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- 검색키워드
- 저자 : Bin Shao (검색결과 41 건)
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Nai-Bin Chen,Bo Qiu,Jun Zhang,Meng-Yun Qiang,Yu-Jia Zhu,Bin Wang,Jin-Yu Guo,Ling-Zhi Cai,Shao-Min Huang,Meng-Zhong Liu,Qun Li,Yong-Hong Hu,Qi-Wen Li,Hui Liu 대한암학회 2020 Cancer Research and Treatment Vol.52 No.1
Purpose The purpose of this study was to compare the survival and toxicities in cervical esophageal squamous cell carcinoma (CESCC) treated by concurrent chemoradiothrapy with either three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT) techniques. Materials and Methods A total of 112 consecutive CESCC patients were retrospectively reviewed. 3D-CRT and IMRT groups had been analyzed by propensity score matching method, with sex, age, Karnofsky performance status, induction chemotherapy, and tumor stage well matched. The Kaplan- Meier method and Cox proportional hazards model were used for overall survival (OS) and progression-free survival (PFS). Toxicities were compared between two groups by Fisher exact test. Results With a median follow-up time of 34.9 months, the 3-year OS (p=0.927) and PFS (p=0.859) rate was 49.6% and 45.8% in 3D-CRT group, compared with 54.4% and 42.8% in IMRT group. The rates of grade ! 3 esophagitis, grade ! 2 pneumonitis, esophageal stricture, and hemorrhage were comparable between two groups, while the rate of tracheostomy dependence was much higher in IMRT group than 3D-CRT group (14.3% vs.1.8%, p=0.032). Radiotherapy technique (hazard ratio [HR], 0.09; 95% confidence interval [CI], 0.01 to 0.79) and pretreatment hoarseness (HR, 0.12; 95% CI 0.02 to 0.70) were independently prognostic of tracheostomy dependence. Conclusion No survival benefits had been observed while comparing IMRT versus 3D-CRT in CESCC patients. IMRT with fraction dose escalation and pretreatment hoarseness were considered to be associated with a higher risk for tracheostomy dependence. Radiation dose escalation beyond 60 Gy should be taken into account carefully when using IMRT with hypofractionated regimen.
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Surgical Treatment for Early Esophageal Squamous Cell Carcinoma
Chen, Shao-Bin,Weng, Hong-Rui,Wang, Geng,Yang, Jie-Sheng,Yang, Wei-Ping,Liu, Di-Tian,Chen, Yu-Ping,Zhang, Hao Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
More studies are needed to clarify treatments and prognosis of early esophageal squamous cell carcinoma (ESCC). This retrospective study was designed to review the outcome of surgical treatment for early ESCC, evaluate the results of a left thoracotomy for selected patients with early ESCC, and identify factors affecting lymph node metastases and survival. The clinicopathological data of 228 patients with early ESCC who underwent transthoracic esophagectomy with lymphadenectomy without preoperative adjuvant treatment were reviewed. The ${\chi}^2$ test or Fisher's exact test were used to detect factors related to lymph node metastasis. Univariate and multivariate analyses were performed to identify prognostic factors. There were 152 males and 76 females with a median age of 55 years. Two hundred and eight patients underwent a left thoracotomy, and the remaining 20 patients with lymph nodes in the upper mediastinum more than 5 mm in short-axis diameter by computed tomography scan underwent a right thoracotomy. No lymph node metastasis was found in the 18 patients with carcinoma in situ, while lymph node metastases were detected in 1.6% (1/62) of patients with mucosal tumours and 18.2% (27/148) of patients with submucosal tumours. Only 7 patients showed upper mediastinal lymph node metastases in the follow-up. The 5- and 10-year overall survival rates were 81.4% and 70.1%, respectively. Only histologic grade (P<0.001) and pT category (P=0.001) significantly correlated with the presence of lymph node metastases. In multivariate analysis, only histologic grade (P=0.026) and pT category (P=0.008) were independent prognostic factors. A left thoracotomy is acceptable for selected patients with early ESCC. Histologic grade and pT category affected the presence of lymph node metastases and were independent prognostic factors for early ESCC.
