EST was performed using the Bruce protocol to evaluate chest pain or exertional dyspnea in 155 patients (men 89, 53±13 years). Blood samples for IMA were obtained before and immediately after EST. According to the EST results and the pattern of ΔIMA, patients were categorized into 3 groups (none was classified as EST(-)/ΔIMA(+)): (1) (EST(-); (2) EST(+)/ΔIMA(-); and (3) EST(+)/ΔIMA(+). After EST, 60 of 155 (38.7%) patients were EST(+) and 14/60 (23.3%) were EST(+)/ΔIMA(+). Duke treadmill score was significantly lower in the EST(+)/ΔIMA(+) group compared with the other groups (-9.0±7.9, -1.7±4.2, 6.7±4.4, respectively, P<0.001); 43/60 (72%) patients with EST(+) underwent coronary angiography and the proportion of patients with a large ischemic burden was higher in the EST(+)/ΔIMA(+)group compared with the EST(+)/ΔIMA(-) group (72.7% vs 15.6%, P=0.001). <B><I>Conclusions:</I></B> Increased IMA after EST suggests a large ischemic burden in coronary artery disease, so the ΔIMA during EST may be useful for predicting the severity of myocardial ischemia. (<I>Circ J</I> 2010; <B>74:</B> 484 - 489)</P>
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Evaluation of Metabolic Syndrome Risk in Korean Premenopausal Women
Hyun, Yae Jung,Kim, Oh Yoen,Jang, Yangsoo,Ha, Jong-Won,Chae, Jey Sook,Kim, Ji Young,Yeo, Hyun Yang,Paik, Jean Kyung,Lee, Jong Ho Japanese Circulation Society. 2008 CIRCULATION JOURNAL Vol.72 No.8
<P><B>Background</B> In clinical practice, using the patient's waist circumference (WC) to evaluate visceral obesity may underestimate disorders with a metabolic origin. This study examined whether or not the WC derived from the cut-off point of the visceral fat area (VFA) can reflect the features of metabolic syndrome (MetS) in premenopausal women. <B>Methods and Results</B> Computed tomography-scanned VFA, MetS components and the concentrations of high-sensitivity C-reactive protein (CRP) and adiponectin were measured in a total of 349 premenopausal women. The VFA at the L1 and the L4 sites was a significant index (p<0.001) of incremental MetS risk. Receiver-operating characteristic curve analysis showed that 75 cm<SUP>2</SUP> of VFA at L4 and 87.5 cm<SUP>2</SUP> at L1 were the optimal thresholds for discrimination of MetS risk. Significant differences in all MetS components, as well as CRP (p<0.05) and adiponectin levels (p<0.005), were observed when subjects were subdivided by the L4 VFA cut-off point (<75/≥75 cm<SUP>2</SUP>), whereas there was a significant difference only in the triglycerides level in the groups divided by WC (WC <88/≥88 cm). Moreover, subjects with a lower WC - higher VFA showed a similar pattern in MetS components and lower adiponectin than those with a higher WC - higher VFA. <B>Conclusions</B> This study clarified that VFA rather than WC is a major determinant of MetS risk in premenopausal women. (<I>Circ J</I> 2008; <B>72:</B> 1308 - 1315)</P>
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