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Experimental and numerical analysis of fatigue behaviour for tubular K-joints
Shao, Yong-Bo,Cao, Zhen-Bin Techno-Press 2005 Structural Engineering and Mechanics, An Int'l Jou Vol.19 No.6
In this paper, a full-scale K-joint specimen was tested to failure under cyclic combined axial and in-plane bending loads. In the fatigue test, the crack developments were monitored step by step using the alternating current potential drop (ACPD) technique. Using Paris' law, stress intensity factor, which is a fracture parameter to be frequently used by many designers to predict the integrity and residual life of tubular joints, can be obtained from experimental test results of the crack growth rate. Furthermore, a scheme of automatic mesh generation for a cracked K-joint is introduced, and numerical analysis of stress intensity factor for the K-joint specimen has then been carried out. In the finite element analysis, J-integral method is used to estimate the stress intensity factors along the crack front. The numerical stress intensity factor results have been validated through comparing them with the experimental results. The comparison shows that the proposed numerical model can produce reasonably accurate stress intensity factor values. The effects of different crack shapes on the stress intensity factors have also been investigated, and it has been found that semi-ellipse is suitable and accurate to be adopted in numerical analysis for the stress intensity factor. Therefore, the proposed model in this paper is reliable to be used for estimating the stress intensity factor values of cracked tubular K-joints for design purposes.
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Bin Liu,Wei Fan,Xu Huang,Xudong Shao,Lijing Kang 한국콘크리트학회 2020 International Journal of Concrete Structures and M Vol.14 No.4
Detailed finite element (FE) models are often employed to predict the impact responses of reinforced concrete (RC) columns. However, they always require substantial investments of time and effort in modeling and analysis so that they are not widely used in practice, particularly in preliminary designs. Moreover, although some simplified models have been established for beams and slabs under impact loading, few attempts have been made on modeling RC columns. For these reasons, this paper proposes a simplified modeling method to accurately capture the impact-induced response and damage of circular RC columns. In the proposed method, a two-degree-of-freedom (DOF) system was used to describe the interaction between the impactor and the impacted column. The formulas, and procedure to estimate the force-deformation relationship with strain-rate effects were presented according to the section-based analysis. The influence of the unloading stiffness on the residual deformation was addressed, and the method to determine the unloading stiffness of circular columns was proposed. Furthermore, a fiber-based beam-column element modeling method was developed to estimate the force-deformation relationship of the columns with strain-rate effects. The proposed simplified method was demonstrated by the drop-hammer impact tests to be capable of predicting the impact response of RC columns well. Its accuracy in the residual deformation is superior to that of the detailed FE simulation. Parametric studies were performed to investigate the damage characteristics of axially-loaded circular RC columns under various impact scenarios.
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Bin Zhu-Zuo,Min Sun-Shu,Yuan Liu-Yi,Ping Huang-Shao 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.4
A large proportion of renewable energy is integrated into power system, resulting in the gradual electrifi cation of the power system and appearing the characteristics of a weak power grid. Under weak grid, current source virtual synchronous generator (VSG) is prone to resonance. To ensure stable and uninterrupted operation of renewable energy through power electronic devices connected to grid, this paper proposes a composite control method based on grid voltage feedforward (GVF) and q-axis impedance reshaping (QAIR) for current source VSG converter resonance suppression. Firstly, sequence impedance modeling (SIM) and stability analysis are conducted on current source VSG converter. Under weak grid, the negative resistance eff ect caused by phase-locked loop (PLL) in the low frequency range makes system unstable in grid connection. To eliminate the negative resistance instability caused by PLL, a current source VSG GVF control resonance suppression method is established. SIM of this method and stability analysis are conducted. Secondly, a QAIR resonance suppression method for current source VSG converter is established. SIM of the method is conducted and stability analyzed. On the basis of above two methods, a composite resonance suppression method based on GVF and QAIR is established, and SIM and stability analysis are conducted. Simulation and experimental tests are conducted on the stability of GVF, QAIR, and GVF + QAIR composite resonance suppression current type VSG systems. The test results showed that the method based on GVF + QAIR resonance suppression is more eff ective, compared to GVF/QAIR resonance suppression method. Under weak grid, it has better ability to eliminate negative resistance eff ects and harmonic suppression caused by PLL, further improving grid-connected stability.
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Shao-rui Chen,Wen-ping Zhang,Jing-mei Bao,Zhong-bin Cheng,Sheng Yin 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.1
Aristoyunnolin H is a novel aristophyllenesesquiterpenoid isolated from the traditional Chinese medicineAristolochia yunnanensis Franch. The presentresearch was designed to explore the anti-fibrotic effects ofaristoyunnolin H in adult rat cardiac fibroblasts (CFs)stimulated with angiotensin II (Ang II). Western blotanalysis data showed that aristoyunnolin H reduced theupregulation of fibronectin (FN), connective tissue growthfactor and collagen I(Col I) production induced by Ang II inCFs. By studying the dynamic intracellular changes ofCa2?, we further found that while aristoyunnolin H relievedthe calcium influx, it has no effect on intracellular calciumstore release. Meanwhile, aristoyunnolin H also inhibitedthe Ang II-stimulated phosphorylation of Ca2?/calmodulindependentprotein kinase II. In conclusion, aristoyunnolin Hmay attenuate extracellular matrix secretion in vitro byinhibiting Ang II-induced calcium signaling.
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An Efficient Algorithm for Dynamic Shortest Path Tree Update in Network Routing
Xiao, Bin,Cao, Jiannong,Shao, Zili,Sha, Edwin H.M. The Korea Institute of Information and Commucation 2007 Journal of communications and networks Vol.9 No.4
Shortest path tree(SPT) construction is essential in high performance routing in an interior network using link state protocols. When some links have new state values, SPTs may be rebuilt, but the total rebuilding of the SPT in a static way for a large computer network is not only computationally expensive, unnecessary modifications can cause routing table instability. This paper presents a new update algorithm, dynamic shortest path tree(DSPT) that is computationally economical and that maintains the unmodified nodes mostly from an old SPT to a new SPT. The proposed algorithm reduces redundancy using a dynamic update approach where an edge becomes the significant edge when it is extracted from a built edge list Q. The average number of significant edges are identified through probability analysis based on an arbitrary tree structure. An update derived from significant edges is more efficient because the DSPT algorithm neglect most other redundant edges that do not participate in the construction of a new SPT. Our complexity analysis and experimental results show that DSPT is faster than other known methods. It can also be extended to solve the SPT updating problem in a graph with negative weight edges.
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Zhang, Shao-Kai,Guo, Lan-Wei,Chen, Qiong,Zhang, Meng,Liu, Shu-Zheng,Quan, Pei-Liang,Lu, Jian-Bang,Sun, Xi-Bin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Background and Aim: No firm evidence of HPV infection in esophageal cancer has been established to date. The aim of this meta-analysis was to investigate the prevalence of HPV 16 in esophageal cancer in China, which had a high burden of the disease. Materials and Methods: Studies on HPV infection and esophageal cancer were identified and a random-effects model was used to pool the summary prevalence and corresponding 95% confidence intervals (CIs). Results: A total of 3,429 esophageal cancer cases were evaluated from 26 eligible studies in this meta-analysis. The summary estimate for HPV16 prevalence was 0.381 (95% CI: 0.283, 0.479). The prevalence varied by geographical areas of the study, publication year, HPV detection method and types of specimen. In sensitivity analysis, HPV 16 prevalence ranged from 0.368 (95% CI: 0.276, 0.460) to 0.397 (95% CI: 0.286, 0.508). Conclusions: The results indicate a relatively high level of HPV 16 prevalence in esophageal cancer among Chinese population, although there was variation between different variables. Further studies are needed to elucidate the role of HPV in esophageal carcinogenesis with careful consideration of study design and laboratory detection method, providing more accurate assessment of the HPV status in esophageal cancer.
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